Dual AAV/IL-10 Plus STAT3 Anti-Inflammatory Gene Delivery Lowers Atherosclerosis in LDLR KO Mice, but without Increased Benefit by Maohua Cao, Junaid A. Khan, Bum-Yong Kang, Jawahar L. Mehta, Paul L. Hermonat

“…Both IL-10 and STAT3 are in the same signal transduction pathway, with IL-10-bound IL10 receptor (R) acting through STAT3 for anti-inflammatory effect. …”
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Bioinformatics Method Was Used to Analyze the Highly Expressed Gene FAM83A of Breast Cancer in Young Women by Yongzhe Tang, Hao Wang, Qi He, Yuanyuan Chen, Jie Wang

“…The active site of PLDc and the functional domain of DUF1669 can be involved in signal transduction and gene expression regulation in tumorigenesis and metastasis. …”
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Hydrogen Peroxide Is Involved in Salicylic Acid-Elicited Rosmarinic Acid Production in Salvia miltiorrhiza Cell Cultures by Wenfang Hao, Hongbo Guo, Jingyi Zhang, Gege Hu, Yaqin Yao, Juane Dong

“…These results indicated that H2O2 is secondary messenger for signal transduction, which can be induced by SA, significantly and promotes RA accumulation.…”
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Genome-Wide Identification of the ABC Gene Family in Rosaceae and Its Evolution and Expression in Response to Valsa Canker by Chenglong Du, Hongqiang Yu, Huanhuan Hu, Zhiqi Dou, Cunwu Zuo, Junqiang Niu

“…Gene ontology (GO) enrichment analysis indicated the involvement of ABC proteins in transmembrane transport and signal transduction pathways. Under <i>Valsa pyri</i> infection, most ABC genes were upregulated in the early stages, highlighting the role of ABCG genes in pathogen response. …”
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Transcriptome Analysis Reveals Complex Defensive Mechanisms in Salt-Tolerant and Salt-Sensitive Shrub Willow Genotypes under Salinity Stress by Dezong Sui, Baosong Wang

“…Compared to JW9-6, JW2372 contained more DEGs involved in the maintenance of the cell wall integrity, ABA, and ethylene signal transduction pathways. In addition, more DEGs encoding heat shock proteins were found in JW2372. …”
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Phylogeny-based comparative analysis of gene expression modulation upon drought stress across three cotton diploids by Tong Huan, Xinyu Zhang, Minghua Lv, Haotian Zhou, Yanyan Zhao, Dongliang Yu, Yuqiang Sun

“…Additionally, we identified 287 genes exhibiting similar regulatory responses to drought across species, highlighting pathways including starch and sucrose metabolism, chlorophyll catabolite degradation and synthesis, and hormone-mediated signal transduction. Notably, 16 transcription factors were identified as potential central regulators of the conserved stress response mechanisms. …”
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Differential Evolutionary Constraints in the Evolution of Chemoreceptors: A Murine and Human Case Study by Ricardo D’Oliveira Albanus, Rodrigo Juliani Siqueira Dalmolin, José Luiz Rybarczyk-Filho, Mauro Antônio Alves Castro, José Cláudio Fonseca Moreira

“…We have observed significant differences regarding the constraints on the orthologous groups and network topologies of chemoreceptors and signal transduction machinery. Our findings suggest that chemosensory receptor genes are less constrained than their signal transducing machinery, resulting in greater receptor diversity and conservation of information processing pathways. …”
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Swimming Exercise Alleviated Insulin Resistance by Regulating Tripartite Motif Family Protein 72 Expression and AKT Signal Pathway in Sprague-Dawley Rats Fed with High-Fat Diet by Jie Qi, Bo Yang, Cailing Ren, Jian Fu, Jun Zhang

“…These results suggest that an 8-week swimming exercise improves HFD-induced insulin resistance maybe through a reduction of TRIM72 in skeletal muscle and enhancement of AKT signal transduction.…”
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Constitutional Nephrin Deficiency in Conditionally Immortalized Human Podocytes Induced Epithelial-Mesenchymal Transition, Supported by β-Catenin/NF-kappa B Activation: A Consequen... by Gian Marco Ghiggeri, Maddalena Gigante, Armando Di Donato

“…The analysis of the main intracellular signal transduction pathways evidenced some major anomalies consequent with the nephrin abrogation. …”
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Bioinformatics analysis of miR-2861 and miR-5011-5p that function as potential tumor suppressors in colorectal carcinogenesis by Alper Aytekin, Hikmet Kadakal, Deniz Mihcioglu, Turkan Gurer

