Evaluation of Digital PCR as a Technique for Monitoring Acute Rejection in Kidney Transplantation by Hyeseon Lee, Young-Mi Park, Yu-Mee We, Duck Jong Han, Jung-Woo Seo, Haena Moon, Yu-Ho Lee, Yang-Gyun Kim, Ju-Young Moon, Sang-Ho Lee, Jong-Keuk Lee

“…Our results further showed that autosomal, sex-specific, and mitochondrial SNPs were suitable markers for identifying donor cfDNA. …”
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Association between Metformin and a Lower Risk of Age-Related Macular Degeneration in Patients with Type 2 Diabetes by Yu-Yen Chen, Ying-Cheng Shen, Yun-Ju Lai, Chun-Yuan Wang, Keng-Hung Lin, Shih-Chao Feng, Chiao-Ying Liang, Li-Chen Wei, Pesus Chou

“…Confounders included for adjustment were age, sex, and comorbidities (hypertension, hyperlipidemia, coronary artery disease, obesity, diabetic retinopathy, chronic kidney disease, and insulin treatment). …”
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A Retrospective Study in Trans Individuals Undergoing Gender Affirming Testosterone Treatment: Can Changes in Prolactin Counteract the Negative Effects on the Lipid Profile? by Jojo Steininger, Katalin Widmann, Ulrike Kaufmann, Marlene Hager, Rodrig Marculescu, Robert Krysiak, Johannes Ott

“…Blood lipids, PRL, and sex steroid hormone levels were evaluated prior to and at 10–14 months after treatment started. …”
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Predictors of direct oral anticoagulant concentrations in the trauma population by Laura Adams, Alan M Smith, Louis Perkins, Dmitri Lerner, Jarrett Santorelli, Leslie Kobayashi

“…In total, 39% of patients had therapeutic and 20% had supratherapeutic anti-Xa levels. Female sex, increased age, decreased height and weight, and lower estimated creatinine clearance were associated with higher anti-Xa levels at admission. …”
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Tear film lipid layer thickness and blink dynamics in patients with blepharospasm by Ji-Sun Paik, Min Jeong Kwon, Ga Hee Nam, Kyungdo Han, Woong-Joo Whang, Ho Sik Hwang, Suk-Woo Yang, Hyun-Seung Kim, Kyung Sun Na, Won-Kyung Cho

“…Results Each 28 eyes from 28 patients with BEB and age- and sex-matched patients with DED were included. When comparing blink dynamics, complete blink rate was significantly higher in the pre-injection BEB group compared to the DED group (5.25 ± 4.32 times/20 s vs. 2.43 ± 2.82 times/20 s, p = 0.0055). …”
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Associations of macrosomia with sociodemographic, anthropometric, lifestyle factors and perinatal outcomes in Southwest Nigeria by Ikeola A. Adeoye, Joshua I. Fakorede, Mobolaji M. Salawu, Kofoworola I. Adediran

“…On bivariate analysis parity (p = 0.009), maternal age (p = 0.012), history of macrosomia (0.021), consumption of protein-rich diets with non-alcoholic beverages (p = 0.021), sex of infants (p = 0.018), and engagement in physical activity (p = 0.036) were significantly associated with macrosomia. …”
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Global, regional, and national disease burden attributable to high systolic blood pressure in youth and young adults: 2021 Global Burden of Disease Study analysis by Chuan He, Saien Lu, Haijie Yu, Yingxian Sun, Xueyao Zhang

“…Therefore, targeted measures are needed to counter the trends in HSBP-related diseases and reduce disparities across regions and sexes.…”
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Time in Range, as a Novel Metric of Glycemic Control, Is Reversely Associated with Presence of Diabetic Cardiovascular Autonomic Neuropathy Independent of HbA1c in Chinese Type 2 D... by Qingyu Guo, Pu Zang, Shaoying Xu, Wenjing Song, Zhen Zhang, Chunyan Liu, Zhanhong Guo, Jing Chen, Bin Lu, Ping Gu, Jiaqing Shao

“…The logistic regression was applied to analyze the relationship between TIR and CAN by adjusting for the age, duration of diabetes, sex, lipid situation, serum creatinine, body mass index, blood pressure, HbA1c (%), and other glycemic variability (GV) metrics. …”
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Efecto de una intervención Act sobre la resistencia aeróbica y evitación experiencial en marchistas / Effect of an ACT Intervention on Aerobic Endurance and Experiential Avoidance... by María Clara Rodríguez-Salazar, Ángela Patricia Valero-Ballesteros

