Mycobacterium avium Complex Infection in a Patient with Sickle Cell Disease and Severe Iron Overload by Kamal Shemisa, Nasima Jafferjee, David Thomas, Gretta Jacobs, Howard J. Meyerson

“…An appreciable number of mycobacterial infection cases have been reported in sickle cell disease patients without immune dysfunction. …”
Get full text

Perceptions and Practice of Early Diagnosis of Sickle Cell Disease by Parents and Physicians in a Southwestern State of Nigeria by Oladele Simeon Olatunya, Adefunke Olarinre Babatola, Ezra Olatunde Ogundare, Babatunde Ajayi Olofinbiyi, Olubunmi Adeola Lawal, Jacob Olumuyiwa Awoleke, Olusola Peter Aduloju, Alaba Olanrewaju Daramola, Eyitayo Ebenezer Emmanuel, Oyebanji Anthony Olajuyin, Akinwumi Kolawole Komolafe, Abiola Olukayode Olaleye

“…Background. Early sickle cell disease (SCD) diagnosis has shown promise in combating SCD in many countries. …”
Get full text

Benchmarking Pain Outcomes for Children with Sickle Cell Disease Hospitalized in a Tertiary Referral Pediatric Hospital by Abi Vijenthira, Jennifer Stinson, Jeremy Friedman, Lori Palozzi, Anna Taddio, Dennis Scolnik, Charles Victor, Melanie Kirby-Allen, Fiona Campbell

“…BACKGROUND: Painful vaso-occlusive crisis (VOC) is the most common reason for hospitalization in children with sickle cell disease.…”
Get full text

Attitudes toward Management of Sickle Cell Disease and Its Complications: A National Survey of Academic Family Physicians by Arch G. Mainous, Rebecca J. Tanner, Christopher A. Harle, Richard Baker, Navkiran K. Shokar, Mary M. Hulihan

“…Objective. Sickle cell disease (SCD) is a disease that requires a significant degree of medical intervention, and family physicians are one potential provider of care for patients who do not have access to specialists. …”
Get full text

Profiles of systemic lupus erythematosus patients with co-existing sickle cell disease: a coincidence or true association? by Hakeem Babatunde Olaosebikan, Etseoghena Igebu, Adebukola Khairat Orolu, Gbenga Joshua Odunlami, Ilo Azizat Bamisebi, Akin Dada, Ebele Uche, Olufemi Adelowo

Subjects: Get full text

High Healthcare Utilization in Adolescents with Sickle Cell Disease Prior to Transition to Adult Care: A Retrospective Study by Julie Kanter, Menaka Bhor, Xin Li, Frank Li, Jincy Paulose

“…**Background:** The transition from pediatric to adult care in the US is often difficult for individuals with sickle cell disease (SCD). Young adults (18 to 25 years of age) have higher acute care utilization and an increased risk of poor outcomes. …”
Get full text

Assessment of healthcare workers’ knowledge and availability of resources for sickle cell disease management in Bukavu, Democratic Republic of the Congo by Nash Mwanza Nangunia, Olivier Mukuku, Viviane Bianga Feza, Yves Mulindilwa Kyembwa, Théophile Barhwamire Kabesha, André Kabamba Mutombo, Stanislas Okitostho Wembonyama

Subjects: “…Sickle Cell Disease…”
Get full text

Base editing HbS to HbG-Makassar improves hemoglobin function supporting its use in sickle cell disease by Zachary Kostamo, Manuel A. Ortega, Chavonna Xu, Patricia R. Feliciano, Elizabeth Budak, Daisy Lam, Valerie Winton, Rebecca Jenkins, Archita Venugopal, Margaret Zhang, John Jamieson, Brent Coisman, Kennedy Goldsborough, Britney Hernandez, Celeste K. Kanne, Erica N. Evans, Jordan Zgodny, Yankai Zhang, Jawa Darazim, Ashwin Patel, Michael A. Pendergast, John Manis, Adam J. Hartigan, Giuseppe Ciaramella, Seung-Joo Lee, S. Haihua Chu, Vivien A. Sheehan

Get full text

Evaluation of Vaso-occlusive Crises in United States Sickle Cell Disease Patients: A Retrospective Claims-based Study by Nirmish Shah, Menaka Bhor, Lin Xie, Steve Arcona, Rashid Halloway, Jincy Paulose, Huseyin Yuce

“…Sickle cell disease (SCD) is a life-threatening vascular disease that burdens affected persons physically. …”
Get full text

Associations between disease severity, depression, health-related quality of life, and physical activity in adults with sickle cell disease by Adekola B. Ademoyegun, Mutiu A. Adeyemo, Babatunde Y. Adewuyi, Adebukola G. Ibitoye, Olalekan I. Akerele, Taofeek O. Awotidebe, Chidozie E. Mbada

“…Abstract Background Individuals with sickle cell disease (SCD) are faced with a plethora of challenges that affect their quality of life, mood, and physical and social participation. …”
Get full text

