A Novel Variant Of Regenerating Iα Gene (REG) In Type II Diabetics Among Pakistani Targeted Population by Sadaf Saleem, Saeeda Baig, Sadia Farrukh, Mazhar Shafiq

“…The regenerating (REG) Iα gene is secreted from damaged β-cell for the synthesis of β-cell. …”
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Cytokine Detection and Modulation in Acute Graft vs. Host Disease in Mice by A. C. Knulst, G. J. M. Tibbe, C. Bril-Bazuin, E. G. Breedland, A. van Oudenaren, R. Benner, H. F. J. Savelkoul

“…The results of this study suggest successive waves of cytokine-secreting cell populations consistent with the induction of an inflammatory response in the development of acute GVH disease.…”
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Virulence is not directly related to strain success in planta in Clavibacter nebraskensis by Molly Veregge, Cory D. Hirsch, Matthew J. Moscou, Liana Burghardt, Peter Tiffin, Devanshi Khokhani

“…A genomic analysis revealed candidate genes, including putative virulence factors (i.e., a secreted cellulase), responsible for among-strain variation in reproductive success.IMPORTANCENon-pathogenic strains of many bacterial pathogens are reported to coexist with pathogenic strains in symptomatic plants. …”
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Selected issues on theory and methodology of the underground press by Wanda Krystyna Roman

“…In the whole world's press history, Polish secret and underground press, before and during the January Uprising of 1863, was a phenomenon never seen on such a scale before. …”
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Cytokine and Chemokine Responses of Peripheral Blood Mononuclear Cells from Dogs Infected with <i>Mycobacterium bovis</i> by Tyler Morrison, Danielle A. Gunn-Moore, Jayne C. Hope, Conor O’Halloran

“…Similarly, cells stimulated with PPDB secreted increased amounts of TNF-α when dogs were seronegative, but cells taken from seropositive dogs did not. …”
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Time Management According to the Perspective of the Late Tuan Guru Haji Nik Abdul Aziz: A Study of the Interpretation of Surah al-'Asr by Abdul Azib Hussain, Khairulnazrin Nasir, Rahim Kamarul Zaman, Hamidi Abdul Ghani

“…His perspective on time management in the surah was an interesting secret to explore. Therefore, this study aims to discuss time management according to the perspective of the late Tuan Guru Haji Nik Abdul Aziz in regard to his interpretation of Surah al-'Asr. …”
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M2 Macrophages as a Potential Target for Antiatherosclerosis Treatment by Ying Bi, Jixiang Chen, Feng Hu, Jing Liu, Man Li, Lei Zhao

“…The M2 phenotype can secrete anti-inflammatory factors such as IL-10 and TGF-β, promote tissue remodeling and repairing through collagen formation, and clear dying cells and debris by efferocytosis. …”
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Chitosan Nanoparticles for Enhanced Immune Response and Delivery of Multi-Epitope <i>Helicobacter pylori</i> Vaccines in a BALB/c Mouse Model by Rita Amaral, Tomás Concha, Jorge Vítor, António J. Almeida, Cecília Calado, Lídia M. Gonçalves

“…The induced immune response was assessed through the levels of antigen-specific IgGs, secreted mucosal SIgA, and cytokines (IL-2, IL-10, and IFN-γ) in immunized BALB/C mice. …”
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Targeting unique ligand binding domain structural features downregulates DKK1 in Y537S ESR1 mutant breast cancer cells by K. S. Young, G. R. Hancock, E. C. Fink, A. Zigrossi, B. Flowers, D. A. Cooper, V. T. Nguyen, M. C. Martinez, K. S. Mon, M. Bosland, D. R. Zak, A. P. Runde, M. N. Sharifi, I. Kastrati, D. D. L. Minh, S. Kregel, Sean W. Fanning

“…RNA sequencing in cells treated with T6I-29 reveals a neomorphic downregulation of DKK1, a secreted glycoprotein known to play oncogenic roles in other cancers. …”
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Analysis of a mouse germ cell tumor model establishes pluripotency-associated miRNAs as conserved serum biomarkers for germ cell cancer detection by Amanda R. Loehr, Dennis M. Timmerman, Michelle Liu, Ad J. M. Gillis, Melia Matthews, Jordana C. Bloom, Peter K. Nicholls, David C. Page, Andrew D. Miller, Leendert H. J. Looijenga, Robert S. Weiss

“…Here, we report that miRNAs in the mouse miR-290-295 cluster, homologs of the human miR-371-373 cluster, were detectable in serum from mice with malignant TGCTs but not from tumor-free control mice or mice with benign teratomas. miR-291-293 were expressed and secreted specifically by pluripotent EC cells, and expression was lost following differentiation induced by the drug thioridazine. …”
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Elevated Serum Extracellular Vesicle‐Packaged SPARC in Hypertension: A Cross‐Sectional Study in a Middle‐Aged and Elderly Population by Xueying Chen, Han Guo, Xinwei Li, Yang Liu, Xinxin Li, Zhengshuo Cui, Huijuan Ma, Jianxun He, Zhechun Zeng, Huina Zhang

“…However, studies on the relevance of EV cargos to hypertension are limited. Secreted protein acidic and rich in cysteine (SPARC) is involved in many metabolic diseases and endothelial dysfunction pathological processes. …”
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S100A8/A9 Molecular Complexes Promote Cancer Migration and Invasion via the p38 MAPK Pathway in Nasopharyngeal Carcinoma by Ning Xu, Bei-Bei Zhang, Xia-Ning Huang, Xiang Yi, Xue-Min Yan, Yan Cai, Qin He, Zi-Jian Han, Yuan-Jiao Huang, Wei Liu, Ai-Jun Jiao

