Evaluation of Epstein-Barr Virus Latent Membrane Protein 2 Specific T-Cell Receptors Driven by T-Cell Specific Promoters Using Lentiviral Vector by Dongchang Yang, Qing Shao, Hua Sun, Xiaoxin Mu, Yun Gao, Runqiu Jiang, Jiajie Hou, Kun Yao, Yun Chen, Beicheng Sun

“…These cells had the potential to recognize subdominant EBV latency antigens as measured by cytotoxicity and IFN-γ secretion. The nude mice also exhibited significant resistance to the HLA-A2 and LMP2-positive CNE tumor cell challenge after being infused with lentiviral transduced CTLs. …”
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Bidirectional Relationship between Gastric Emptying and Plasma Glucose Control in Normoglycemic Individuals and Diabetic Patients by Bogdan Mircea Mihai, Cătălina Mihai, Cristina Cijevschi-Prelipcean, Elena-Daniela Grigorescu, Mihaela Dranga, Vasile Drug, Ioan Sporea, Cristina Mihaela Lăcătușu

“…Once nutrients enter the intestine, the secretion of incretins (hormonal products of intestinal cells) is stimulated. …”
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A Novel Adjuvant “Sublancin” Enhances Immune Response in Specific Pathogen-Free Broiler Chickens Inoculated with Newcastle Disease Vaccine by Yangke Liu, Jiang Zhang, Shuai Wang, Yong Guo, Tao He, Rui Zhou

“…In addition, it was also observed that sublancin has the potential to induce the secretion of IFN-γ, IL-10, and IL-4. In conclusion, these findings suggested that sublancin could promote both humoral and cellular immune responses and has the potential to be a promising vaccine adjuvant.…”
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Characterization of Novel Nonobese Type 2 Diabetes Rat Model with Enlarged Kidneys by Ayaka Domon, Kentaro Katayama, Yuki Tochigi, Hiroetsu Suzuki

“…Oral glucose tolerance tests showed glucose intolerance and decreased insulin secretion in response to glucose loading in affected males, features which were exacerbated with age. …”
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Rapamycin Improves Palmitate-Induced ER Stress/NF κ B Pathways Associated with Stimulating Autophagy in Adipocytes by Jiajing Yin, Liping Gu, Yufan Wang, Nengguang Fan, Yuhang Ma, Yongde Peng

“…Furthermore, rapamycin decreased PA-induced nuclear translocation of NFκB P65 subunit, thereby NFκB-dependent inflammatory cytokines MCP-1 and IL-6 expression and secretion. In conclusion, rapamycin attenuated PA-induced ER stress/NFκB pathways to counterbalance adipocytes stress and inflammation. …”
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Transcriptomic Profile Analysis of Brain Tissue in the Absence of Functional TRPM8 Calcium Channel by Erick B. Saldes, Alexandra Erdmier, Jai Velpula, Timothy E. Koeltzow, Michael X. Zhu, Swapna Asuthkar

“…<b>Background/Objectives:</b> Transient Receptor Potential Melastatin 8 (TRPM8) is a non-selective, Ca²⁺-permeable cation channel involved in thermoregulation and other physiological processes, such as basal tear secretion, cell differentiation, and insulin homeostasis. …”
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FAM98 Family Proteins Play Distinct Roles in Osteoclastogenesis and Bone Resorption by Lei Wang, Tarun Minocha, Bhaba K. Das, Mikaela D. Kunika, Aarthi Kannan, Ling Gao, Subburaman Mohan, Weirong Xing, Kottayil I. Varughese, Haibo Zhao

“…We have previously reported that Fam98a interacts with Plekhm1 in murine osteoclasts and functions in lysosome trafficking/secretion and bone resorption in osteoclasts in vitro. …”
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Identification of Epinastine as CD96/PVR inhibitor for cancer immunotherapy by Xiangrui Zhang, Lihan Zhang, Beibei Li, Qingchao Wang, Peixin Chen, Ranran Shi, Xiuman Zhou, Xiaoshuang Niu, Wenjie Zhai, Yahong Wu, Wenhui Shen, Xiaowen Zhou, Wenshan Zhao

