Adipokines as Drug Targets in Diabetes and Underlying Disturbances by Vinícius Andrade-Oliveira, Niels O.S. Câmara, Pedro M. Moraes-Vieira

“…White adipose tissue is recognized as a multifactorial organ that secretes several adipose-derived factors that have been collectively termed “adipokines.” …”
Get full text

Mathematical insights on psoriasis regulation: Role of Th1 and Th2 cells by Amit Kumar Roy, Priti Kumar Roy, Ellina Grigorieva

“…Hyper-proliferation of Keratinocytes may occur due to over expression of pro-inflammatory cytokines secreted by Th1-Cells viz. Interferon gamma ( $\mbox{IFN}-{γ}$ ), Transforming growth factor beta ( $\mbox{TGF}-β$ ) and Tumor necrosis factor alpha ( $\mbox{TNF}-α$ ) etc. …”
Get full text

Antigen Presentation in the Gut by W Doe, P Pavli

“…In the inflamed colon there is infiltration of the lamina propria by large numbers of monocytes which secrete interleukin-1, and the release of interferon-gamma appears to induce class II protein expression on colonic epithelial cells. …”
Get full text

Citric Acid Promotes the Mobilization of Phosphorus under the Lower Concentration of Low Molecular Weight Organic Acids in Acidic Forest Soil by He Zhu, Haijian Bing, Yanhong Wu

“…Low molecular weight organic acids (LMWOAs) secreted by plant roots enhanced the release of inorganic P (Pi) and organic P (Po) into the soil solution and thereby increased plant-available Pi in soils. …”
Get full text

Tolerogenic Splenic IDO+ Dendritic Cells from the Mice Treated with Induced-Treg Cells Suppress Collagen-Induced Arthritis by Jie Yang, Yiming Yang, Huahua Fan, Hejian Zou

“…In this study, we found that after treatment with iTregs, splenic CD11c+DCs, termed “DCiTreg,” expressed tolerogenic phenotypes, secreted high levels of IL-10, TGF-β, and IDO, and showed potent immunosuppressive activity in vitro. …”
Get full text

Monocyte-Derived Macrophages Are Impaired in Myelodysplastic Syndrome by Yu Han, Huaquan Wang, Zonghong Shao

“…Further, we demonstrated that the ex vivo phagocytic function of macrophages from MDS patients was impaired and levels of reorganization receptors CD206 and SIRPα were lower. Levels of iNOS secreted by macrophages in MDS were increased. Conclusions. …”
Get full text

Tubular MYDGF Slows Progression of Chronic Kidney Disease by Maintaining Mitochondrial Homeostasis by Xiaohan Liu, Yang Zhang, Youzhao Wang, Yujie Yang, Zhe Qiao, Ping Zhan, Huiying Jin, Qianqian Xu, Wei Tang, Yu Sun, Yan Zhang, Fan Yi, Min Liu

“…Myeloid‐derived growth factor (MYDGF), a novel secreted protein, plays important roles in multiple cardiovascular diseases, but the function of MYDGF in tubular epithelial cells remains unknown. …”
Get full text

Pyoverdine, the Major Siderophore in Pseudomonas aeruginosa, Evades NGAL Recognition by Mary E. Peek, Abhinav Bhatnagar, Nael A. McCarty, Susu M. Zughaier

“…Bacteria such as P. aeruginosa secrete siderophores (iron-chelating molecules) and the host limits bacterial growth by producing neutrophil-gelatinase-associated lipocalin (NGAL) that specifically scavenges bacterial siderophores, therefore preventing bacteria from establishing infection. …”
Get full text

Effect of Toll-Like Receptor 4 on Synovial Injury of Temporomandibular Joint in Rats Caused by Occlusal Interference by Jingjing Kong, Yingying Yang, Shuzhen Sun, Jianli Xie, Xuefen Lin, Ping Ji

“…Some investigations suggested that the increasing expression of IL-1β secreted by synovial lining cells plays an important role in synovial inflammation and cartilage destruction in TMJ. …”
Get full text

Evasion of Early Antiviral Responses by Herpes Simplex Viruses by Paula A. Suazo, Francisco J. Ibañez, Angello R. Retamal-Díaz, Marysol V. Paz-Fiblas, Susan M. Bueno, Alexis M. Kalergis, Pablo A. González

“…During these processes, infected and noninfected neighboring cells, as well as tissue-resident and patrolling immune cells, will sense viral components and cell-associated danger signals and secrete soluble mediators. While type-I interferons aim at limiting virus spread, cytokines and chemokines will modulate resident and incoming immune cells. …”
Get full text

