Immunomodulatory Effects of Tigecycline in Balb/C Mice by Elhayek Shada Y., Fararjeh Mohammad A., Assaf Areej M., Abu-Rish Eman Y., Bustanji Yasser

“…In splenocyte cultures, tigecycline suppressed splenocyte proliferation with IC50 3-5 mmol L-1, significantly increased IL-2 secretion and reduced IL-17 secretion in a dose dependent mode. …”
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Squamosamide Derivative FLZ Protects Pancreatic β-Cells from Glucotoxicity by Stimulating Akt-FOXO1 Pathway by Xiangchen Kong, Longmei Zhang, Xianxin Hua, Xiaosong Ma

“…Chronic hyperglycemia increases apoptosis and reduces glucose-stimulated insulin secretion. Although protective agents have been searched extensively, none has been found so far. …”
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An Assessment of the Intestinal Lumen as a Site for Intervention in Reducing Body Burdens of Organochlorine Compounds by Ronald J. Jandacek, Stephen J. Genuis

“…Non-absorbable dietary fats and fat absorption inhibitors, however, can reduce the re-absorption of OCs and other lipophiles involved in EHC and may enhance the secretion of these compounds into the large intestine—thereby hastening their elimination. …”
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Development of hyaluronic acid-based edible film for alleviating dry mouth by Dong-Keon Kweon, Jung-Ah Han

“…The optimum site for film attachment in mouth was the palate, and 800F was the most effective for stimulating saliva secretion, eliciting a 38 % increase compared to control (without film), tested by the elderly over 65 years old. …”
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Mutational Analysis of KCNQ1 Gene in Type 2 Diabetes Mellitus: A Case-control Study by Ankush Ganjewar, Ishwar B Bagoji, Sharan Badiger, Rudragouda B Bulagouda, Gurushnatappa Kadakol

“…KCNQ1 is also associated with impaired insulin secretion in Type 2 Diabetes Mellitus (T2DM), suggesting that this impairment might underlie the diabetes susceptibility conferred by rs151290, which is associated with 30-min C-peptide levels during an Oral Glucose Tolerance Test (OGTT) and first-phase insulin secretion. …”
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DC-Based Immunotherapy Combined with Low-Dose Methotrexate Effective in the Treatment of Advanced CIA in Mice by Jun-Eui Park, Jinah Jang, Ji-Hye Choi, Mi-sun Kang, Yun-Ju Woo, Young-Rim Seong, Chan-Bum Choi, Hye-Soon Lee, Sang-Cheol Bae, Yong-Soo Bae

“…Combination therapy reduced the secretion of interferon-γ (IFN-γ) and IL-17 with little influence on the IL-4 secretion in the mixed leukocyte reaction. …”
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Copper Does Not Induce Tenogenic Differentiation but Promotes Migration and Increases Lysyl Oxidase Activity in Adipose-Derived Mesenchymal Stromal Cells by Marta Milewska, Anna Burdzińska, Katarzyna Zielniok, Katarzyna Siennicka, Sławomir Struzik, Piotr Zielenkiewicz, Leszek Pączek

“…Moreover, a high level of CuSO4 stimulated the action of intracellular superoxide dysmutase. The hASC secretion profile after a 5-day exposure to 50 μM cupric sulfate differed from that of untreated cells and was similar to the secretion profile of human tenocytes. …”
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Novel Indices of Glucose Homeostasis Derived from Principal Component Analysis: Application for Metabolic Assessment in Pregnancy by Tina Stopp, Michael Feichtinger, Ingo Rosicky, Gülen Yerlikaya-Schatten, Johannes Ott, Hans Christian Egarter, Christian Schatten, Wolfgang Eppel, Peter Husslein, Martina Mittlböck, Andrea Tura, Christian S. Göbl

“…This study is aimed at assessing the association of previously developed indices of glucose homeostasis derived from principal component analysis (PCA) with parameters of insulin action, secretion, and beta cell function during pregnancy. …”
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Mechanistic Framework for Establishment, Maintenance, and Alteration of Cell Polarity in Plants by Pankaj Dhonukshe

“…The emerging mechanism for AGC-3 kinases action suggests that kinases phosphorylate PINs mainly at the plasma membrane after initial symmetric PIN secretion for eventual PIN internalization and PIN sorting into distinct ARF-GEF-regulated polar recycling pathways. …”
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Escherichia coli O127 group 4 capsule proteins assemble at the outer membrane. by Matthew R Larson, Kassia Biddle, Adam Gorman, Sarah Boutom, Ilan Rosenshine, Mark A Saper

