Ten Machine Learning Models for Predicting Preoperative and Postoperative Coagulopathy in Patients With Trauma: Multicenter Cohort Study by Xiaojuan Xiong, Hong Fu, Bo Xu, Wang Wei, Mi Zhou, Peng Hu, Yunqin Ren, Qingxiang Mao

“…Multivariate logistic regression revealed that patients with PPTIC faced significantly higher risks of sepsis (1.75-fold), heart failure (1.5-fold), delirium (3.08-fold), abnormal coagulation (3.57-fold), tracheostomy (2.76-fold), mortality (2.19-fold), and urinary tract infection (1.95-fold), along with longer hospital and intensive care unit stays. …”
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Targeted Antibiotic Prophylaxis for Lung Transplantation in Cystic Fibrosis Patients Colonised with Pseudomonas aeruginosa Using Multiple Combination Bactericidal Testing by Helmy Haja Mydin, Paul A. Corris, Audrey Nicholson, John D. Perry, Gerard Meachery, Emma C. L. Marrs, Steven Peart, Christine Fagan, James L. Lordan, Andrew J. Fisher, Frances K. Gould

“…Two patients in the MCBT group developed septicaemia, 13 in the conventional group (P≤0.05, 2-tailed Fisher's test). Sepsis was attributable to P. aeruginosa in one patient from the MCBT group and seven patients in the conventional group (P=0.15). …”
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The Role of Rotational Thromboelastometry in Early Detection of the Hemostatic Derangements in Neonates with Systemic Candida Infection by Rozeta Sokou, Alexia Eleftheria Palioura, Aikaterini Konstantinidi, Alexandra Lianou, Maria Lampridou, Martha Theodoraki, Daniele Piovani, Stefanos Bonovas, Konstantina A. Tsante, Petros Ioannou, Nicoletta Iacovidou, Andreas G. Tsantes

“…Background: Systemic <i>Candida</i> infection (SCI) is the third most common cause of late-onset sepsis in Neonatal Intensive Care Units (NICU). While platelet involvement in fungal infections has been extensively studied, evaluation of the hemostatic mechanism in Candida infections, especially in neonates, has not been widely investigated. …”
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Treatment of autonomous intestinal neuropathy in critical care by prucalopride and multistrain probiotic by A. L. Kovaleva, A. I. Ulyanin, O. Yu. Kiselyova, Ye. A. Poluektova, O. S. Shifrin, A. S. Tertychny, V. T. Ivashkin

“…Laboratory and instrumental investigation revealed obstructive right-sided abscessing pyelohephritis with development of sepsis; antibacterial therapy included meropenem in daily dose of 3.0 g along with correction of hypoalbuminemia and detoxication therapy. …”
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29 m6A-RNA Methylation (Epitranscriptomic) Regulators Are Regulated in 41 Diseases including Atherosclerosis and Tumors Potentially via ROS Regulation – 102 Transcriptomic Dataset... by Ming Liu, Keman Xu, Fatma Saaoud, Ying Shao, Ruijing Zhang, Yifan Lu, Yu Sun, Charles Drummer, Li Li, Sheng Wu, Satya P. Kunapuli, Gerard J. Criner, Jianxin Sun, Huimin Shan, Xiaohua Jiang, Hong Wang, Xiaofeng Yang

