Economic evaluation of integrated services for non-communicable diseases and HIV: costs and client outcomes in rural Malawi by Luckson Dullie, Emily B Wroe, Elizabeth L Dunbar, Noel Kalanga, Lawrence Nazimera, Adarsh Shah, Bright Mailosi, Chiyembekezo Kachimanga, Ryan K McBain, Natalie Price, Mahlet Gizaw, Chantelle Boudreaux, Liberty Neba

“…Furthermore, we measured clinical outcomes for HIV (viral load), hypertension (controlled blood pressure), diabetes (average blood glucose), asthma (asthma severity) and epilepsy (seizure frequency).Results The annualised total cost of providing integrated HIV and NCD care was $2 461 901 to provide care to 9471 enrollees, or $260 per capita. …”
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Glycogen Storage Disease Type Ia: A Retrospective Claims Analysis of Complications, Resource Utilization, and Cost of Care by Eliza Kruger, Justin Nedzesky, Nina Thomas, Jeffrey D. Dunn, Andrew A. Grimm

“…Chronic complications (eg, gout, osteoarthritis, chronic kidney disease, and neoplasms) were more common in adults with GSDIa, whereas acute complications (eg, poor growth, gastrostomy, seizure, and hypoglycemia) were more common in children with GSDIa. …”
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Diospyros mespilifoemis hochst Modulates the Hippocampus and Prefrontal Cortex of Wistar Rat following Lithium chloride pilocarpine-induced Epilepsy by Sunday Yinka Olatunji, Oluwafemi Ezekiel Kale, Oluseyi Abimbola Ogunsola, John Afees Olanrewaju, Ijeoma Esiaba, Taiye Adelodun, Olubunmi Philip Ogunnaike

“….) + pilocarpine (30 mg/kg, i.p.) to induce seizure. Following induction, C, D, and E received 50 mg/kg, 200 mg/kg DM and 10 mg/kg sodium valproate respectively (p.o) while B was left untreated. …”
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Analysis of Ethereum transactions during the prevention and investigation of criminal offenses by V. V. Nosov, O. V. Manzhai, Ye. V. Panchenko

“…The technical side of law enforcement training on the seizure of cryptocurrency assets has been revealed. …”
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The safety and effectiveness of tDCS for epileptic patients: A systematic review and meta-analysis by Xiao-Tong Ding, Ming-Yu Hu, Chi Wang, Wei-Ye Kang, Jin-Zhao Huang, Rui-Yu Wang, Qiu-Song Shen, Hou-Ming Kan

“…For the primary outcome metrics, tDCS can reduce the frequency of epileptic seizures (SMD = − 0.63, 95 % CI = [-0.90, − 0.36], P < 0.00001). …”
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Vaccination and Infection as Causative Factors in Japanese Patients With Rasmussen Syndrome: Molecular Mimicry and HLA Class I by Yukitoshi Takahashi, Kazumi Matsuda, Yuko Kubota, Jiro Shimomura, Etsuko Yamasaki, Tatsuya Kudo, Katsuyuki Fukushima, Hitoshi Osaka, Noriyuki Akasaka, Atsushi Imamura, Shinji Yamada, Naomi Kondo, Tateki Fujiwara

“…Almost half of the patients have some preceding causative factors, with infections found in 38.2%, vaccinations in 5.9% and head trauma in 8.9% of Japanese patients. In a patient with seizure onset after influenza A infections, cross-reaction of the patient's lymphocytes with GluRε2 and influenza vaccine components was demonstrated by lymphocyte stimulation test. …”
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Anti-GAPDH Autoantibody Is Associated with Increased Disease Activity and Intracranial Pressure in Systemic Lupus Erythematosus by Jingjing Sun, Xue Li, Haotian Zhou, Xiaoyun Liu, Jingjing Jia, Qizhi Xie, Sijia Peng, Xiaolin Sun, Qingwen Wang, Li Yi

