Prevalence of GCKR rs1260326 Variant in Subjects with Obesity Associated NAFLD and T2DM: A Case-Control Study in South Punjab, Pakistan by Tayyaba Nisar, Kashan Arshad, Zahid Abbas, Maira Ali Khan, Sohail Safdar, Rehan Sadiq Shaikh, Ali Saeed

“…The glucokinase regulatory protein (GCKR) regulates glycogen metabolism and insulin secretion, and the GCKR rs1260326 is a putative single nucleotide polymorphism (SNP) associated with metabolic disorders including nonalcoholic fatty liver disease (NAFLD) and type 2 diabetes mellitus (T2DM). …”
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Noncanonical effects of vasopressin in angiogenesis by I. I. Khegay

“…Platelet adhesion on endothelium activates cellular secretion of growth factors and enzymes for intercellular matrix glucosamine metabolism. …”
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The malaria parasite PP1 phosphatase controls the initiation of the egress pathway of asexual blood-stages by regulating the rounding-up of the vacuole. by Marie Seveno, Manon N Loubens, Laurence Berry, Arnault Graindorge, Maryse Lebrun, Catherine Lavazec, Mauld H Lamarque

“…These events are coordinated by two intracellular second messengers, cGMP and calcium ions (Ca2+), that control the activation of their dedicated kinases, PKG and CDPKs respectively, and thus the secretion of parasitic factors that assist membranes rupture. …”
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Mycobacterium tuberculosis Protein Rv3841 Activates Dendritic Cells and Contributes to a T Helper 1 Immune Response by Seunga Choi, Han-Gyu Choi, Ki-Won Shin, Yong Woo Back, Hye-Soo Park, Jae Hwi Lee, Hwa-Jung Kim

“…We found that Rv3841 functionally activated DCs by upregulating costimulatory molecules and increased secretion of proinflammatory cytokines. Activation of DCs by Rv3841 was mediated by Toll-like receptor 4 (TLR4), followed by triggering of mitogen-activated protein kinase and nuclear factor-κB signaling pathways. …”
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Regulation of Hypoxia-Induced Cell Death in Human Tenocytes by Min Liang, Hannah R. Cornell, Nasim Zargar Baboldashti, Mark S. Thompson, Andrew J. Carr, Philippa A. Hulley

“…Hypoxia markedly upregulated VEGF-A mRNA, followed by increased VEGF protein secretion. However treatment with VEGF did not improve tenocyte survival. …”
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The Effect of IL-35 on the Expression of Nasal Epithelial-Derived Proinflammatory Cytokines by Mingrong Nie, Qingxiang Zeng, Luo Xi, Yiquan Tang, Renzhong Luo, Wenlong Liu

“…However, the effect of IL-35 on human nasal epithelial cells (HNECs) especially the secretion of nasal epithelial-derived proinflammatory cytokines as well as the possible mechanism is still unclear. …”
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Older Age Is Associated with Decreased Levels of VDR, CYP27B1, and CYP24A1 and Increased Levels of PTH in Human Parathyroid Glands by Yi Jiang, Liyan Liao, Jina Li, Larry Wang, Zhongjian Xie

“…We hypothesized that the expression of CYP27B1 or VDR in parathyroid glands decreases with age, which might account for the increased serum levels of iPTH due to decreased suppression of parathyroid hormone (PTH) secretion by 1,25(OH)2D in older people. To test this hypothesis, we examined relative expression levels of VDR, CYP27B1, CYP24A1, and PTH in specimens from parathyroid glands unintentionally removed during thyroidectomy for 70 patients varying in age from 10 to 70 years. …”
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Reflections on COVID-19: A Literature Review of SARS-CoV-2 Testing by Chin Shern Lau, Helen M. L. Oh, Tar Choon Aw

“…Studies demonstrated robust antibody secretion with each vaccine dose and could last for several months post-vaccination. …”
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L-theanine modulates tissue cortisol levels in zebrafish after single stress by Vinícius Luís da Silva, Mariana Spanamberg Mayer, Andriele dos Reis Severo, Andressa Leal Zambra, Joanna Moraes De Almeida, Laura Moura Sestari, Mariana Migliorini Parisi, Ana Cristina Vendrametto Varrone Giacomini, Murilo Sander De Abreu, Josiane Woutheres Bortolotto, Gabriela Bonfanti-Azzolin

“…Stress is a situation characterized by the stimulus to cortisol secretion and without specific pharmacological therapies. …”
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Identification of retinol dehydrogenase 10 as a shared biomarker for metabolic dysfunction-associated steatotic liver disease and type 2 diabetes mellitus by Fangyu Li, Rui Li, Hongjun Deng

“…Finally, we used RT-qPCR, immunofluorescence, Western blotting and Elisa to validate hub gene expression in MASLD and T2DM mouse models.ResultsThis analysis identified 20 genes shared by MASLD and T2DM that were enriched in the bile secretion, phototransduction, cancer, carbohydrate digestion and absorption, cholesterol/glycerol metabolism, and retinol metabolism. …”
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Role of Mast Cells and Type 2 Innate Lymphoid (ILC2) Cells in Lung Transplantation by Esmaeil Mortaz, Saeede Amani, Sharon Mumby, Ian M. Adcock, Mehrnaz Movassaghi, Jelle Folkerts, Johan Garssen, Gert Folkerts

