A Large-Scale Agricultural Land Classification Method Based on Synergistic Integration of Time Series Red-Edge Vegetation Index and Phenological Features by Huansan Zhao, Chunyan Chang, Zhuoran Wang, Gengxing Zhao

“…Using Shandong Province, northern China’s agricultural heartland, as a case study, we first established a foundation with time series red-edge vegetation indices (REVI) from Sentinel-2 imagery, uniquely combining the normalized difference red edge index (NDRE₇₀₅) and plant senescence reflectance index (PSRI). Moving beyond conventional time series analysis, we innovatively amplified key temporal characteristics through newly designed spatial feature parameters (SFPs) and phenological feature parameters (PFPs). …”
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T-cell immune status in patients with acute exacerbation of chronic obstructive pulmonary disease: a case-control study by Xiao-feng Xiong, Xiao-feng Xiong, Min Zhu, Min Zhu, Hong-xia Wu, Zuo-hong Wu, Li-li Fan, De-yun Cheng

“…AECOPD patients may have cellular immune suppression, immune dysfunction, abnormal activation, and higher senescence depletion of T cells.…”
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Influence of Gender on Cardiac and Encephalic Inflammation in the Elderly with Cysticercosis: A Case Control Study by Camila Lourencini Cavellani, Rosana Rosa Miranda Corrêa, Mara Lúcia Fonseca Ferraz, Laura Penna Rocha, Ana Carolina Guimarães Faleiros, Ruy de Souza Lino Junior, Marlene Antônia dos Reis, Vicente de Paula Antunes Teixeira

“…Furthermore, there are differences concerning gender in the intensity of the inflammatory response due to cysticerci in the heart and brain parenchyma during senescence. Even during this period, women continue to have a more intense response to the parasitosis.…”
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Intercellular TIMP-1-CD63 signaling directs the evolution of immune escape and metastasis in KRAS-mutated pancreatic cancer cells by Chu-An Wang, Ya-Chin Hou, Yi-Kai Hong, Yu-Jing Tai, Chieh Shen, Pei-Chi Hou, Jhao-Lin Fu, Cheng-Lin Wu, Siao Muk Cheng, Daw-Yang Hwang, Yung-Yeh Su, Yan-Shen Shan, Shaw-Jenq Tsai

“…This study investigates how KRAS-mutated epithelial cells acquire the capacity to escape senescence or even immune clearance, thereby progressing to advanced PDAC. …”
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Functional Characterization of the <i>PoWHY1</i> Gene from <i>Platycladus orientalis</i> and Its Role in Abiotic Stress Tolerance in Transgenic <i>Arabidopsis thaliana</i> by Chun Ou, Zhiyu Dong, Xudong Zheng, Wenhui Cheng, Ermei Chang, Xiamei Yao

“…It was found that overexpression of <i>PoWHY1</i> increased seed germination, decreased malondialdehyde accumulation, increased proline content, and delayed the senescence process under salt stress. The expression levels of <i>JAZ1</i>, <i>LOX1</i>, <i>ABI1</i>, and <i>ABI2</i> were decreased, while the expression levels of <i>RAB18</i>, <i>APX1</i>, <i>GSTF6</i>, and <i>DREB2A</i> were increased, indicating that overexpression of <i>PoWHY1</i> enhanced the salt stress tolerance of <i>A. thaliana</i>. …”
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Antioxidant Effect of Beer Polyphenols and Their Bioavailability in Dental-Derived Stem Cells (D-dSCs) and Human Intestinal Epithelial Lines (Caco-2) Cells by Marina Di Domenico, Antonia Feola, Pasqualina Ambrosio, Federica Pinto, Giovanni Galasso, Armando Zarrelli, Giovanni Di Fabio, Marina Porcelli, Salvatore Scacco, Francesco Inchingolo, Lucio Quagliuolo, Andrea Ballini, Mariarosaria Boccellino

“…In the presence of an intense stressing event, cells activate specific responses to counteract cell death or senescence which is known to act as a key-task in the onset of age-related pathologies and in the loss of tissue homeostasis. …”
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Mesenchymal Stem Cell Therapy for Diabetic Kidney Disease: A Review of the Studies Using Syngeneic, Autologous, Allogeneic, and Xenogeneic Cells by Christian Sávio-Silva, Stephany Beyerstedt, Poliana E. Soinski-Sousa, Expedito B. Casaro, Maria Theresa A. Balby-Rocha, Antônio Simplício-Filho, Jamille Alves-Silva, Érika B. Rangel

