Chemical Activation of the Hypoxia-Inducible Factor Reversibly Reduces Tendon Stem Cell Proliferation, Inhibits Their Differentiation, and Maintains Cell Undifferentiation by Alessandra Menon, Pasquale Creo, Marco Piccoli, Sonia Bergante, Erika Conforti, Giuseppe Banfi, Pietro Randelli, Luigi Anastasia

“…However, adult stem cells are usually limited in number and difficult to be expanded in vitro, and they usually tend to quickly lose their potency with passages, as they differentiate and become senescent. Culturing stem cells under reduced oxygen tensions (below 21%) has been proposed as a tool to increase cell proliferation, but many studies reported opposite effects. …”
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Distinct immune cell infiltration patterns in pancreatic ductal adenocarcinoma (PDAC) exhibit divergent immune cell selection and immunosuppressive mechanisms by Shivan Sivakumar, Ashwin Jainarayanan, Edward Arbe-Barnes, Piyush Kumar Sharma, Maire Ni Leathlobhair, Sakina Amin, David J. Reiss, Lara Heij, Samarth Hegde, Assaf Magen, Felicia Tucci, Bo Sun, Shihong Wu, Nithishwer Mouroug Anand, Hubert Slawinski, Santiago Revale, Isar Nassiri, Jonathon Webber, Gerard D. Hoeltzel, Adam E. Frampton, Georg Wiltberger, Ulf Neumann, Philip Charlton, Laura Spiers, Tim Elliott, Maria Wang, Suzana Couto, Thomas Lila, Pallavur V. Sivakumar, Alexander V. Ratushny, Mark R. Middleton, Dimitra Peppa, Benjamin Fairfax, Miriam Merad, Michael L. Dustin, Enas Abu-Shah, Rachael Bashford-Rogers

“…Using TCR data, we see the largest clonal expansions in CD8 effector memory, senescent cells, and highly activated regulatory T cells which are induced within the tumour from naïve cells. …”
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Autoserum: An Optimal Supplement for Bone Marrow Mesenchymal Stem Cells of Liver-Injured Rats by Qinglin Zhang, Xun Sun, Jianxun Ding, Ping He, Yujia Liu, Hongjing Cheng, Changlin Zhou, Xiangwei Meng

“…The results showed that BMSCs cultured with autoserum or allogeneic serum exhibited better MSC-specific morphology, lower rate of cell senescent, and higher proliferation kinetics than those with FBS. …”
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Increased matrix metalloproteinase-1 expression by coexposure to UVA and cigarette sidestream smoke and contribution of histone acetylation by Ryoma Ito, Yukako Komaki, Yuko Ibuki

“…The basal expression of MMP-1 was higher in senescent cells than in normal cells, with a pronounced increase after coexposure to UVA and CSS. …”
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Intraventricular Neurilemmoma (Schwannoma): Shall GFAP Immunostaining Be Regarded as a Histogenetical Tag or as a Mere Histomimetical Trait? by Miguel Fdo. Salazar, Martha Lilia Tena Suck, Daniel Rembao Bojórquez, Citlaltepetl Salinas Lara

“…Verocay bodies were not present but vessel hyalinisation, pericellular reticulin, and senescent atypia were observed. The immunoperoxidase reactions were also consistent with neurilemmal differentiation; however, glial fibrillary acidic protein expression was widespread and unexpectedly seen. …”
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The insertion of an ancestral gene in Nicotiana tabacum plants reduces free radicals during saline irrigation by Claudia Marissa Calderón Torres, Victoria Abril Mancilla Galván, Miguel Murguía Romero

“…Seedlings of transgenic and wild type Nicotiana tabacum germinated in standard conditions were divided into two irrigation groups, with 100 mM of NaCl and with tap water; and, after 50 days, in the non-senescent adult leaves of the plants, the total chlorophyll a and b and the total chlorophyll content were determined by spectrophotometry and the reactive oxygen species production (*OH, 1O2, H2O2) was quantified by a 2',7'-dichlorodihydrofluorescein assay. …”
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Inflammation and ER Stress Downregulate BDH2 Expression and Dysregulate Intracellular Iron in Macrophages by Susu M. Zughaier, Brandon B. Stauffer, Nael A. McCarty

