Effect of genomic regions harboring putative lethal haplotypes on reproductive performance in closed experimental selection lines of Nellore cattle by Gustavo R. D. Rodrigues, Joslaine N. S. G. Cyrillo, Lúcio F. M. Mota, Patrícia I. Schmidt, Júlia P. S. Valente, Eduarda S. Oliveira, Lúcia G. Albuquerque, Luiz F. Brito, Maria E. Z. Mercadante

“…The gene networks were involved in metabolic pathways including ovarian steroidogenesis, oocyte meiosis, and insulin secretion. Matings between carrier dam and carrier sire led to a reduction of up to -203.46% in pregnancy success probability, an increase of 275.15% in probability of pregnancy loss, 295.03% for stillbirth occurrence, and 301.40% for pre-weaning mortality when compared to non-carrier dam and sire matings. …”
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The use of Kutikulin for treatment and prevention of gastrointestinal diseases in calves and piglets by M. V. Koryukina, V. N. Makarova, O. B. Badeeva, I. N. Simanova

“…The paper presents  the results of tests of Kutikulin, a product made at the Vologda Branch of the FSC VIEV, which consists of chicken gizzard cuticle containing a keratoid secretion and a number of biologically active enzymes. …”
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CD109, a master regulator of inflammatory responses by Adel Batal, Adel Batal, Setareh Garousi, Setareh Garousi, Kenneth W. Finnson, Kenneth W. Finnson, Anie Philip, Anie Philip

“…CD109 exerts its effects by modulating processes such as cytokine secretion, immune cell recruitment, macrophage polarization, T helper cell function and cancer cell phenotype and function. …”
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Sleep recovery ameliorates submandibular salivary gland inflammation associated with paradoxical sleep deprivation in male Wistar rats by Jude Ijuo Abeje, Shehu-Tijani T. Shittu, Olayinka Olawale Asafa, Bimpe Bolarinwa, Taye J. Lasisi

“…Abstract Submandibular salivary gland inflammation has been suggested as one of the mechanisms underlying impaired salivary secretion associated with sleep deprivation (SD). However, whether the salivary inflammatory response occurs to the same extent in paradoxical sleep deprivation with or without sleep recovery remains unknown. …”
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<i>Cuphea hookeriana</i>: Phytochemical Profile and the Cosmeceutical and Dermatological Properties of Its Active Fraction from the Whole Plant by Xing Wu, Meng-Fei Wanyan, Bao-Bao Shi, Rong Huang, Hui-Xiang Yang, Xian Wang, Ji-Kai Liu

“…In a model where ultraviolet light promotes the increase in melanin secretion in guinea pig skin tissues, both α-arbutin and the fine active fraction can reduce melanogenesis, and the effect of the fine active fraction is better than that of α-arbutin.…”
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PPAR-α regulates metabolic remodelling and participates in myocardial fibrosis in patients with atrial fibrillation of rheumatic heart disease by Xiaoying Hu, Daisong Jiang, Zheng Zhang, Zhenmei An

“…The changes of phenotype transformation of myocardial fibroblasts were detected by cellular immunofluorescence, the secretion level of supernatant collagen was detected by ELISA. …”
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The Emerging Role of Implementing Machine Learning in Food Recommendation for Chronic Kidney Diseases Using Correlation Analysis by Sachin Gupta, Neeraj Garg, Divyanshu Sinha, Babita Yadav, Bhoomi Gupta, Shahajan Miah

“…The correlation analysis has been done to observe the impact of eight independent variables that are age, gender, blood sugar, serum albumin, creatinine, potassium, bacteria, and pus secretion on the two dependent variables that are the risk of CKD occurrence and ML accuracy. …”
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Linking Endotoxins, African Dust PM10 and Asthma in an Urban and Rural Environment of Puerto Rico by Mario G. Ortiz-Martínez, Rosa I. Rodríguez-Cotto, Mónica A. Ortiz-Rivera, Cedric W. Pluguez-Turull, Braulio D. Jiménez-Vélez

“…Urban extracts were highly toxic, proinflammatory (IL-6/IL-8 secretion), and induced higher TLR4 expression and NF-κB activation compared to rural extracts. …”
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Smoking-Induced Inhibition of Number and Activity of Endothelial Progenitor Cells and Nitric Oxide in Males Were Reversed by Estradiol in Premenopausal Females by Yijia Shao, Liang Luo, Zi Ren, Jiayi Guo, Xingxing Xiao, Jiana Huang, Haitao Zeng, Hong Zhan

“…Furthermore, there was significant correlation between EPC number and activity, plasma NO level, and NO secretion by EPCs and FMD. Conclusions. Estradiol was deemed to play an important role in enhancing the number and activity of EPCs and NO production in premenopausal women even when affected by smoking, which may be the important mechanisms underlying vascular protection of estradiol in premenopausal women, but not in age-matched men.…”
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Transcriptomic Response in Pseudomonas aeruginosa towards Treatment with a Kaempferol Isolated from Melastoma malabathricum Linn Leaves by Mourouge Saadi Alwash, Wan Syaidatul Aqma, Wan Yaacob Ahmad, Nazlina Ibrahim

