Rapamycin Alleviates 2,4,6-Trinitrobenzene Sulfonic Acid-Induced Colitis through Autophagy Induction and NF-κB Pathway Inhibition in Mice by Zhen Ni, Hao Li, Dong Mu, Juanni Hou, Xiaoyan Liu, Shanhong Tang, Shumei Zheng

“…Rapamycin protects against colitis through induction of autophagy, thus inhibiting the activation of NF-κB pathway and secretion of TNF-α.…”
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Exercise Induced Adipokine Changes and the Metabolic Syndrome by Saeid Golbidi, Ismail Laher

“…Adipokines, or adipose tissue-derived proteins, play a pivotal role in this scenario. Increased secretion of proinflammatory adipokines leads to a chronic inflammatory state that is accompanied by insulin resistance and glucose intolerance. …”
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Adropin as an indicator of T2DM and its complications by Hu Zhang, Ning Chen

“…It should be noted that the secretion of adropin can be induced by diets, aerobic exercise and other interventions. …”
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Beta-Human Chorionic Gonadotropin Producing Osteosarcoma of the Sacrum in a 26-Year-Old Woman: A Case Report and Review of the Literature by Ryan Glass, Jaya Ruth Asirvatham, Leonard Kahn, Mohamed Aziz

“…Ectopic secretion of beta-human chorionic gonadotropin is considered a poor prognostic marker in epithelial tumors. …”
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Endocrine Actions of Osteocalcin by Aurora Patti, Luigi Gennari, Daniela Merlotti, Francesco Dotta, Ranuccio Nuti

“…Once transcribed, this protein undergoes posttranslational modifications within osteoblastic cells before its secretion, including the carboxylation of three glutamic residues in glutamic acid, which is essential for hydroxyapatite binding and deposition in the extracellular matrix of bone. …”
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The Oxidative State of Chylomicron Remnants Influences Their Modulation of Human Monocyte Activation by Sandra Armengol Lopez, Kathleen M. Botham, Charlotte Lawson

“…Lipid accumulation and ROS production were significantly increased in primary human monocytes incubated with CRLPs, whilst secretion on monocyte chemoattractant protein-1 was reduced, but oxCRLPs had no additional effect. …”
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Cytokine Profile of Mouse Vaginal and Uterus Lymphocytes at Estrus and Diestrus by Maria C. Lopez, Margaret A. Stanley

“…Data also suggest that NK cells are at least partially responsible for IFN-γ secretion. Our data indicate that vaginal and uterus lymphoid cells isolated at diestrus were in vivo activated to secrete cytokines after ex vivo culture. …”
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Surface topography modulates initial platelet adhesion to titanium substrata by Cecilia Yan Guo, Raymond Mo, Hugh Kim

“…There was greater platelet adhesion to the rougher AE and SB surfaces, however, the concentration of the secreted growth factors was comparable on all surfaces. …”
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Identification and Functional Characterization of P159L Mutation in in a Family with Maturity-Onset Diabetes of the Young 5 (MODY5) by Eun Ky Kim, Ji Seon Lee, Hae Il Cheong, Sung Soo Chung, Soo Heon Kwak, Kyong Soo Park

“…Mutation in HNF1B, the hepatocyte nuclear factor-1β (HNF-1β) gene, results in maturity-onset diabetes of the young (MODY) 5, which is characterized by gradual impairment of insulin secretion. However, the functional role of HNF-1β in insulin secretion and glucose metabolism is not fully understood. …”
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The MicroRNA-106a/20b Strongly Enhances the Antitumour Immune Responses of Dendritic Cells Pulsed with Glioma Stem Cells by Targeting STAT3 by Hui Zhou, Chengmei Sun, Cong Li, Shiting Hua, Feng Li, Ruichun Li, Dongpeng Cai, Yuxi Zou, Yingqian Cai, Xiaodan Jiang

“…Moreover, the reduction in STAT3 levels in GSC-DCs enhanced the generation of CD8+ T cells and reduced the generation of Foxp3+ regulatory T cells. Meanwhile, the secretion of the T cell cytokine IFN-γ was significantly increased. …”
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Long-Term Postpartum Outcomes of Insulin Resistance and β-cell Function in Women with Previous Gestational Diabetes Mellitus by Zhirong Miao, Honghua Wu, Liu Ren, Nan Bu, Lili Jiang, Huixia Yang, Junqing Zhang, Xiaohui Guo

