Woxuanzhongzhou formula improves DHEAS and high-fat diet-induced IR and anovulatory mice via AMPK/PGC1- α/Irisin pathway by Haijuan Liu, Guohua Wang, Conglu Sui, Yanan Guo, Xiangyu He

“…These effects may be mediated through the activation of AMPK/PGC1-α pathway in muscle to promote the secretion of irisin.…”
Get full text

Sulfated Cyclocarya paliurus polysaccharides exert immunomodulatory potential on macrophages via Toll-like receptor 4 mediated MAPK/NF-κB signaling pathways by Yue Yu, Haibin Zhu, Mingyue Shen, Qiang Yu, Yi Chen, Shiru Mo, Jianhua Xie

“…The underlying molecular mechanism was that SCP3 activates macrophages via TLR4 receptors to promote ROS production, which in turn activates the downstream MAPK/NF-κB signaling pathway and then increases the secretion levels of cytokines and NO.…”
Get full text

The Effectiveness of Rapamycin Combined with Eltrombopag in Murine Models of Immune-Mediated Bone Marrow Failure by Shaoxue Ding, Xiaowei Liang, Tian Zhang, Rong Fu

“…We did not observe the difference in the curative effect of the Rapa group and CsA group, but for IL-10/Tregs ratio, the Rapa group was superior to the CsA group. And the IFN-r secretion of CD8+T cells in AA mice decreased significantly after the combination therapy of Rapa and Elt than Rapa alone. …”
Get full text

The Mycoplasma hyopneumoniae protein Mhp274 elicits mucosal and systemic immune responses in mice by Mengqi Xie, Zhongshun Huang, Yun Zhang, Yujie Gan, Huiying Li, Dan Li, Honglei Ding

“…Nevertheless, rMhp336 induced only IgG, IgG1 and IgG2 production in sera; the secretion of IFN-γ and IL-4 in sera and BALF; the expression of IFN-γ and IL-4 mRNAs in the splenocyte population; and lymphocyte proliferation.ConclusionMhp170 and Mhp274 induced Th1/Th2/Th17 immune responses, and Mhp336 stimulated mixed Th1/Th2-type immune responses, in mice. …”
Get full text

Health benefits of algae and marine-derived bioactive metabolites for modulating ulcerative colitis symptoms by Najmeh Oliyaei, Saghar Zekri, Aida Iraji, Alireza Oliyaei, Romina Tanideh, Nadiar M. Mussin, Amin Tamadon, Nader Tanideh

“…This review focused on the pathology of ulcerative colitis, pathogenesis and key inflammatory pathways, and the role of algae and marine-based metabolites for reduction of ulcerative colitis signs via alleviating the inflammation cytokines secretion, and improving the barrier function and gut microbiota.…”
Get full text

Characterization of the Vibrio anguillarum VaRyhB regulon and role in pathogenesis by Yingjie Li, Xinran Yu, Peng Li, Xin Li, Lushan Wang

“…In addition, two aspects of the type VI secretion system and molybdenum cofactor biosynthesis were first identified as being regulated by VaRyhB. …”
Get full text

GPIHBP1 increase accounts for rheumatic arthritis-related hypotriglyceridemia by facilitating lipids uptake of white adipose tissues by Meng-Ke Song, Meng-Fan Gu, Ling Liu, Lian-Jun He, Peng Ye, Kui Yang, Dan-Dan Wang, Opeyemi Joshua Olatunji, Qin Yin, Jian Zuo

“…Conclusion RA-associated inflammation induces GPIHBP1 secretion of endothelial cells, which facilitates blood TG hydrolysis and uptake to compensate the loss in WAT.…”
Get full text

Function and Morphology of the Meibomian Glands Using a LipiView Interferometer in Rotating Shift Medical Staff by Jing Zhang, Zhengzheng Wu, Liangnan Sun, Xin-hua Liu

“…MG loss occurred in 45.16% of affected eyes in the MS group and 16.13% of affected eyes in the control group, and the difference was statistically significant (χ2 = 14.352, P=0.001). MG yielding liquid secretion and MG yielding secretion score were significantly lower in the MS group than in the control group (Z = −3.641, P=0.001; Z = −3.146, P=0.001, resp.). …”
Get full text

Two Cases of γ-Heavy Chain Disease and a Review of the Literature by I. Ramasamy, Z. Rudzki