“…We performed a database mining on 102 transcriptomic datasets for the expressions of 29 m6A-RNA methylation (epitranscriptomic) regulators (m6A-RMRs) in 41 diseases and cancers and made significant findings: (1) a few m6A-RMRs were upregulated; and most m6A-RMRs were downregulated in sepsis, acute respiratory distress syndrome, shock, and trauma; (2) half of 29 m6A-RMRs were downregulated in atherosclerosis; (3) inflammatory bowel disease and rheumatoid arthritis modulated m6A-RMRs more than lupus and psoriasis; (4) some organ failures shared eight upregulated m6A-RMRs; end-stage renal failure (ESRF) downregulated 85% of m6A-RMRs; (5) Middle-East respiratory syndrome coronavirus infections modulated m6A-RMRs the most among viral infections; (6) proinflammatory oxPAPC modulated m6A-RMRs more than DAMP stimulation including LPS and oxLDL; (7) upregulated m6A-RMRs were more than downregulated m6A-RMRs in cancer types; five types of cancers upregulated ≥10 m6A-RMRs; (8) proinflammatory M1 macrophages upregulated seven m6A-RMRs; (9) 86% of m6A-RMRs were differentially expressed in the six clusters of CD4+Foxp3+ immunosuppressive Treg, and 8 out of 12 Treg signatures regulated m6A-RMRs; (10) immune checkpoint receptors TIM3, TIGIT, PD-L2, and CTLA4 modulated m6A-RMRs, and inhibition of CD40 upregulated m6A-RMRs; (11) cytokines and interferons modulated m6A-RMRs; (12) NF-κB and JAK/STAT pathways upregulated more than downregulated m6A-RMRs whereas TP53, PTEN, and APC did the opposite; (13) methionine-homocysteine-methyl cycle enzyme Mthfd1 downregulated more than upregulated m6A-RMRs; (14) m6A writer RBM15 and one m6A eraser FTO, H3K4 methyltransferase MLL1, and DNA methyltransferase, DNMT1, regulated m6A-RMRs; and (15) 40 out of 165 ROS regulators were modulated by m6A eraser FTO and two m6A writers METTL3 and WTAP. …”
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The Role of von Willebrand Factor in Vascular Inflammation: From Pathogenesis to Targeted Therapy by Felice Gragnano, Simona Sperlongano, Enrica Golia, Francesco Natale, Renatomaria Bianchi, Mario Crisci, Fabio Fimiani, Ivana Pariggiano, Vincenzo Diana, Andreina Carbone, Arturo Cesaro, Claudia Concilio, Giuseppe Limongelli, Mariagiovanna Russo, Paolo Calabrò

“…Moreover, VWF and ADAMTS13 have been recently proposed as prognostic biomarkers in cardiovascular, metabolic, and inflammatory diseases, such as diabetes, stroke, myocardial infarction, and sepsis. All these features make VWF an attractive therapeutic target in thromboinflammation. …”
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lncRNA-SNHG14 Plays a Role in Acute Lung Injury Induced by Lipopolysaccharide through Regulating Autophagy via miR-223-3p/Foxo3a by Jun Hong, Shijing Mo, Fangxiao Gong, Zongbin Lin, Hanhui Cai, Ziqiang Shao, Xianghong Yang, Renhua Sun, Qiangnu Zhang, Jingquan Liu

“…It suggested that lncRNA-SNHG14 may serve as a potential therapeutic target for patients with sepsis-induced ALI.…”
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Decrease in platelet count in patients with AKI and its association with major adverse kidney events by Ramón Medina-González, Jose J. Zaragoza, Eduardo M. Hernández-Barajas, Juarez Correa-de Leon, Rolando Claure-Del Granado, Armando Vazquez-Rangel, Liliana M. Pineda-Segura, Martha K. Franco-Garcia, Gael Chávez-Alonso, Juan A. Gómez-Fregoso, Francisco G. Rodríguez-García, Guillermo Navarro-Blackaller, Luz Alcantar-Vallin, Alejandro Martínez Gallardo-González, Gabriela J. Abundis-Mora, Guillermo García-García, Jonathan S. Chávez-Iñiguez

“…The mean age was 54 years, 60% were male, and 44% had sepsis. The mean baseline platelet count was 194 x 103 cells/µL, and 65% of the KDIGO3 patients met these criteria. …”
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Emerging burden of post-cancer therapy complications on unplanned hospitalisation and costs among Australian cancer patients: a retrospective cohort study over 14 years by Rashidul Alam Mahumud, Md. Shahjalal, Padam Kanta Dahal, Md. Parvez Mosharaf, Sabuj Kanti Mistry, Kamrun Nahar Koly, Sujana Haque Chowdhury, Andre M. N. Renzaho, Jeff Gow, Khorshed Alam, Olivia Wawryk

