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1961
Metagenomics: a new frontier for routine pathology testing of gastrointestinal pathogens
Published 2025-01-01“…With the development of newer sequencing assays, it is now feasible to test for a wide range of target organisms in a sample using a single mNGS test. …”
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Article -
1962
The N‐terminal domain of gasdermin D induces liver fibrosis by reprogrammed lipid metabolism
Published 2025-01-01“…We analyzed differentially expressed genes by RNA sequencing and explored their biological functions. …”
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Article -
1963
A Transcriptomic Dataset of Liver Tissues from Global and Liver-Specific Bmal1 Knockout Mice
Published 2025-02-01“…To explore the transcriptional changes associated with Bmal1 deletion in liver tissues, we collected liver tissues from global and liver-specific Bmal1 knockout mice, along with their respective control groups, at two circadian time points (CT2 and CT14) and used them for transcriptome sequencing analysis. Genotyping, locomotor activity analysis, and comprehensive quality control analyses, including base quality scores, GC content, and mapping rates, confirmed the high quality of sequencing data. …”
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Article -
1964
TET2-mediated 5-hydroxymethylcytosine of TXNIP promotes cell cycle arrest in systemic anaplastic large cell lymphoma
Published 2025-01-01“…The ALK-positive cell line, Su-DHL-1, and the ALK-negative cell line, DL-40, were utilized as in vitro experimental models. RNA-sequencing and hMeDIP-sequencing assays were performed to explore the potential functions of TET2 in cell cycle regulation. …”
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Article -
1965
Hepatitis E virus infection among blood donors in Ningbo
Published 2025-01-01“…Furthermore, HEV gene sequencing was performed for genotyping analysis, and donors with reactive nucleic acid testing results were followed up to confirm their infection status. …”
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Article -
1966
A Missense Mutation in OPA1 Causes Dominant Optic Atrophy in a Chinese Family
Published 2019-01-01“…Four affected family members and one unaffected family member were selected for whole exome sequencing. Sanger sequencing was used to confirm and screen the identified mutation in 18 members of the family. …”
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Article -
1967
Intercropping of Saccharum spp. with Dictyophora indusiata: effects on microbial communities and metabolite profiles during bagasse degradation
Published 2025-01-01“…Metabarcoding sequencing showed that DIBA significantly altered the bacterial and fungal communities, reducing microbial diversity. …”
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Article -
1968
Novel Compound Heterozygous BBS2 and Homozygous MKKS Variants Detected in Chinese Families with Bardet–Biedl Syndrome
Published 2021-01-01“…Sanger sequencing was used to verify the variants and to perform a segregation analysis. …”
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Article -
1969
Chromosome-level genome assembly and annotation of largemouth bronze gudgeon (Coreius guichenoti)
Published 2025-01-01“…Hi-C sequencing data was utilized for chromosome assembly and 25 chromosome sequences were ultimately yielded, with a total length of 1076.8 Mb. …”
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Article -
1970
Polysaccharide extract from Rosa laevigata fruit attenuates inflammatory obesity by targeting redox balance and gut interface in high-fat diet-fed rats
Published 2023-03-01“…Moreover, 16S rRNA sequencing coupled with metagenome sequencing showed that RLPs had significantly reduced the ratio of Firmicutes/Bacteroidetes from 8.01 to 2.37, and significantly increased the relative abundances of Alistipes, Prevotella, and Akkermansia from 0.36 %, 1.10 % and 2.61 % to 0.65 %, 2.37 % and 4.42 %, respectively. …”
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Article -
1971
The potential role of differentially expressed tRNA-derived fragments in high glucose-induced podocytes
Published 2024-12-01“…In this study, tRFs were identified, and their roles in podocyte injury induced by high-glucose (HG) treatment were explored. High-throughput sequencing of podocytes treated with HG was performed to identify differentially expressed tRFs. …”
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Article -
1972
The impact of glucocorticoid receptor transactivation on context-dependent cell migration dynamics
Published 2025-02-01“…Cell proliferation increased in TN and decreased in ER + cells upon GR activation, reversed by GR antagonist. RNA sequencing revealed dex’s impact on cell adhesion and extracellular matrix signalling in TN cells and on DNA replication in ER + cells. …”
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Article -
1973
Wilson and Walker's Principles and Techniques of Biochemistry and Molecular Biology /
Published 2018Table of Contents: “…Biochemical and molecular biological methods in life sciences studies -- Basic principles -- Cell culture techniques -- Recombinant DNA techniques and molecular cloning -- Preparative protein biochemistry -- Electrophoretic techniques -- Immunochemical techniques -- Flow cytometry -- Radioisotope techniques -- Principles of clinical biochemistry -- Microscopy -- Centrifugation and ultracentrifugation -- Spectroscopic techniques -- Basic techniques probing molecular structure and interactions -- Mass spectrometric techniques -- Fundamentals of bioinformatics -- Fundamentals of chemoinformatics -- The python programming language -- Data analysis -- Fundamentals of genome sequencing and annotation -- Fundamentals of proteomics -- Fundamentals of metabolomics -- Enzymes and receptors -- Drug discovery and development.…”
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1974
Perspectives of International Human Epigenome Consortium
Published 2013-03-01“…Epigenome data will cover from whole genome bisulfite sequencing, histone modification, and chromatin access information to miRNA-seq. …”
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Article -
1975
Identification of Dietzia spp. from Cardiac Tissue by 16S rRNA PCR in a Patient with Culture-Negative Device-Associated Endocarditis: A Case Report and Review of the Literature
Published 2016-01-01“…Here we describe the identification of Dietzia natronolimnaea/D. cercidiphylli by PCR amplification and sequencing of the 16S rRNA encoding gene from cardiac tissue in a patient with culture-negative device-associated endocarditis.…”
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1976
A case of CDKL5 deficiency disorder with a novel intragenic multi-exonic duplication
Published 2024-11-01“…Abstract We present a case of suspected CDKL5 deficiency disorder (CDD) in which a novel intragenic multi-exonic duplication in the CDKL5 gene was identified using next-generation sequencing and multiple ligation-dependent probe amplification. …”
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Article -
1977
Angelman-Like Syndrome: A Genetic Approach to Diagnosis with Illustrative Cases
Published 2016-01-01“…With the advancement of genomic technology like array comparative genomic hybridization and next generation sequencing methods, it is found that some patients of these test negative Angelman-like Syndromes actually have alternative diagnoses. …”
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1978
Bacteremia with an Unusual Pathogen: Mycobacterium neoaurum
Published 2016-01-01“…Isolation of this organism is challenging yet the advent of 16s ribosomal sequencing paved the way for more sensitive detection. …”
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Article -
1979
Investigation of a novel PROS1 splicing variant in a patient with protein S deficiency
Published 2024-07-01“…Qualitative and quantitative analysis of pathogenic splicing variants at the mRNA level was performed by long-range PCR-based targeted DNA and RNA sequencing. A base substitution in the exon 4 splicing donor site activates a potential splicing donor site in intron 4, resulting in an in-frame insertion of 48 bases (16 amino acids).…”
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Article -
1980
Parascedosporium and its relatives: phylogeny and ecological trends
Published 2011-06-01“…Species complexes were clearly resolved by rDNA ITS sequencing. Significantly different ecological trends were observed between resolved species aggregates. …”
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Article