A Micro-RNA Connection in BRafV600E-Mediated Premature Senescence of Human Melanocytes by Gang Ren, Jingwei Feng, Ila Datar, Aaron H. Yeung, Srinivas Vinod Saladi, Yongqing Feng, Ivana de la Serna, Kam C. Yeung

“…Ectopic expression of some of these induced microRNAs increased the expression of senescence markers and induced growth arrest and senescence in primary melanocytes. …”
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Differing Pattern of Ambulatory Blood Pressure in Very Elderly Men Expresses Dynamics in Atherosclerotic Load in the Senescence by Arkadiusz Siennicki-Lantz, Sölve Elmståhl

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OGG1 and MUTYH repair activities promote telomeric 8-oxoguanine induced senescence in human fibroblasts by Mariarosaria De Rosa, Ryan P. Barnes, Ariana C. Detwiler, Prasanth R. Nyalapatla, Peter Wipf, Patricia L. Opresko

“…Preventing BER initiation suppresses PARylation and confers resistance to the synergistic effects of PARP inhibitors on 8oxoG-induced senescence. However, OGG1 activity is essential for preserving cell growth after chronic telomeric 8oxoG formation, whereas MUTYH promotes senescence to prevent chromosomal instability from unrepaired damage. …”
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High p16INK4A expression in glioblastoma is associated with senescence phenotype and better prognosis by Soon Sang Park, Tae Hoon Roh, Yoshiaki Tanaka, Young Hwa Kim, So Hyun Park, Tae-Gyu Kim, So Yeong Eom, Tae Jun Park, In-Hyun Park, Se-Hyuk Kim, Jang-Hee Kim

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Exploring the genetic profiles linked to senescence in thyroid tumors: insights on predicting disease progression and immune responses by Baoliang Zhang, Yanping Pang

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Growth, Development, and Mineral Nutrient Accumulation and Distribution in Tulip from Planting through Postanthesis Shoot Senescence by Carl E. Niedziela, Paul V. Nelson, David A. Dickey

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Characterization and Expression of Senescence Marker in Prolonged Passages of Rat Bone Marrow-Derived Mesenchymal Stem Cells by Noridzzaida Ridzuan, Akram Al Abbar, Wai Kien Yip, Maryam Maqbool, Rajesh Ramasamy

“…However, a decline in cell growth was observed at passage 4 onwards and it was further deciphered through apoptosis, cell cycle, and senescence assays. Despite the enhanced cell viability at later passages (P4-5), the expression of senescence marker, β-galactosidase, was significantly increased at passage 5. …”
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Regulation of senescence-associated secretory phenotypes in osteoarthritis by cytosolic UDP-GlcNAc retention and O-GlcNAcylation by Donghyun Kang, Jeeyeon Lee, Geunho Yook, Sehan Jeong, Jungkwon Shin, Mi-Sung Kim, Yi-Jun Kim, Hyeryeon Jung, Jinsung Ahn, Tae Woo Kim, Moon Jong Chang, Chong Bum Chang, Seung-Baik Kang, Won Ho Yang, Yong-ho Lee, Jin Won Cho, Eugene C. Yi, Chanhee Kang, Jin-Hong Kim

“…Mechanistically, upregulated O-GlcNAcylation governs the senescence-associated secretory phenotype (SASP) by stabilizing GATA4 via O-GlcNAcylation at S406, which compromises its degradation by p62-mediated selective autophagy. …”
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Cellular senescence-associated gene IFI16 promotes HMOX1-dependent evasion of ferroptosis and radioresistance in glioblastoma by Yuchuan Zhou, Liang Zeng, Linbo Cai, Wang Zheng, Xinglong Liu, Yuqi Xiao, Xiaoya Jin, Yang Bai, Mingyao Lai, Hainan Li, Hua Jiang, Songling Hu, Yan Pan, Jianghong Zhang, Chunlin Shao

“…This study establishes a radioresistant GBM cell model through repeated irradiation and observes a cellular senescence-like phenotype in these cells. Comprehensive genomic and transcriptomic analyses identify IFI16 as a central regulator of this phenotype and contributes to radioresistance. …”
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Differential Susceptibility to Particulate Matter-Induced Cardiac Remodeling and Senescence: A Comparative Study in Young and Aged Mice by Dunia Waked, Gabriel Henrique Rodella Guedes, Raissa Macedo, Paulo Hilário Nascimento Saldiva, Mariana Matera Veras, Ana Paula Cremasco Takano

