Family-focused intervention programme to foster adolescent mental health and well-being: protocol for a multicountry cluster randomised factorial trial (FLOURISH Phase 2) by Heather M Foran, Marija Raleva, Nina Heinrichs, Graham Moore, Yulia Shenderovich, Xiang Zhao, Judith Simon, Antonio Piolanti, Viorel Babii, Janina Mueller, Franziska Waller, Dennis Wienand, Swetha Sampathkumar, Ivo Kunovski

“…Introduction Adolescent mental health problems represent a significant global health issue, particularly in low- and middle-income countries, such as the Republic of North Macedonia and the Republic of Moldova. Effective and scalable interventions are urgently needed to address these challenges.Methods and analysis This protocol outlines a multicountry cluster randomised factorial trial, implemented according to the multiphase optimisation strategy (Phase 2), which evaluates the effectiveness and costs of three add-on components for the Parenting for Lifelong Health for Parents and Teens programme: adolescent mental health tools based on UNICEFs Helping Adolescents Thrive comics, adolescent peer support based on UNICEFs ‘I Support My Friends’ intervention and engagement booster designed to enhance attendance and programme completion through incentives. …”
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Resident action in smart waste management during landfill disclosure transition: Insights from Yogyakarta's smart city initiatives by Sapta Suhardono, Chun-Hung Lee, Thi Thanh Thuy Phan, I Wayan Koko Suryawan

“…The novelty of this research lies in its holistic integration of technological solutions and social dynamics, offering a scalable and adaptable model for smart waste management. …”
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Evaluation of two electronic-rehabilitation programmes for persistent knee pain: protocol for a randomised feasibility trial by Philip G Conaghan, Kim L Bennell, Mark Conner, Rana S Hinman, Sarah R Kingsbury, Elizabeth M A Hensor, Gretl A McHugh, Christine Comer, Dawn Groves-Williams, Rachel K Nelligan

“…Education and exercise treatment are advocated in all clinical guidelines; however, the increasing prevalence of persistent knee pain presents challenges for health services regarding appropriate and scalable delivery of these treatments. Digital technologies may help address this, and this trial will evaluate the feasibility and acceptability of two electronic-rehabilitation interventions: ‘My Knee UK’ and ‘Group E-Rehab’.Methods and analysis This protocol describes a non-blinded, randomised feasibility trial with three parallel groups. …”
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First demonstration of a TES based cryogenic Li $$_2$$ 2 MoO $$_4$$ 4 detector for neutrinoless double beta decay search by G. Bratrud, C. L. Chang, R. Chen, E. Cudmore, E. Figueroa-Feliciano, Z. Hong, K. T. Kennard, S. Lewis, M. Lisovenko, L. O. Mateo, V. Novati, V. Novosad, E. Oliveri, R. Ren, J. A. Scarpaci, B. Schmidt, G. Wang, L. Winslow, V. G. Yefremenko, J. Zhang, D. Baxter, M. Hollister, C. James, P. Lukens, D. J. Temples

“…Abstract Cryogenic calorimetric experiments to search for neutrinoless double-beta decay ( $$0\nu \beta \beta $$ 0 ν β β ) are highly competitive, scalable and versatile in isotope. The largest planned detector array, CUPID, is comprised of about 1500 individual Li $$_{2}$$ 2 $$^{100}$$ 100 MoO $$_4$$ 4 detector modules with a further scale up envisioned for a follow up experiment (CUPID-1T). …”
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Using satellite-based Sun-induced chlorophyll fluorescence and spectral reflectance for improving terrestrial CO2 flux estimates of India by Aparnna Ravi, Dhanyalekshmi Pillai, Christoph Gerbig, Stephen Sitch, Sönke Zaehle, Vishnu Thilakan, Chandra Sekhar Jha, Thara Anna Mathew

“…The use of satellite observations, as demonstrated in this study, offers a scalable solution for regions lacking sufficient ground-based observations to estimate biospheric carbon fluxes reliably.…”
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Resourceful and economical designing of fermentation medium for lab and commercial strains of yeast from alternative feedstock: ‘transgenic oilcane’ by Shraddha Maitra, Bruce Dien, Kristen Eilts, Nurzhan Kuanyshev, Yoel R. Cortes-Pena, Yong-Su Jin, Jeremy S. Guest, Vijay Singh

