Locally administered liposomal drug depot enhances rheumatoid arthritis treatment by inhibiting inflammation and promoting cartilage repair by Zongquan Zhang, Guan Wang, Zhuo Zhang, Xiaoya Liang, Guoshuang Wang, Maochang Xu, Xi Yang, Xiaolin Zhong, Chunhong Li, Meiling Zhou

“…In vitro studies demonstrated that this formulation exhibited sustained drug release, enhanced uptake by inflammatory macrophages, reduced secretion of inflammatory factors (TNF-α, IL-1β), and significantly decreased chondrocyte apoptosis induced by inflammatory factors. …”
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Delta-opioid receptor signaling alleviates neuropathology and cognitive impairment in the mouse model of Alzheimer’s disease by regulating microglia homeostasis and inhibiting HMGB... by Yuan Xu, Naiyuan Shao, Feng Zhi, Ronghua Chen, Yilin Yang, Jiahui Li, Ying Xia, Ya Peng

“…DOR activation inhibited HMGB1 secretion and its translocation from nuclear to cytoplasm. …”
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Impact of Ramadan Intermittent Fasting on Salivary pH, Flow Rate, and Electrolyte Levels in Healthy Adult Men by Sinda Yacoub, Mehdi Khemiss, Amira Besbes, Helmi Ben Saad

“…There is a need for further research on the effects of RIF on saliva secretion.…”
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GLP-1 Receptor Agonists’ Impact on Fertility - A Review by Joanna Wojda, Katarzyna Lesiczka-Fedoryj, Anna Walczak, Zuzanna Kościuszko, Adam Sobiński, Matylda Czerwonka, Katarzyna Kurza, Julianna Podolec, Silvia Ciraolo, Agnieszka Kulczycka-Rowicka

“…They manage glucose metabolism, appetite, as well as insulin secretion. Alongside their metabolic influence, research demonstrates that GLP-1 analogs may have an effect on the reproductive system, involving fertility via metabolic and hormonal pathways.     …”
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New Genomic Approaches to Enhance Biomass Degradation by the Industrial Fungus Trichoderma reesei by Renato Graciano de Paula, Amanda Cristina Campos Antoniêto, Liliane Fraga Costa Ribeiro, Cláudia Batista Carraro, Karoline Maria Vieira Nogueira, Douglas Christian Borges Lopes, Alinne Costa Silva, Mariana Taíse Zerbini, Wellington Ramos Pedersoli, Mariana do Nascimento Costa, Roberto Nascimento Silva

“…We also discuss new perspectives about control of secretion and cellulase expression based on RNA-seq and functional characterization data of T. reesei growth in different carbon sources, which comprise glucose, cellulose, sophorose, and sugarcane bagasse.…”
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Post-Translational Modifications of Proteins Orchestrate All Hallmarks of Cancer by Pathea Shawnae Bruno, Aneeta Arshad, Maria-Raluca Gogu, Natalie Waterman, Rylie Flack, Kimberly Dunn, Costel C. Darie, Anca-Narcisa Neagu

“…All cancer hallmarks develop due to PTMs of proteins, which modulate gene transcription, intracellular and extracellular signaling, protein size, activity, stability and localization, trafficking, secretion, intracellular protein degradation or half-life, and protein–protein interactions (PPIs). …”
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The role of interleukin-17 in inflammation-related cancers by Xingru Zhang, Xingru Zhang, Bangjie Li, Tian Lan, Tian Lan, Conner Chiari, Xiaoyang Ye, Kepeng Wang, Ju Chen

“…Additionally, dynamic changes in the microbiome can influence the secretion of IL-17, thereby affecting tumor development. …”
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Mycorrhizal fungi mitigate cadmium leaching losses by decreasing the inorganic cadmium proportion in soil solutions by Wei Li, Jiong Wu, Jie Yan, Xinran Liang, Xiaoyi Li, Yongmei He, Bo Li, Fangdong Zhan

“…In the soil with AMF, the proportion of organic-bound Cd increased and the proportion of inorganic-bound Cd decreased by promoting the secretion of LMWOAs via mycelium, thus reducing Cd leaching loss.…”
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Inhibition of A2B Adenosine Receptor Attenuates Intestinal Injury in a Rat Model of Necrotizing Enterocolitis by Lie Huang, Juan Fan, Yan-Xiang Chen, Jian-Hui Wang

“…Adenosine receptor A2B (A2BR) regulates the inflammation cytokine secretion and immune cell infiltration in the colonic pathophysiology conditions. …”
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The endonuclease activity of MCPIP1 controls the neoplastic transformation of epithelial cells via the c-Met/CD44 axis by Paulina Marona, Rafał Myrczek, Iga Piasecka, Judyta Gorka, Oliwia Kwapisz, Ewelina Pospiech, Janusz Rys, Jolanta Jura, Katarzyna Miekus

“…Proteomic analysis of mouse plasma revealed increased secretion of cancer-related proteins (CXCL13, CXCL16, and MMP2) in the MCPIP1-mutant group. …”
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Molecular mechanisms and therapeutic strategies of Naegleria fowleri Carter (1970): a review of the fatal brain-eating amoeba by N. Datta