“…MCs can have pro- and anti-inflammatory functions, thereby regulating the outcome of lung transplantation through secretion of mediators that allow interaction with other cell types, particularly innate lymphoid cells (ILC2). …”
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Nanoparticles containing intracellular proteins modulate neutrophil functional and phenotypic heterogeneity by Leonore Raudszus, Farbod Bahreini, Susanne Allan, Kai-Uwe Kalies, Charles C. Caldwell, Kathrin Kalies

“…Additionally, CDNPs induce the secretion of IL-10, shift PMA-induced cell death toward apoptosis, and increase the expression of CD80. …”
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Structure elucidation, immunomodulatory activity, antitumor activity and its molecular mechanism of a novel polysaccharide from Boletus reticulatus Schaeff by Siyuan Su, Xiang Ding, Yiling Hou, Binbin Liu, Zhouhe Du, Junfeng Liu

“…Bioactivity assays indicated that BRS-X displayed a strong proliferative activity in T cells and B cells and promoted the secretion of immunoglobulin G (IgG), IgE, IgD and IgM. …”
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Akram’s lifestyle: An effective remedy for the management of gastroesophageal reflux disease by Sadia A. Khan, Javeria Z. Khan, Tayyab S. Akhter, Hamama-Tul-Bushra Khaar, Talay Yar, Mohammad A. Randhawa

“…Reduced gastric acid secretion, TLESRs and enhanced gastric emptying could be the potential contributing factors in causing this improvement. …”
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Acute hepatitis of non-specified etiology by Ye. V. Tsyganova, O. O. Znoyko, N. D. Yushchuk, K. R. Dudina, M. G. Isagulyants, N. V. Petrakova, T. V. Petrova, M. I. Mikhaylov

“…Investigation of patients with acute hepatitis of non-specified etiology included clinical, epidemiologic, routine laboratory, serological methods; molecular biological method (RNA of hepatitis A, C, Е, G viruses; DNA of hepatitis B virus, TTV, CMV, EBV, HHV of 1, 2, 6 and 8 types, PV B-19, NV-f – qualitative analysis); method of immunofluorescence (assessment of antimitochondrial and antinuclear antibodies); immunologic methods (laboratory diagnostic methods) – independent assessment of specific antibodies for individual HCV antigens spectrum, including structural and unstructural proteins and compound peptides, representing the whole HCV polyprotein (overall 38 antigens: 34 HCV antigens and 4 control antigens) in blood serum by EIA method; investigation of Т-cellular immune response to HCV antigens by blast-cell lymphocytes transformation method under stimulation by HCV antigens with quantitative evaluation of cytokine secretion; instrumental method – ultrasound investigation of abdominal organs.Conclusions. …”
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Hippocampal Neurogenesis and Antidepressive Therapy: Shocking Relations by Peter Rotheneichner, Simona Lange, Anna O’Sullivan, Julia Marschallinger, Pia Zaunmair, Christian Geretsegger, Ludwig Aigner, Sebastien Couillard-Despres

“…Following application of electroconvulsive shocks, intricate interactions between neurogenesis, angiogenesis, and microglia activation, the hypothalamic-pituitary-adrenal axis and the secretion of neurotrophic factors have been documented. …”
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Cisplatin-Induced Renal Salt Wasting Requiring over 12 Liters of 3% Saline Replacement by Phuong-Chi Pham, Pavani Reddy, Shaker Qaqish, Ashvin Kamath, Johana Rodriguez, David Bolos, Martina Zalom, Phuong-Thu Pham

“…A diagnosis of syndrome of inappropriate antidiuretic hormone secretion (SIADH) was initially made. Despite free water restriction, patient’s SNa continued to decrease in association with acute onset of headaches, nausea, and dizziness. …”
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Tremella fuciformis Polysaccharides Attenuate Oxidative Stress and Inflammation in Macrophages through miR-155 by Yang Ruan, Hong Li, Lianmei Pu, Tao Shen, Zening Jin

“…LPS induced inflammation and ROS production and promoted the secretion of cytokines such as TNF-α and IL-6. LPS also enhanced the nuclear translocation of NFκB, which promoted inflammation by oxidative stress. …”
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A Comparative Study between outcome of 25% glucose in glycerin and submucosal human placental extract injection in the management of Primary Atrophic Rhinitis by Amlan Debbarma, Bidhan Das, Santanu Saha

“…Progressive atrophy of nasal mucosa and underlying turbinates, formation of scanty viscid secretion and crusts causing foul odor are the cardinal features of this disease. …”
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Immunohistochemistry for (Pro)renin Receptor in Humans by Satoshi Morimoto, Noriko Morishima, Daisuke Watanabe, Yoichiro Kato, Noriyuki Shibata, Atsuhiro Ichihara

“…The (pro)renin receptor is a multifunctional protein with roles in angiotensin-II-dependent and -independent intracellular cell signaling and roles as an intracellular accessory protein for the vacuolar H+-ATPase, including hormone secretion. While (pro)renin receptor mRNA is widely expressed in various human tissues, localization of (pro)renin receptor protein expression has not yet been systemically determined. …”
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