The Response of Tissue Mast Cells to TLR3 Ligand Poly(I:C) Treatment by Piotr Witczak, Ewa Brzezińska-Błaszczyk, Justyna Agier

“…Presented data on modulated FcεRI-mediated MC secretion of mediators upon poly(I:C) treatment suggests that dsRNA-type virus infection could influence the severity of allergic reactions.…”
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Electroporated Antigen-Encoding mRNA Is Not a Danger Signal to Human Mature Monocyte-Derived Dendritic Cells by Stefanie Hoyer, Kerstin F. Gerer, Isabell A. Pfeiffer, Sabrina Prommersberger, Sandra Höfflin, Tanushree Jaitly, Luca Beltrame, Duccio Cavalieri, Gerold Schuler, Julio Vera, Niels Schaft, Jan Dörrie

“…None of those RNAs induced changes in the expression of CD25, CD40, CD83, CD86, and CD70 or the secretion of the cytokines IL-8, IL-6, and TNFα of more than 1.5-fold compared to the control condition, while an mRNA encoding an NF-κB-activation protein as positive control induced massive secretion of the cytokines. …”
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Effect of Antifungal-Treated Host Macrophages on Candida glabrata by Hong-Bin Li, Na Li, Shu-Ran Wen, Ming-Yue Qiang, Zheng-Hui Yang, Tian-Xiang Dong, Yu-Ye Li, Yi-Qun Kuang

“…C. glabrata stimulated macrophages to secrete cytokines. Neither ICZ nor AmB affected the secretion of interleukin-6 (IL-6), interleukin-8 (IL-8), or tumor necrosis factor-α (TNF-α) by C. glabrata-infected macrophages. …”
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Positive Pneumocystis jirovecii Sputum PCR Results with Negative Bronchoscopic PCR Results in Suspected Pneumocystis Pneumonia by Kelly Pennington, John Wilson, Andrew H. Limper, Patricio Escalante

“…Of these 24 patients, 10 (46%) patients had a positive sputum or tracheal secretion sample with negative BAL or bronchial washings. …”
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TREM2 promotes the formation of a tumor-supportive microenvironment in hepatocellular carcinoma by Hanrui Guo, Meiling Wang, Caiya Ni, Chun Yang, Chunxue Fu, Xiaoman Zhang, Xueling Chen, Xiangwei Wu, Jun Hou, Lianghai Wang

“…Trem2-deficient macrophages presented increased chemokine secretion. TGF-β1 was found to be positively correlated with TREM2 expression in HCC, and TGF-β blockade reversed TREM2 induction. …”
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15-Deoxy-Δ12,14-prostaglandin J2 Induces Apoptosis and Upregulates SOCS3 in Human Thyroid Cancer Cells by Carlos Antônio Trindade-da-Silva, Carolina Fernandes Reis, Lara Vecchi, Marcelo Henrique Napimoga, Marcelo Sperandio, Bruna França Matias Colombo, Patrícia Terra Alves, Laura Sterian Ward, Carlos Ueira-Vieira, Luiz Ricardo Goulart

“…TPC-1 cells treated with 15d-PGJ2 decreased the secretion and expression of IL-6 and STAT3, while it increased SOCS1 and SOCS3. …”
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All-Trans Retinoic Acid Improves the Effects of Bone Marrow-Derived Mesenchymal Stem Cells on the Treatment of Ankylosing Spondylitis: An In Vitro Study by Deng Li, Peng Wang, Yuxi Li, Zhongyu Xie, Le Wang, Hongjun Su, Wen Deng, Yanfeng Wu, Huiyong Shen

“…ATRA pretreatment increased interleukin-6 (IL-6) secretion of MSCs. Th17 and Treg subset populations were increased and reduced by ATRA-pretreated MSCs, respectively. …”
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Genome wide identification of MATE and ALMT gene family in lentil (Lens culinaris Medikus) and expression profiling under Al stress condition by Ankita Tripathi, Dharmendra Singh, Jyotika Bhati, Deepti Singh, Jyoti Taunk, Jawaher Alkahtani, Abdulrahman Al-Hashimi, Madan Pal Singh

“…Abstract Background The membrane transporters viz. multidrug and toxic compound extrusion (MATE) and aluminum-activated malate transporter (ALMT) are associated with aluminum (Al) tolerance by accelerating secretion of organic acids, which can influence nutrient availability and stress response. …”
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Differential risk of cardiovascular complications in patients with type-2 diabetes mellitus in Ghana: A hospital-based cross-sectional study. by Christian Obirikorang, Evans Asamoah Adu, Anthony Afum-Adjei Awuah, Samuel Nkansah Darko, Frank Naku Ghartey, Samuel Ametepe, Eric N Y Nyarko, Enoch Odame Anto, William Kwame Boakye Ansah Owiredu

“…This underscores the importance of considering differences in adiposity, insulin secretion, and sensitivity indices when making clinical decisions for patients with T2DM.…”
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Baicalein Protects against Type 2 Diabetes via Promoting Islet β-Cell Function in Obese Diabetic Mice by Yu Fu, Jing Luo, Zhenquan Jia, Wei Zhen, Kequan Zhou, Elizabeth Gilbert, Dongmin Liu

