Effect of Vernonia amygdalina leaf meal on growth performance, intestinal mucosa activity, digestive enzymes, absorption capacity, and immunity in broiler chickens by B.M. Tokofai, B.M. Orounladji, K. Idoh, O.E. Oke, A. Agbonon

“…This supported the premise that 3 g/kg VALM in feed can improve gastric immunity status and digestive enzyme secretion.…”
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Platelet-Rich Plasma Improves the Wound Healing Potential of Mesenchymal Stem Cells through Paracrine and Metabolism Alterations by Barbara Hersant, Mounia Sid-Ahmed, Laura Braud, Maud Jourdan, Yasmine Baba-Amer, Jean-Paul Meningaud, Anne-Marie Rodriguez

“…In addition, we found that PRP treatment stimulated in vitro, in a dose-dependent manner, the proangiogenic potential of MSC through enhanced secretion of soluble factors like VEGF and SDF-1. Moreover, PRP treatment ameliorated the survival and activated the proliferation of in vitro cultured MSC and that these effects were accompanied by an alteration of the MSC energetic metabolism including oxygen consumption rate and mitochondrial ATP production. …”
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MiR-181a-5p Delivered by Adipose-Derived Mesenchymal Stem Cell Exosomes Alleviates Klebsiella pneumonia Infection-Induced Lung Injury by Targeting STAT3 Signaling by Ren-Jing Hu, Xiao-Chun Chen, Lei Xu, Xiao-Hong Rui, Lin Wan, Jie Lu, Jun Liu, Hao Pei

“…The level of miR-181a-5p was detected by real-time PCR. The secretion of inflammatory factors was determined by ELISA. …”
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Striatal Injury with 6-OHDA Transiently Increases Cerebrospinal GFAP and S100B by Cristiane Batassini, Núbia Broetto, Lucas Silva Tortorelli, Milene Borsoi, Caroline Zanotto, Fabiana Galland, Tadeu Mello Souza, Marina Concli Leite, Carlos-Alberto Gonçalves

“…However, the 6-OHDA-induced S100B secretion was confirmed in astrocyte cultures. Current data reinforce the idea that glial changes precede neuronal damage in PD; however, these findings also indicate that caution is necessary regarding the interpretation of data in this PD model.…”
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The Effects of 5-Hydroxytryptophan in Combination with Different Fatty Acids on Gastrointestinal Functions: A Pilot Experiment by Helene Sauer, Isabelle Mack, Silke Kohler, Stefanie Siegle, Nicole Rieber, Stephan Zipfel, Bärbel Otto, Yvonne Ritze, Stephan C. Bischoff, Paul Enck

“…Diverse FAs have different effects on GE and secretion of orexigenic and anorexigenic hormones. …”
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The Efficacy of Lubiprostone in Patients of Constipation: An Updated Systematic Review and Meta‐Analysis by Umar Akram, Obaid Ur Rehman, Eeshal Fatima, Zain Ali Nadeem, Omer Usman, Waqas Rasheed, Ramsha Ali, Khawaja Abdul Rehman, Abdulqadir J. Nashwan

“…ABSTRACT Background and Aim Lubiprostone increases chloride and water secretion in the intestines, and several studies have demonstrated the efficacy of lubiprostone in treating functional constipation. …”
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DMAV in Drinking Water Activated NF-κB Signal Pathway and Increased TGF-β and IL-1β Expressions in Bladder Epithelial Cells of Rats by Siqi Cao, Shengnan Liu, Fei Wang, Jieyu Liu, Mengdan Li, Chen Wang, Shuhua Xi

“…In addition, DMAV treated rats exhibited significantly increased inflammatory factor TGF-β immunoreactivity in bladder epithelium and IL-1β secretion in urine. These data suggest that DMAV could activate NF-κB signal pathway and increase TGF-β and IL-1β expressions in bladder epithelial cells of rats.…”
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Administration of a Probiotic Mixture Ameliorates Cisplatin-Induced Mucositis and Pica by Regulating 5-HT in Rats by Yuanhang Wu, Jianlin Wu, Zhikun Lin, Qian Wang, Ying Li, Aman Wang, Xiu Shan, Jiwei Liu

