Studies on Prion Replication in Spleen by Alex J. Raeber, Fabio Montrasio, Ivan Hegyi, Rico Frigg, Michael A. Klein, Adriano Aguzzi, Charles Weissmann

Subjects: Get full text

Prion meeting 2023: implications of a growing field by Tiago F. Outeiro, Tuane C. R. G. Vieira

“…Neuropathological examination of the brains from CJD and Kuru patients, and of brains of sheep with scrapie disease revealed significant similarities and suggested a possible common mode of infection that, at the time, was thought to derive from an unknown virus that caused slow infections. …”
Get full text

Sympathetic Prions by Markus Glatzel

“…Bovine spongiform encephalopathy, scrapie of sheep, and Creutzfeldt-Jakob disease are among the most notable transmissible spongiform encephalopathies. …”
Get full text

Distinct patterns of prion strain deposition and toxicity in a novel whole brain organotypic slice culture system by Hailey Pineau, Valerie L. Sim

“…We have adapted this approach to a coronally sliced whole brain organotypic culture and demonstrate distinct profiles of cytotoxicity and neuronal loss upon exposure to four mouse-adapted scrapie strains. We were able to induce infection both diffusely through submersion of slice cultures in infectious media and locally through contact with prion-coated stainless-steel wires. …”
Get full text

From Prion Diseases to Prion-Like Propagation Mechanisms of Neurodegenerative Diseases by Isabelle Acquatella-Tran Van Ba, Thibaut Imberdis, Véronique Perrier

“…In animals, the most frequent prion diseases are scrapie in sheep and goat, bovine spongiform encephalopathy in cattle, and the emerging chronic wasting disease in wild and captive deer in North America. …”
Get full text

Prion Diseases and the Gastrointestinal Tract by Gwynivere A Davies, Adam R Bryant, John D Reynolds, Frank R Jirik, Keith A Sharkey

“…These are human and animal diseases that include bovine spongiform encephalopathy, scrapie and Creutzfeldt-Jakob disease. They are uniformly fatal neurological diseases, which are characterized by ataxia and vacuolation in the central nervous system. …”
Get full text

INTERRELATION OF PRIONS WITH NON-CODING RNAS by R. N. Mustafin, E. K. Khusnutdinova

“…For the protein PrPC (PrP – prion protein, С – common), a prion conformation, called PrPSc (S – scrapie), is pathological. For example, in mammals the PrPSc prion causes transmissible spongiform encephalopathies accumulating in the brain tissues of PrPSc aggregates that have amyloid properties. …”
Get full text