Alpha-defensins increase NTHi binding but not engulfment by the macrophages enhancing airway inflammation in Alpha-1 antitrypsin deficiency by Jungnam Lee, Naweed Mohammad, Kyudong Han, Kyudong Han, Tammy Flagg-Dowie, Maria Magallon, Mark L. Brantly, Karina A. Serban, Karina A. Serban

“…The decreased phagocytosis was associated with TLR4 activation, downstream signaling via NF-κB p65 and marked increased secretion of inflammatory cytokines, CXCL8, IL-1b, and TNFα by the α-defensin-treated and NTHi-infected MDMs. …”
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Clinical Characteristics of Aldosterone- and Cortisol-Coproducing Adrenal Adenoma in Primary Aldosteronism by Lu Tang, Xintao Li, Baojun Wang, Xin Ma, Hongzhao Li, Yu Gao, Liangyou Gu, Wenyuan Nie, Xu Zhang

“…Screening for excess cortisol secretion is necessary for PA patients.…”
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Enhanced Immunogenicity of Foot-and-Mouth Disease Virus-like Particles Using a Water-in-Oil-in-Water Adjuvant by Yujie Zhou, Wenzhu Yin, Zhidong Teng, Yanyan Zhao, Yu Lu, Yingjuan Qian, Bihua Deng

“…The VLPs+WT vaccine also enhanced the secretion of Th1-related (IgG2a, IFN-γ) and Th2-related (IgG1, IL-4) molecules. …”
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Fractional-order PID feedback synthesis controller including some external influences on insulin and glucose monitoring by Kottakkaran Sooppy Nisar, Muhammad Farman, Khadija Jamil, Saba Jamil, Evren Hincal

“…A novel fractional-order diabetes mellitus model is proposed, incorporating a nonsingular, nonlocal kernel (Mittag-Leffler function) to account for the effect of epinephrine on suppressing insulin secretion and the dynamics of beta-cell mass. As beta-cell mass increases in the presence of adrenaline, the system remains highly responsive to rising blood glucose and falling insulin levels, driven by the hormone’s suppressive effects. …”
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Oral Supplementation with Three Vegetable Oils Differing in Fatty Acid Composition Alleviates High-Fat Diet-Induced Obesity in Mice by Regulating Inflammation and Lipid Metabolism by Waleed Aldamarany, Huang Taocui, Deng Liling, Yang Wanfu, Geng Zhong

“…It also decreased leptin, pro-inflammatory cytokines, such as tumor necrosis factor-alpha (TNF-α), interleukin (IL)-6, and (IL)-1beta (IL-1β), and increased anti-inflammatory adipokine adiponectin at both secretion and mRNA expression levels in the epididymal adipose tissue (EAT). …”
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Bacterial pathogens dynamic during multi-species infections by Barny, Marie-Anne, Thieffry, Sylvia, Gomes de Faria, Christelle, Thebault, Elisa, Pédron, Jacques

“…Soft rot Pectobacteriacea (SRP) gathers more than 30 bacterial species that collectively rot a wide range of plants by producing and secreting a large set of plant cell wall degrading enzymes (PCWDEs). …”
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12 Weeks of Combined Endurance and Resistance Training Reduces Innate Markers of Inflammation in a Randomized Controlled Clinical Trial in Patients with Multiple Sclerosis by Nathalie Deckx, Inez Wens, Amber H. Nuyts, Niel Hens, Benedicte Y. De Winter, Gudrun Koppen, Herman Goossens, Pierre Van Damme, Zwi N. Berneman, Bert O. Eijnde, Nathalie Cools

“…Overall, our findings suggest that the 12-week exercise program reduces the secretion of inflammatory mediators upon TLR stimulation and promotes the immunoregulatory function of circulating pDC, suggestive for a favorable impact of exercise on the underlying immunopathogenesis of MS.…”
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Akkermansia muciniphila-directed polyphenol chlorogenic acid intervention for obesity in mice by Xiaoxiang Gao, Chenbo Yue, Ruocen Tian, Leilei Yu, Fengwei Tian, Jianxin Zhao, Wei Chen, Qixiao Zhai

“…Furthermore, we found that CGA did not directly promote A. muciniphila growth or mucin secretion. Microbiome and metabolomics revealed that the increased abundance of A. muciniphila resulted from the inhibition of CGA on Desulfovibrio and Alistipes and the influence of docosahexaenoic acid, β-hydroxybutyrate, and N-acetyl-lactosamine. …”
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hnRNPA2/B1 Ameliorates LPS-Induced Endothelial Injury through NF-κB Pathway and VE-Cadherin/β-Catenin Signaling Modulation In Vitro by Yi Chen, Dan Tang, Linjie Zhu, Tianjie Yuan, Yingfu Jiao, Hexin Yan, Weifeng Yu

“…Moreover, knockdown of hnRNPA2/B1 aggravated endothelial injury by increasing EC permeability and promoting the secretion of the inflammatory cytokines TNF-α, IL-1β, and IL-6. …”
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Infection and HLA-G Molecules in Nasal Polyposis by Roberta Rizzo, Nicola Malagutti, Daria Bortolotti, Valentina Gentili, Antonella Rotola, Enrico Fainardi, Teresa Pezzolo, Claudia Aimoni, Stefano Pelucchi, Dario Di Luca, Antonio Pastore

“…HPV-11 positive SNP-WoAD patients presented with mHLA-G and IL-10R on epithelial cells from nasal polyps and showed secretion of sHLA-G and IL-10 in culture supernatants. …”
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Olivetol’s Effects on Metabolic State and Gut Microbiota Functionality in Mouse Models of Alimentary Obesity, Diabetes Mellitus Type 1 and 2, and Hypercholesterolemia by Anastasia A. Zabolotneva, Katerina E. Popruga, Valentin V. Makarov, Sergei M. Yudin, Andrei M. Gaponov, Sergei A. Roumiantsev, Aleksandr V. Shestopalov