“…The sample consisted of ten walkers of either sex, with an average age of 16.70 years, and a range between 15 and 20 years old, belonging to the Bogotá Athletics League. …”
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Biological and psychosocial factors associated with the persistence of pruritus symptoms: protocol for a prospective, exploratory observational study in Germany (individual project... by Sonja Ständer, Stefan W Schneider, Gudrun Schneider, Stefan Kahnert, Manuel Pedro Pereira, Christian Mess, Volker Huck, Konstantin Agelopoulos, Gina Frank

“…Within 1 year, patients and 80 age-matched and sex-matched healthy controls will be examined at three time points, allowing cross-sectional comparison and a longitudinal investigation of predictive outcome factors in patients under treatment according to existing guidelines.Ethics and dissemination The study has been approved by the ethics committees of Hamburg (2020-10200-BO-ff) and Münster (2020-676 f-S), Germany. …”
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Predictors of biochemical and structural response to medical therapy in patients with active acromegaly following surgery: a real-world perspective by Maryam Rafieemanesh, Manizhe Ataee Kachuee, Ali Zare Mehrjardi, Alireza Khajavi, Mohammad Ghorbani, Mohammad Reza Mohajeri-Tehrani, Nahid Hashemi-Madani, Mohammad E. Khamseh

“…Moreover, 51.4% of the patients showed a structural response. Applying the age-sex adjusted model, post-operative IGF-1 was inversely associated with TBR [OR 0.34, P = 0.006] and BC [OR 0.30, P = 0.004]. …”
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Factors Responsible For School Dropout At Different Levels of Education in Selected Academic Institutions in Kisoro Municipality Southern Division Kisoro District. by Kamahoro, Phionah

“…The study findings showed that the remedies or possible measures to address the problem of dropout may include introducing alternative forms of education as reported by 46(21 % ), re-organizations of school systems 23(10% ), investing and improving in quality of schooling 55(25%), enactment of various national laws 32914%), strengthening the USE program 40(18%) and sex education 26(12%). The researcher concluded that in Kisoro municipality there are rampant cases of school dropouts as evidenced by the research findings from the field. …”
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Habitual alcohol consumption associated with reduced semen quality and changes in reproductive hormones; a cross-sectional study among 1221 young Danish men by Anders Juul, Niels Jørgensen, Niels E Skakkebæk, Shanna H Swan, Tina Kold Jensen, Mads Gottschau, Jens Otto Broby Madsen, Anne-Maria Andersson, Tina Harmer Lassen, Lærke Priskorn

“…Total alcohol consumption: (1) in the week preceding (habitual/typical) the visit (recent alcohol intake), (2) in a typical week and (3) frequency of ‘binge drinking’ (consuming more than 5 units/day)) in the past 30 days was estimated.Main outcome measures Semen quality (volume, sperm concentration, total sperm count, and percentages of motile and morphologically normal spermatozoa) and serum concentration of reproductive hormones (follicle-stimulating hormone, luteinising hormone, testosterone, sex hormone binding globulin, oestradiol, free testosterone and inhibin B).Results Sperm concentration, total sperm count and percentage of spermatozoa with normal morphology were negatively associated with increasing habitual alcohol intake. …”
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Clinical outcomes of COVID-19 in patients with liver cirrhosis - a propensity-matched analysis from a multicentric Brazilian cohort by Luanna Silva Monteiro Menezes, Pedro Ferrari Sales da Cunha, Magda Carvalho Pires, Lucas Rocha Valle, Flávia Carvalho Cardoso Costa, Maria Angélica Pires Ferreira, Milton Henriques Guimarães Júnior, Saionara Cristina Francisco, Marcelo Carneiro, Daniel Vitório Silveira, Fernando Graça Aranha, Rafael Lima Rodrigues de Carvalho, Teresa Cristina de Abreu Ferrari, Milena Soriano Marcolino

“…A propensity score model was used to adjust for potential confounding variables, incorporating some predictors: age, sex at birth, number of comorbidities, hospital of admission, whether it was an in-hospital clinical manifestation of COVID-19, and admission year. …”
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Short-acting beta agonist, antibiotics, oral corticosteroid and association with mortality and cardiopulmonary events in patients with COPD: a retrospective cohort study in Alberta... by Mohit Bhutani, Irvin Mayers, Arsh Randhawa, Manisha Talukdar, Suzanne McMullen, Phongsack Manivong, Aaron Gelfand