“…In both type 1 (T1D) and type 2 diabetes (T2D), the deterioration of glycemic control over time is primarily caused by an inadequate mass and progressive dysfunction of β-cell, leading to the impaired insulin secretion. Here, we show that dietary supplementation of baicalein, a flavone isolated from the roots of Chinese herb Scutellaria baicalensis, improved glucose tolerance and enhanced glucose-stimulated insulin secretion (GSIS) in high-fat diet (HFD-) induced middle-aged obese mice. …”
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Efficacy of Hi-Lo Evac Endotracheal Tube in Prevention of Ventilator-Associated Pneumonia in Mechanically Ventilated Poisoned Patients by Ahmad Ghoochani Khorasani, Shahin Shadnia, Mohammad Mashayekhian, Mitra Rahimi, Abbas Aghabiklooei

“…To prevent this complication, aspiration of subglottic secretions using Hi-Lo Evac endotracheal tube (Evac ETT) is a recommended intervention. …”
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Effect of sodium alginate-based hydrogel loaded with lutein on gut microbiota and inflammatory response in DSS-induced colitis mice by Pengxiang Xu, Shuwei Luo, Jiangfeng Song, Zhuqing Dai, Dajing Li, Cai’e Wu

“…In order to effectively deliver lutein to the inflamed colon and better exert its pharmacological activity, this paper constructed a sodium alginate hydrogel-based delivery system loaded with lutein nanoparticles, evaluated the regulation on the expression and secretion of related inflammatory factors in mice with colitis, and its impact on intestinal microbial environment. …”
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Reprogramming the tumor immune microenvironment using engineered dual-drug loaded Salmonella by Dinh-Huy Nguyen, Sung-Hwan You, Hien Thi-Thu Ngo, Khuynh Van Nguyen, Khang Vuong Tran, Tan-Huy Chu, So-young Kim, Sang-Jun Ha, Yeongjin Hong, Jung-Joon Min

“…Localized secretion of FlaB promotes phenotypic and functional remodeling of intratumoral macrophages that markedly inhibits tumor metastasis in mice bearing tumors of mouse and human origin. …”
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In-depth proteomic profiling identifies potentiation of the LPS response by 7-ketocholesterol by Iain R. Phair, Magdalena Sovakova, Noor Alqurashi, Raid B. Nisr, Alison D. McNeilly, Douglas Lamont, Graham Rena

“…These changes were however insufficient alone to drive changes in cytokine and chemokine secretion. Rather, they prime the macrophage, potentiating LPS-stimulated TNF alpha secretion and key pro-inflammatory enzymes. …”
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Pain in pancreatitis: issue and ways out by A. V. Okhlobystin

“…Medical treatment of pain includes, first of all, elimination of toxic factors and stimulations of pancreatic secretion. Smoking cessation is important no less. …”
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RNAi-based ALOX15B silencing augments keratinocyte inflammation in vitro via EGFR/STAT1/JAK1 signalling by Megan A. Palmer, Rebecca Kirchhoff, Claudia Buerger, Yvonne Benatzy, Nils Helge Schebb, Bernhard Brüne

“…Using a cytokine cocktail containing IL-17A, interferon-gamma and tumour necrosis factor-alpha to produce a psoriasis-like phenotype, a role for ALOX15B in human epidermal keratinocyte inflammation was investigated. siRNA-mediated silencing of ALOX15B increased CCL2 expression and secretion. In addition to CCL2, secretion of CCL5 and CXCL10 were elevated in skin equivalents treated with lipoxygenase inhibitor ML351. …”
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Synergistic Stimulation with Different TLR7 Ligands Modulates Gene Expression Patterns in the Human Plasmacytoid Dendritic Cell Line CAL-1 by Tobias Hilbert, Folkert Steinhagen, Christina Weisheit, Georg Baumgarten, Andreas Hoeft, Sven Klaschik

“…CL264 in combination with 9.2s RNA significantly enhanced cytokine and interferon secretion to supra-additive levels. This effect was due to a stronger stimulation of already regulated genes (by monostimulation) as well as to recruitment of thus far unregulated genes. …”
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Smac127 Has Proapoptotic and Anti-Inflammatory Effects on Rheumatoid Arthritis Fibroblast-Like Synoviocytes by D. Lattuada, R. Gualtierotti, K. Crotta, P. Seneci, F. Ingegnoli, C. Corradini, R. Viganò, O. Marelli, C. Casnici

“…Also the secretion of the anti-inflammatory cytokine IL-10 is dramatically increased in the presence of Smac127. …”
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A Novel Role of Globular Adiponectin in Treatment with HFD/STZ Induced T2DM Combined with NAFLD Rats by Hong Ma, Guo-Ping You, Xuan-Pu Zhang, Xiang-Jiu Yang, Hua-Dong Lu, Yan-Ling Huang, Wen-Qiang Zhang

“…Globular adiponectin could ameliorate the hepatic steatosis and vary the expressions of adiponectin receptors in liver and skeletal muscle by stimulating insulin secretion.…”
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Stress-Induced Hyperprolactinemia: Pathophysiology and Clinical Approach by Samara Levine, Ozgul Muneyyirci-Delale

“…This review will provide an overview of prolactin physiology, the role of stress in prolactin secretion, as well as the general clinical approach to hyperprolactinemia.…”
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