“…Conversely, MSCs derived from DM2 individuals are usually dysfunctional, exhibiting higher rates of senescence and apoptosis and a decrease in clonogenicity, proliferation, and angiogenesis potential. …”
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Microbial Metagenomes Across a Complete Phytoplankton Bloom Cycle: High-Resolution Sampling Every 4 Hours Over 22 Days by Brook L. Nunn, Emma Timmins-Schiffman, Miranda C. Mudge, Deanna L. Plubell, Gabriella Chebli, Julia Kubanek, Michael Riffle, William S. Noble, Elizabeth Harvey, Tasman A. Nunn, Tatiana Rynearson, Marcel Huntemann, Kurt LaButti, Brian Foster, Bryce Foster, Simon Roux, Krishnaveni Palaniappan, Supratim Mukherjee, T. B. K. Reddy, Chris Daum, Alex Copeland, I-Min A. Chen, Natalia N. Ivanova, Nikos C. Kyrpides, Tijana Glavina del Rio, Emiley A. Eloe-Fadrosh

“…This dataset also has time-matched nutrient analyses, flow cytometry data, and physical parameters of the environment at a single point of sampling within a coastal ecosystem that experiences regular bloom events, facilitating a range of modeling efforts that can be leveraged to understand microbial community structure and their influences on the growth, maintenance, and senescence of phytoplankton blooms.…”
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Metabolomics and gene expression levels reveal the positive effects of teaseed oil on lifespan and aging process in Caenorhabditis elegans by Yanan Wang, Jiachen Shi, Kun Liu, Yu Wang, Yongjiang Xu, Yuanfa Liu

“…In this paper, the metabolic profiling and gene expression levels of Caenorhabditis elegans were investigated to explore the effects of different edible oils on senescence and lifespan. The results showed that teaseed oil (TO) could prolong the life expectancy and slow down the aging process of C. elegans. …”
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FBR2 modulates ferroptosis via the SIRT3/p53 pathway to ameliorate pulmonary fibrosis by Yu Cheng, Yang Jiao, Wan Wei, Mengjia Kou, Yaodong Cai, Yang Li, Hao Li, Tonghua Liu

“…The use of 3-TYP further confirmed FBR2’s intervention in ferroptosis and cellular senescence through the SIRT3/p53 pathway.ConclusionFBR2 shows therapeutic potential in a BLM-induced pulmonary fibrosis mouse model, with its effects mediated through modulation of the ferroptosis pathway via the SIRT3/p53 mechanism. …”
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Thymus ad astra, or spaceflight-induced thymic involution by Wataru Muramatsu, Wataru Muramatsu, Maria Maryanovich, Maria Maryanovich, Maria Maryanovich, Taishin Akiyama, Taishin Akiyama, George S. Karagiannis, George S. Karagiannis, George S. Karagiannis, George S. Karagiannis, George S. Karagiannis, George S. Karagiannis

“…Cosmic radiation, an omnipresent hazard beyond Earth’s magnetosphere, accelerates DNA damage and cellular senescence in thymic epithelial cells, impairing thymopoiesis and increasing the risk of immune dysregulation. …”
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Anti-Inflammatory Effects of Concentrated Ethanol Extracts of Edelweiss (Leontopodium alpinum Cass.) Callus Cultures towards Human Keratinocytes and Endothelial Cells by Lulli Daniela, Potapovich Alla, Riccardo Maurelli, Dellambra Elena, Pressi Giovanna, Kostyuk Vladimir, Dal Toso Roberto, De Luca Chiara, Pastore Saveria, Korkina Liudmila

“…Trichostatin A, a sirtuin inhibitor, was used to induce keratinocyte inflammatory senescence. ECC55 (10–50 μg/mL) protected PHK from solar UV-driven damage, by enhancing early intracellular levels of nitric oxide, although not affecting UV-induced expression of inflammatory genes. …”
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A study on the classification of coastal wetland vegetation based on the Suaeda salsa index and its phenological characteristics by Weicheng Huang, Xianyun Fei, Weiwei Yang, Zhen Wang, Yajun Gao, Hong Yan

“…Therefore, in this study, based on the analysis of the spectral separability of Suaeda salsa (S. salsa) and native vegetation, two new Red Suaeda salsa Indices (RSSI and RSSI(1)) were constructed by selecting the red, green and near-infrared bands of the Sentinel 2 multispectral band, and then, based on the sample points, we constructed the RSSI time series and fitted using Fourier function fitting, and extracted (a) Difference Of RSSI (DOR), (b) Sum Of RSSI (SOR), (c) Ratio Of Green-up RSSI (ROGR), and (d) Ratio Of Senescence RSSI (ROSR) from the phenological fitting curve. …”
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Indications for an antidepressive effect of thymosin alpha-1 in a small open-label proof of concept study in common variable immune deficiency patients with depression by Daniël G. Aynekulu Mersha, Sarah E. Fromme, Frank van Boven, Gara Arteaga-Henríquez, Annemarie Wijkhuijs, Marianne van der Ent, Raf Berghmans, Bernard T. Baune, Hemmo A. Drexhage, Virgil Dalm

