Karyopherin Alpha 2-Expressing Pancreatic Duct Glands and Intra-Islet Ducts in Aged Diabetic C414A-Mutant-CRY1 Transgenic Mice by Satoshi Okano, Akira Yasui, Shin-ichiro Kanno, Kennichi Satoh, Masahiko Igarashi, Osamu Nakajima

“…Our earlier studies demonstrated that cysteine414- (zinc-binding site of mCRY1-) alanine mutant mCRY1 transgenic mice (Tg mice) exhibit diabetes characterized by the reduction of β-cell proliferation and by β-cell dysfunction, presumably caused by senescence-associated secretory phenotype- (SASP-) like characters of islets. …”
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Inflammatory and immunological markers and risk for mortality and cognitive impairment in a longitudinal study of older adults from the longevous project by M.R. Caldeira, C.M. Almada-Filho, M.C. Brunialti, R. Salomão, M.S. Cendoroglo

“…Senescence of the immunological system is characterized by alterations in immune system cells associated with aging, often linked to cognitive disorders and mortality.Objective:To determine the prevalence of immunological changes, including immunological risk profile (IRP), and its association with cognitive impairments or mortality in oldest-old individuals.Method:A longitudinal study of 201 older adults aged ≥80 years, able to walk unaided, with no cognitive or immunological impairment, and with no serious disease at baseline was conducted. …”
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A lower atherogenic index of plasma was associated with a higher incidence of sarcopenia by Zhiping Duan, Yunda Huang, Xiaoling Liu, Huiyu Tang, Guihua Jiang, Wei Huang, Runfen Du, Dan Zhou, Hong Yang

“…Abstract Sarcopenia is an age-related muscle senescence disease that leads to functional limitations, physical disability and premature death in older adults. …”
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Mesenchymal Stem/Stromal Cells Derived from Induced Pluripotent Stem Cells Support CD34pos Hematopoietic Stem Cell Propagation and Suppress Inflammatory Reaction by Mohsen Moslem, Irina Eberle, Iuliia Weber, Reinhard Henschler, Tobias Cantz

“…In direct comparison to BM-MSCs our iPSC-MSCs exhibited a similar surface marker expression profile but shorter doubling times without reaching senescence within 20 passages. Considering functional capabilities, iPSC-MSCs provided supportive feeder layer for CD34+ hematopoietic stem cells’ self-renewal and colony forming capacities. …”
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Endothelial-Ercc1 DNA repair deficiency provokes blood-brain barrier dysfunction by Cathrin E. Hansen, Davide Vacondio, Lennart van der Molen, Annika A. Jüttner, Wing Ka Fung, Manon Karsten, Bert van het Hof, Ruud D. Fontijn, Gijs Kooij, Maarten E. Witte, Anton J. M. Roks, Helga E. de Vries, Inge Mulder, Nienke M. de Wit

“…In vitro, ERCC1-deficient brain ECs displayed increased senescence-associated secretory phenotype expression, reduced BBB integrity, and higher sprouting capacities due to an underlying dysregulation of the Dll4-Notch pathway. …”
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The Natural History of Uterine Leiomyomas: Light and Electron Microscopic Studies of Fibroid Phases, Interstitial Ischemia, Inanosis, and Reclamation by Gordon P. Flake, Alicia B. Moore, Deloris Sutton, Grace E. Kissling, John Horton, Benita Wicker, David Walmer, Stanley J. Robboy, Darlene Dixon

“…This cycle can be arbitrarily divided on the basis of morphologic assessment of the collagen content into 4 phases: (1) proliferation, (2) proliferation and synthesis of collagen, (3) proliferation, synthesis of collagen, and early senescence, and (4) involution. Involution occurs as a result of both vascular and interstitial ischemia. …”
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Thyroid hormone receptor- and stage-dependent transcriptome changes affect the initial period of Xenopus tropicalis tail regeneration by Shouhong Wang, Liezhen Fu, Bin Wang, Yanmei Cai, Jianping Jiang, Yun-Bo Shi

