Blood-based epigenome-wide association study and prediction of alcohol consumption by Elena Bernabeu, Aleksandra D. Chybowska, Jacob K. Kresovich, Matthew Suderman, Daniel L. McCartney, Robert F. Hillary, Janie Corley, Maria Del C. Valdés-Hernández, Susana Muñoz Maniega, Mark E. Bastin, Joanna M. Wardlaw, Zongli Xu, Dale P. Sandler, Archie Campbell, Sarah E. Harris, Andrew M. McIntosh, Jack A. Taylor, Paul Yousefi, Simon R. Cox, Kathryn L. Evans, Matthew R. Robinson, Catalina A. Vallejos, Riccardo E. Marioni

“…We explore the effect of pre-filtering for CpG features ahead of elastic net, as well as differential patterns by sex and by units consumed in the last week relative to an average week. …”
Get full text

Addressing the Teen Mom Situation in Thailand: A Systematic Review on Challenges, Initiatives and Recommendations for Improvement by Jukkrit Wungrath, Phinphot Phrommasen, Wanchalerm Ritthimon

“…This review highlights the need for comprehensive sex education, improved access to contraception, youth-friendly sexual and reproductive health services, and targeted support programs for teenage mothers, emphasizing a multi-sectoral approach involving government agencies, Non-Governmental Organizations (NGOs), educational institutions, healthcare providers, and communities. …”
Get full text

Oral pre-exposure prophylaxis implementation in South Africa: a case study of USAID-supported programs by Jerome Wendoh Milimu, Lauren Parmley, Mahlodi Matjeng, Mathata Madibane, Mandisi Mabika, Jacques Livingston, Joseph Lawrence, Orapeleng Motlhaoleng, Hasina Subedar, Rethabile Tsekoa, Zandile Mthembu

“…(vi) USAID-supported PrEP initiations have been highest among females of reproductive age in the general population and men who have sex with men among key populations, priority populations in South Africa. …”
Get full text

The association between stress-induced hyperglycemia ratio and cardiovascular events as well as all-cause mortality in patients with chronic kidney disease and diabetic nephropathy by Boning Cao, Zhendong Guo, Dan-Ting Li, Le-Ying Zhao, Zhen Wang, Ya-Bin Gao, Yao-Xian Wang

“…Model 1 did not account for any covariates, Model 2 adjusted for age, sex, and race, while Model 3 additionally incorporated adjustments for educational attainment, marital status, body mass index, smoking behavior, hypertension, hyperlipidemia, and cardiovascular disease. …”
Get full text

‘It is scary to pause treatment’: perspectives on HIV cure-related research and analytical treatment interruptions from women diagnosed during acute HIV in Durban, South Africa: So... by Deli Mthimkhulu, Krista L. Dong, Mzwakhe Wiseman Ngcobo, Deborah Mindry, Ayanda Zulu, Ntombifuthi Langa, Luyanda Maphalala, Vanessa Pillay, Maud Mthembu, Annie Miall, Whitney Tran, Ana Dillen, Fang Wan, Ali Ahmed, Jamila K. Stockman, Maryam Hussain, Thumbi Ndung’u, Karine Dubé

“…Trust in the research team and close monitoring were seen as positive factors, while fears around sharing of HIV/ATI status and transmission to sex partners complicated decision-making. Participants expressed a need for psychological counseling and access to community resources to manage ATI-related stressors. …”
Get full text

Assessment of Attentional Functioning in Health Professionals of a Brazilian Tertiary Referral Hospital for COVID-19 by Eelco van Duinkerken, Guilherme J. Schmidt, Ana Lúcia Taboada Gjorup, Carolina Ribeiro Mello, André Casarsa Marques, Áureo do Carmo Filho, Paula Regina Yuri Fukusawa, Simone Gonçalves de Assis, Júlio Cesar Tolentino, Sergio L. Schmidt

“…A MANCOVA was performed to examine between-group differences, using age, sleep quality, sex, education level, previous COVID-19 infection, and profession as covariates. …”
Get full text

MET-PREVENT: metformin to improve physical performance in older people with sarcopenia and physical prefrailty/frailty – protocol for a double-blind, randomised controlled proof-of... by Andrew Clegg, James Wason, Miles Witham, Nina Wilson, Claire J Steves, Helen C Hancock, Avan A P Sayer, Leanne Marsay, Claire McDonald, Thomas von Zglinicki, Katherine J Rennie, Penny Bradley, Stephen Connolly, Shaun Hiu, Laura Robertson, Laura Simms, Alison J Steel, Bryony Storey