“…In vitro co-culture experiments further revealed that Epinastine effectively restored the ability of Jurkat cells to secrete IL-2. In the MC38 tumor-bearing model, Epinastine significantly enhanced the infiltration of T cells and NK cells into the tumor site and augmented their secretion of IFN-γ, leading to effective suppression of tumor growth. …”
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Fungal Biocontrol Agents in the Management of Postharvest Losses of Fresh Produce—A Comprehensive Review by Phathutshedzo Ramudingana, Ndivhuho Makhado, Casper Nyaradzai Kamutando, Mapitsi Silvester Thantsha, Tshifhiwa Paris Mamphogoro

“…There is increasing consensus that utilization of biological control agents (BCAs), mainly fungi, represents a more sustainable and effective strategy for controlling postharvest losses compared to physical and chemical treatments. Secretion of antifungal compounds, parasitism, as well as competition for nutrients and space are the most common antagonistic mechanisms employed by these BCAs. …”
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Vitamin D Deficiency Contributes to the Reduction and Impaired Function of Naïve CD45RA+ Regulatory T Cell in Chronic Heart Failure by Yan-hui Ma, Yun-lan Zhou, Chao-yan Yue, Guang-hui Zhang, Lin Deng, Guo-hua Xie, Wei-ping Xu, Li-song Shen

“…Naïve Treg cell (CD4+CD45RA+Foxp3loT) subset, rather than whole Treg cells, contributes to the reduction of Treg in CHF. 1,25(OH)2D treatment maintained partial expression of CD45RA on CD4+T cell after αCD3/CD28 monoclonal antibodies activation and ameliorated the impaired CD4+CD45RA+T cell function from CHF patients through upregulating Foxp3 expression and IL-10 secretion in vitro. Low level of vitamin D receptor (VDR) was detected in CD4+CD45RA+T cell of CHF than control, while 1,25(OH)2D treatment increased the VDR expression to exert its immunosuppression on T cell. …”
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Next-generation sequencing and immuno-informatics for designing a multi-epitope vaccine against HSV-1-induced uveitis by He Cao, Zhi Cao, Yue Han, Jing Shan

“…The multi-epitope construct effectively activated cytokine production, immunoglobulin secretion, and T cell responses in in-silico immune simulations. …”
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Effect of Rosiglitazone and Insulin Combination Therapy on Inflammation Parameters and Adipocytokine Levels in Patients with Type 1 DM by Metin Guclu, Ozen Oz Gul, Soner Cander, Oguzkaan Unal, Guven Ozkaya, Emre Sarandol, Canan Ersoy

“…These results are suggesting that insulin sensitizing and anti-inflammatory characteristics of TZDs were likely to be more pronounced in patients who were not totally devoid of endogenous insulin secretion.…”
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The Identification of Key Genes and Pathways in Glioma by Bioinformatics Analysis by Mingfa Liu, Zhennan Xu, Zepeng Du, Bingli Wu, Tao Jin, Ke Xu, Liyan Xu, Enmin Li, Haixiong Xu

“…PPI network and module analysis found 12 hub genes, which were enriched in synaptic vesicle cycling rheumatoid arthritis and collecting duct acid secretion. The four key genes CDK17, GNA13, PHF21A, and MTHFD2 were identified in both generation (GSE4412) and validation (GSE4271) dataset, respectively. …”
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Sex Difference in the Association of Osteoporosis and Osteopenia Prevalence in Patients with Adrenal Adenoma and Different Degrees of Cortisol Excess by Shoichiro Izawa, Kazuhisa Matsumoto, Kazuhiko Matsuzawa, Takuyuki Katabami, Takanobu Yoshimoto, Michio Otsuki, Masakatsu Sone, Yoshiyu Takeda, Shintaro Okamura, Takamasa Ichijo, Mika Tsuiki, Tomoko Suzuki, Mitsuhide Naruse, Akiyo Tanabe

