Comparison of propofol-ketamine and propofol-fentanyl combinations for sedation in patients undergoing gastrointestinal endoscopy: a randomized clinical trial by Milena Vasconcelos Falcão, João Nogueira Neto, Ed Carlos Rey Moura, Caio Márcio Barros Oliveira, Rodrigo Pinto Diniz, Almir Vieira Dibai-Filho, Plínio da Cunha Leal

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Evaluation of the Efficacy of Nasal Sedation Midazolam Compared with Dexmedetomidine in the Management of Uncooperative Children with Down Syndrome during Dental Treatment by Mohamad Nabil Hamod, Chaza Kouchaji, Faten Rostom, Hasan Alzoubi, Imad Katbeh, Nikolay Tuturov

“…Both midazolam and dexmedetomidine nasal can be used to sedate children with Down syndrome.…”
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Use of Video Laryngoscope in Sedated Spontaneously Breathing Patients with Predicted Difficult Tracheal Intubation and Impossibility of Using Fibreoptic Bronchoscopy by Alba Piroli, Ida Marsili, Franco Marinangeli, Silvia Costanzi, Luca Gentili, Antonella Paladini

“…In such situations, the video laryngoscope can be a useful alternative, as long as it is associated with adequate sedation of the patient. In fact, it ensures excellent viewing of the glottis, allowing for successful orotracheal intubation to be performed even in case of difficult airways, while keeping the patient spontaneously breathing throughout the procedure. …”
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Development and validation of a prognostic nomogram for predicting of patients with acute sedative-hypnotic overdose admitted to the intensive care unit by Guo Tang, Tianshan Zhang, Ping Zhang, Sha Yang, Tao Cheng, Rong Yao

Subjects: “…Acute Sedative-hypnotic overdose…”
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Clinical Effectiveness of an Anesthesiologist-Administered Intravenous Sedation Outside of the Main Operating Room for Pediatric Upper Gastrointestinal Endoscopy in Thailand by Somchai Amornyotin, Prapun Aanpreung

“…Objectives. To review our sedation practice and to evaluate the clinical effectiveness of an anesthesiologist-administered intravenous sedation outside of the main operating room for pediatric upper gastrointestinal endoscopy (UGIE) in Thailand. …”
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No Difference between Spinal Anesthesia with Hyperbaric Ropivacaine and Intravenous Dexmedetomidine Sedation with and without Intrathecal Fentanyl: A Randomized Noninferiority Trial by Seung Cheol Lee, Tae Hyung Kim, So Ron Choi, Sang Yoong Park

“…Under intravenous dexmedetomidine sedation, the duration of spinal anesthesia with hyperbaric ropivacaine alone was noninferior to that of hyperbaric ropivacaine with intrathecal fentanyl. …”
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Phenobarbital as an adjunctive agent for sedation in pediatric intensive care unit patients: A single-center, retrospective study from Colorado by Kelli Jo Welter, Mackenzie N. DeVine, Sharon E. Gordon, Gina Demasellis

“…Conclusions: The use of phenobarbital as an adjunct sedative was associated with a statistically significant increase in time spent in the goal sedation score range and decrease in ME, BZDE, and concomitant sedative boluses.…”
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Estimating the Need for Sedation in Patients with Dental Anxiety and Medical Complexities Reporting to Tertiary Care Dental Hospital Using the IOSN Tool by Beenish Abbas, Ayesha Maqsood, Syeda Rabia Rahat Geelani, Madeeha Sattar, Majida Rahim, Zohaib Khurshid

“…To provide consistent method for assessment of sedation need among patients undergoing dental treatment based on specific risk factors that is dental anxiety, medical status, and treatment complexity of needed dental treatment using IOSN (indication of sedation need) tool for assisting the clinician in decision making process. …”
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Efficacy and safety of ciprofol versus propofol for induction of general anaesthesia or sedation: A systematic review and meta-analysis of randomised controlled trials by Abdallah Saeed, Mariam Elewidi, Ahmad Nawlo, Amr Elzahaby, Asmaa Khaled, Abdalla Othman, Mohamed Abuelazm, Basel Abdelazeem