“…Randomisation will be performed using a web-based minimisation system with a random element, balancing on sex and baseline walk speed. Participants will be followed up for 4 months post-randomisation, with outcomes collected at baseline and 4 months. …”
Get full text

Relationship Among Macronutrients, Dietary Components, and Objective Sleep Variables Measured by Smartphone Apps: Real-World Cross-Sectional Study by Jaehoon Seol, Masao Iwagami, Megane Christiane Tawylum Kayamare, Masashi Yanagisawa

“…Models were adjusted for age, sex, and BMI. ResultsGreater protein intake was associated with longer TST in the third (+0.17, 95% CI 0.09-0.26 h) and fourth (+0.18, 95% CI 0.09-0.27 h) quartiles. …”
Get full text

Kidney failure-related excess mortality during the first three years of the COVID-19 pandemic in the United States: a nation-wide, population-based analysis by Zhenhu Chen, Pingping Jia, Di Xie, Jingyu Xie, Juan Liu, Wangnan Cao, Lefei Han, Jinjun Ran, Shengzhi Sun, Shi Zhao, Yang Ge, Leonardo Martinez, Xin Chen, Peihua Cao

“…Additionally, disparities in mortality were evident among various demographic groups, including age, sex, racial/ethnic subgroups, and geographic regions. …”
Get full text

Mental health phenotypes of well-controlled HIV in Uganda by Leah H. Rubin, Leah H. Rubin, Leah H. Rubin, Leah H. Rubin, Kyu Cho, Jacob Bolzenius, Julie Mannarino, Rebecca E. Easter, Raha M. Dastgheyb, Aggrey Anok, Stephen Tomusange, Deanna Saylor, Maria J. Wawer, Noeline Nakasujja, Gertrude Nakigozi, Robert Paul

“…Inferential statistics compared select demographic (age, sex, education), viral load, and early life adversity between clusters.ResultsWe identified four MH phenotypes. …”
Get full text

Plasma C1q/TNF-Related Protein-9 Levels Are Associated with Atherosclerosis in Patients with Type 2 Diabetes without Renal Dysfunction by Mariko Asada, Tomoaki Morioka, Yuko Yamazaki, Yoshinori Kakutani, Reina Kawarabayashi, Koka Motoyama, Katsuhito Mori, Shinya Fukumoto, Atsushi Shioi, Tetsuo Shoji, Masanori Emoto, Masaaki Inaba

“…Multivariate analyses revealed that plasma CTRP9 levels were positively associated with carotid IMT in the non-CKD group, independent of age, sex, body mass index, adiponectin, and other cardiovascular risk factors. …”
Get full text

Associations between Prospective Memory, Executive Function and Physical Activity in Schoolchildren by Anouk Irina Glättli, Markus Gerber, Sebastian Ludyga

“…Results Partial correlations that controlled for age and sex showed that higher MVPA (recorded from subjective and objective assessments) was associated with higher accuracy on the prospective memory task. …”
Get full text

Role of the Specialized Proresolving Mediator Resolvin D1 in Systemic Lupus Erythematosus: Preliminary Results by Luca Navarini, Tiziana Bisogno, Domenico Paolo Emanuele Margiotta, Alessandra Piccoli, Silvia Angeletti, Alice Laudisio, Massimo Ciccozzi, Antonella Afeltra, Mauro Maccarrone

“…Thirty patients with SLE and thirty age- and sex-matched healthy subjects (HSs) have been consecutively recruited at Campus Bio-Medico University Hospital. …”
Get full text

Proteomics unveil candidate biomarkers and pathogenesis of subacute thyroiditis by Litong Ran, Xiufei Liu, Yongfeng Tian, Jiaran Zhu, Zhengyuan Gong, Qiao Qiao, Xin Jiang, Yuren Wang, Guojun Yang, Hongting Zheng, Yi Zheng, Hua Qu

“…Moreover, the top three high-abundance proteins (nicotinamide N-methyltransferase (NNMT), FTL and thymidine phosphorylase (TYMP)) were further validated in the plasma from a larger SAT cohort using an enzyme-linked immunosorbent assay. After adjusting for sex, Spearman correlation analysis showed that NNMT, FTL and TYMP levels were positively correlated with FT3, FT4, T3, T4, Tg and erythrocyte sedimentation rate and negatively correlated with thyroid-stimulating hormone. …”
Get full text