Sickle Cell Disease Activates Peripheral Blood Mononuclear Cells to Induce Cathepsins K and V Activity in Endothelial Cells by Philip M. Keegan, Sindhuja Surapaneni, Manu O. Platt

“…Sickle cell disease is a genetic disease that increases systemic inflammation as well as the risk of pediatric strokes, but links between sickle-induced inflammation and arterial remodeling are not clear. …”
Get full text

A Child as a Donor for Hematopoietic Stem Cell Transplantation: Bioethical Justification—A Case Study on Sickle Cell Disease by Andrea Z. Pereira, Ricardo Hellman, Nelson Hamerschlak, Andrea Kondo, Polianna Mara Rodrigues de Souza, Wilson Leite Pedreira, Luiz Fernando Alves Lima Mantovani, Eduardo Juan Troster, Henrique Grunspun, Marco Aurélio Scarpinella Bueno

“…Hematopoietic stem cell transplantation (HSCT) is an important treatment option for children with severe and refractory sickle cell disease (SCD) with debilitating clinical complications. …”
Get full text

Effectiveness of implementation of sickle cell disease referral guidelines and other measures in paediatric department at a tertiary hospital in Saudi Arabia by Muhammad Matloob Alam, Abdulrhman Alathaibi, Hamdan Alghamdi, Jean Barrientos De Asis, Reynan Bautista, Mansour Aladwani, Mustafa Mohamed Selim

“…Background Sickle cell disease (SCD) is an autosomal recessive genetic blood disorder. …”
Get full text

Association Between Vaso-Occlusive Crises and Opioid Prescriptions Among Patients with Sickle Cell Disease: A Retrospective Claims-Based Study by Hyeun Ah Kang, Jamie C. Barner, Kristin M. Richards, Menaka Bhor, Jincy Paulose, Abdullah Kutlar

“…**Background/Objectives:** Among sickle cell disease (SCD) patients, vaso-occlusive crises (VOCs) are recurrent and unpredictable attacks of acute pain. …”
Get full text

The added role of Doppler ultrasound evaluation of sickle cell disease vasculopathy as a state of arterial stiffness and decreased nitric oxide bioavailability by Marwa Mohammed Mohammed Onsy, Sonia Ali El-Saiedi, Douaa Mohammed Mohammed Elsheshtawy, Marwa Abd-Elhady Abd-Elsamad

“…Abstract Background Sickle cell disease is an inherited hemoglobinopathy resulting in chronic hemolysis and painful vaso-occlusive crises. …”
Get full text

Elevated Circulating Angiogenic Progenitors and White Blood Cells Are Associated with Hypoxia-Inducible Angiogenic Growth Factors in Children with Sickle Cell Disease by Solomon F. Ofori-Acquah, Iris D. Buchanan, Ifeyinwa Osunkwo, Jerry Manlove-Simmons, Feyisayo Lawal, Alexander Quarshie, Arshed A. Quyyumi, Gary H. Gibbons, Beatrice E. Gee

Get full text

Effect of empowerment-based interventions on self-efficacy and self-care capacity among patients with sickle cell disease: A randomized controlled trial by Zohour Ibrahim Rashwan, Hasan Abdali Khalil, Leena Mohamed Khonji, Gayathripriya Narayanan, Marwan Kamal Altheeb, Roseben Pradeep, Rajeswari Krishnasamy, Magda Mohamed Bayoumi

Subjects: Get full text

A pilot randomized controlled trial of the iPeer2Peer program in adolescents with sickle cell disease: A mixed method study by Lauren Kelenc, Brittany Wiles, Fareha Nishat, Chitra Lalloo, Anya Nair, Craig Eling, Melanie Kirby-Allen, Ewurabena Simpson, Roona Sinha, Richard Ward, William T. Zempsky, Sara Ahola Kohut, Jennifer N. Stinson

Subjects: Get full text

Dissemination of Evidence-Based Recommendations for Sickle Cell Disease to Primary Care and Emergency Department Providers in North Carolina: A Cost Benefit Analysis by Paula Tanabe, Audrey L. Blewer, Emily Bonnabeau, Hayden B. Bosworth, Denise H. Clayton, Nancy Crego, Marian F. Earls, Kern Eason, Grayson Forlines, Gary Rains, Matthew Young, Nirmish Shah

“…**Background:** Sickle cell disease (SCD) is a genetic condition affecting primarily individuals of African descent, who happen to be disproportionately impacted by poverty and who lack access to health care. …”
Get full text

Pentazocine Misuse among Sickle Cell Disease Patients and The Role of Lack of Enforcement of Opioid Dispensing Regulations by Community Pharmacies: A Descriptive Observational Study by Oluomachi Charity Nnachi, Chinedu Obasi Akpa, Favour Ogonna Nwani, Oghenevwogaga Obukohwo Edenya

“…Introduction. Sickle cell disease (SCD) is a chronic disease characterized by debilitating bone pains which commonly necessitate the use of analgesic drugs including opioids and psychotropic substances such as pentazocine which are controlled medicines in Nigeria. …”
Get full text