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Muscle Relaxant and Sedative-Hypnotic Activities of Extract of Viola betonicifolia in Animal Models Supported by Its Isolated Compound, 4-Hydroxy Coumarin by Naveed Muhammad, Mohammad Saeed, Haroon Khan, Achyut Adhikari, Khalid Mohammed Khan

“…Nevertheless, 4HC was devoid of sedative and hypnotic potentials. In conclusion, VBME had strong muscle relaxant and sedative-hypnotic properties, while its isolated compound, 4HC, possessed a significant muscle relaxant action with substantial safety profile without sedative-hypnotic effects.…”
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Ultrasound-Guided Pudendal Nerve Block Combined with Propofol Deep Sedation versus Spinal Anesthesia for Hemorrhoidectomy: A Prospective Randomized Study by Jian He, Lei Zhang, Dong L. Li, Wan Y. He, Qing M. Xiong, Xue Q. Zheng, Mei J. Liao, Han B. Wang

“…Ultrasound-guided bilateral PNB combined with deep sedation using propofol could successfully be applied to Milligan–Morgan hemorrhoidectomy. …”
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Comparison of a ready-to-use intranasal dexmedetomidine spray with traditional intranasal dexmedetomidine drops for sedation in preschool children: a prospective, randomized, controlled study by Qi-Qi Jin, Wei-Cha Cai, Ying-Feng Zhou, Yan-Tong Zhang, Gang Chen, Meng-Ting Xu, Jun Li, Kai-Ming Yuan

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Relevance of anaesthesia type on early neurological outcome in acute ischemic stroke patients undergoing mechanical thrombectomy by L. Šalaševičius, A. Vilionskis

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Risk Factors of Delirium Following Reconstructive Surgery for Head and Neck Tumors: A Retrospective Clinical Trial by Li L, Zhang L, Wu X, Zeng Z

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Sedoanalgesia with dexmedetomidine in daily anesthesia practices: a prospective randomized controlled trial by Ali Kendal Oğuz, Celaleddin Soyalp, Yunus Emre Tunçdemir, Arzu Esen Tekeli, Nureddin Yüzkat

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“Wake Me Up before You Go-Go”. Drug, ‘Wham’, Scope, then Snooze. Can’t We do Better with Conscious Sedation for Endoscopy? by Michael F Byrne

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Targeting Cutaneous Leishmaniasis with Thiadiazine Thione Derivatives: An In Vivo Study of Its Anti-Inflammatory, Anti-Pyretic, Anti-Nociceptive, and Anti-Sedative Properties by Sarah Sarwar, Nadia Sarwar, Haleema Ali, Rafiullah, Rasool Khan, Ajaz Ahmad, Amin Ullah, Ho Soonmin, Nazif Ullah

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Sedation/Analgesia Administration Practice Varies according to Endoscopy Facility (Hospital- or Office-Based) Setting: Results from a Nationwide Survey in Greece by Georgios Tziatzios, Dimitrios N. Samonakis, Theocharis Tsionis, Spyridon Goulas, Dimitrios Christodoulou, Konstantinos Triantafyllou

“…To examine the impact of endoscopy setting (hospital-based vs. office-based) on sedation/analgesia administration and to provide nationwide data on monitoring practices among Greek gastroenterologists in real-world settings. …”
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Local anesthesia with and without conscious sedation versus general anesthesia for oral surgical procedures in pediatric patients: a retrospective cross-sectional study by Ana López-Velasco, Francisco Javier Carrera-Hueso, Miguel Puche-Torres, Francisco Javier Silvestre, Pedro Vázquez-Ferreiro

“…Objectives: To compare the effectiveness of general anesthesia versus local anesthesia with or without conscious sedation for minor oral surgery procedures in pediatric patients. …”
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Dexmedetomidine Combined With Patient-Controlled Analgesia for Palliative Sedation in Terminal-Stage Cancer Patients With Refractory Pain: A Retrospective Analysis of Nine Cases by Na Li, Yumei Wang, Meng Cui

“…Conclusion: DEX emerges as a promising option for palliative sedation in terminal-stage cancer patients. When used in conjunction with PCA, DEX has been shown to effectively, safely, and stably control refractory pain without inducing adverse effects such as respiratory/circulatory depression.…”
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