“…Elevated serum anti-GAPDH was correlated with increased SLEDAI-2K (P=0.017), ESR, IgG, and IgM and associated with increased intracranial pressure and incidence of cerebrovascular lesions, but it was protective for seizure disorder incidence. Conclusions. Serum anti-GAPDH autoantibody was increased in both groups of SLE patients with or without neuropsychiatric symptoms and associated with disease severity. …”
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Infantile epileptic spasms syndrome: an etiologic study of 361 patients with infantile epileptic spasms syndrome by Linghui Zhu, Linghui Zhu, Yuan Xia, Yuan Xia, Hao Ding, Tong Zhang, Jun Li, Baomin Li, Baomin Li

“…Patients administered adrenocorticotropic hormone (ACTH) exhibited a higher likelihood of attaining seizure control, and those who responded favorably to the medication saw improved results.ConclusionThe predominant etiology of IESS is structural, succeeded by genetic factors, with significant pathogenic genes comprising TSC2, NF1, SCN8A, and KCNQ2. …”
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Valproic acid targets IDH1 mutants through alteration of lipid metabolism by Lubayna S. Elahi, Michael C. Condro, Riki Kawaguchi, Yue Qin, Alvaro G. Alvarado, Brandon Gruender, Haocheng Qi, Tie Li, Albert Lai, Maria G. Castro, Pedro R. Lowenstein, Matthew C. Garrett, Harley I. Kornblum

“…In this study, we show that valproic acid (VPA), a brain penetrant anti-seizure medication and histone deacetylase inhibitor, inhibits the growth of IDH1 mutant tumors in vivo and in vitro, with at least some selectivity over IDH1 wild-type tumors. …”
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Hubungan Pemakaian Fenobarbital Rutin dan Tidak Rutin Pada Anak Kejang Demam dengan Attention Deficit Hyperactivity Disorder (ADHD) by Sara Fadila, Nadjmir ., Rahmatini .

“…The purpose of this study to determine the correlation of the use of continous and uncontinous phenobarbital in febrile seizures children with ADHD. This research using observational analytic cross sectional design performed on 32 samples, consisting of 16 patients with febrile seizures regularly taking phenobarbital daily and 16 patients with febrile seizures do not routinely taking phenobarbital. …”
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Medicinal plants with neuroprotective potential in East African countries: A systematic review by Ibe Michael Usman, Ekom Monday Etukudo, Elna Owembabazi, Wusa Makena, Augustine Oviosun, Makeri Danladi, Vivian Ojiakor, Patrick Maduabuchi Aja, Emeka Anyanwu, Yanurkis Duranones Rosales, Mario Edgar Fernandez Diaz, Josiah Ifie, Ismahil Adekunle Adeniyi, Ilemobayo Victor Fasogbon, Victor Bassey Archibong

“…Behavioral outcomes aligned with these biochemical changes, showing marked improvements in memory and learning, motor activity, seizure threshold, and anxiety-like behavior. Conclusion: The included studies collectively suggest a strong neuroprotective activity, with the biochemical enhancements contributing to better neurological health and functional recovery. …”
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Critical biomarkers for responsive deep brain stimulation and responsive focal cortex stimulation in epilepsy field by Zhikai Yu, Binghao Yang, Penghu Wei, Hang Xu, Yongzhi Shan, Xiaotong Fan, Huaqiang Zhang, Changming Wang, Jingjing Wang, Shan Yu, Guoguang Zhao

“…The Detrended Fluctuation Analysis (DFA) exponent is chosen as the classification exponent, and the disparities between indicators representing distinct seizure states and the classification efficacy of rudimentary machine learning models are computed. …”
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Cerebral Microhemorrhages in Children With Congenital Heart Disease: Prevalence, Risk Factors, and Association With Neurodevelopmental Outcomes by Kristen N. Andersen, Sicong Yao, Brian R. White, Marin Jacobwitz, Jake Breimann, Jharna Jahnavi, Alexander Schmidt, Wesley B. Baker, Tiffany S. Ko, J. William Gaynor, Arastoo Vossough, Rui Xiao, Daniel J. Licht, Evelyn K. Shih

“…In multivariable analysis, neurodevelopmental duration (P<0.0001), use of extracorporeal membrane oxygenation support (P<0.0005), postoperative seizure(s) (P=0.02), and lower birth weight (P=0.03) were associated with new or worsened CMH postoperatively. …”
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Long-term neuropsychologic outcome of pre-emptive mTOR inhibitor treatment in children with tuberous sclerosis complex (TSC) under 4 months of age (PROTECT), a two-arm, randomized,... by Jan H. Driedger, Julian Schröter, PROTECT-Study Group, Steffen Syrbe, Afshin Saffari