“…Taken together, our present findings suggest that the secreted soluble inflammatory factors S100A8/A9 might promote cancer migration and invasion via the p38 MAPK signaling pathway along with invasion/migration associated proteins overexpression in the tumor microenvironment of NPC. …”
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Otodectes cynotis (Acari: Psoroptidae) infestations in Southern pudus (Pudu puda): In situ and ex situ data of an unexpected host-parasite record by Caroline Wilhelm, Edwin Kniha, Pamela Muñoz, Ángelo Espinoza, Laura Platner, Saskia Dreyer, Lisa Grund, Zoë Tess Lara Lindhorst, Ulrich Gärtner, Julia Walochnik, Anja Taubert, Dominik Fischer, Stephan Hering-Hagenbeck, Carlos Hermosilla, David Ebmer

“…During clinical work, two free-ranging pudus temporarily rehabilitated at the Centro de Rehabilitación de Fauna Silvestre (CEREFAS), Valdivia, Chile, were observed with low to moderate yellowish-brown secretions and encrustations inside the pinna and external auditory canal accompanied by an inflammatory Otitis externa. …”
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Unveiling the novel role of circadian rhythms in sepsis and septic shock: unexplored implications for chronotherapy by Stewart D. Ramsay, Stewart D. Ramsay, Stewart D. Ramsay, Marni A. Nenke, Marni A. Nenke, Emily J. Meyer, Emily J. Meyer, David J. Torpy, David J. Torpy, Richard L. Young, Richard L. Young, Richard L. Young, Richard L. Young

“…Examples of circadian disruptions during sepsis and septic shock include alteration or loss of hormonal rhythms controlling blood pressure and inflammation, white blood cell counts, and cytokine secretions. These changes to circadian rhythms hinder sepsis and septic shock recovery and also increase mortality. …”
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Screening and identification of host signaling pathways for alleviating influenza-induced production of pro-inflammatory cytokines, IP-10, IL-8, and MCP-1, using a U937 cell-based... by Si Chen, Si Chen, Yang Yu, Yue Su, Xiaoqin Lian, Lefang Jiang, Zhuogang Li, Mingxin Zhang, Yarou Gao, Haonan Zhang, Xingjian Zhu, Jiaxin Ke, Xulin Chen

“…To identify the key host signaling pathways responsible for producing pro-inflammatory cytokines, we utilized a U937 cell model that secretes IP-10, IL-8, and MCP-1 in response to influenza infection. …”
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Insight into the role of antioxidant in microbial lignin degradation: Ascorbic acid as a fortifier of lignin-degrading enzymes by Aipeng Li, Weimin Wang, Shuqi Guo, Changzhi Li, Xinying Wang, Qiang Fei

“…Ascorbic acid (AA) is well-known for its antioxidant properties, while Trametes versicolor is a commonly used lignin-degrading fungus capable of secreting laccase (Lac) and manganese peroxidase (MnP). …”
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Toll-Like Receptor-1 and Receptor-2 and Beta-Defensin in Postcholecystectomy Bile Duct Injury by Alejandra Guillermina Miranda-Díaz, José Manuel Hermosillo-Sandoval, Martha Arisbeth Villanueva-Pérez, Luis Miguel Román-Pintos, Trinidad García-Iglesias, Adolfo Daniel Rodríguez-Carrizalez, Ernesto Germán Cardona-Muñoz

“…The biliary cells participate in secreting cytokines and in expression of immune response receptors. …”
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Effective gene therapy for metachromatic leukodystrophy achieved with minimal lentiviral genomic integrations by Lucas Tricoli, Sunetra Sase, Julia L. Hacker, Vi Pham, Maxwell Chappell, Laura Breda, Stephanie N. Hurwitz, Naoto Tanaka, Carlo Castruccio Castracani, Amaliris Guerra, Zhongqi Hou, Lars Schlotawa, Karthikeyan Radhakrishnan, Matthew Hogenauer, Aoife Roche, John Everett, Frederic Bushman, Peter Kurre, Rebecca Ahrens-Nicklas, Laura A. Adang, Adeline L. Vanderver, Stefano Rivella

“…Our top-performing vector (EA1) showed at least 4× more ARSA activity than the currently US and European Union (EU)-approved vector and a superior ability to secrete vesicle-associated ARSA, a critical modality to transfer functional enzymes from microglia to oligodendrocytes. …”
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The Construction of Heterothallic Strains of <i>Komagataella kurtzmanii</i> Using the I-SceI Meganuclease by Daria D. Sokolova, Philipp I. Akentyev, Kristina O. Petrova, Lyudmila V. Lyutova, Aleksei A. Korzhenkov, Irek I. Gubaidullin, Stepan V. Toshchakov, Dmitry G. Kozlov

“…However, the ability of the Y-727-2(alpha)-derived producers to efficiently secrete recombinant β-galactosidase was unaffected by this genomic rearrangement.…”
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The Role of Butirprost^® as an Adjuvant in Enhancing the Effect of Antibiotics in Patients Affected by Chronic Bacterial Prostatitis: A Randomized Prospective Trial by Felice Crocetto, Armando Calogero, Michele Santangelo, Agostino Fernicola, Filippo Varlese, Benito Fabio Mirto, Fabio Machiella, Alfonso Falcone, Giovanni Pagano, Fabrizio Dinacci, Gaetano Giampaglia, Domenico Varriale, Francesco Trama, Salvatore Iaconis, Francesco Del Giudice, Gian Maria Busetto, Matteo Ferro, Francesco Lasorsa, Giuseppe Lucarelli, Ciro Imbimbo, Biagio Barone

“…Bacterial prostatitis (BP) is a common prostatic infection characterized by pain and urinary symptoms, often with negative bacterial cultures from prostatic secretions. It affects young and older men bimodally and impacts quality of life (QoL) significantly. …”
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