“…Furthermore, KF also increased the expression of genes associated with ATP-binding cassette transporters, flagella, type III secretion system proteins, and DNA replication and repair, which may further influence nutrient uptake, motility, and growth. …”
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Selective ATP-Binding Cassette Subfamily C Gene Expression and Proinflammatory Mediators Released by BEAS-2B after PM2.5, Budesonide, and Cotreated Exposures by Jarline Encarnación-Medina, Rosa I. Rodríguez-Cotto, Joseph Bloom-Oquendo, Mario G. Ortiz-Martínez, Jorge Duconge, Braulio Jiménez-Vélez

“…., particulate matter 2.5 (PM2.5)) and drug metabolites outside the cells. IL-6 secretion is related with the activation of the ABCC transporters. …”
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Hydroxysafflor Yellow A Inhibits LPS-Induced NLRP3 Inflammasome Activation via Binding to Xanthine Oxidase in Mouse RAW264.7 Macrophages by Xiaolong Xu, Yuhong Guo, Jingxia Zhao, Ning Wang, Junying Ding, Qingquan Liu

“…These findings suggest that XO may be a potential target of HSYA via direct binding inhibition and the combination of HSYA-XO suppresses LPS-induced ROS generation, contributing to the depression of NLRP3 inflammasome and inhibition of IL-1β secretion in macrophages.…”
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Migration, Distribution, and Safety Evaluation of Specific Phenotypic and Functional Mouse Spleen-Derived Invariant Natural Killer T2 Cells after Adoptive Infusion by Dongzhi Chen, Wenbin Xu, Jingfang Teng, Huifang Liu, Yuanyuan Wang, Yan Wang, Shujie Cheng, Ming Meng

“…Cytometric bead array (CBA) assay was used to detect cytokine secretion in the supernatant stimulated by iNKT cells. …”
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Pathogenic and therapeutic role of bile acids at reflux-gastritis by T. L. Lapina, I. M. Kartavenko, V. T. Ivashkin

“…Increase of endocellular calcium stimulates secretion of pepsinogen and acid production in the stomach,  that in the case of decreased cytoprotective factors by DGR can cause changes mucosal injury. …”
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An Overview of Long Noncoding RNAs Involved in Bone Regeneration from Mesenchymal Stem Cells by Shuping Peng, Lihua Cao, Shiwei He, Yancheng Zhong, Haotian Ma, Yanru Zhang, Cijun Shuai

“…It is a multiple-step- and multiple-gene-involved complex process, including the matrix secretion and calcium mineralization by osteoblasts differentiated from mesenchymal stem cells (MSCs) and the absorption of calcium and phosphorus by osteoclasts differentiated from hematopoietic stem cells. …”
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Suppressive Effects of GSS on Lipopolysaccharide-Induced Endothelial Cell Injury and ALI via TNF-α and IL-6 by Lei Yi, Zengding Zhou, Yijuan Zheng, Mengling Chang, Xiaoqin Huang, Feng Guo, Quanming Zhao, Jingning Huan

“…In this study, we found that GSS not only downregulated the levels of TNF-α and IL-6 in the lung and serum of mice in vivo but also inhibited the expression and secretion of TNF-α and IL-6 in ECs. Importantly, we also found that GSS blocked LPS-induced TNF-α and IL-6 expression in ECs via the Myd88/NF-κB signaling pathway. …”
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The gut microbiota‐derived metabolite indole‐3‐propionic acid enhances leptin sensitivity by targeting STAT3 against diet‐induced obesity by Zhiwei Wang, Shaying Yang, Liangju Liu, Aiqin Mao, Hao Kan, Fan Yu, Xin Ma, Lei Feng, Tingting Zhou

“…High‐fat diet (HFD), rather than genetic factors, induces excessive secretion of antimicrobial peptides by Paneth cells, inhibiting the growth of Clostridia in the gut and resulting in decreased production of the beneficial metabolite IPA. …”
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Elotuzumab Enhances CD16-Independent NK Cell-Mediated Cytotoxicity against Myeloma Cells by Upregulating Several NK Cell-Enhancing Genes by Yan-Hua Wang, Shotaro Hagiwara, Hiroshi Kazama, Yuki Iizuka, Norina Tanaka, Junji Tanaka

“…Upon direct simulation of CD16-independent NK cells with Elo, increased levels of CD107a degranulation and IFN-γ secretion were observed along with the upregulation of granzyme B, TNF-α, and IL-1α gene expression. …”
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The Mast Cell Is an Early Activator of Lipopolysaccharide-Induced Neuroinflammation and Blood-Brain Barrier Dysfunction in the Hippocampus by Yiwei Wang, Huanhuan Sha, Leting Zhou, Yinan Chen, Qin Zhou, Hongquan Dong, Yanning Qian

“…Notably, LPS-induced proinflammatory cytokine secretion, microglial activation, and BBB damage were inhibited in KitW-sh/W-sh mice. …”
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Ameliorative effect of Lacticaseibacillus rhamnosus Fmb14 from Chinese yogurt on hyperuricemia by Hongyuan Zhao, Xiaoyu Chen, Fanqiang Meng, Libang Zhou, Xinyi Pang, Zhaoxin Lu, Yingjian Lu

“…L. rhamnosus Fmb14 CFE treatment ameliorates hyperuricemia through xanthine oxidase (XOD) inhibition and ATP-binding cassette subfamily G member 2 (ABCG2) promotion, both of which are responsible for uric acid (UA) synthesis and secretion in HepG2 and Caco2 cells, respectively. The in vivo results showed that the serum UA level decreased from 236.28 to 149.28 μmol/L after 8 weeks of oral administration of L. rhamnosus Fmb14 in inosine-induced hyperuricemia model mice. …”
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