“…A significant proportion of patients (71%) experienced multiple complications, with the most common being anemia (26%), sepsis (15%), nausea and vomiting (14%), and neutropenia (11%). …”
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Adoptive cell transfer of piezo-activated macrophage rescues immunosuppressed rodents from life-threating bacterial infections by Xiaoyi Liu, Wenxiu Xu, Junkun Feng, Ying Wang, Kai Li, Yi Chen, Wenjun Wang, Weiwei Zhao, Shaohua Ge, Jianhua Li

“…Moreover, we test the use of these piezo-activated macrophages (piezoMϕ) as adoptive cell therapy (ACT) for treating various immunosuppressive bacterial infections, including sepsis, pneumonia and peritonitis. Our study thus highlights the potential application of catalytic nanoparticles as a promising alternative to conventional infection treatment to effectively modulate the innate immune responses and to engineer macrophages for immunotherapy purposes.…”
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Comparison of the efficacy and safety of Landiolol and Esmolol in critically ill patients: a propensity score-matched study by Xiang Si, Hao Yuan, Rui Shi, Wenliang Song, Jiayan Guo, Jinlong Jiang, Tao Yang, Xiaoxun Ma, Huiming Wang, Minying Chen, Jianfeng Wu, Xiangdong Guan, Xavier Monnet

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Epidemiology and Resistance Profiles of Bacteria Isolated From Blood Samples in Septic Patients at Emergency Department Admission: A 6-Year Single Centre Retrospective Analysis Fro... by Valeria Cento, Sara Carloni, Riccardo Sarti, Linda Bussini, Zian Asif, Paola Morelli, Francesco De Fazio, Federica Maria Tordato, Maddalena Casana, Debora Mondatore, Antonio Desai, Elena Generali, Nicola Pugliese, Elena Costantini, Massimo Vanoni, Maurizio Cecconi, Stefano Aliberti, Giorgio Da Rin, Erminia Casari, Michele Bartoletti, Antonio Voza

“…., cancer, diabetes), infection source, presence of central venous catheters (CVC), ongoing therapies, and sepsis severity. Microbiological data included pathogen identification and antimicrobial susceptibility. …”
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COVID-19 in discharged patients with diabetes and chronic kidney disease: one-year follow-up and evaluation by Enrong Ran, Enrong Ran, Yutong Zou, Chuanyi Zhao, Kai Liu, Jiamin Yuan, Wenjie Yang, Lijun Zhao, Qing Yang, Jia Yang, Xuegui Ju, Linli Cai, Yanlin Lang, Xingyuan Li, Ke Liu, Fang Liu, Fang Liu

“…Cox proportional hazards regression indicated that sepsis and mechanical ventilation were major risk factors for post-discharge all-cause mortality. …”
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Global insights into MRSA bacteremia: a bibliometric analysis and future outlook by Jia-Yi Lin, Jia-Yi Lin, Jia-Kai Lai, Jia-Kai Lai, Jian-Yi Chen, Jian-Yi Chen, Jia-Yu Cai, Jia-Yu Cai, Zhan-Dong Yang, Zhan-Dong Yang, Liu-Qingqing Yang, Liu-Qingqing Yang, Liu-Qingqing Yang, Ze-Tao Zheng, Ze-Tao Zheng, Xu-Guang Guo, Xu-Guang Guo, Xu-Guang Guo

“…The journal with the most publications is Antimicrobial Agents and Chemotherapy, while the most cited global publication is Vincent JL’s article “Sepsis in European Intensive Care Units: Results of the SOAP Study” published in Critical Care Medicine in 2006. …”
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Antimicrobial resistance (AMR) and spread of New Delhi Metallo-β-Lactamase (NDM) in Italy: A call for policymakers by Gabriella Nucera

“…According to its Agenzia Regionale di Sanità (ARS) data, between November 2018 and 27 October 2019, NDM producing CREs have been identified in the blood of 129 patients and the rate of mortality in patients with sepsis was as 33% [13]. Tuscany has an effective antibiotic resistance monitoring system (SMART network) [14], but in Italy systems for surveillance of AMR at regional level are only in place in a few regions. …”