“…Macrophages play a very important role in host defense and in iron homeostasis by engulfing senescent red blood cells and recycling iron. Hepcidin is the master iron regulating hormone that limits dietary iron absorption from the gut and limits iron egress from macrophages. …”
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Phenotype of Hypertension-altered Waist and its Association with the Components of Metabolic Changes in Gerontics by Giorgiet Galiano Guerra, Yamila Lastre Diéguez, Grettel Galiano Guerra, Dailenys García Céspedes, Yordanis Alberto Fonseca Atencio, Ariel Sosa Remón

“…The components of the metabolic syndrome with higher association with senescents affected by the endocrinopathy were dyslipidemia followed by glycaemia disturbances. …”
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The Influence of Aging on the Regenerative Potential of Human Adipose Derived Mesenchymal Stem Cells by Monika Marędziak, Krzysztof Marycz, Krzysztof A. Tomaszewski, Katarzyna Kornicka, Brandon Michael Henry

“…Compared to younger cells, aged hASCs had decreased proliferation rates, decreased chondrogenic and osteogenic potential, and increased senescent features. A shift in favor of adipogenic differentiation with increased age was also observed. …”
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Molecular and Cellular Mechanisms of Immunosenescence: Modulation Through Interventions and Lifestyle Changes by Luca Pangrazzi, Andreas Meryk

“…At the cellular level, immunosenescence manifests as decreased production of naive T and B cells, accumulation of memory and senescent cells, thymic involution, and dysregulated cytokine production. …”
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Comprehensive Review of Biological Functions and Therapeutic Potential of Perilla Seed Meal Proteins and Peptides by Yangfan Hu, Huan Luo, Vasudeva Reddy Netala, He Li, Zhijun Zhang, Tianyu Hou

“…Perilla peptides exhibit robust anti-aging properties by activating the Nrf2 pathway, enhancing cellular antioxidant capacity, and supporting skin health through the promotion of keratinocyte growth, maintenance of collagen integrity, and reduction in senescent cells. Additionally, they demonstrate antidiabetic activity by inhibiting α-amylase and α-glucosidase. …”
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Bioactive Anti-Aging Substances: Geroprotectors by Anna D. Fokina, Anna D. Vesnina, Anna S. Frolova, Darya Yu. Chekushkina, Larisa A. Proskuryakova, Larisa M. Aksenova

“…These biologically active substances prevent oxidative stress, accumulation of lipofuscin, and senescent cells. The most effective anti-aging agents come from Vitis amurensis, Rhodiola rosea, Schisandra chinensis, Galega officinalis, Eleutherococcus senticosus, Withania somnifera, and Panax ginseng.…”
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Transgenic plants as genetic models for studying functions of plant genes by A. V. Kochetov, V. K. Shumny

“…It was believed that S-like RNase functions concern mainly phosphate remobilization from senescent organs. However, expression patterns of some genes coding for S-like RNases were similar to some pathogen-responsive genes (both local and systemic induction after wounding or pathogen inoculation). …”
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Outer retina micro-inflammation is driven by T cell responses prior to retinal degeneration in early age-related macular degeneration by Lucas Stürzbecher, Lucas Stürzbecher, Lucas Stürzbecher, Lucas Stürzbecher, Hendrik Bartolomaeus, Hendrik Bartolomaeus, Hendrik Bartolomaeus, Hendrik Bartolomaeus, Theda U. P. Bartolomaeus, Theda U. P. Bartolomaeus, Theda U. P. Bartolomaeus, Theda U. P. Bartolomaeus, Sylvia Bolz, Andjela Sekulic, Marius Ueffing, Marius Ueffing, Simon J. Clark, Simon J. Clark, Simon J. Clark, Nadine Reichhart, Sergio Crespo-Garcia, Nicola Wilck, Nicola Wilck, Nicola Wilck, Nicola Wilck, Olaf Strauß