“…In addition, the regulated genes specific to the nonregenerative group were highly enriched with genes involved in cellular senescence. Finally, T3 treatment at stage 56, while not inducing any measurable tail resorption, inhibited tail regeneration in the wild type but not TRDKO tadpoles. …”
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Transcriptome integration analysis revealed that miR-103-3p regulates goat myoblast proliferation by targeting FGF18 by Kunyu Li, Yize Song, Yekai Fan, Hui Zhang, Mingxing Chu, Yufang Liu

“…A functional enrichment analysis of these targeted genes revealed significant enrichment in pathways closely correlated with skeletal muscle growth, development, and senescence. Notably, chi-miR-103-3p was identified among the DE miRNAs and appeared to play an important role in skeletal myoblast proliferation. …”
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METTL14-mediated m6A modification of DDIT4 promotes its mRNA stability in aging-related idiopathic pulmonary fibrosis by Dan Li, Li Qian, Yufeng Du, Lifang Liu, Ziyue Sun, Yongkang Han, Xiangrui Guo, Chao Shen, Zheng Zhang, Xuejun Liu

“…Moreover, we established an animal model and a senescent model of A549 cells to explore the associated molecular mechanism. …”
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Benzo-pyrrolidinyl substituted silicon phthalocyanines: A novel two-photon lysosomal nanoprobe for in vitro photodynamic therapy by Xiuqin Chen, Guizhi Chen, Sitong Cao, Ruoxin Ye, Ruoyi Qiu, Xiangyu Yang, Yiru Peng, Hong Sun

“…Lysosomes are pivotal in diverse physiological phenomena, encompassing autophagy, apoptosis, and cellular senescence. The demand for precise tumors treatment has led to the development of specific lysosome-targeting probes capable of elucidating lysosomal dynamics and facilitating targeted cell death. …”
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Inhibition of NLRP3 enhances pro-apoptotic effects of FLT3 inhibition in AML by Helene Sieberer, Michela Luciano, Diana Amend, Constantin Blöchl, Anna Eglseer, Alina Steinkellner, Sebastian Rieser, Ancuela Andosch, Philip Steiner, Laura Hummer, Peter W. Krenn, Hieu-Hoa Dang, Christian G. Huber, Fritz Aberger, Theresa Neuper, Jutta Horejs-Hoeck

“…Our findings reveal that NLRP3 inhibition induces cell cycle arrest as well as signs of senescence in multiple AML cell lines. In contrast, NLRP3 inhibition selectively induced apoptosis in FLT3 mutant AML cell lines, but not in FLT3 wild-type AML cells. …”
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Mechanism of <italic>Hedyotis Diffusa</italic> in Treatment of Osteosarcoma based on Network Pharmacology and Molecular Docking by Qin LIU, Xinwei DUAN, Xihai LI

“…The 155 pathways of Hedyotis diffusa interfering with osteosarcoma were analyzed by KEGG enrichment based on 98 core genes, such as IL-17 signaling pathway, apoptosis, TNF signaling pathway, p53 signaling pathway and cellular senescence. The molecular docking results showed that the binding affinity between AKT1, CCND1, FOS, MAPK1, TP53, MYC and quercetin, ERS1 and 2-methoxy-3-methyl-9, 10-anthraquinone, JUN and beta-sitosterol were all less than-7 kcal/mol.Conclusion:The process of osteosarcoma can be intervened by Hedyotis diffusa through multiple components interacting with multiple targets of osteosarcoma and regulating multiple pathways, which can provide reference for the clinical application and development of Hedyotis diffusa.…”
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Synergistic interaction between wheat streak mosaic virus and Triticum mosaic virus modulates wheat transcriptome to favor disease severity by Haritha Nunna, Nathan A. Palmer, Gautam Sarath, Stephen N. Wegulo, Satyanarayana Tatineni, Satyanarayana Tatineni

“…Gene ontology, protein domain and KEGG (Kyoto Encyclopedia of Genes and Genomes) pathway enrichment analysis revealed that genes specifically related to photosynthesis, growth, stress, senescence, and defense were differentially enriched. …”
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TAp63γ is the primary isoform of TP63 for tumor suppression but not development by Xinbin Chen, Wenqiang Sun, Xiangmudong Kong, Xin Ming, Yanhong Zhang, Wensheng Yan, Shakur Mohibi, Mingyi Chen, Keith Mitchell, Jin Zhang