“…These gfc proteins may form a complex at the outer membrane for group 4 capsule secretion or for a yet unknown function.…”
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Analysis of Gene Expression in Human Dermal Fibroblasts Treated with Senescence-Modulating COX Inhibitors by Jeong A. Han, Jong-Il Kim

“…Aspirin up-regulated the gene set involved in protein secretion, and down-regulated gene sets involved in RNA transcription. …”
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Combined Dexamethasone Suppression-Corticotropin-Releasing Hormone Stimulation Test in Studies of Depression, Alcoholism, and Suicidal Behavior by Leo Sher

“…The hypothalamic-pituitary-adrenal (HPA) axis controls the secretion of corticotropin-releasing hormone (CRH), corticotropin (adrenocorticotropic hormone, ACTH), and cortisol. …”
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Increasing GLP-1 Circulating Levels by Bariatric Surgery or by GLP-1 Receptor Agonists Therapy: Why Are the Clinical Consequences so Different? by Chloé Amouyal, Fabrizio Andreelli

“…During the absorption of meals, the gut is thought to regulate insulin secretion by secreting a specific factor that targets pancreatic beta cells. …”
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Manifestation of Clinical Categories of Ocular Graft-versus-Host Disease by Yuan Qiu, Jing Hong, Rongmei Peng

“…Eye dryness (115 of 127, 90.6%), increased fibrous secretion (53 of 127, 41.7%), photophobia (50 of 127, 39.4%), and alacrimia (45 of 127, 35.4%) were the most common symptoms. …”
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Extreme and Cyclical Blood Pressure Elevation in a Pheochromocytoma Hypertensive Crisis by V. Larouche, N. Garfield, E. Mitmaker

“…Pheochromocytomas are rare adrenal neoplasms characterized by excess secretion of catecholamines. We describe the case of a 65-year-old man, known for hypertension, with no family history of hereditary pheochromocytoma syndromes. …”
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Acute stimulation of PBMCs drives switch from dopamine-induced anti- to proinflammatory phenotype of monocytes only in women by Leonie Fleige, Silvia Capellino

“…We found a B cell-driven downregulation in cytokine secretion of monocytes exclusively from women under physiological conditions in vitro. …”
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Regulation and Roles of Urocortins in the Vascular System by Kazunori Kageyama, Ken Teui, Naoki Tamasawa, Toshihiro Suda

“…Ucn1 and Ucn2 have strong effects on interleukin (IL)-6 gene expression and secretion in rat aortic smooth muscle A7r5 cells. The increase that we observed in IL-6 levels following Ucn treatment of A7r5 cells suggests that smooth muscle cells may be a source of IL-6 secretion under physiological stress conditions. …”
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High Glucose Aggravates the Detrimental Effects of Pancreatic Stellate Cells on Beta-Cell Function by Min Zha, Wei Xu, Qing Zhai, Fengfei Li, Bijun Chen, Zilin Sun

“…In vitro, PSCs-CM caused impaired INS-1 cell viability and insulin secretion and increased apoptosis, which were more pronounced in the presence of high glucose. …”
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Nocturnal Light Pollution Synergistically Impairs Glucose Metabolism With Age and Weight in Monkeys by Shuxing Wang, Xuange Cheng, Zihao Liang, Zhenyi Chen, Jiankai Zhang, Qiang Xu

“…Data pertaining to the mortality rate of preexisting diabetes, incidence of light-induced diabetes and IGT, and alterations in insulin secretion were collected and analyzed. The results show that nocturnal light (1) caused premature deaths in individuals with preexisting diabetes; (2) intensity-dependently induced diabetes and IGT in previous healthy monkeys; (3) intensity-dependently reduced melatonin secretion; (4) had a synergistic impairing effect on glucose metabolism with aging and weight; and (5) although monkeys would eventually adapt to the environment, the disrupted glucose metabolism would not fully recover in most individuals. …”
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New Insights in Genetic Cholestasis: From Molecular Mechanisms to Clinical Implications by Eva Sticova, Milan Jirsa, Joanna Pawłowska

“…Cholestasis is characterised by impaired bile secretion and accumulation of bile salts in the organism. …”
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