“…HOMA-IR and HOMA-β were used to assess insulin resistance and insulin secretion levels with different glucose statuses. Results. …”
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Ginger polysaccharide UGP1 suppressed human colon cancer growth via p53, Bax/Bcl-2, caspase-3 pathways and immunomodulation by Yanfang Qian, Chenying Shi, Chen Cheng, Dengwei Liao, Junping Liu, Gui-tang Chen

“…Moreover, UGP1 significantly stimulated RAW264.7 cell proliferation and secretion activity. Similarly, UGP1 inhibited tumor proliferation on tumor-bearing mice, increased the expression of p53 and the ratio of Bax/Bcl-2, enhanced the secretion of pro-inflammatory cytokines TNF-α, IL-2, IL-6 and decreased the secretion of pro-tumor cytokines TGF-β and bFGF in serum. …”
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CCR2 signaling regulates anti-chlamydia T cell immune responses in the airway. by Shuaini Yang, Jinxi Yu, Xue Dong, Jiajia Zeng, Lu Tan, Hong Zhang, Ruoyuan Sun, Yuqing Tuo, Jing Yang, Chunxiao Wan, Hong Bai

“…Moreover, ccr2 deficiency greatly diminishes STAT1 phosphorylation, a key regulator of IFN-γ secretion by Th1 cells. Meanwhile, we also observed a significant reduction in IFN-γ secretion by CD8+ T cells following ccr2 deficiency. …”
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In Vitro Free Radical Scavenging Properties and Anti-Inflammatory Activity of Ilex paraguariensis (Maté) and the Ability of Its Major Chemical Markers to Inhibit the Production of... by Ingrid Vicente Farias, Eduarda Fratoni, Lais Cristina Theindl, Angela Machado de Campos, Eduardo Monguilhott Dalmarco, Flavio Henrique Reginatto

“…The IA extract also showed the lowest inhibition of NOx secretion (50.10±8.97%) as well as inhibition of TNF-α (83.33±4.01%). …”
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LR12 Promotes Liver Repair by Improving the Resolution of Inflammation and Liver Regeneration in Mice with Thioacetamide- (TAA-) Induced Acute Liver Failure by Yongjuan Wang, Xiaoli Xie, Hongqun Liu, Huimin Liu, Huiqing Jiang

“…Cytokine protein microarray analysis suggested that LR12 promoted the secretion of C-C chemokine ligand 20 (CCL20) from macrophages. …”
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The MIR181A2HG/miR‐5680/VCAN‐CD44 Axis Regulates Gastric Cancer Lymph Node Metastasis by Promoting M2 Macrophage Polarization by Weijie Zang, Yongpu Yang, Junjie Chen, Qinsheng Mao, Wanjiang Xue, Yilin Hu

“…On one hand, VCAN interacts with CD44 receptors on the surface of TAMs through paracrine secretion, promoting M2 macrophage polarization and subsequently enhancing the secretion of VEGF‐C, ultimately facilitating lymphangiogenesis. …”
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Pancreatic Function, Type 2 Diabetes, and Metabolism in Aging by Zhenwei Gong, Radhika H. Muzumdar

“…In this review, we summarize the current evidence on how aging affects pancreatic β cell function, β cell mass, insulin secretion and insulin sensitivity. …”
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Toll-like receptor 1/2 activation reduces immunoglobulin free light chain production by multiple myeloma cells in the context of bone marrow stromal cells and fibronectin. by Jahan Abdi, Frank Redegeld

“…These effects have been suggested to be partly due to increase in secretion of cytokines such as IL-6 or IFNα among others from MM cells following TLR activation. …”
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Effect of Modified Roux-en-Y Gastric Bypass Surgery on GLP-1, GIP in Patients with Type 2 Diabetes Mellitus by Shao-Wei Xiong, Jing Cao, Xian-Ming Liu, Xing-Ming Deng, Zeng Liu, Fang-Ting Zhang

“…The results suggested that modified Roux-en-Y gastric bypass can promote GLP-1 secretion in patients with T2DM, while reducing the secretion of GIP. …”
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The Roles of Thyroid and Thyroid Hormone in Pancreas: Physiology and Pathology by Chaoran Chen, Zhenxing Xie, Yingbin Shen, Shu Fang Xia

“…It is widely accepted that thyroid hormones (THs), secreted from the thyroid, play important roles in energy metabolism. …”
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