“…These mechanisms include the expression of various surface molecules that mediate adhesion, motility, and phagocytosis of host cells, as well as the secretion of proteases and other factors that degrade host extracellular matrix and modulate host immune response. …”
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In situ delivery of synthetic preimplantation factor using aldehyde-modified hyaluronic acid hydrogel with immobilized complexes of chondroitin sulfate derivatives by Tutut Habibah, Andrea Exnerová, Kristina Nešporová, Una FitzGerald, Abhay Pandit, Marek Ingr, Martin Pravda, Vladimír Velebný

“…Additionally, the release of FITC-SPIF enhanced TGF-β secretion in THP-1 macrophages, indicating preserved biological activity. …”
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NLRP3 Inflammasome Simultaneously Involved in Autophagy and Phagocytosis of THP-1 Cells to Clear Aged Erythrocytes by Qin Li, Fengyong Zhao, Jiamin Zhang, Ying Yang, Zhonghui Guo, Chen Wang, Qixiu Yang, Ying Sun, Ziyan Zhu

“…These findings may be a potential strategy for regulating the clearance rate of phagocytes to aged RBCs and the secretion of proinflammatory cytokines to ensure transfusion safety.…”
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Oxygenation and function of endocrine bioartificial pancreatic tissue constructs under flow for preclinical optimization by Brenden N Moeun, Florent Lemaire, Alexandra M Smink, Hamid Ebrahimi Orimi, Richard L Leask, Paul de Vos, Corinne A Hoesli

“…Intervascular BAPs were cultured under flow for up to 3 days and BAPs without internal flow for up to 7 days, showing glucose-responsive insulin secretion quantified through at-line non-disruptive sampling. …”
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Evaluation of the Effectiveness of Using LED Light Combined With Chromophore Gel in Treating Acne Vulgaris – Preliminary Study by Deda AE, Hartman-Petrycka M, Wilczyński S

“…The treatments lead to a significant reduction in erythema, reduction in the volume of atrophic scars, improvement of skin hydration and regulation of sebum secretion. These effects can be identified quantitatively. …”
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A Case of Recurrent Hemorrhagic Corpus Luteum with Elevated Follicle-Stimulating Hormone, Controlled by Estrogen/Gestagen Therapy by Yoshihide Inayama, Koji Yamanoi, Baku Nakakita, Shimpei Shitanaka, Jumpei Ogura, Tsutomu Ohara, Mie Sakai, Haruka Suzuki, Koji Yasumoto, Ichiro Kishimoto, Yusuke Sagae, Yoshimi Kitawaki, Koh Suginami

“…A high secretion of follicle-stimulating hormone (FSH) in reproductive-aged women is unusual. …”
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Association between early‐stage diabetic nephropathy and the delayed monophasic glucose peak during oral glucose tolerance test in type 2 diabetes mellitus by Han Zhang, Hanqing Tang, Yunjuan Gu, Zhuqi Tang, Xiaoqin Zhao, Ranran Zhou, Ping Huang, Rongping Zhang, Xinlei Wang

“…Results With the delay in glucose peak time, blood glucose levels increased, insulin secretion function and insulin sensitivity decreased. …”
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Exploiting gasdermin-mediated pyroptosis for enhanced antimicrobial activity of phage endolysin against Pseudomonas aeruginosa by Dorota Kuc-Ciepluch, Karol Ciepluch, Daria Augustyniak, Grzegorz Guła, Barbara Maciejewska, Artur Kowalik, Ewelina Jop, Zuzanna Drulis-Kawa, Michał Arabski

“…ABSTRACT Pyroptosis is an inflammatory immune response of eukaryotic cells to bacterial lipopolysaccharide (LPS) and other pathological stimuli, leading to the activation of the gasdermin D (GSDMD) and secretion of pore-forming domain GSDMDNterm, facilitating the release of cytokines. …”
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Recurrent nocturnal hypoglycemic hemiplegia: a case report and review of the literature by Hanako Toyama, Kazuyuki Takahashi, Tatsunori Shimizu, Izumi Otaka, Sakiko Abe, Shunsuke Kato, Sayaka Ando, Takehiro Sato, Tsukasa Morii, Hiroki Fujita, Hironori Waki

“…In our patient, depleted endogenous insulin secretion and lipodystrophy at the injection site, may have acted as additional factors, leading to severe hypoglycemia despite the absence of apparent autonomic neuropathy. …”
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Interleukin-1 signaling and CD4+ T cells control B cell recruitment to the lungs in chronic beryllium disease by Joseph M. Gaballa, Caley Valdez, Douglas G. Mack, Faiz Minhajuddin, Masoom Raza, Tabrez A. Mohammad, Allison K. Martin, Andrew Getahun, Charles A. Dinarello, Andrew P. Fontenot, Shaikh M. Atif

“…Be-exposure causes activation of the innate immune system, resulting in the secretion of interleukins and chemokines that drive the accumulation of B and T cells in the lungs. …”
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