“…Additionally, loss of p63γ shortens the lifespan of tumor-free mice potentially via increased cellular senescence. Moreover, mice deficient in p63γ are prone to chronic inflammation in multiple organs and liver steatosis potentially via altered lipid metabolism. …”
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A Large-Scale Agricultural Land Classification Method Based on Synergistic Integration of Time Series Red-Edge Vegetation Index and Phenological Features by Huansan Zhao, Chunyan Chang, Zhuoran Wang, Gengxing Zhao

“…Using Shandong Province, northern China’s agricultural heartland, as a case study, we first established a foundation with time series red-edge vegetation indices (REVI) from Sentinel-2 imagery, uniquely combining the normalized difference red edge index (NDRE₇₀₅) and plant senescence reflectance index (PSRI). Moving beyond conventional time series analysis, we innovatively amplified key temporal characteristics through newly designed spatial feature parameters (SFPs) and phenological feature parameters (PFPs). …”
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T-cell immune status in patients with acute exacerbation of chronic obstructive pulmonary disease: a case-control study by Xiao-feng Xiong, Xiao-feng Xiong, Min Zhu, Min Zhu, Hong-xia Wu, Zuo-hong Wu, Li-li Fan, De-yun Cheng

“…AECOPD patients may have cellular immune suppression, immune dysfunction, abnormal activation, and higher senescence depletion of T cells.…”
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Influence of Gender on Cardiac and Encephalic Inflammation in the Elderly with Cysticercosis: A Case Control Study by Camila Lourencini Cavellani, Rosana Rosa Miranda Corrêa, Mara Lúcia Fonseca Ferraz, Laura Penna Rocha, Ana Carolina Guimarães Faleiros, Ruy de Souza Lino Junior, Marlene Antônia dos Reis, Vicente de Paula Antunes Teixeira

“…Furthermore, there are differences concerning gender in the intensity of the inflammatory response due to cysticerci in the heart and brain parenchyma during senescence. Even during this period, women continue to have a more intense response to the parasitosis.…”
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Intercellular TIMP-1-CD63 signaling directs the evolution of immune escape and metastasis in KRAS-mutated pancreatic cancer cells by Chu-An Wang, Ya-Chin Hou, Yi-Kai Hong, Yu-Jing Tai, Chieh Shen, Pei-Chi Hou, Jhao-Lin Fu, Cheng-Lin Wu, Siao Muk Cheng, Daw-Yang Hwang, Yung-Yeh Su, Yan-Shen Shan, Shaw-Jenq Tsai

“…This study investigates how KRAS-mutated epithelial cells acquire the capacity to escape senescence or even immune clearance, thereby progressing to advanced PDAC. …”
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Functional Characterization of the <i>PoWHY1</i> Gene from <i>Platycladus orientalis</i> and Its Role in Abiotic Stress Tolerance in Transgenic <i>Arabidopsis thaliana</i> by Chun Ou, Zhiyu Dong, Xudong Zheng, Wenhui Cheng, Ermei Chang, Xiamei Yao

“…It was found that overexpression of <i>PoWHY1</i> increased seed germination, decreased malondialdehyde accumulation, increased proline content, and delayed the senescence process under salt stress. The expression levels of <i>JAZ1</i>, <i>LOX1</i>, <i>ABI1</i>, and <i>ABI2</i> were decreased, while the expression levels of <i>RAB18</i>, <i>APX1</i>, <i>GSTF6</i>, and <i>DREB2A</i> were increased, indicating that overexpression of <i>PoWHY1</i> enhanced the salt stress tolerance of <i>A. thaliana</i>. …”
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Stem cell-derived exosome delivery systems for treating atherosclerosis: The new frontier of stem cell therapy by Hassan Tariq, Syeda Zunaira Bukhari, Ruibing An, Jian Dong, Ayesha Ihsan, Muhammad Rizwan Younis

“…Exosomes are involved in strategic phases of the onset and development of atherosclerosis because they have been identified to control pathophysiologic pathways including inflammation, angiogenesis, or senescence. This review investigates the potential role of stem cell-derived exosomes in atherosclerosis management. …”
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