Sirtuin1 Targeting Reverses Innate and Adaptive Immune Tolerance in Septic Mice by Ayana N. Martin, Martha Alexander-Miller, Barbara K. Yoza, Vidula Vachharajani, Charles E. McCall

“…Whether SIRT1 inhibition during sepsis treatment concomitantly reverses innate and T cell antigen-specific immune tolerance is unknown. …”
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Morbidity and Mortality in Preterm Infants following Antacid Use: A Retrospective Audit by Natasha Singh, Aparna Dhayade, Abdel-Latif Mohamed, Tejasvi Vasant Chaudhari

“…Information regarding late onset sepsis, NEC, mortality, ranitidine/omeprazole use, and other neonatal/hospital factors was collected for each neonate. …”
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MitoQ Modulates Lipopolysaccharide-Induced Intestinal Barrier Dysfunction via Regulating Nrf2 Signaling by Shengfeng Zhang, Qingniao Zhou, Youcheng Li, Yunli Zhang, Yinmei Wu

“…Gut barrier dysfunction with alterant mucosal permeability during sepsis is a challenge problem in clinical practice. …”
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Hemovigilance data: An effective approach for evaluating bacterial protection systems for platelet transfusions by Meshari I. Alabdullatif

“…MATERIALS AND METHODS: HV data with definite transfusion-associated bacterial sepsis in PCs were obtained from Australia, Canada, the United Kingdom (U. …”
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Empedobacter brevis Meningitis in a Neonate: A Very Rare Case of Neonatal Meningitis and Literature Review by Deepak Sharma, Ankur Patel, Priyanka Soni, Pradeep Sharma, Basudev Gupta

“…The novelty of the case report is that this is the first case report of neonatal sepsis caused by Empedobacter brevis.…”
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Why do we use transpulmonary thermodilution and pulmonary artery catheter in severe shock patients? by Xavier Monnet, Christopher Lai, Daniel De Backer

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Neuropsychiatric Lupus and Lupus Nephritis Successfully Treated with Combined IVIG and Rituximab: An Alternative to Standard of Care by Mohamed M. Cheikh, Abdullah K. Bahakim, Moayad K. Aljabri, Saad M. Alharthi, Sanad M. Alharthi, Abdullah K. Alsaeedi, Saad F. Alqahtani

“…There is a paucity of evidence to support the co-management of SLE with major organ involvement and sepsis. We describe the clinical response of a 35-year-old male diagnosed with SLE; then, he developed severe sepsis and a flare of SLE with major organ involvement including lupus nephritis (LN), myocarditis, and neuropsychiatric systemic lupus erythematosus (NPSLE). …”
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Sinonasal Melioidosis in a Returned Traveller Presenting with Nasal Cellulitis and Sinusitis by Rebecca Sin Mei Lim, Sam Flatman, Markus C. Dahm

“…We illustrate a case involving a 51-year-old man who presented to a tertiary hospital with sepsis secondary to an abscess of the nasal vestibule and pustular eruptions of the nasal mucosa. …”
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Risk Factors for Hospital-Acquired Infection in a Neonatology Service by Hilda María Delgado Acosta, Sadis Suárez del Villar Seuret, Mabel Vega Galindo

“…Infants whose mothers had presented vaginal sepsis had a higher risk for infection (62, 3%, OR = 5.9). …”
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mTOR Modulates the Endoplasmic Reticulum Stress-Induced CD4+ T Cell Apoptosis Mediated by ROS in Septic Immunosuppression by Hao Wang, Jianwei Chen, Guangxu Bai, Wen Han, Ran Guo, Na Cui

“…Introduction. When sepsis attacks the body, the excessive reactive oxygen species (ROS) production can result to endoplasmic reticulum stress (ERS) and eventually cause lymphocyte apoptosis. …”
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Urinary I-FABP, L-FABP, TFF-3, and SAA Can Diagnose and Predict the Disease Course in Necrotizing Enterocolitis at the Early Stage of Disease by Stepan Coufal, Alena Kokesova, Helena Tlaskalova-Hogenova, Barbora Frybova, Jiri Snajdauf, Michal Rygl, Miloslav Kverka