Geography and age drive racial and ethnic disparities in hospital mortality for paediatric community-acquired pneumonia in the United States: a retrospective population based cohor... by Cody-Aaron L. Gathers, Nadir Yehya, Anireddy Reddy, Paula M. Magee, Vanessa C. Denny, Michelle R. Mayeda, Amanda O’Halloran, Sanjiv D. Mehta, Stephanie Wanamaker, Jessica C. Fowler, Garrett Keim

“…Motivated by disparities related to age and geography in paediatric sepsis, we evaluated the association between the joint exposure of race/ethnicity, age, and geographic region and mortality for community-acquired pneumonia to provide opportunities for assessment of future interventions that provide equitable healthcare. …”
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Panitumumab plus 5-fluorouracil and folinic acid or 5-fluorouracil and folinic acid alone as maintenance therapy in RAS wild-type metastatic colorectal cancer (PanaMa, AIO KRK 0212... by Arndt Stahler, Meinolf Karthaus, Stefan Fruehauf, Ullrich Graeven, Lothar Müller, Ludwig Fischer von Weikersthal, Karel Caca, Eray Goekkurt, Alexej Ballhausen, Greta Sommerhäuser, Annabel H.S. Alig, Swantje Held, Armin Jarosch, David Horst, Anke Reinacher-Schick, Stefan Kasper, Volker Heinemann, Sebastian Stintzing, Tanja Trarbach, Dominik P. Modest

“…The most frequent adverse event (AE) grade ≥3 was rash (FU/FA + panitumumab: n = 15, 12.0%, FU/FA: n = 17, 6.9%). 141 patients (37.3%) experienced at least one serious AE One treatment-related death occurred (neutropenic sepsis, FU/FA). Interpretation: Panitumumab plus FU/FA might be considered a standard of care maintenance regimen since a potential re-induction therapy with panitumumab cannot be guaranteed at the time of maintenance treatment decision. …”
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HELLO: a protocol for a cluster randomized controlled trial to enhance interpersonal relationships and team cohesion among ICU healthcare professionals by Elie Azoulay, Nancy Kentish Barnes, Sheila Nainan Myatra, Maria-Cruz Martin Delgado, Yaseen Arabi, Carole Boulanger, Giovanni Mistraletti, Maria Theodorakopoulou, Vernon Van Heerden, José-Artur Paiva, Oktay Demirkýran, Gabriel Heras La Calle, Abdulrahman Al Fares, Gaston Burghi, Guy Francois, Anita Barth, Jan De Waele, Samir Jaber, Michael Darmon, Maurizio Cecconi

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Selected Abstracts of the 20th International Workshop on Neonatology and Pediatrics; Cagliari (Italy); October 23-26, 2024 by --- Various Authors

“…RENAL INVOLVEMENT IN TWO PEDIATRIC CASES OF SEPSIS • F. Zanco, V. Sanneris, M. Cossu, M. Olla, F. …”
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Analysis of fatty acid-derived lipids in critically ill patients after cardiac surgery yields novel pathophysiologically relevant mediators with possible relevance for systemic inf... by Holger Neb, Verena Roth, Jessica Roos, Jessica Roos, Tom Bauer, Anja Urbschat, Ulrike Heinicke, Carlo Angioni, Dieter Steinhilber, Dieter Steinhilber, Matthias Piesche, Matthias Piesche, Nerea Ferreirós, Robert Gurke, Robert Gurke, Gerd Geisslinger, Gerd Geisslinger, Edith Utech, Kai Zacharowski, Patrick Meybohm, Patrick Meybohm, Patrick Paulus, Elke Schmitt, Elke Schmitt, Thorsten Jürgen Maier, Thorsten Jürgen Maier

“…IntroductionCritically ill patients suffer from a wide variety of clinical events, most of them leading to pro-inflammatory states such as sepsis or simply as consequence of major surgery. …”
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