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Declining precipitation frequency may drive earlier leaf senescence by intensifying drought stress and enhancing drought acclimation by Xinyi Zhang, Xiaoyue Wang, Constantin M. Zohner, Josep Peñuelas, Yang Li, Xiuchen Wu, Yao Zhang, Huiying Liu, Pengju Shen, Xiaoxu Jia, Wenbin Liu, Dashuan Tian, Prajal Pradhan, Adandé Belarmain Fandohan, Dailiang Peng, Chaoyang Wu

“…Abstract Precipitation is an important factor influencing the date of foliar senescence, which in turn affects carbon uptake of terrestrial ecosystems. …”
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DNA hypomethylation-mediated upregulation of GADD45B facilitates airway inflammation and epithelial cell senescence in COPD by Yuan Zhan, Qian Huang, Zhesong Deng, Shanshan Chen, Ruonan Yang, Jiaheng Zhang, Yating Zhang, Maocuo Peng, Jixing Wu, Yiya Gu, Zhilin Zeng, Jungang Xie

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Postharvest Pruning Guide for Hops in Florida by Mariel Gallardo, Shinsuke Agehara, Chistopher DelCastillo, Jack Rechcigl

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Delivery of FGF18 using mRNA-LNP protects the cartilage against degeneration via alleviating chondrocyte senescence by Keyu Kong, Baixing Li, Yongyun Chang, Chen Zhao, Hua Qiao, Minghao Jin, Xinru Wu, Wenxuan Fan, Liao Wang, Yansong Qi, Yongsheng Xu, Zanjing Zhai, Peixiang Ma, Huiwu Li

“…Furthermore, delivering FGF18 mRNA activates FOXO3a-autophagy pathway, which protects against chondrocyte degeneration and senescence. Local intra-articular injection of FGF18 mRNA-LNP significantly alleviates OA symptoms in DMM and senile OA models. …”
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Metformin Ameliorates D-Galactose-Induced Senescent Human Bone Marrow-Derived Mesenchymal Stem Cells by Enhancing Autophagy by Pingting Ye, Lei Feng, Dan Zhang, Ruihao Li, Yixuan Wen, Xiaohan Tong, Shuo Shi, Chunyan Dong

“…Here, we used D-galactose (D-gal) to establish an appropriate model of senescent hBMSCs to explore the antiaging effects of metformin. …”
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p53-Dependent Senescence in Mesenchymal Stem Cells under Chronic Normoxia Is Potentiated by Low-Dose γ-Irradiation by Ines Höfig, Yashodhara Ingawale, Michael J. Atkinson, Heidi Hertlein, Peter J. Nelson, Michael Rosemann

“…This was accompanied by increased senescence under normoxia but not associated with telomere shortening. …”
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IL-6/GATA2/SERPINE1 pathway is implicated in regulating cellular senescence after acute kidney injury by Hongshuang Su, Xiaoxi Lin, Ayinuer Paredong, Ayinuer Paredong, Congcong Yao, Yan Zhang, Mengke Geng, Yuqian Guan, Lichao Gong, Feng Jiang, Qi Lv, Songtao Shou, Heng Jin

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Corrigendum to “Mitochondrial (Dys) Function in Inflammaging: Do MitomiRs Influence the Energetic, Oxidative, and Inflammatory Status of Senescent Cells?” by Angelica Giuliani, Francesco Prattichizzo, Luigina Micolucci, Antonio Ceriello, Antonio Domenico Procopio, Maria Rita Rippo

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Acute Leukemia Induces Senescence and Impaired Osteogenic Differentiation in Mesenchymal Stem Cells Endowing Leukemic Cells with Functional Advantages by Ximena Bonilla, Natalia-Del Pilar Vanegas, Jean Paul Vernot

“…We found that leukemic cells induced in MSC a significant increase both in senescence-associated β-galactosidase activity and in p53 gene expression. …”
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Timing of nitrogen fertilization and shading affect the transition of nitrogen metabolism in senescing leaves of ripening wheat (Triticum aestivum L.) by Hideki Araki, Hirotaka Ueno, Keisuke Mizuta, Tadashi Takahashi, Masaru Shibata, Jun’ichi Mano

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