“…Next, we compared their levels with the type of the disease (NEC or sepsis) and its severity. Already at the time of NEC suspicion, infants who developed NEC had significantly higher levels of all tested biomarkers than controls and higher levels of I-FABP and L-FABP than those who will later develop sepsis. …”
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Morbidity and mortality patterns of preterm low birthweight neonates admitted to referral hospitals in the Amhara region of Ethiopia: retrospective follow-up study by Yalemtsehay Dagnaw Genie, Belete Fenta Kebede, Mulualem Silesh Zerihun, Desalew Tilahun Beyene

“…Hypothermia, sepsis, respiratory distress, jaundice and congenital anomalies were the common morbidities. …”
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Protective Effects of Polydatin on Septic Lung Injury in Mice via Upregulation of HO-1 by Xiao-hui Li, Xia Gong, Li Zhang, Rong Jiang, Hong-zhong Li, Meng-jiao Wu, Jing-yuan Wan

“…The model of cecal ligation and puncture (CLP-)induced sepsis was employed. Pretreatment of mice with PD (15, 45, and 100 mg/kg) dose-dependently reduced sepsis-induced mortality and lung injury, as indicated by alleviated lung pathological changes and infiltration of proteins and leukocytes. …”
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Impact of Inappropriate Empiric Antimicrobial Therapy on Mortality of Septic Patients with Bacteremia: A Retrospective Study by Saoraya Lueangarun, Amorn Leelarasamee

“…Case record forms of patients diagnosed as sepsis, severe sepsis, or septic shock with positive hemoculture during 2009 were retrieved from the medical wards, Siriraj Hospital. …”
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Characterization of Nosocomial Infection in a Pediatric Intensive Care Unit. Cienfuegos 2005-2009 by Lourdes Elena Duany Badell, Dagmaris Losa Pérez, Mabel Ávila Ramírez, Jorge Emilio Barletta del Castillo, Sara Hernández Malpica, Aymahara Gómez Morejón

“…The sample consisted of 70 patients who developed nosocomial sepsis and were admitted directly to the service. …”
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Trained Innate Immunity by Repeated Low-Dose Lipopolysaccharide Injections Displays Long-Term Neuroprotective Effects by Xiao-yan Zhou, Rong Gao, Jian Hu, Da-peng Gao, Yan-ling Liao, Jian-jun Yang

“…Disrupted immune response is an important feature of many neurodegenerative conditions, including sepsis-associated cognitive impairment. Accumulating evidence has demonstrated that immune memory occurs in microglia, which has a significant impact on pathological hallmarks of neurological diseases. …”
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Risk Factors in Intraepithelial Lesions of the Cervix by Martha Palma Osorio, Alejandro David Romero Flores, Ana Isabel Torres Mesa

“…Erosion and vaginal sepsis were the most significant due to the logistic regression model. …”
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Inhibition of the mTOR Pathway Exerts Cardioprotective Effects Partly through Autophagy in CLP Rats by Wen Han, Hao Wang, Longxiang Su, Yun Long, Na Cui, Dawei Liu

“…Background. Sepsis-induced myocardial dysfunction is a severe clinical problem. …”
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miR-197 Participates in Lipopolysaccharide-Induced Cardiomyocyte Injury by Modulating SIRT1 by Miaomiao Liu, Ying Zhang, Xiantong Cao, Tao Shi, Yang Yan

“…Sepsis is a systemic inflammation and is capable of inducing myocarditis, which is a major leading cause of death in patients. …”
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Emodin Ameliorates Intestinal Dysfunction by Maintaining Intestinal Barrier Integrity and Modulating the Microbiota in Septic Mice by Mina Zhang, Bo Lian, Rui Zhang, Yuhong Guo, Jingxia Zhao, Shasha He, Yunjing Bai, Ning Wang, Yan Lin, Xuerui Wang, Qingquan Liu, Xiaolong Xu

“…Sepsis-induced inflammatory response leads to intestinal damage and secondary bacterial translocation, causing systemic infections and eventually death. …”
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