Association of p53 with Neurodegeneration in Parkinson’s Disease by Qiang Luo, Wei Sun, Yi-Fan Wang, Ji Li, Da-Wei Li

“…p53 is a vital transcriptional protein implicated in regulating diverse cellular processes, including cell cycle arrest, DNA repair, mitochondrial metabolism, redox homeostasis, autophagy, senescence, and apoptosis. Recent studies have revealed that p53 levels and activity are substantially increased in affected neurons in cellular and animal models of Parkinson’s disease (PD) as well as in the brains of PD patients. p53 activation in response to neurodegenerative stress is closely associated with the degeneration of dopaminergic neurons accompanied by mitochondrial dysfunction, reactive oxygen species (ROS) production, abnormal protein aggregation, and impairment of autophagy, and these pathogenic events have been implicated in the pathogenesis of PD. …”
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Age-Dependent Constraints of Sex Allocation in a Parasitoid Wasp by Takatoshi Ueno

“…Physiological constraints such as sperm depletion and senescence are a likely cause. Also, maternal control in response to female age may be an alternative explanation. …”
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Sirtuin activators as an anti-aging intervention for longevity by Puja Sah, Anita K. Rai, Donkupar Syiem

“…The mammalian sirtuins comprise seven members that have a role in energy metabolism, DNA repair, inflammation, cell survival, apoptosis, cellular senescence, oxidative stress, and mitochondrial production. …”
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PIK3CA and p53 Mutations by Next Generation Sequencing in Lymphoepithelioma-Like Carcinoma of the Endometrium by Lucie Bienfait, Nicky D’Haene, Xavier Catteau, Jean-Christophe Noël

“…Nevertheless, in endometrial lymphoepithelioma-like carcinoma, the alterations on cell cycle, apoptosis, and/or senescence secondary to p53 mutations could potentially be counterbalanced by the antitumoral response induced by CD8 cytotoxic T-lymphocytes numerous in these tumors.…”
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Effect of compost formulation and postharvest management on quality parameters of button mushroom by Mohammad Ebrahim Ranjbar, Zahra Ghahremani

“…Quality parameters including color (browning due to microbial activity), cap opening and the weight loss (senescence) were evaluated. Results The nature of the manure employed as base material in the substrate can affect the postharvest browning ratio of mushroom. …”
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Black Pepper’s Anti-Aging and Chemoprevention Properties: A Review by Endah

“…Overall, the anti-aging properties of black pepper and its constituents are exhibited through several pathways, including senescence prevention, antioxidant protection, control of ROS levels, and the inhibition of aging-related enzymes. …”
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The future of physiological research: A greater understanding of female master athletes and aging? by Lorcan S. Daly

“…Such analyses would improve our understanding of senescence in women and may inform interventions targeting the promotion of physical function in older adults.…”
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Artificial Light at Night (ALAN) as an Emerging Urban Stressor for Tree Phenology and Physiology: A Review by Luisa Friulla, Laura Varone

“…Changes in phenology such as delayed senescence and altered budburst timing demonstrated species-specific responses, often compounded by other urban stressors like heat and drought. …”
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A Hypothesis Concerning a Potential Involvement of Ceramide in Apoptosis and Acantholysis Induced by Pemphigus Autoantibodies by Wendy B. Bollag

“…Our hypothesis is that: (1) the autoantibodies generate pathology through an alteration in ceramide metabolism in targeted keratinocytes, resulting in apoptosis and/or cell death and acantholysis, but only when the cell's ability to metabolize ceramide is exceeded, and (2) apoptosis in response to this altered ceramide metabolism is initiated and/or exacerbated by other agents that increase ceramide levels, such as cytokines, ultraviolet irradiation, and senescence.…”
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Hemoglobin: A Nitric-Oxide Dioxygenase by Paul R. Gardner

“…NOD knockout organisms and cells expressing recombinant NODs are helping to advance our understanding of NO actions in microbial infection, plant senescence, cancer, mitochondrial function, iron metabolism, and tissue O2 homeostasis. …”
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Higher-Order Chromatin Regulation of Inflammatory Gene Expression by Jin-Wen Xu, Shuang Ling, Jun Liu