“…Furthermore, in vitro, the probiotic mixture had direct inhibitory effects on the 5-HT secretion by EC cells. The probiotic mixture protects against cisplatin-induced intestine injury, exhibiting both anti-inflammatory and antiemetic properties. …”
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Association Between Body Mass Index, Abdominal Obesity and Menopause-Related Symptoms in Postmenopausal Women by Brianna A Rice, Patricia Heavey

“…This is caused by a reduction of the secretion of oestrogen and progesterone, leading to reduced ovarian function. …”
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Structural studies of the IFNλ4 receptor complex using cryoEM enabled by protein engineering by William S. Grubbe, Bixia Zhang, Aileen Kauffman, Fabian Byléhn, Kasia Padoł, Hae-Gwang Jung, Seung Bum Park, Jessica M. Priest, Engin Özkan, Juan J. de Pablo, T. Jake Liang, Minglei Zhao, Juan L. Mendoza

“…Further, we perform a structural analysis using molecular modeling and simulation to identify a unique region of IFNλ4 that, when replaced, enables secretion of the protein from cells. These findings provide a structural and functional understanding of the IFNλ4 protein and enable future comprehensive studies towards correcting IFNλ4 dysfunction in large populations of affected patients.…”
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TNF Superfamily: A Growing Saga of Kidney Injury Modulators by Maria D. Sanchez-Niño, Alberto Benito-Martin, Sara Gonçalves, Ana B. Sanz, Alvaro C. Ucero, Maria C. Izquierdo, Adrian M. Ramos, Sergio Berzal, Rafael Selgas, Marta Ruiz-Ortega, Jesus Egido, Alberto Ortiz

“…While TNF only activates canonical NF-kappaB signaling, TWEAK promotes both canonical and noncanonical NF-kappaB activation in tubular cells, regulating different inflammatory responses. TWEAK promotes the secretion of MCP-1 and RANTES through NF-kappaB RelA-containing complexes and upregulates CCl21 and CCL19 expression through NF-kappaB inducing kinase (NIK-) dependent RelB/NF-kappaB2 complexes. …”
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Electroacupuncture for mild-to-moderate dry eye: study protocol for a multicentre, randomised, single-blind, sham-controlled trial by Yue Zhao, Guang Yang, Yun-Qiong Lu, Mei-Yan Li, Jue Hong, Yan-Ting Yang, Xue-Jun Wang, Xie-He Kong, Zhao Ma, Xin-Yun Huang, Yue-Lan Zou, Xing-Tao Zhou, Xiao-Peng Ma

“…Clinical evidence shows that electroacupuncture (EA) can improve DE symptoms, tear secretion and tear film stability, but it remains controversial whether it is just a placebo effect. …”
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Antagonism of Eucalyptus endophytic fungi against some important crop fungal diseases by Parmida Aleahmad, Leila Ebrahimi, Naser Safaie, Hassan Reza Etebarian

“…VL3 were selected for further investigation, which included examining their chitinase and cellulase secretion capabilities as potential antagonism mechanisms and their ability to solubilize phosphate as a growth-promoting mechanism. …”
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The ANGPTL8 rs2278426 (C/T) Polymorphism Is Associated with Prediabetes and Type 2 Diabetes in a Han Chinese Population in Hebei Province by Guangsen Hou, Yong Tang, Luping Ren, Yunpeng Guan, Xiaoyu Hou, Guangyao Song

