The Pivotal Immunomodulatory and Anti-Inflammatory Effect of Histone-Lysine N-Methyltransferase in the Glioma Microenvironment: Its Biomarker and Therapy Potentials by Seidu A. Richard, Kuugbee D. Eugene

“…The suppression of EZH2 gene secretion was capable of reversing temozolomide resistance in patients with glioma. …”
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Mechanism of Action of Lacticaseibacillus paracasei HNU502 and Fecal Microbiota Transplantation in Alleviating Antibiotic Side Effects by CHEN Lin, LI Ao, LI Jiahe, ZHANG Zeng, ZHANG Jiachao

“…Moreover, the two approaches ameliorated the metabolic disorders of short-chain fatty acids, inhibited the secretion of pro-inflammatory cytokines such as interleukin (IL)-1β, IL-6 and tumor necrosis factor (TNF)-α as well as blood urea nitrogen (BUN), and effectively reduced virulence factor enrichment. …”
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Ethyl Caffeate Ameliorates Collagen-Induced Arthritis by Suppressing Th1 Immune Response by Shikui Xu, Aixue Zuo, Zengjun Guo, Chunping Wan

“…In vivo, ECF treatment reduced the severity of CIA, inhibited IFN-γ and IL-6 secretion, and decreased the proportion of CD11b+Gr-1+ splenic neutrophil. …”
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An Adrenocortical Carcinoma Associated with Non-Islet Cell Tumor Hypoglycemia and Aberrant ACTH Production by M. D. S. A. Dilrukshi, A. W. Wickramarachchi, D. D. K. Abeyaratne, Brian Shine, Bahram Jafar-Mohammadi, N. P. Somasundaram

“…Adrenocortical carcinomas (ACCs) are infrequently reported to present with severe hypoglycemia syndrome resulting from the secretion of insulin-like growth factor II (IGF-II) by tumor cells. …”
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Relationship of asprosin and diabetes: a meta-analysis by Xiandong Zeng, Xin Sun, Wei He, Jing Xie, Caihong Xin

“…Previous research suggests that asprosin may contribute to the development of diabetes by regulating glucose homeostasis, appetite, insulin secretion, and insulin sensitivity. Although some studies have shown that asprosin levels are higher in patients with diabetes than in healthy individuals, the association between asprosin levels and diabetes remains controversial. …”
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The Role of TLR4 on B Cell Activation and Anti-β2GPI Antibody Production in the Antiphospholipid Syndrome by Si Cheng, Haibo Wang, Hong Zhou

“…However, TLR4 provides a third signal for B cell activation and then promotes B cells better receiving signals from both B cell antigen receptor (BCR) and CD40, thus promoting B cell activation, surface molecules expression, anti-β2GPI Ab production, and cytokines secretion and making B cell functioning like an antigen presenting cell (APC). …”
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Control of Intracellular Francisella tularensis by Different Cell Types and the Role of Nitric Oxide by Sarah L. Newstead, Amanda J. Gates, M. Gillian Hartley, Caroline A. Rowland, E. Diane Williamson, Roman A. Lukaszewski

“…Combined stimulation with LPS and IFN-γ produced a significant reduction in intracellular bacteria that occurred whether high levels of NO were produced or not, indicating that NO secretion is not the only defensive cellular mechanism operating in virulent Francisella infections. …”
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Distinct plasmablast developmental intermediates produce graded expression of IgM secretory transcripts by Evelyn P. Sievert, Marissa C. Franke, Kayla B. Thomas, Yoseop Yoon, Yongsheng Shi, Roger Sciammas

“…Summary: Differentiation into plasma cells (PCs) enables secretion of ∼10,000 immunoglobulin molecules per second. …”
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Mechanisms of Chronic State of Inflammation as Mediators That Link Obese Adipose Tissue and Metabolic Syndrome by Eduardo Fuentes, Francisco Fuentes, Gemma Vilahur, Lina Badimon, Iván Palomo

“…Meanwhile, the chronic inflammation in adipose tissue is regulated by a series of transcription factors, mainly PPARs and C/EBPs, that in conjunction regulate the expression of hundreds of proteins that participate in the metabolism and storage of lipids and, as such, the secretion by adipocytes. Therefore, the management of the metabolic syndrome requires the development of new therapeutic strategies aimed to alter the main genetic pathways involved in the regulation of adipose tissue metabolism.…”
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Role of the Renin-Angiotensin System and Aldosterone on Cardiometabolic Syndrome by P. Stiefel, A. J. Vallejo-Vaz, S. García Morillo, J. Villar

