PROcalcitonin and NEWS2 evaluation for Timely identification of sepsis and Optimal use of antibiotics in the emergency department (PRONTO): protocol for a multicentre, open-label, randomised controlled trial by David Taylor-Robinson, Steve Goodacre, Neil French, Richard Body, Kerenza Hood, Emma Thomas-Jones, Jane Daniels, Sarah Walker, Ingeborg Welters, Mike Bradburn, Paul Schmidt, Enitan Carrol, Lucy Brookes-Howell, Sarah Milosevic, Andrew Tabner, Philip Pallmann, Stephen Aston, Gavin Barlow, Emma Richards, Emmanuel Nsutebu, Philip Howard, Matthew Inada-Kim, Stacy Todd, Fiona McGill, Martin Llewelyn, Louis Wihelmus Niessen, Joanne Euden, Julie Carman, Stephanie Gilbert, Sam Clarkstone, Jacqui Hughes, Lena Meister, Angela Brain, Matthew Scarborough, Sian O'Shea, Claire James

“…Introduction Sepsis is a common, potentially life-threatening complication of infection. …”
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Club Cell Protein 16 Attenuates CD16brightCD62dim Immunosuppressive Neutrophils in Damaged Tissue upon Posttraumatic Sepsis-Induced Lung Injury by Nils Becker, Philipp Störmann, Andrea Janicova, Kernt Köhler, Klemens Horst, Ildiko Rita Dunay, Claudia Neunaber, Ingo Marzi, Jan Tilmann Vollrath, Borna Relja

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Prevalence of Neonatal Sepsis and Associated Factors among Neonates in Neonatal Intensive Care Unit at Selected Governmental Hospitals in Shashemene Town, Oromia Regional State, Ethiopia, 2017 by Aytenew Getabelew, Mihret Aman, Endashaw Fantaye, Tomas Yeheyis

“…The overall prevalence of neonatal sepsis in this study was 77.9%. From this 65% and 35% of neonates developed early onset neonatal sepsis and late onset neonatal sepsis, respectively. …”
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miR-199a-5p Exacerbated Intestinal Barrier Dysfunction through Inhibiting Surfactant Protein D and Activating NF-κB Pathway in Sepsis by Xianjin Du, Dan Tian, Jie Wei, Chen Yan, Peng Hu, Xu Wu, Wenbin Yang, Zhanyong Zhu

“…Sepsis is a severe disease, which results from the excessive inflammatory response to the infection. …”
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Cost Impact Model of a Novel Multi-mRNA Host Response Assay for Diagnosis and Risk Assessment of Acute Respiratory Tract Infections and Sepsis in the Emergency Department by John E. Schneider, Jonathan Romanowsky, Philipp Schuetz, Ivana Stojanovic, Henry K. Cheng, Oliver Liesenfeld, Ljubomir Buturovic, Timothy E. Sweeney

“…**Results:** Compared to standard of care including procalcitonin, the superior test characteristics of HostDx Sepsis resulted in an average cost savings of approximately US$1974 per patient (-31.3%) exclusive of the cost of HostDx Sepsis. …”
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Head-to-head comparison of pre-hospital qSOFA and lactate-qSOFA for predicting sepsis in patients with and without suspected infection.... by Francisco Martín-Rodríguez, Raúl López-Izquierdo, Miguel A. Castro Villamor, Carlos delPozo-Vegas, Irene Sánchez-Soberón, Juan F. Delgado-Benito, Virginia Carbajosa Rodíguez, Rodrigues Leonardo, José Luis Martín-Conty

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Bacteriophage and Phage-Encoded Depolymerase Exhibit Antibacterial Activity Against K9-Type <i>Acinetobacter baumannii</i> in Mouse Sepsis and Burn Skin Infection Models by Alexander I. Borzilov, Nikolay V. Volozhantsev, Olga V. Korobova, Lyubov V. Kolupaeva, Evgenia S. Pereskokova, Tatiana I. Kombarova, Mikhail M. Shneider, Konstantin A. Miroshnikov, Ivan A. Dyatlov, Anastasia V. Popova

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LncRNA DLEU1 contributes to the progression of septic myocardial dysfunction by targeting miR-381-3p by Tian Tian, Na Zhang, Guoxin Hu, Rong Lu, Jian Liu

