Thrombin Promotes Matrix Metalloproteinase-13 Expression through the PKCδ/c-Src/EGFR/PI3K/Akt/AP-1 Signaling Pathway in Human Chondrocytes by Chun-Yin Huang, Hsiu-Jung Lin, Hsin-Shui Chen, Shi-Yann Cheng, Horng-Chaung Hsu, Chih-Hsin Tang

“…We found that stimulation with thrombin led to increased secretion of MMP-13 in cultured human chondrocytes. …”
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Enpostil Lowers Elevated Serum Gastrin Concentrations in Patients with Pernicious Anemia by P Kirdeikis, M Mant, L Zuk, D Fisher, L Bynum, ABR Thomson

“…The mechanism of this effect remains to be established, but it is clearly independent of an effect on acid secretion.…”
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Mechanism of Ferroptosis and Its Role in Type 2 Diabetes Mellitus by Wenxin Sha, Fei Hu, Yang Xi, Yudong Chu, Shizhong Bu

“…It is involved in glucose-stimulated insulin secretion (GSIS) impairment and arsenic-induced pancreatic damage in the pathogenesis of diabetes. …”
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Root cap border cells as regulators of rhizosphere microbiota by N. A. Omelyanchuk, V. A. Cherenko, E. V. Zemlyanskaya

“…A rhizosphere (a narrow area of soil around plant roots) is an ecological niche, within which beneficial microorganisms and pathogens compete with each other for organic carbon compounds and for the opportunity to colonize roots. The roots secrete rhizodeposits into the rhizosphere, which include border cells, products of root cell death and liquids secreted by living cells (root exudates). …”
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Gene Identification and Characterization of Correlations for DEPs_DEGs Same Trend Responding to Salinity Adaptation in Scylla paramamosain by Huan Wang, Hongling Wei, Lei Tang, Junkai Lu, Changkao Mu, Chunlin Wang

“…KEGG pathway enrichment correlation revealed that protein digestion and absorption (Ko04974), proximal tubule bicarbonate (Ko04964), and bile secretion (Ko04976) played important roles in Na+/H+ and Na+/K+ exchange. …”
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Regulation of CXCR6 Expression on Adipocytes and Osteoblasts Differentiated from Human Adipose Tissue-Derived Mesenchymal Stem Cells by Seung-Cheol Lee, Yoo-Jung Lee, Min Kyoung Shin, Jung-Suk Sung

“…Human mesenchymal stem cells derived from adipose tissue (hADMSCs) are a desirable candidate in regenerative medicine. hADMSCs secrete growth factors, cytokines, and chemokines and also express various receptors that are important in cell activation, differentiation, and migration to injured tissue. …”
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ET-1 Promotes Differentiation of Periodontal Ligament Stem Cells into Osteoblasts through ETR, MAPK, and Wnt/β-Catenin Signaling Pathways under Inflammatory Microenvironment by Li Liang, Wei Zhou, Nan Yang, Jifeng Yu, Hongchen Liu

“…ET-1 promoted differentiation of PDLSCs into osteoblasts by increasing secretion of TNF-α, IL-1β, and IL-6 in a dose- and time-dependent manner. …”
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Th17 Cell Enhances CD8 T-Cell Cytotoxicity via IL-21 Production in Emphysema Mice by Min-Chao Duan, Ying Huang, Xiao-Ning Zhong, Hai-Juan Tang

“…The in vitro experiments showed that IL-21 significantly augmented the secretion of perforin and granzyme B in CD8+ T cells from CS-exposed mice. …”
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Outer Membrane Vesicles Derived from Adherent-Invasive Escherichia coli Induce Inflammatory Response and Alter the Gene Expression of Junction-Associated Proteins in Human Intestin... by Bahareh Nadalian, Banafsheh Nadalian, Mohammad Reza Zali, Abbas Yadegar

“…Gene expression of occludin, ZO-1, claudin-2, E-cadherin, TLR-2, and TLR-4 in response to OMVs was assessed in Caco-2 cells by RT-qPCR. Moreover, the secretion of IL-8 and TNF-α into the supernatant of Caco-2 cells upon treatment with OMVs was measured using ELISA. …”
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Grape Seed Procyanidin Extract Improves Insulin Production but Enhances Bax Protein Expression in Cafeteria-Treated Male Rats by Lídia Cedó, Anna Castell-Auví, Victor Pallarès, Mayte Blay, Anna Ardévol, Montserrat Pinent

“…The results have confirmed that the cafeteria model is a robust model mimicking a prediabetic state, as these rats display insulin resistance, increased insulin synthesis and secretion, and increased apoptosis in the pancreas. …”
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β-Cell Specific Overexpression of GPR39 Protects against Streptozotocin-Induced Hyperglycemia by Kristoffer L. Egerod, Chunyu Jin, Pia Steen Petersen, Nils Wierup, Frank Sundler, Birgitte Holst, Thue W. Schwartz