“…These subjects are characterized by reduced naïve T cells and a premature T cell senescence similar to that of patients with major depressive disorder (MDD). …”
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<i>Agrobacterium rhizogenes</i>-Mediated Hairy Root Transformation in <i>Rosa</i> by Jun Lu, Yuwen Huang, Yuhan Guo, Chunguo Fan, Guozhen Yuan, Rui Zhou, Jingjing Sun, Mengjuan Bai, Kun Wang, Jinyi Liu, Changquan Wang

“…Improving ornamental qualities (color, aroma, flower shape, plant architecture, petal senescence), agronomic traits (disease resistance, stress tolerance), and other traits would add value to cultivated roses. …”
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Multiomics identify the gene expression signature of the spinal cord during aging process by Lintao Xu, Jingyu Wang, Jinjie Zhong, Weiwei Lin, Gerong Shen, Ning He, Xingjia Mao, Chunyan Fu, Zhaobo Huang, Fengdong Zhao, Xin Ye, Yongjian Zhu, Mingzhi Zheng, Hui Li, Lin-lin Wang, Kai Zhong, Lijun Zhu, Ying-ying Chen

“…However, the current understanding of the senescent spinal cord remains insufficient. Bulk RNA sequencing reveals that 526 genes are upregulated and 300 genes are downregulated in senescent spinal cords. …”
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Deficiency of ATF3 facilitates both angiotensin II‐induced and spontaneously formed aortic aneurysm and dissection development by activating cGAS–STING pathway by Yifan Du, Poyi Hu, Xiangchao Ding, Dashuai Wang, Jingjing Luo, Sheng Le, Lingyun Ren, Manhua Chen, Ping Ye, Jiahong Xia

“…Interestingly, older Atf3 cKO mice exhibited spontaneous aortic dissections and senescence of the aortic wall. Mechanistically, ATF3 deficiency led to the degradation of P21 through ubiquitination. …”
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Positive impacts of typical desert photovoltaic scenarios in China on the growth and physiology of sand-adapted plants by Ruibing Meng, Ruibing Meng, Ruibing Meng, Zhongju Meng, Zhongju Meng, Zhongju Meng, Xiaomeng Ren, Jiale Cai, Jiale Cai, Jiale Cai, Xufang Tong, Xufang Tong, Xufang Tong

“…Notably, superoxide dismutase (SOD) and peroxidase (POD) activities were higher in all treated plants compared to those of CK, effectively removing O2− and providing H2O2 protection, thereby delaying plant senescence and demonstrating strong adaptability. Through membership function analysis, the plant’s tolerance levels at various positions around the PV panels ranked under panels &gt; before panels &gt; behind panels &gt; CK. …”
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Evaluation of patient immunocompetence for immune checkpoint inhibitor therapy using the psoas muscle index: a retrospective cohort study by Toshiaki Tsurui, Toshiaki Tsurui, Toshiaki Tsurui, Toshiaki Tsurui, Kazuyuki Hamada, Emiko Mura, Risako Suzuki, Nana Iriguchi, Tomoyuki Ishiguro, Yuya Hirasawa, Ryotaro Ohkuma, Masahiro Shimokawa, Hirotsugu Ariizumi, Yutaro Kubota, Atsushi Horiike, Satoshi Wada, Satoshi Wada, Kiyoshi Yoshimura, Kiyoshi Yoshimura, Mayumi Tsuji, Yuji Kiuchi, Yuji Kiuchi, Takuya Tsunoda

“…Skeletal muscle interacts with the immune system, and sarcopenia is associated with immune senescence. However, the association between sarcopenia and the response to immune checkpoint inhibitor (ICI) therapy remains unclear.MethodsThis retrospective study included patients with advanced or recurrent non-small cell lung cancer treated with nivolumab or pembrolizumab monotherapy. …”
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Sex differences in epigenetic ageing for older people living with HIVResearch in context by Carrie D. Johnston, Alina P.S. Pang, Eugenia L. Siegler, Charlene Thomas, Chelsie O. Burchett, Mia Crowley, Rochelle O'Brien, Lishomwa C. Ndhlovu, Marshall J. Glesby, Michael J. Corley

“…We found epigenetic age acceleration associated with plasma proteomic markers involved in inflammation, senescence, immune regulation, kidney function, and tissue homoeostasis (p < 0.0001). …”
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