“…Secondary endpoints include neuropsychologic outcomes at 12 months of age, seizure frequency, cardiac and cerebral tumor load, and safety assessments. …”
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Impact of the COVID-19 pandemic on violent extremism and organized crime in the Republic of Serbia by Đorić Marija, Životić Ilija

“…Drug trafficking was particularly intense, and the Customs Administration seized during the pandemic from 01.03.2020 to 01.08.2021 5630.53 grams of cocaine, which is 60 percent more than in 2019; 2063 grams of heroin, which is a drop to only 5 percent of the total seizure in 2019. In the same period, 1,180 tablets of ecstasy and MDMA were seized, which is five times more than in 2019, as well as 36 weapons. …”
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Clinical and radiological evaluation of the Bristow–Latarjet procedure in patients with 30 or more years of follow-up by Arnaldo Amado Ferreira Neto, MD, PhD, Mauro Emilio Conforto Gracitelli, MD, PhD, Jorge Henrique Assunção, MD, PhD, Fernando Brandão de Andrade e Silva, MD, PhD, Verônica Yulin Prieto Chang, MD, Eduardo Angeli Malavolta, MD, PhD

“…We evaluated clinical scores—the Rowe, Western Ontario Shoulder Instability, Single Assessment Numeric Evaluation, and visual analog scale—as well as clinical outcomes: the recurrency (dislocation or subluxation) and seizure. Screw and graft positioning were assessed by computed tomography, the degree of arthropathy by radiography, and subscapularis fatty degeneration as rotator cuff tears by magnetic resonance imaging. …”
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Neuronal cell type specific roles for Nprl2 in neurodevelopmental disorder-relevant behaviors by Brianne Dentel, Lidiette Angeles-Perez, Abigail Y. Flores, Katherine Lei, Chongyu Ren, Andrea Pineda Sanchez, Peter T. Tsai

“…Broad neuronal deletion of Nprl2 resulted in seizures, social and learning deficits, and hyperactivity. …”
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Developmental dysfunction in a preclinical model of Kcnq2 developmental and epileptic encephalopathy by Miaomiao Mao, Nikola Jancovski, Yafit Kushner, Lucas Teasdale, Phan Truong, Kun Zhou, Samuel Reid, Linghan Jia, Ye Htet Aung, Melody Li, Christopher A. Reid, Sean Byars, Ingrid Scheffer, Steven Petrou, Snezana Maljevic

“…Treatment for DEEs is currently limited to seizure control and provides no benefits to the patients' developmental and cognitive outcomes. …”
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A multicenter analysis to identify the risk factors for stroke recurrence and mortality within 1 year by Eman A. Alraddadi, Eman A. Alraddadi, Hashim F. Alotaibi, Hashim F. Alotaibi, Yasser Alatawi, Ahmed Aljabri, Ahmed A. Alghamdi, Ahmed A. Alghamdi, Fahad Alturki, Fahad Alturki, Faisal F. Alamri, Faisal F. Alamri

“…Multivariable analysis confirmed that history of stroke, receiving tPA, experiencing seizures, and depression were significantly associated with stroke recurrence. …”
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Pharmacological approaches in drug-resistant pediatric epilepsies caused by pathogenic variants in potassium channel genes by Ilaria Filareto, Ilaria Mosca, Elena Freri, Francesca Ragona, Laura Canafoglia, Roberta Solazzi, Barbara Castellotti, Giuliana Messina, Cinzia Gellera, Maria Virginia Soldovieri, Paolo Ambrosino, Maurizio Taglialatela, Jacopo C. DiFrancesco, Tiziana Granata

“…The application in vivo of fluoxetine to counteract GoF effects induced by Kv3.1 or KNa1.1 variants determined a significant reduction of both seizure frequency and behavior disturbances in patient #4 (Kv3.1 V425M), and in both subjects carrying KNa1.1 variants (#5, S937G and #6, R262Q). …”
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