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Constructing stellar solutions with spherical symmetry through quadratic anisotropy in f(Q) gravity
Published 2025-01-01Get full text
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63083
UPLC-MS/MS Method for Givinostat in Rat Plasma: Development, Validation, in vivo Pharmacokinetics Study and in vitro Metabolic Stability Research
Published 2025-01-01“…Ruanjuan Zhan,1,* Yanan Liu,1,2,* Jun Wu,1,2 Yuxin Shen,1,2 Xinhao Xu,1,2 Guanyang Lin,1,2 Xiaocheng Chen1 1The First Affiliated Hospital of Wenzhou Medical University, Zhejiang, People’s Republic of China; 2School of Pharmaceutical Sciences, Wenzhou Medical University, Zhejiang, People’s Republic of China*These authors contributed equally to this workCorrespondence: Guanyang Lin; Xiaocheng Chen, Email 13867702133@163.com; cxcwzcn@139.comBackground: Givinostat, a potent histone deacetylase (HDAC) inhibitor, is promising for the treatment of relapsed leukemia and myeloma.Purpose: This study aimed to develop and verify a quick assay for the measurement of givinostat concentration using ultra-performance liquid chromatography tandem mass spectrometry (UPLC-MS/MS) with eliglustat as the internal standard (IS), establishing a basic pharmacokinetic profile for its pre-clinical application and metabolic stability in vitro.Methods: Sample preparation was performed via protein precipitation using acetonitrile. …”
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The Analysis of Biomechanical Properties of Proximal Femur after Implant Removal
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Prevalence of disability in Iranian older adults in Tehran, Iran: A population-based study
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Trajectories of Change, Illness Understanding, and Parental Worries in Children and Adolescents Undergoing Internet-Delivered Cognitive-Behavioral Therapy for Functional Abdominal...
Published 2025-01-01“…FAPDs are associated with diminished quality of life, school absence, increased health care use, and comorbid anxiety and depression. …”
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Targeted generative data augmentation for automatic metastases detection from free-text radiology reports
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ChatGPT-4 Performance on German Continuing Medical Education—Friend or Foe (Trick or Treat)? Protocol for a Randomized Controlled Trial
Published 2025-02-01“…MethodsWe designed a randomized controlled trial, in which adult high school students attempt to solve CME tests across six medical specialties in three study arms in total with 18 CME training courses per study arm under different interventional conditions with varying amounts of permitted use of ChatGPT-4. …”
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Economic value of HPC experience for new STEM professionals: Insights from STEM hiring managers
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Improvement of Citrus Yield Prediction Using UAV Multispectral Images and the CPSO Algorithm
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The dual impact: physiological and psychological effects of rapid weight loss in wrestling
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