“…Finally, overweight and obesity promote the adrenal secretion of aldosterone, increasing the predisposition to type 2 diabetes mellitus. …”
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Piperazine sulfonamides as DPP-IV inhibitors: Synthesis, induced-fit docking and in vitro biological evaluation by Khalaf Reema Abu, Alwarafi Ebtisam, Sabbah Dima

“…Dipeptidyl peptidase-IV (DPP-IV) inhibitors minimize glucagon and blood glucose levels by increasing the incretin levels, glucagon-like peptide (GLP-1) and glucose-dependent insulinotropic poly-peptide (GIP), leading to insulin secretion from pancreatic beta cells. In the present study, nine 1,4-bis(phenylsulfonyl) piperazine derivatives 1a-i were synthesized and identified using 1H NMR, 13C NMR, MS and IR spectroscopies. …”
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The NLRP3 Inflammasome as a Novel Player of the Intercellular Crosstalk in Metabolic Disorders by Elisa Benetti, Fausto Chiazza, Nimesh S. A. Patel, Massimo Collino

“…NLRP3 inflammasome activation leads to the processing and secretion of the proinflammatory cytokines interleukin- (IL-) 1β and IL-18. …”
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The Effect of Paricalcitol on Vascular Calcification and Cardiovascular Disease in Uremia: Beyond PTH Control by Mario Cozzolino, Florjan Mehmeti, Paola Ciceri, Elisa Volpi, Andrea Stucchi, Irene Brenna, Daniele Cusi

“…Paricalcitol is a selective VDRA that suppresses PTH secretion with minimal increases on serum calcium and phosphate. …”
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MicroRNA-Regulated Proinflammatory Cytokines in Sarcopenia by Jingjing Fan, Xianjuan Kou, Yi Yang, Ning Chen

“…In this paper, we have systematically discussed regulatory mechanisms of miRNAs for the expression and secretion of inflammatory cytokines during sarcopenia, which will provide some novel targets and therapeutic strategies for controlling aging-related atrophy of skeletal muscle and corresponding chronic inflammatory diseases.…”
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Trafficking in cancer: from gene deregulation to altered organelles and emerging biophysical properties by Julie Patat, Kristine Schauer, Kristine Schauer, Hugo Lachuer

“…Intracellular trafficking supports all cell functions maintaining the exchange of material between membrane-bound organelles and the plasma membrane during endocytosis, cargo sorting, and exocytosis/secretion. Several proteins of the intracellular trafficking machinery are deregulated in diseases, particularly cancer. …”
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Role of PPARG in Chemosensitivity-Regulating Network for Hypopharyngeal Squamous Cell Carcinoma by Fanyong Kong, Boxuan Han, Jiaming Chen, Xixi Shen, Lizhen Hou, Jugao Fang, Meng Lian

“…PPARG gets enriched in several key functional groups that have been implicated in the regulation of chemosensitivity, including those associated with the response to nutrients, vitamins, and peptides, the cellular response to chemical stress, and the regulation of hormone secretion and growth. Our results emphasize the involvement of PPARG and its interconnectedness with other genes in the regulation of HSCC chemosensitivity.…”
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Remimazolam Combined with Andrographolide Improve Postoperative Cognitive Dysfunction in Rats after Cardiopulmonary Bypass through the AMPK/SIRT1 Signaling Pathway by Chong Chen, Lixia Lan, Kai Xu

“…Results: The results indicated that both Re and AP independently improved cognitive function in rats after CPB and inhibited the secretion of inflammatory factors and apoptosis in hippocampal tissues. …”
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Obesity-Related Metabolic Syndrome: Mechanisms of Sympathetic Overactivity by Maria Paola Canale, Simone Manca di Villahermosa, Giuliana Martino, Valentina Rovella, Annalisa Noce, Antonino De Lorenzo, Nicola Di Daniele

“…Sympathetic activation can be triggered by reflex mechanisms as arterial baroreceptor impairment, by metabolic factors as insulin resistance, and by dysregulated adipokine production and secretion from visceral fat with a mainly permissive role of leptin and antagonist role of adiponectin. …”
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How endocrine disruptors affect fish reproduction on multiple levels: A review by Socha Magdalena, Chyb Jarosław, Suder Aleksandra, Bojarski Bartosz

“…They can affect the functioning of certain systems within the hypothalamus (Kiss/GPR54, GnRH) and can also impact luteinizing hormone (LH) secretion in the pituitary. These compounds have negative impacts on gonads, oocyte maturation, steroidogenesis, and gametes. …”
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Nephrogenic Syndrome of Inappropriate Antidiuresis by D. Morin, J. Tenenbaum, B. Ranchin, T. Durroux

“…Symptomatic children, however, typically present with clinical and biological features suggesting inappropriate antidiuretic hormone secretion with severe hyponatremia and high urine osmolality, but a low plasma arginine vasopressin level. …”
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