“…Objective The purpose of the study was to examine the association between short-acting beta agonist (SABA), antibiotic and oral corticosteroid (OCS) use and mortality and cardiopulmonary outcomes in chronic obstructive pulmonary disease (COPD).Design Retrospective cohort study using administrative health data from 1 April 2011 to 31 March 2020.Setting Alberta, Canada.Participants Patients ≥35 years old with COPD were identified using diagnostic codes.Primary and secondary outcome measures Patient characteristics included age, sex, geographical zone and comorbidities (as defined by the Charlson Comorbidity Index). …”
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Are noise and air pollution related to the incidence of dementia? A cohort study in London, England by Derek G Cook, Frank J Kelly, Iain M Carey, H Ross Anderson, David P Strachan, Richard W Atkinson, Sean D Beevers, David Dajnak, John Gulliver

“…HRs from Cox models were adjusted for age, sex, ethnicity, smoking and body mass index, with further adjustments explored for area deprivation and comorbidity.Results 2181 subjects (1.7%) received an incident diagnosis of dementia (39% mentioning Alzheimer’s disease, 29% vascular dementia). …”
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Diagnostic Capability of Pattern Electroretinogram and Three Circumpapillary Retinal Nerve Fiber Layer Thickness Circle Diameter Scans in Glaucoma Suspects by Tirsi A, Tsai J, Abizadeh A, Kacaj D, Procyk O, Gliagias V, Leung N, Yang H, Park SC, Tello C

“…Independent t-test and areas under the receiver operating characteristic curve (AUC) were obtained to determine the diagnostic capability of PERG and OCT.Results: Independent t-test revealed significant differences between controls and GS in age, sex, central corneal thickness (CCT), all PERG parameters, and global RNFLT (gRNFLT) in three circle diameters. …”
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A LASSO-derived clinical score to predict severe acute kidney injury in the cardiac surgery recovery unit: a large retrospective cohort study using the MIMIC database by Qi Guo, Jingjing Huang, Yuewei Li, Hongwei Li, Jingfeng Wang, Yong Xie, Tucheng Huang, Wanbing He, Wenyu Lv, Jieping Huang, Yangxin Chen

“…Objectives We aimed to develop an effective tool for predicting severe acute kidney injury (AKI) in patients admitted to the cardiac surgery recovery unit (CSRU).Design A retrospective cohort study.Setting Data were extracted from the Medical Information Mart for Intensive Care (MIMIC)-III database, consisting of critically ill participants between 2001 and 2012 in the USA.Participants A total of 6271 patients admitted to the CSRU were enrolled from the MIMIC-III database.Primary and secondary outcome Stages 2–3 AKI.Result As identified by least absolute shrinkage and selection operator (LASSO) and logistic regression, risk factors for AKI included age, sex, weight, respiratory rate, systolic blood pressure, diastolic blood pressure, central venous pressure, urine output, partial pressure of oxygen, sedative use, furosemide use, atrial fibrillation, congestive heart failure and left heart catheterisation, all of which were used to establish a clinical score. …”
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The Association of Autoimmune Diseases with Type 1 Diabetes Mellitus in Children Depends Also by the Length of Partial Clinical Remission Phase (Honeymoon) by Gulsum Ozen, Angela Zanfardino, Santino Confetto, Alessia Piscopo, Francesca Casaburo, Nadia Tinto, Fernanda Iafusco, Gulsah Ozen, Emanuele Miraglia del Giudice, Medine Aysin Tasar, Arzu Yilmaz, Dario Iafusco

“…Our results showed that younger age at the onset of Type 1 DM in children, predicts Celiac Disease. Female sex and low HCO3 levels at the onset of DM had a high predictive value on patients who did not experience longer Partial Clinical Remission phase. …”
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Retrospective cross-sectional study on bronchiectasis in adult Aboriginal Australians: disease characteristics and comparison with ethnically diverse global bronchiectasis registry... by Timothy Howarth, Subash Heraganahally, Claire Gibbs, Lata Jayaram, Asanga Abeyaratne, Shiidheshwar J Ravichandran, Davaadorj Erdenebayar, Winnie Chen, Hubertus Jersmann

“…In comparison with international and non-Aboriginal Australian national cohorts, Aboriginal Australians were younger (median 56 years (IQR (48, 65)); however, sex distribution (55% female) and body mass index (23 kg/m2 (IQR 19.4–27)) were comparable . …”
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