“…ANGPTL8 rs2278426 may be involved in the mechanism of insulin secretion and could lead to an increased risk of pre-DM and T2DM.…”
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Palmitic Acid Induces Production of Proinflammatory Cytokines Interleukin-6, Interleukin-1β, and Tumor Necrosis Factor-α via a NF-κB-Dependent Mechanism in HaCaT Keratinocytes by Bing-rong Zhou, Jia-an Zhang, Qian Zhang, Felicia Permatasari, Yang Xu, Di Wu, Zhi-qiang Yin, Dan Luo

“…Our results showed that palmitic acid induced an upregulation of IL-6, TNF-α, IL-1β secretions, accompanied by NF-κB nuclear translocation and activation. …”
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Hufu Tongbian Guasha in the treatment of bloating and constipation in a patient with cholestatic jaundice (虎符铜砭刮痧改善1例胆汁淤积性黄疸患者腹胀和便秘的护理)... by WANG Rui (王蕊), HU Jinrui (胡金瑞)

“…Patient received a comprehensive treatment including liver protection, lowering transaminase and inhibiting gastric acid secretion. Based on the theory of Traditional Chinese Medicine syndrome differentiation, the Hufu Tongbian Guasha therapy was carried out in combination with nursing interventions on daily living, dietary and emotion of the patient. …”
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A network medicine approach to investigating ME/CFS pathogenesis in severely ill patients: a pilot study by Li-Yuan Hung, Chan-Shuo Wu, Chia-Jung Chang, Peng Li, Kimberly Hicks, Joshua J. Dibble, Braxton Morrison, Chimere L. Smith, Ronald W. Davis, Wenzhong Xiao

“…Our pathway analysis revealed potential associations between ME/CFS and conditions such as COVID-19, Epstein–Barr virus (EBV) infection, neurodegenerative diseases, and pathways involved in cortisol synthesis and secretion, supporting the hypothesis that ME/CFS is a neuroimmune disorder. …”
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Inhibiting ATP6V0D2 Aggravates Liver Ischemia-Reperfusion Injury by Promoting NLRP3 Activation via Impairing Autophagic Flux Independent of Notch1/Hes1 by Ziyi Wang, Hao Wang, Xuejiao Chen, Sheng Han, Yulin Zhu, Hanhua Wang, Feng Cheng, Liyong Pu

“…We first found that the expression of specific ATP6V0D2 in liver macrophages was upregulated with the induction of inflammatory cascade after liver IR surgery, and knockdown of ATP6V0D2 resulted in increased secretion of proinflammatory factors and chemokines, which enhanced activation of NLRP3 and aggravation of liver injury. …”
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GEN-27, a Newly Synthetic Isoflavonoid, Inhibits the Proliferation of Colon Cancer Cells in Inflammation Microenvironment by Suppressing NF-κB Pathway by Yajing Wang, Ping Lu, Weifeng Zhang, Qianming Du, Jingjing Tang, Hong Wang, Jinrong Lu, Rong Hu

“…The results indicated that GEN-27 inhibited the proliferation of human colon tumor HCT116 cells stimulated by culture supernatants of LPS-induced human monocytes THP-1 cells and significantly decreased LPS-induced secretion of proinflammatory cytokines interleukin-6 and interleukin-1β in THP-1 cells. …”
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Sustainable Immunomodulatory via Macrophage P2Y12 Inhibition Mediated Bioactive Patche for Peritendinous Antiadhesion by Zaijin Tao, Shuo Wang, Jingwen Liu, Tonghe Zhu, Jia Jiang, Shen Liu, Xin Ma

“…In vitro experiments showed that CA, when specifically bound to the P2Y12 receptor, down‐regulated the expression and function of active P2Y12, effectively inhibiting the aberrant activation of macrophages and the secretion of inflammatory chemokines. BPSN addresses the foreign body reaction induced by macrophage‐dominated biomaterial implantation and the issue of the short‐term release of drugs at later stages of adhesion, providing a feasible strategy for the prevention and treatment of tissue adhesion, and more broadly, the well‐known implant‐derived inflammatory responses.…”
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