Differential Susceptibility to Propofol and Ketamine in Primary Cultures of Young and Senesced Astrocytes by Liang Huang, Ferit Tuzer, Abigail Murtha, Michael Green, Claudio Torres, Henry Liu, Shadi Malaeb

“…In this study, we examined the survival and viability of both young and senescent astrocytes in culture after adding propofol and ketamine to the media at varying strengths. …”
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Specific types of male infertility are correlated with T cell exhaustion or senescence signatures by Giada Amodio, Giorgia Giacomini, Luca Boeri, Massimiliano Raffo, Simone Cilio, Edoardo Pozzi, Federico Belladelli, Fausto Negri, Anna Maria Ferrara, Alessia d’Arma, Francesca Romana Santoni de Sio, Luca Pagliardini, Enrico Papaleo, Eugenio Ventimiglia, Massimo Alfano, Francesco Montorsi, Andrea Salonia, Silvia Gregori

“…Transcriptomic profiling confirms the upregulation of genes associated with the interferon-gamma and -alpha responses in peripheral blood T cells of infertile men with oligo-astheno-teratozoospermia or non-obstructive azoospermia, with distinct T cell signatures of exhaustion and senescence discriminating the two infertile conditions. …”
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The crosstalk between senescence, tumor, and immunity: molecular mechanism and therapeutic opportunities by Zehua Wang, Chen Chen, Jiaoyu Ai, Yaping Gao, Lei Wang, Shurui Xia, Yongxu Jia, Yanru Qin

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UFMylation maintains YAP stability to promote vascular endothelial cell senescence by Yanan Liu, Min Zuo, Aiwei Wu, Zhaoxiang Wang, Siting Wang, Yongping Bai, Junzhi Zhou, Hu Wang

“…Summary: Endothelial cell (EC) senescence is an accomplice for vascular aging, which leads to cardiovascular diseases (CVDs). …”
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Cellular senescence-associated genes in rheumatoid arthritis: Identification and functional analysis. by You Ao, Qing Lan, Tianhua Yu, Zhichao Wang, Jing Zhang

“…Next, we pinpointed 29 differentially expressed genes (DEGs) linked to cellular senescence in RA, aligning them with genes from CellAge. …”
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SenPred: a single-cell RNA sequencing-based machine learning pipeline to classify deeply senescent dermal fibroblast cells for the detection of an in vivo senescent cell burden by Bethany K. Hughes, Andrew Davis, Deborah Milligan, Ryan Wallis, Federica Mossa, Michael P. Philpott, Linda J. Wainwright, David A. Gunn, Cleo L. Bishop

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Increase of circulating IGFBP-4 following genotoxic stress and its implication for senescence by Nicola Alessio, Tiziana Squillaro, Giovanni Di Bernardo, Giovanni Galano, Roberto De Rosa, Mariarosa AB Melone, Gianfranco Peluso, Umberto Galderisi

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Resolution of oncogene-induced senescence markers in HPV-infected cervical cancer tissue by Ashraf I. Khasawneh, Sofian Al Shboul, Nisreen Himsawi, Amani Al Rousan, Nisreen Abu Shahin, Mohammed El-Sadoni, Ahmad Alhesa, Ala’ Abu Ghalioun, Suzan Khawaldeh, Bayan Shawish, Salem Abu Mahfouz, Mais Al-Shayeb, Shatha Abo Dawoud, Raghad Tlilan, Mohammad Nuseir, Moureq R. Alotaibi, Ola Abu Al Karsaneh, Fida Asali, Marcos Yébenes Mayordomo, Raghda Barham, Rame Khasawneh, Tareq Saleh

Subjects: “…Oncogene-induced senescence…”
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MSC-sEVs exacerbate senescence by transferring bisecting GlcNAcylated GPNMB by Yihan Ma, Chongfu Zhao, Jingjing Feng, Junjie Gou, Enci Kang, Feng Guan, Qiong Wu, Xiang Li