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Pantoea eucrina: Catheter‐Related Bloodstream Infection in a Woman With Short Bowel Syndrome by Ida Saksenborg Kølle, Lars Vinter‐Jensen, Morten Eneberg Nielsen, Hans Linde Nielsen

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Level of adaptative stress of the organism and cellular reactivity of patients with acute festering-inflammatory diseases of the kidneys and paranephral tissues by V. Stepan, R. Sydorchuk, A. Iftodiy, N. Stepan, L. Sydorchuk

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Extremely early initiation of vasopressors might not decrease short-term mortality for adults with septic shock: a systematic review and meta-analysis by Cheng-Hsin Ma, Jack Healy, Ebrima Kinteh, Cheng-Chin Ma, Ching-Fang Tiffany Tzeng, Eric H. Chou, Chin-Chieh Wu, Shih-Chieh Shao, Kuan-Fu Chen

Subjects: “…Sepsis…”
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Dexmedetomidine pretreatment enhances protective effect efficacy of pericytes agaist acute lung injury in septic mice by LUO Xi, ZHANG Zisen, YANG Ao

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A Reinforcement Learning Model for Optimal Treatment Strategies in Intensive Care: Assessment of the Role of Cardiorespiratory Features by Cristian Drudi, Maximiliano Mollura, Li-wei H. Lehman, Riccardo Barbieri

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“Unmasking the Uncommon”: A case series of multi-drug resistant Elizabethkingia meningoseptica causing late-onset sepsis and meningitis in preterm neonates [version 2; peer review: 2 approved] by Anisha Maria Fernandes, Sinchana Bhat, Suchitra Shenoy M., Prajnha U.P.

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<i>Vismia guianensis</i> Improves Survival of <i>Tenebrio molitor</i> and Mice During Lethal Infection with <i>Candida albicans</i> by Arthur André Castro Costa, Elizangela Pestana Motta, Aluísio Silva Oliveira, Pamela Gomes Santos, Josivan Regis Farias, Danielle Cristine Gomes Franco, Mayara Cristina Pinto Silva, Nicolle Teixeira Barbosa, Simone Batista Muniz, Luís Douglas Miranda. Silva, Lucilene Amorim Silva, Claudia Quintino Rocha, Flavia Raquel Fernandes Nascimento, Rosane Nassar Meireles Guerra

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Exosomes Derived from Apelin-Pretreated Mesenchymal Stem Cells Ameliorate Sepsis-Induced Myocardial Dysfunction by Alleviating Cardiomyocyte Pyroptosis via Delivery of miR-34a-5p by Li T, Zhao Y, Cao Z, Shen Y, Chen J, Huang X, Shao Z, Zeng Y, Chen Q, Yan X, Li X, Zhang Y, Hu B

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Early onset neonatal bloodstream infections in South African hospitals by Genevieve Theron, Adrie Bekker, Larisse Bolton, Andrew Whitelaw, Arnoldus Engelbrecht, Louisa Erasmus, Aaqilah Fataar, Chandre Geldenhuys, Marlize Kunneke, Dave Le Roux, Natasha O’Connell, Kessendri Reddy, Natasha Rhoda, Lloyd Tooke, Mark Wates, Thandi Wessels, Angela Dramowski

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Point-of-care tests in the emergency medical services: a scoping review by T. H. M. Moore, S. Dawson, K. Kirby, R. Body, A. Thompson, Y. O. Adepoju, R. Perry, H. Nicholson, J. Dinnes, K. Mitchell, J. Savović, S. Voss, J. R. Benger

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Evaluation of the immunological functions of placental alkaline phosphatase in vivo using ALPP transgenic mice by Tse-Ching Chen, Kwai-Fong Ng, Ning Chen, Yi-Ling Pan, Chun-An Cheng, Hsiao-Chun Wu, Yi-Jen Hsueh, Nien-Yi Chiang, Hsi-Hsien Lin, Hsi-Hsien Lin, Hsi-Hsien Lin, Hsi-Hsien Lin

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A Prospective Observational Comparative study Between qSOFA and SIRS Scores for Early Prediction of Sepsis Outcome in an Emergency Medicine Department , Kozhencherry, South Central Kerala,India by Rahul Rajeev, , J S Krishna Raj, Anu T R, Pratibha Dabas, Roshni, Seeja Sumedhan

“… Background Sepsis remains a significant challenge in emergency medicine, with early identification crucial for improved outcomes. …”
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