Reduced NLRP3 Gene Expression Limits the IL-1β Cleavage via Inflammasome in Monocytes from Severely Injured Trauma Patients by Shinwan Kany, Johann-Philipp Horstmann, Ramona Sturm, Katharina Mörs, Borna Relja

“…Reduced IL-1β secretion was paralleled by significantly lowered gene expression of NLRP3 in monocytes from TP compared to those of HV. …”
Get full text

The Efficacy of Clinical Tests to Diagnose Evaporative Dry Eye Disease Related to Meibomian Gland Dysfunction by Jerry R. Paugh, Tiffany Nguyen, Alan Sasai, Elaine Chen, Melinda Thomas De Jesus, Justin Kwan, Andrew Loc Nguyen, Marjan Farid, Sumit Garg, James V. Jester

“…EDED-specific tests of eyelid marginal signs, gland secretion quality, and gland loss did not demonstrate acceptable test efficacy or differences between normal and EDED subjects. …”
Get full text

Bioceramic Surface Topography Regulating Immune Osteogenesis by Jianxin Hao, Lin Du, Yuening He, Chengtie Wu

“…Results: The large spacing micro-groove structure can promote the M2 polarization and osteoinductive cytokine secretion of macrophage. The reason is that the large spacing micro-groove structure can induce directional arrangement of macrophage so as to change the phenotype and cytokine secretion. …”
Get full text

Comprehensive characterization of platelet function in dogs with hyperadrenocorticism by Sanggu Kim, Dohee Lee, Preeti Kumari Chaudhary, Hakhyun Kim, Byeong-Teck Kang, Soochong Kim

“…Various platelet functional responses including platelet aggregation and dense-granule secretion were evaluated. 2-MeSADP- and low concentration of thrombin-induced platelet aggregation and secretion were significantly inhibited in dogs with HAC compared to normal dogs. …”
Get full text

Differential Effects of Chronic Pulsatile versus Chronic Constant Maternal Hyperglycemia on Fetal Pancreatic β-Cells by Mackenzie S. Frost, Aqib H. Zehri, Sean W. Limesand, William W. Hay, Paul J. Rozance

“…Constant maternal hyperglycemia limits, while pulsatile maternal hyperglycemia may enhance, fetal glucose-stimulated insulin secretion (GSIS) in sheep. However, the impact of such different patterns of hyperglycemia on the development of the fetal β-cell is unknown. …”
Get full text

Melatonin Induces per1a Expression in Zebrafish Brain by Cher Ryn Lim, Zhen Xuen Brandon Low, Tomoko Sogo, Yatinesh Kumari

“…The major key output of the circadian clock is the secretion of melatonin in the pineal gland. Melatonin secretion remains low during the daytime and increases significantly at night. …”
Get full text

Hepatic macrophages in liver fibrosis: pathogenesis and potential therapeutic targets by Hai Li, Hong You, Jidong Jia, Xu Fan

“…Many studies demonstrated that while hepatic macrophages promoted fibrosis through the recruitment of proinflammatory immune cells, and the secretion of proinflammatory cytokines and chemokines in the early stages, these also promoted the resolution of hepatic fibrosis through the secretion of matrix metalloproteinases in the late stages. …”
Get full text

Structure and Physiological Actions of Ghrelin by Christine Delporte

“…Ghrelin exerts wide physiological actions throughout the body, including growth hormone secretion, appetite and food intake, gastric secretion and gastrointestinal motility, glucose homeostasis, cardiovascular functions, anti-inflammatory functions, reproductive functions, and bone formation. …”
Get full text

Development and characterization of a chicory extract fermented by Akkermansia muciniphila: An in vitro study on its potential to modulate obesity-related inflammation by A. Chervet, R. Nehme, C. Defois-Fraysse, C. Decombat, C. Blavignac, C. Auxenfans, B. Evrard, S. Michel, E. Filaire, J.-Y. Berthon, A. Dreux-Zigha, L. Delort, F. Caldefie-Chézet

“…The anti-inflammatory and anti-obesity activities of C-Akm extract were studied by testing the extract (50 μg/mL) on the polarization of THP-1 into macrophages, the secretion of pro-inflammatory cytokines in LPS-stimulated PBMCs, and the secretion of leptin and adiponectin in adipospheroids derived from human adipose stem cells. …”
Get full text