Exosomes of Antler Mesenchymal Stem Cells Improve Postoperative Cognitive Dysfunction in Cardiopulmonary Bypass Rats through Inhibiting the TLR2/TLR4 Signaling Pathway by Chun Yang, Shengnan Sun, Qi Zhang, Jia Guo, Tengfei Wu, Ying Liu, Min Yang, Yan Zhang, Yinghua Peng

“…Mesenchymal stem cells (MSCs) are multipotent cells that have therapeutic potentials mainly through paracrine action via secreting growth factors and cytokines. Exosomes are one of the important paracrine factors and have been reported as potential cell-free therapy for the treatment of autoimmune and central nervous system disorders. …”
Get full text

CBP22, a Novel Bacteriocin Isolated from Clostridium butyricum ZJU-F1, Protects against LPS-Induced Intestinal Injury through Maintaining the Tight Junction Complex by Tenghao Wang, Jie Fu, Xiao Xiao, Zeqing Lu, Fengqin Wang, Mingliang Jin, Yizhen Wang, Xin Zong

“…A novel bacteriocin secreted by Clostridium butyricum ZJU-F1 was isolated using ammonium sulfate fractionation, cation exchange chromatography, affinity chromatography, and reverse-phase high-performance liquid chromatography (RP-HPLC). …”
Get full text

Biomineralization Performance of Bacillus sphaericus under the Action of Bacillus mucilaginosus by Yingying Hu, Weitao Liu, Wenjing Wang, Xinlei Jia, Lanjuan Xu, Qing Cao, Jianjun Shen, Xiangming Hu

“…The former has an outstanding urease production ability, and the latter can secrete carbonic anhydrase in vitro. Bacillus mucilaginosus was introduced into the culture solution of Bacillus sphaericus in the most suitable culture environment, and the changes of mineralization rate and mineralization yield of Bacillus sphaericus were observed and analyzed. …”
Get full text

An Integrated Image Encryption Scheme Based on Elliptic Curve by Ijaz Khalid, Tariq Shah, Sayed M. Eldin, Dawood Shah, Muhammad Asif, Imran Saddique

“…Initially, the users share a secret parameter using Diffie-Hellman over the elliptic curve and pass it through SHA-256. …”
Get full text

Maternal Aerobic Exercise during Pregnancy Can Increase Spatial Learning by Affecting Leptin Expression on Offspring's Early and Late Period in Life Depending on Gender by Ayfer Dayi, Sinem Agilkaya, Seda Ozbal, Ferihan Cetin, Ilkay Aksu, Celal Gencoglu, Sultan Cingoz, Cetın Pekcetin, Kazim Tugyan, Berkant Muammer Kayatekin, Nazan Uysal

“…Leptin is an adipocytokine which is secreted from adipose tissues and has positive effects on learning, memory, and synaptic plasticity. …”
Get full text

Orbital Prosthetic Rehabilitation in “ADAM Complex” Multiple Orofacial-Cleft Disruption Syndrome by Aparna Barabde, Shailesh M. Barabde, Ashish Bhagat, Amar Thakare

“…, since nature seems nowhere accustomed more openly to display, its secret mysteries than in cases where it shows traces of its workings apart from the beaten path. …”
Get full text

Role of periodontal ligament fibroblasts in periodontitis: pathological mechanisms and therapeutic potential by Yijie Huang, Ying Tang, Ruiqi Zhang, Xiao Wu, Li Yan, Xiling Chen, Qianqi Wu, Yiyan Chen, Yingtao Lv, Yuan Su

“…On the other hand, PDLFs can become dysfunctional and acquire an inflammatory phenotype to secret various inflammatory cytokines when affected by pathological factors. …”
Get full text

Circulating Irisin Levels Are Not Regulated by Nutritional Status, Obesity, or Leptin Levels in Rodents by Mar Quiñones, Cintia Folgueira, Estrella Sánchez-Rebordelo, Omar Al-Massadi

“…Irisin is a cleaved and secreted fragment of fibronectin type III domain containing 5 (FNDC5) that is mainly released by skeletal muscle and was proposed to mediate the beneficial effects of exercise on metabolism. …”
Get full text

Activated Circulating T Follicular Helper Cells Are Associated with Disease Severity in Patients with Psoriasis by Ying Wang, Lili Wang, Haoyu Yang, Weichang Yuan, Jingyi Ren, Yanping Bai

“…Furthermore, the frequency of cTfh cells and the levels of cytokines secreted by cTfh cells were all significantly decreased after 1-month treatment.…”
Get full text

Impact of Solvent-Mediated Phase Transitions by Artificial Gastrointestinal Buffers on Efavirenz Polymorphs by Yoga Windhu Wardhana, Eli Nuraisyah, Angga Prawira Kautsar, Patihul Husni, Arif Budiman, Anis Yohana Chaerunisaa

“…These findings indicate that variability in the pH of digestive secretions are essential steps in developing successful pharmaceutical formulations. …”
Get full text