“…Mice deficient in the zinc-sensor GPR39, which has been demonstrated to protect cells against endoplasmatic stress and cell death in vitro, display moderate glucose intolerance and impaired glucose-induced insulin secretion. Here, we use the Tet-On system under the control of the proinsulin promoter to selectively overexpress GPR39 in the β cells in a double transgenic mouse strain and challenge them with multiple low doses of streptozotocin, which in the wild-type littermates leads to a gradual increase in nonfasting glucose levels and glucose intolerance observed during both food intake and OGTT. …”
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Effects of pollen enriched diet on hypopharyngeal glands’ morphology and morphometry and vitellogenin transcription levels in honey bees by Claudia D’Emilio, Viviana Valenzano, Paola Maiolino, Karen Power, Manuela Martano, Gennaro Di Prisco

“…Our results confirm that a diet rich in pollen is necessary for the normal development and function of HPGs and that the amount of secretion is positively correlated with glandular activity and acinar size. …”
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A Rapid Biochemical and Radiological Response to the Concomitant Therapy with Temozolomide and Radiotherapy in an Aggressive ACTH Pituitary Adenoma by Ana Misir Krpan, Tina Dusek, Zoran Rakusic, Mirsala Solak, Ivana Kraljevic, Vesna Bisof, David Ozretic, Darko Kastelan

“…Concurrent treatment with temozolomide and irradiation appears to be highly effective in the achievement of the tumor volume control as well as in the control of ACTH secretion in aggressive ACTH adenoma.…”
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Migration, Proliferation, and Differentiation of Cord Blood Mesenchymal Stromal Cells Treated with Histone Deacetylase Inhibitor Valproic Acid by Leah A. Marquez-Curtis, Yuanyuan Qiu, April Xu, Anna Janowska-Wieczorek

“…We found that in MSC, VPA increased (i) the gene and total protein expression of CXCR4 and CXCR7 and primed migration towards a low gradient of SDF-1, (ii) the gene expression of MMP-2 and secretion and activation of proMMP-2, (iii) the proliferation and gene expression of pluripotency markers SOX2 and Oct-4, and exposure to lower concentrations of VPA (≤5 mM) had no effect on their differentiation to osteocytes and chondrocytes. …”
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Bone Marrow Mesenchymal Stem Cells Enhance the Differentiation of Human Switched Memory B Lymphocytes into Plasma Cells in Serum-Free Medium by Guillaume Bonnaure, Catherine Gervais-St-Amour, Sonia Néron

“…In these cultures, the secretion of CXCL12 and TGF-β, usually found in the bone marrow, was linked to the presence of MSC. …”
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Resistant stomach ulcer at Cushing disease: clinical case by N. V. Novozhilov, Yu. O. Shulpekoa, S. V. Mironov, Ye. K. Baranskaya, A. A. Sheptulin, V. T. Ivashkin

“…Hypercorticoidism is one of the causes of treatment-resistant stomach ulcers that is due to increase in gastric secretion and depression of collagen formation under the effect of hydrocortisone. …”
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Temperature Depended Role of Shigella flexneri Invasion Plasmid on the Interaction with Acanthamoeba castellanii by Amir Saeed, David Johansson, Gunnar Sandström, Hadi Abd

“…The virulence genes required for invasion are clustered on a large 220 kb plasmid encoding type three secretion system (TTSS) apparatus and virulence factors such as adhesions and invasion plasmid antigens (Ipa). …”
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Examining the Effect of Consuming C8 Medium-Chain Triglyceride Oil for 14 Days on Markers of NLRP3 Activation in Healthy Humans by Helena Neudorf, Garett Jackson, Jonathan P. Little

“…Specifically, caspase-1 activation and secretion of its downstream product interleukin (IL)-1β were unchanged following 14 days of C8 MCT oil supplementation when measured in unstimulated and LPS-stimulated whole blood cultures (all P>0.05). …”
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Androgenic Anabolic Steroids Cause Thiol Imbalance in the Vascular Endothelial Cells by Halszka Ponamarczuk, Maria Światkowska, Marcin Popielarski

“…In addition, AASs increased oxidation of the non-enzymatic thiol buffer, glutathione (GSH), reduced secretion of thiol oxidoreductase protein disulphide isomerase (PDI) from endothelial cells and affected the thiol pattern of PDI. …”
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Ethanol Extract of Sesamum indicum Linn. Inhibits FcεRI-Mediated Allergic Reaction via Regulation of Lyn/Syk and Fyn Signaling Pathways in Rat Basophilic Leukemic RBL-2H3 Mast Cell... by Hyun Ju Do, Tae Woo Oh, Kwang-Il Park

“…SIE inhibited the degranulation and secretion of inflammatory mediators in antigen/IgE-sensitized mast cells. …”
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