Enhancement of CD8+T cell cytotoxicity activity by IFN-α implies alternative pathologic role in systemic lupus erythematosus by Chen-xing Zhang, You-ying Mao, Yu-pin Tan, Mei-yu Zhang, Kang Shao, Shu-jun Wang, Ping Ji, Jia-yuan Wang, Lei Yin, Ying Wang

“…Meanwhile, increased secretion of granzyme B was also detected in CD8+T cells of SLE compared with HC, which correlated with the disease activity (SLEDAI). …”
Get full text

Esophageal Inlet Patch by C. Behrens, Peggy P. W. Yen

“…Most inlet patches are largely asymptomatic, but in problematic cases complications related to acid secretion such as esophagitis, ulcer, web and stricture may occur. …”
Get full text

A Possible Change Process of Inflammatory Cytokines in the Prolonged Chronic Stress and Its Ultimate Implications for Health by Rui Tian, Gonglin Hou, Dan Li, Ti-Fei Yuan

“…At the early stage of stress, the activated hypothalamus-pituitary-adrenal (HPA) axis and sympathetic nervous system (SNS) axis can upregulate the levels of glucocorticoid (GCs) and catecholamines (CAs), respectively, and then they in turn inhibit the secretion of proinflammatory cytokines directly or indirectly while promoting the secretion of anti-inflammatory cytokines. …”
Get full text

Leptin Promotes Glioblastoma by Johnathan E. Lawrence, Nicholas J. Cook, Richard A. Rovin, Robert J. Winn

“…In animal models of colon cancer and melanoma, a decline in the expression and secretion of leptin resulted in a reduction of tumor growth. …”
Get full text

Supernumerary breast. A case Presentation by Juan Miguel Guerra Cabrera, María Elena Antelo Gordillo

“…On physical examination, a supernumerary nipple with milky secretion out from it was found in her right axilla and secretion throughout the contralateral axilla through the skin pores, with absence of nipple and areola in that axillary region. …”
Get full text

Protein-Mediated Interactions of Pancreatic Islet Cells by Paolo Meda

“…The islets of Langerhans collectively form the endocrine pancreas, the organ that is soley responsible for insulin secretion in mammals, and which plays a prominent role in the control of circulating glucose and metabolism. …”
Get full text

Cytokine/Chemokine/Growth Factor Profiles Contribute to Understanding the Pathogenesis of the Salivary Gland Dysfunction in Euthyroid Hashimoto’s Thyroiditis Patients by K. Morawska, M. Maciejczyk, S. Zięba, Ł. Popławski, A. Kita-Popławska, J. Krętowski, A. Zalewska

“…It is suggested that, in addition to thyroid gland dysfunction, HT is responsible for impaired secretion from the salivary glands. The aim of this study was to evaluate the extent of symptoms of salivary gland dysfunction. …”
Get full text

Evaluating the usefulness of plasma chromogranin A measurement in cyclic ACTH-dependent Cushing’s syndrome by Keisuke Kakizawa, Miho Yamashita, Yuto Kawauchi, Akira Ikeya, Kenji Ohba, Akio Matsushita

“…Despite the short peak secretion period of ACTH (approximately one week), immunostaining of the surgically removed tumor confirmed ACTH positivity. …”
Get full text

Detection of Insulin in Insulin-Deficient Islets of Patients with Type 1 Diabetes by Yuliya Krivova, Alexandra Proshchina, Dmitry Otlyga, Anastasia Kharlamova, Sergey Saveliev

“…However, endogenous insulin secretion persists in such patients as evidenced by the measurement of plasma C-peptide. …”
Get full text

Optimization of a Rabbit Dry Eye Model Induced by Topical Instillation of Benzalkonium Chloride by Carlos Carpena-Torres, Jesús Pintor, María Jesús Pérez de Lara, Fernando Huete-Toral, Almudena Crooke, Cristina Pastrana, Gonzalo Carracedo

“…Conversely, there was a decrease in tear secretion with anesthesia P<0.001, tear breakup time P=0.007, tear osmolarity P<0.001, density of goblet cells P<0.001, and height of mucin cloud P<0.001. …”
Get full text

IL-33 signaling is dispensable for the IL-10-induced enhancement of mast cell responses during food allergy by Dylan Krajewski, Saurav Ranjitkar, Nathan Jordan, Sallie S. Schneider, Clinton B. Mathias

“…ST2-/- BMMCs exhibited reduced cytokine secretion in response to IgE-dependent activation. …”
Get full text