“…Patients. 237 patients with adrenal adenoma associated with CE, including Cushing’s syndrome and mild autonomous cortisol secretion (MACS), diagnosed in 10 referral centers in Japan. …”
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Investigation of the Molecular Mechanism of Asthma in Meishan Pigs Using Multi-Omics Analysis by Weilong Tu, Hongyang Wang, Yingying Zhang, Ji Huang, Yuduan Diao, Jieke Zhou, Yongsong Tan, Xin Li

“…Mitochondrial reactive oxygen species, glutathione S-transferases, arginase 1 and RORC in immune regulation, the Notch pathway, YPEL4 in cell proliferation, and MARCKS in airway mucus secretion play roles in asthma pathogenesis. This study highlights that many cytokines and signaling pathways contribute to asthma. …”
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Intra-tumoral sphingobacterium multivorum promotes triple-negative breast cancer progression by suppressing tumor immunosurveillance by Zhikai Mai, Liwu Fu, Jiyan Su, Kenneth K.W. To, Chuansheng Yang, Chenglai Xia

“…Mechanistically, S. multivorum promoted the secretion of chemokines CCL20 and CXCL8 from tumor cells. …”
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False Positive Radioiodinated Metaiodobenzylguanidine (123I-MIBG) Uptake in Undifferentiated Adrenal Malignant Tumor by Hee Soo Jung, Seok Jun Moon, Yun Mi Kim, Hye Rim Kang, Seok Mo Lee, Soo Jin Jung, Seok Jin Choi, Tae Kyoon Kim, Min Jeong Kwon, Jeong Hyun Park, Soon Hee Lee

“…Metastatic carcinoma of unknown origin was suspected from a lymph node biopsy, and surgical resection was performed for definitive diagnosis and correction of excess hormonal secretion. A final diagnosis of undifferentiated adrenal malignant tumor was rendered, instead of histologically malignant pheochromocytoma, despite the uptake of 123I-MIBG demonstrated by scintigraphy.…”
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Dimethoate Induced Behavioural Changes in Juveniles of Cyprinus carpio var. communis under Temperate Conditions of Kashmir, India by Imtiyaz Qayoom, Feroz A. Shah, Malik Mukhtar, Masood H. Balkhi, Farooz A. Bhat, Bilal A. Bhat

“…The fishes elicited various behavioural responses such as uncoordinated movements, convulsions, excessive mucus secretion, and imbalanced swimming which ended in a collapse to the bottom of the aquarium. …”
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Differential responses of Bradyrhizobium sp. SUTN9-2 to plant extracts and implications for endophytic interactions within different host plants by Teerana Greetatorn, Pakpoom Boonchuen, Pongdet Piromyou, Pongpan Songwattana, Jenjira Wongdee, Kamonluck Teamtisong, Nantakorn Boonkerd, Shusei Sato, Neung Teaumroong, Panlada Tittabutr

“…Transcriptomic and cytological analyses revealed that genes associated with CAMP resistance, nitrogen metabolism, nitrogen fixation, defense responses, and secretion systems were upregulated, while genes related to the cell cycle and certain CAMP-resistance mechanisms were downregulated, particularly in response to chili extract. …”
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Lung-homing nanoliposomes for early intervention in NETosis and inflammation during acute lung injury by Jungbum Kim, Donghyuk Seo, So-Yeol Yoo, Hye-Jin Lee, Jisun Kim, Ji Eun Yeom, Jae-Young Lee, Wooram Park, Kyung Soo Hong, Wonhwa Lee

“…Isolated neutrophils from blood samples of severe ARDS patients demonstrated significant anti-NETosis effects, as well as reduced proinflammatory cytokine secretion. Furthermore, in a murine model of LPS-induced ALI, we confirmed improvements in lung histopathology, and early respiratory function. …”
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