Neuroprotective role of epigallocatechin-3-gallate, albeginin and melanoxetin in alzheimer's disease by Arif Malik, Mehreen Hassan, Sulayman Waquar, Muhammad Wasim, Anam Naz, Faryal M. Awan, Muhammad T. Khan, Ali I. Khawaja, Sumera Zaib, Jamshed Iqbal, Ayesha Zahid, Marvi Marvi, Javeid Iqbal, Heng Wang, Dong-Qing Wei

“…Study design: The study targeted specific AD-related proteins, including acetylcholinesterase (AChE), alpha serine/threonine-protein kinase (AKT-1), β-secretase-1 (BACE-1), cyclooxygenase-2 (COX-2), caspase-3, glycogen synthase kinase-3 (GSK-3), interleukin-6 (IL-6), mitogen-activated protein kinase-2 (MAPK-2), matrix metalloproteins-8 (MMP-8), N-methyl-d-aspartate receptor (NMDAR), Peptidyl arginine deiminase-2 (PAD-2), Presenilin-1 (PSEN-1), mitogen-activated protein kinase-14 (MAPK-14/P38), and tumor necrosis factor-alpha (TNF-α). …”
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Imaging lipid rafts reveals the principle of ApoE4-induced Aβ upregulation in human neurons by Se-In Lee, Heejin Lim, Na Yeon Kim, Jichang Yu, Joonho Cho, Hyein Lee, Dae Won Moon, Jinsoo Seo

“…Amyloid-β (Aβ), a hallmark of Alzheimer’s disease (AD), is generated from the sequential cleavage of amyloid precursor proteins (APPs) by β- and γ-secretases, primarily within endosomes after APP endocytosis by canonical clathrin-mediated endocytosis in neurons. …”
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