“…Results: According to the results of the study, olivetol caused a lowering of body weight in C57Bl6 mice fed a high-fat diet and in <i>ldlr</i>(−/−) mice, decreased serum glucose levels in <i>db</i>/<i>db</i> mice, improved lipid metabolism in <i>ldlr</i>(−/−) mice, and prevented inflammatory infiltration of the pancreas and loss of insulin secretion in NOD mice. In addition, olivetol affected the composition and functional activity of gut microbiota communities, inducing an expansion of probiotic species such as <i>Akkermansia muciniphila</i> and <i>Bacteroides acidifaciens</i> and depleting the representation of pathobionts such as <i>Prevotella</i>, although olivetol supplementation did not influence the diversity or richness of the communities. …”
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Glioblastoma drives protease-independent extracellular matrix invasion of microglia by Chia-Wen Chang, Ashwin Bale, Rohit Bhargava, Brendan A.C. Harley

“…Here, we combine microfluidic systems with 3-D collagen hydrogels to systematically investigate microglia activation, invasion, contractility and cytokine secretion in response to GBM-microglia crosstalk. GBM inflammatory biomolecules significantly promote activation and 3D invasion of microglia. …”
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REDD1 mediates HDM-induced nuclear-cytoplasmic translocation and release of IL-33 in airway epithelial cells by downregulating Nrf2 by Tian Luo, Wentao Ji, Yuxin Gong, Lichang Chen, Chao Liu, Dandan Zhang, Xi Li, Yanhua Lv

“…Moreover, treatment with the Nrf2 agonist curcumin inhibited HDM-induced nuclear-to-cytoplasmic translocation and extracellular secretion of IL-33, whereas the opposite effect was observed when using the Nrf2 antagonist ML385. …”
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Bibliometric analysis of glycolysis and prostate cancer research from 2004 to 2024 by Congxu Zhu, Jingjing Yang, Lumei Liu, Bonan Li, Tiansong Sun, Wen Sheng, Qinghu He

“…Enhanced glycolysis and excessive lactate secretion are recognized as critical factors driving the progression of various cancers. …”
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Ex Vivo Expansion of Murine MSC Impairs Transcription Factor-Induced Differentiation into Pancreatic β-Cells by Dario Gerace, Rosetta Martiniello-Wilks, Rosaline Habib, Binhai Ren, Najah Therese Nassif, Bronwyn Anne O’Brien, Ann Margaret Simpson

“…This was followed by the characterization of pancreatic transdifferentiation via reverse transcriptase polymerase chain reaction (RT-PCR) and static and glucose-stimulated insulin secretion (GSIS). INS-FUR-expressing MSCs were assessed for their ability to reverse diabetes after transplantation into streptozotocin- (STZ-) diabetic NOD/Scid mice (n=5). …”
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Assessment of Exercise-Induced Dehydration Status Based on Oral Mucosal Moisture in a Field Survey by Gen Tanabe, Tetsuya Hasunuma, Yasuo Takeuchi, Hiroshi Churei, Kairi Hayashi, Kaito Togawa, Naoki Moriya, Toshiaki Ueno

“…The salivary flow and s-IgA secretion rates were lower after the exercise period than before, whereas the s-IgA concentration was higher. …”
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Effect of the Hydroethanolic Extract of Bixa orellana Linn (Bixaceae) Leaves on Castor Oil-Induced Diarrhea in Swiss Albino Mice by Michel Archange Fokam Tagne, Hypolyte Akaou, Paul Aimé Noubissi, Angèle Foyet Fondjo, Yaouke Rékabi, Henri Wambe, René Kamgang, Jean-Louis Essame Oyono

“…The effects of the aqueous extract of hydroethanolic extract of Bixa orellana leaves on intestinal secretion were evaluated by measuring the volume of the intestinal content and by dosing the electrolytes (Na+, K+, and Cl-) in the intestinal content by the colorimetric method. …”
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Curdione combined with borneol treats bacterial mixed HPV infection by regulating the crosstalk among immune cells by Jingwei Liu, Jingwei Liu, Tong Shu, Yiheng Mu, Wanlin Zheng, Xiaohuan Lu, Xiaohuan Lu, Hong Tao, Hong Tao

“…Finally, the molecular mechanisms and therapeutic efficacy of curdione and borneol were confirmed in vivo using an LPS/TC-1 cervical orthotopic injection model.ResultsCurdione and borneol selectively inhibit the secretion of interleukin-6 (IL-6) and interleukin-1β (IL-1β) by macrophages. …”
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Clinical features of autonomic dysfunction in children with anti-N-methyl-D aspartic receptor encephalitis by Dongqing Li, Jing Sun, Guannan Li, Shuo Miao, Jian Yang, Jianzhao Zhang

“…Other symptoms included gland secretion dysfunction (19/22, 86%),ventilate dysfunction(3/22,14%), thermoregulatory dysfunction (3/22,14%), bladder dysfunction(2/22,9%). …”
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Sex differences in the neuroinflammatory signaling pathway: effect of miRNAs on fatty acid synthesis in microglia by Haolin Zheng, Akiko Mizokami, Sergio Romera-Giner, Jaime Llera-Oyola, Yosuke Yamawaki, Tomomi Sano, Eijiro Jimi, Francisco García-García, Takashi Kanematsu

“…Consequently, the suppression of FASN expression led to reduced expression and secretion of tumor necrosis factor-alpha following LPS stimulation in MG6 cells. …”
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