Use of thymidine kinase 1 autoantibody, thymidine kinase antigen, extracellular protein kinase A autoantibody, and C‐reactive protein for early detection of malignant tumors in dog... by Yoonhee Kim, Wonhee Lee, Byunggak Kim, Bonghwan Jang, Kyung‐Rok Yu, Hong Sook Kim, Minok Ryu, Yein Oh, Kyoungwon Seo, Chul Park, Ulsoo Choi, Dongha Bhang, Hwayoung Youn

“…Objectives To investigate the most optimal model by combining thymidine kinase 1 (TK1) autoantibody, extracellular protein kinase A (ECPKA) autoantibody, TK1 antigen, C‐reactive protein (CRP), age, breed, and sex. Animals Serum samples from 1702 dogs were collected from local animal hospitals and referral animal medical centers in Korea. …”
Get full text

Comparative study of mouse models of atopic dermatitis by Siqi Ye, Lian Zhu, Tao Ruan, Jinjing Jia, Xiumei Mo, Fenggen Yan, Junfeng Liu, Yu Zhang, Dacan Chen

“…We summarized and compared 614 articles, including details on mouse strains, sex, age, irritants, modeling cycles, and spontaneous mouse models. …”
Get full text

Diagnostic Accuracy of Non-Invasive Diagnostic Tests for Nonalcoholic Fatty Liver Disease: A Systematic Review and Network Meta-Analysis by Sun Y, Hu D, Yu M, Liang SB, Zheng Y, Wang X, Tong G

“…The participants included patients with suspected or confirmed NAFLD, irrespective of age, sex, ethnicity. Statistical analysis was conducted using R 4.0.3 for Bayesian NMA and STATA 17.0 for pairwise meta-analysis. …”
Get full text

Risk factors for ocular biological parameters in Chinese preschool children: a cohort study from the Beijing whole childhood eye study by Xi Qin, Yunyun Sun, Yunyun Sun, Shana Wang, Xiaolan Xie, Lei Gao, Huijian Li, Huijian Li, Ruihua Wei, Jing Fu, Jing Fu, Bidan Zhu

“…One-way analysis of variance, univariate analysis, and multiple linear regression models (with age, sex, height, weight, parental myopia, continuous near-work time, electronic products use, and outdoor activity time as variables) were used to compare the effects of different variables on the AL, CR, and AL/CR ratio.ResultsOverall, 1,353 participants (708 boys; mean age, 4.37 ± 0.82 years) were included in this study. …”
Get full text

Human-Centered Design of an mHealth Tool for Optimizing HIV Index Testing in Wartime Ukraine: Formative Research Case Study by Nancy Puttkammer, Elizabeth Dunbar, Myroslava Germanovych, Mariia Rosol, Matthew Golden, Anna Hubashova, Vladyslav Fedorchenko, Larisa Hetman, Liudmyla Legkostup, Jan Flowers, Olena Nesterova

“…The study involved 3 steps: formative HCD, including in-depth individual interviews with clients, such as men who have sex with men and people who inject drugs, and internet-based design workshops with HCWs from rural and urban HIV clinics in Chernihiv and Dnipro; software platform assessment and heuristic evaluation, including assessment of open-source mHealth platforms against CASI-Plus requirements, prototype development, and testing of the REDCap (Research Electronic Data Capture) prototype based on usability heuristics; and usability walk-throughs, including simulated cases with HCWs and clients. …”
Get full text

Gambaran Faktor Risiko dan Tipe Stroke pada Pasien Rawat Inap di Bagian Penyakit Dalam RSUD Kabupaten Solok Selatan Periode 1 Januari 2010 - 31 Juni 2012 by Cintya Agreayu Dinata, Yuliarni Safrita Safrita, Susila Sastri

“…<br />Kata kunci: stroke ischemic, stroke hemorrhagic, faktor risiko stroke<br />Abstract<br />Stroke is a disease caused by disorder of brain blood circulation with many risk factors that contribute in this disease, consist of non modifiable risk factor including age and sex and modifiable risk factors example hypertension, high glucose level, dyslipidemia, and jobs. …”
Get full text