“…In the second patient, histopathology identified a separate clone responsible for the secretion of the gamma heavy chain. Studies on the clonal evolution of the disease may provide insight into therapeutic implications and the genomic complexity of the disease.…”
Get full text

Coelomocytes: Biology and Possible Immune Functions in Invertebrates with Special Remarks on Nematodes by Qudsia Tahseen

“…They are involved in important immune functions, such as phagocytosis, encapsulation, graft rejection, and inflammation, as well as the synthesis and secretion of several humoral factors especially in annelids and echinoderms. …”
Get full text

Renal Denervation Influences Angiotensin II Types 1 and 2 Receptors by Hajaralsadat Hosseini-Dastgerdi, Fatemeh Kharazmi, Ali-Asghar Pourshanazari, Mehdi Nematbakhsh

“…These two systems interact with each other so that angiotensin II (Ang II) has the presynaptic effect on the norepinephrine secretion. Another aspect of this interaction is that the sympathetic nervous system affects the function and expression of local RAS receptors, mainly Ang II receptors. …”
Get full text

A Fractional Epidemiological Model for Bone Remodeling Process by Muath Awadalla, Yves Yannick Yameni Noupoue, Kinda Abuasbeh

“…These are chemical substances, namely, calcitonin secretion, osteoclastic and osteoblastic, which are involved in the bone’s formation process. …”
Get full text

Bacterial Glycosulphatases and Sulphomucin Degradation by Anthony M Roberton, Damian P Wright

“…The presence of a high bacterial population in a region of the gastrointestinal tract is usually associated with the secretion of sulphomucins into the mucus gel covering that region. …”
Get full text

Regulatory mechanism of Reelin activity: a platform for exploiting Reelin as a therapeutic agent by Mitsuharu Hattori

“…Reelin is a secreted glycoprotein that was initially investigated in the field of neuronal development. …”
Get full text

NKT Cells in Sepsis by Briana Leung, Hobart W. Harris

“…Previous studies suggest that the pathophysiology of sepsis involves the hyperactivation of complex proinflammatory cascades that include the activation of various immune cells and the exuberant secretion of proinflammatory cytokines by these cells. …”
Get full text

Role of serotonin in physiology and diseases of gastro-intestinal tract by E. F. Barinov, O. N. Sulayeva

“…Immunomodulating role of serotonin realized by modulation of cytokine secretion of dendritic cells and lymphocytes is demonstrated.…”
Get full text

Fractalkine and Other Chemokines in Primary Biliary Cirrhosis by Shinji Shimoda, Carlo Selmi, M. Eric Gershwin

“…On this basis, it has been suggested that the targeted biliary epithelial cells (BEC) play an active role in the perpetuation of autoimmunity by attracting immune cells via chemokine secretion. To address this issue, we challenged BEC using multiple toll-like receptor (TLR) ligands as well as autologous liver infiltrating mononuclear cells (LMNC) with subsequent measurement of BEC phenotype and chemokine production and LMNC chemotaxis by quantifying specific chemokines, specially CX3CL1 (fractalkine). …”
Get full text

Growth Hormone and Reproduction: A Review of Endocrine and Autocrine/Paracrine Interactions by Kerry L. Hull, Steve Harvey

“…Moreover, recent studies indicate GH produced within reproductive tissues differs from pituitary GH in terms of secretion and action. Accordingly, GH is increasingly used as a fertility adjunct in males and females, both humans and nonhumans. …”
Get full text

The Golgi in Cell Migration: Regulation by Signal Transduction and Its Implications for Cancer Cell Metastasis by Valentina Millarte, Hesso Farhan

“…In this paper we will give an overview on how polarized secretion and microtubule nucleation at the Golgi regulate directional cell migration. …”
Get full text

Severe Symptomatic Hyponatremia Secondary to Escitalopram-Induced SIADH: A Case Report with Literature Review by Rishi Raj, Aasems Jacob, Ajay Venkatanarayan, Mohankumar Doraiswamy, Manjula Ashok

“…We hereby report a case of a 93-year-old female who presented with generalized tonic-clonic seizure and was diagnosed with severe hyponatremia due to escitalopram-induced syndrome of inappropriate antidiuretic hormone secretion (SIADH). With this article, we want to emphasize clinicians about this rare side effect of escitalopram use and look for the risk factors leading to SIADH.…”
Get full text