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Daily Feeding of Fructooligosaccharide or Glucomannan Delays Onset of Senescence in SAMP8 Mice by Sadako Nakamura, Naoyuki Kondo, Yoshitake Yamaguchi, Michiru Hashiguchi, Kenichi Tanabe, Chihiro Ushiroda, Miho Kawahashi-Tokuhisa, Katsuyuki Yui, Mana Miyakoda, Tsuneyuki Oku

“…We hypothesized that daily intake of nondigestible saccharides delays senescence onset through the improvement of intestinal microflora. …”
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Identification of Senescence-Associated Biomarkers in Diabetic Glomerulopathy Using Integrated Bioinformatics Analysis by Li Zhang, Zhaoxiang Wang, Fengyan Tang, Menghuan Wu, Ying Pan, Song Bai, Bing Lu, Shao Zhong, Ying Xie

“…Background. Cellular senescence is thought to play a significant role in the onset and development of diabetic nephropathy. …”
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Growth and senescence of mavuno, marandu, ipyporã and mulato II grasses subjected to stockpiling by Bruno Humberto Rezende Carvalho, Gustavo Segatto Borges, Dallety Haloma Alves Miler de Oliveira, Geovana Lopes Nascimento, Khazuê Ubagai Machado, Manoel Eduardo Rosalino Santos

“… The objective of this study was to evaluate, during the stockpiling period, the growth and senescence of marandu, mavuno, ipyporã and mulato II grasses. …”
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Blockades of effector T cell senescence and exhaustion synergistically enhance antitumor immunity and immunotherapy by Xia Liu, Emily Shaw, Fusheng Si, Guangyong Peng, Yan Tao, Feiya Ma, David Bagley, Yuanqin Zhang

“…Therefore, a better understanding of the molecular mechanism responsible for T cell senescence in the TME and development of novel strategies to prevent effector T cell senescence are urgently needed for cancer immunotherapy.Methods Senescent T cell populations in the TMEs in mouse lung cancer, breast cancer, and melanoma tumor models were evaluated. …”
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Expression and prognosis of cellular senescence genes in head and neck squamous cell carcinoma by Chen Feng, Lijuan Zhu, Wei Mao, Pin Dong, Xinwei Chen

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Identification of cardiac premature senescence markers through GEO database interaction approach by Tiwuk Susantiningsih, Ani Retno Prijanti, Novi Silvia Hardiany, Fadilah

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Waterlogging of soil induces diverging rates of senescence in Svalbard reindeer forage plants by Emilie K. S. Andersen, Samantha P. H. Dwinnell, Leif Egil Loe, Caroline Iveland, René van der Wal

“…These results indicate that soil moisture moderates rates of plant senescence, with some species benefiting from saturated soils. …”
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Human Endogenous Retroviruses and Their Putative Role in Pathogenesis of Alzheimer’s Disease, Inflammation, and Senescence by Patrycja Kozubek, Julia Kuźniar, Magdalena Czaja, Hanna Sitka, Urszula Kochman, Jerzy Leszek

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Erythrocyte Senescence in a Model of Rat Displaying Hutchinson-Gilford Progeria Syndrome by Manoj Kumar Chaudhary, Syed Ibrahim Rizvi

“…In the present study, attempts have been made to explore the differential response of young and senescent erythrocytes separated by density gradient centrifugation from accelerated senescence model of rats mimicking Hutchinson-Gilford progeria syndrome and naturally aged rats. …”
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Impact of Periodontitis and Oral Dysbiosis Metabolites in the Modulation of Accelerating Ageing and Human Senescence by Mariacristina Amato, Alessandro Polizzi, Gaia Viglianisi, Francesco Leonforte, Marco Mascitti, Gaetano Isola

“…Lastly, therapeutic strategies targeting periodontitis and oral dysbiosis to mitigate senescence and its associated morbidities will be discussed.…”
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Therapeutic implications and comprehensive insights into cellular senescence and aging in the tumor microenvironment of sarcoma by Pengfei Zan, Yi Zhang, Yidong Zhu, Qingjing Chen, Zhengwei Duan, Yonghao Guan, Kaiyuan Liu, Anquan Shang, Zihua Li

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