“…Importantly, the activation of T cells found at early AMD-like stages prior to degeneration possessed long-lasting cytotoxic properties and adopted typical features of senescent immune cells. T cells were intimately associated with the RPE, suggesting transmigration and participating in local micro-inflammation.DiscussionOur data support that activation and accumulation of memory T cells can be considered as a hallmark of early AMD, and that adaptive immunosenescence likely to contribute to the chronic inflammation associated with RPE damage and the progression to large lesions as seen in GA.…”
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Targeting EP2 Receptor Improves Muscle and Bone Health in Dystrophin^−/−/Utrophin^−/− Double-Knockout Mice by Xueqin Gao, Yan Cui, Greg Zhang, Joseph J. Ruzbarsky, Bing Wang, Jonathan E. Layne, Xiang Xiao, Johnny Huard

“…Treatment of DKO-Hom mice with the EP2 antagonist PF04418948 for 2 weeks increased body weight and reduced HO and muscle pathology by decreasing both total macrophages (CD68⁺) and senescent macrophages (CD68⁺P21⁺), while increasing endothelial cells (CD31⁺). …”
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Tracing microbial community across endophyte-to-saprotroph continuum of Cinnamomum camphora (L.) Presl leaves considering priority effect of endophyte on litter decomposition by Jiamin Xiao, Zaihua He, Xingbing He, Yonghui Lin, Xiangshi Kong

“…Endophytes typically coexist with plants in symbiosis and transition into the saprobic system as plant tissues senesce, participating in the decomposition process of litter. …”
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Vieillesse, savoir et genre. Réflexions sur les discours consacrés à la vieillesse dans l'Antiquité by Beate Wagner-Hasel

“…Les commentaires sur les figures mythologiques de Tithon et de la Sybille, êtres hybrides sénescents, établissent en outre une relation étroite entre vieillesse et savoir. …”
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Ambient pollution at hip fracture units and impact on mortality and post-operative delirium: A hormetic effect? by Chika Edward Uzoigwe, Rana Muhammad Anss Bin Qadir, Ahmed Daoub

“…Using the UK National Hip Fracture Database and Defra Data (Department of Environmental, Food & Rural Affairs) we determined the annual mean PM2.5 PM10 and nitrogen dioxide exposure for all the units treating senescent hip fracture patients. We correlated these ambient pollutant levels with all-cause 30-day mortality and incidence of post-operative delirium for hip fracture patients. …”
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Life history, reproductive, and demographic parameters for bottlenose dolphins (Tursiops truncatus) in Sarasota Bay, Florida by Randall S. Wells, Aleta A. Hohn, Michael D. Scott, Jay C. Sweeney, Forrest I. Townsend, Jason B. Allen, Aaron A. Barleycorn, Katherine A. McHugh, Kim Bassos-Hull, Gretchen N. Lovewell, Deborah A. Duffield, Cynthia R. Smith, A. Blair Irvine

“…Ten percent of females were considered to be reproductively senescent, having gone >13 years without producing a calf. …”
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The Pathogenic Role of Expanded CD8⁺CD28^null Angiogenic T Cells in ANCA-Associated Vasculitis by Haomiao Shen, Jinlin Miao, Haoyang Sun, Kui Zhang, Renli Liu, Zichao Li, Leyang Zhang, Peiyan Zhang, Jiawei Wang, Bei Zhang, Longyu Chen, Zhaohui Zheng, Ping Zhu

“…<b>Objectives:</b> Angiogenic T cells (Tang) are crucial in promoting angiogenesis, with the loss of CD28 serving as a marker for highly differentiated and senescent T cells. This study aims to investigate the characteristics and potential roles of CD8⁺CD28^null Tang in patients with ANCA-associated vasculitis (AAV). …”
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