“…Whether it is caused by viruses and bacteria infection, or low-grade chronic inflammation of atherosclerosis and cellular senescence, the transcription factor (TF) NF-κB plays a central role in the inducible expression of inflammatory genes. …”
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Mechanisms of liver disease in patients infected with HIV by Matthew B Kaspar, Richard K Sterling

“…A thorough understanding of the mechanisms driving the development of liver disease in these patients is essential when evaluating and caring for these patients.Methods The literature regarding mechanisms of liver disease by which different disease entities may cause hepatic injury and fibrosis was reviewed and synthesised.Results A number of discrete mechanisms of injury were identified, to include: oxidative stress, mitochondrial injury, lipotoxicity, immune-mediated injury, cytotoxicity, toxic metabolite accumulation, gut microbial translocation, systemic inflammation, senescence and nodular regenerative hyperplasia. Disease states may use any number of these mechanisms to exert their effect on the liver.Conclusions The mechanisms by which liver injury may occur in patients with HIV infection are numerous. …”
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Paracrine Proangiogenic Function of Human Bone Marrow-Derived Mesenchymal Stem Cells Is Not Affected by Chronic Kidney Disease by Femke C. C. van Rhijn-Brouwer, Bas W. M. van Balkom, Diana A. Papazova, Diënty H. M. Hazenbrink, Anke J. Meijer, Isaac Brete, Vidalmar Briceno, Arjan D. van Zuilen, Raechel J. Toorop, Joost O. Fledderus, Hendrik Gremmels, Marianne C. Verhaar

“…BM MSC differentiation capacity, proliferation, and senescence-associated β-galactosidase activity was assessed. …”
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NEAT1 regulates BMSCs aging through disruption of FGF2 nuclear transport by Zifei Wang, Wenyu Zhen, Qing Wang, Yuqiang Sun, Siyu Jin, Sensen Yu, Xing Wu, Wenhao Zhang, Yulong Zhang, Fei Xu, Rui Wang, Yuxuan Xie, Wansu Sun, Jianguang Xu, Hengguo Zhang

“…LncRNA NEAT1 is considered as a proliferative inhibitory role during cellular senescence, but the relevant mechanisms remain insufficient. …”
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Evaluation of Pigeon Pea Lines for Biological Soil Decompaction by Rodolfo Godoy, Osny Oliveira Santos Bacchi, Fernando Almeida Moreira, Klaus Reichardt

“…Soil decompaction is generally achieved through mechanical cultivation practices; however biological processes can significantly add to this process through root growth, development, and later senescence. This study was carried out in Piracicaba, SP, Brazil and had the purpose of selecting, among forty one pure pigeon pea lines, the most efficient genotypes that promote soil decompaction by roots penetrating compacted soil layers. …”
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ATM in immunobiology: From lymphocyte development to cancer immunotherapy by Ji-Hoon Lee

“…Additionally, it addresses ATM's involvement in inflammation and immune senescence, linking DNA damage response to age-related immune decline. …”
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Current Progress in the Rejuvenation of Aging Stem/Progenitor Cells for Improving the Therapeutic Effectiveness of Myocardial Repair by Gurleen Kaur, Chuanxi Cai

“…However, donor cells from aging patients are more likely to be in a senescent stage. Rejuvenation is required to reverse the damage levied by aging and promote a youthful phenotype. …”
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Aging, cancer, and autophagy: connections and therapeutic perspectives by Begoña Zapatería, Esperanza Arias, Esperanza Arias

“…As organisms age, cellular stress, genomic instability, and an accumulation of senescent cells create a pro-inflammatory environment conducive to cancer development. …”
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Sirtuin 1 and Aging Theory for Chronic Obstructive Pulmonary Disease by V. Conti, G. Corbi, V. Manzo, G. Pelaia, A. Filippelli, A. Vatrella

“…The present review focuses on the involvement of SIRT1 in the regulation of redox state, inflammation, and premature senescence, all crucial characteristics of COPD phenotypes. …”
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Moving from an “anti-aging” paradigm toward the concept of “disease-free aging”: the role of senolytics in modern medicine by Ivan Aprahamian, Andréia Pain, Virgílio Garcia Moreira

“…Senescent cells increase with aging and are related to the promotion of inflammation and neoplasia through the senescence-associated secretory phenotype (SASP). …”
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