“…The GO and KEGG pathway analysis showed that miR-2861 and miR-5011-5p may participate in multiple the biological process, cellular components, and molecular function subcategories such as mitotic cell cycle, regulation of small GTPase mediated signal transduction, cell death, and acid binding transcription factor activity. …”
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Artificial molecular communication network based on DNA nanostructures recognition by Junke Wang, Mo Xie, Lilin Ouyang, Jinggang Li, Lianhui Wang, Chunhai Fan, Jie Chao

“…The developed DR-AMCN enhances our understanding of signal transduction mechanisms, dynamic processes, and regulatory networks in organisms, contributing to the solution of informatics and computational problems, as well as having potential in computer science, biomedical engineering, information technology and other related fields.…”
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Gut microbiota in the association between obesity and kidney function decline: a metagenomics-based study in a rat model by Akehu Alemasi, Lijiang Gu, Yilun Zhou

“…Functional analysis indicated that the gut microbiota in the HFD group primarily correlated with infectious diseases, signal transduction, and signaling molecules and interactions.Conclusions This study provides evidence that the consumption of a HFD induces modifications in the composition and functionality of the gut microbiome in rats, which may serve as a potential mechanism underlying the relationship between obesity and the progression of kidney function decline.…”
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Diacylglycerol kinase alpha regulates post-hepatectomy liver regeneration by Hiroki Nakamoto, Shunsuke Shichi, Chisato Shirakawa, Takuto Suzuki, Hidemitsu Kitamura, Akinobu Taketomi

“…Abstract Diacylglycerol kinases (DGKs) phosphorylate diacylglycerol to generate phosphatidic acid, which plays important roles in intracellular signal transduction. DGKα is reportedly associated with progression of tumors, including hepatocellular carcinomas, but its relationship with liver regeneration has not been examined. …”
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Cow milk αs1-casein induces allergic responses in a mouse model of atopy by Guangyu Wang, Xiaofeng Yu, Yanjun Cong, Linfeng Li

“…In conclusion, the levels of specific IgE, mast cell proteinase, histamine, IL-4, IL-5, IL-10 and some inflammatory factors could possibly serve as allergic biomarkers of αs1-casein, however, additional studies on signal transduction and gene expression are necessary in future.…”
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Protein Kinase Cα Modulates Estrogen-Receptor-Dependent Transcription and Proliferation in Endometrial Cancer Cells by Alicia M. Thorne, Twila A. Jackson, Van C. Willis, Andrew P. Bradford

“…Evidence suggests that PKCα and estrogen signal transduction pathways functionally interact, to modulate ER-dependent growth and transcription. …”
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SKIP Downregulation Increases TGF-β1-Induced Matrix Metalloproteinase-9 Production in Transformed Keratinocytes by Jelena Kocić, Victor Villar, Aleksandra Krstić, Juan F. Santibanez

“…Recently, Ski-interacting protein (SKIP) has been described as a regulator of TGF-β1 signal transduction, but its role in the induction of cell malignance by TGF-β1 has not been fully elucidated so far. …”
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Genetic approaches to the investigation of serotonergic neuron functions in animals by U. S. Drozd, E. V. Shaburova, N. N. Dygalo

“…Finally, the application of these genetic approaches in optogenetics and chemogenetics provided a new resource for studying the functions, discharge activity, and signal transduction of serotonergic neurons. Nevertheless, the advantages and limitations of the discussed genetic approaches should be taken into consideration in the course of creating models of pathological conditions and developing pharmacological treatments for their correction.…”
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Triptolide Inhibits Th17 Response by Upregulating microRNA-204-5p and Suppressing STAT3 Phosphorylation in Psoriasis by Qi He, Xingyue Wu, Quan Shi

“…The combination between microRNA-204-5p (miR-204-5p) and signal transduction and transcription activator-3 (STAT3) was confirmed by luciferase reporter assay. …”
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BMSCs Interactions with Adventitial Fibroblasts Display Smooth Muscle Cell Lineage Potential in Differentiation and Migration That Contributes to Neointimal Formation by Y. Wendan, J. Changzhu, S. Xuhong, C. Hongjing, S. Hong, Y. Dongxia, X. Fang

“…Our results indicate that the pathogenesis of vascular remodeling might perform via TGF-β1/Smad3 signal transduction pathways.…”
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Promising horizons in achondroplasia along with the development of new drugs by Keiichi Ozono, Takuo Kubota, Toshimi Michigami

“…The downstream signal transduction of FGFR3 consists of STAT1 and RAS/RAF/MEK/ERK pathways. …”
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