“…However, limited tolerance of industrially recognized yeasts towards inhibitors generated during the processing of lignocellulosic biomass to produce fermentable sugars is a major challenge in developing scalable processes for second-generation drop-in fuel production. …”
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Monitoring of hepatitis E virus infection and replication by functional tagging of the ORF2 protein by Maliki Ankavay, Nathalie Da Silva, Angela Pollán, Noémie Oechslin, Katja Dinkelborg, Patrick Behrendt, Darius Moradpour, Jérôme Gouttenoire

“…Conclusions: We describe a convenient, quantitative and potentially scalable system for the monitoring of HEV infection and replication in tissue culture. …”
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Implementing a Care Model for Bedridden Stroke Survivors: A Qualitative Study in Northeastern Thailand by Panpanit L, Jongudomkarn D, Doungmungkorn A, Boontoch K, Neelasmith S, Manorat M, Maneerat T

“…Its adoption by local administrative organizations could provide ongoing support, offering a scalable solution for improving the care of bedridden individuals both in Thailand and globally.Keywords: the KKU Bedridden Care Model, community caregivers, family caregivers, stroke survivors, long-term care, Northeastern Thailand…”
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Analysis and Recommendation of Outdoor Activities for Smart City Users Based on Real-Time Contextual Data by S. R. Mani Sekhar, D. M. Mushtaq Ahmed, G. M. Siddesh

“…It contributes to the growing field of Smart Cities by introducing a scalable and adaptable framework that harnesses the power of deep learning to improve urban living. …”
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The effect of depth data and upper limb impairment on lightweight monocular RGB human pose estimation models by Gloria-Edith Boudreault-Morales, Cesar Marquez-Chin, Xilin Liu, José Zariffa

“…Abstract Background and objectives Markerless vision-based human pose estimation (HPE) is a promising avenue towards scalable data collection in rehabilitation. Deploying this technology will require self-contained systems able to process data efficiently and accurately. …”
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A Large-Scale Agricultural Land Classification Method Based on Synergistic Integration of Time Series Red-Edge Vegetation Index and Phenological Features by Huansan Zhao, Chunyan Chang, Zhuoran Wang, Gengxing Zhao

“…Our approach advances the field by introducing a robust, scalable methodology that not only utilizes the full potential of time series data but also strategically enhances critical temporal features for improved classification accuracy, particularly valuable for regions with complex farming systems and diverse crop patterns.…”
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Validating a digital depression prevention program for adolescents in Jordan: cultural adaptation and user testing in a randomized controlled trial by Latefa Ali Dardas, Obada Al-leimon, Tracy Gladstone, Abd Arrahman Dabbas, Insaf Alammouri, Benjamin Van Voorhees

“…PurposeDigital health interventions (DHIs) offer scalable solutions for improving mental health care access in underserved settings. …”
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Exploring Innovative Approaches for the Analysis of Micro- and Nanoplastics: Breakthroughs in (Bio)Sensing Techniques by Denise Margarita Rivera-Rivera, Gabriela Elizabeth Quintanilla-Villanueva, Donato Luna-Moreno, Araceli Sánchez-Álvarez, José Manuel Rodríguez-Delgado, Erika Iveth Cedillo-González, Garima Kaushik, Juan Francisco Villarreal-Chiu, Melissa Marlene Rodríguez-Delgado

“…Advancements in these innovative approaches pave the way for more accurate, scalable, and environmentally compatible detection solutions, contributing to improved monitoring and remediation strategies. …”
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Study protocol of a pilot randomised controlled trial assessing the feasibility and acceptability of RecoverEsupport: a digital health intervention to enhance recovery in women und... by Christopher Oldmeadow, Mitch J Duncan, Penny Reeves, Priscilla Viana da Silva, Rebecca Wyse, Helen Moore, Alison Zucca, Sancha Robinson, Stephen Ridley Smith, Emma Sansalone, Owen Morris, Rebecca Chenery, Lara Riley, Anna Palazzi-Parsons

“…A digital health intervention (DHI) may provide an effective, cost-effective and scalable solution. This pilot trial aims to assess the feasibility of conducting a trial of RecoverEsupport and the acceptability of the RecoverEsupport intervention to support patients to recover from breast cancer surgery.Methods and analysis Participants will be recruited from the perioperative clinic and breast surgery units at a major cancer hospital in New South Wales, Australia and randomised (1:1) to receive (1) control: usual care or (2) intervention: usual care plus RecoverEsupport. …”
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EV Hybrid Battery With Integrated Multilevel Neutral-Point-Clamped Interfacing and Lossless Intermodule State-of-Charge Balancing by Gabriel Garcia-Rojas, Sergio Busquets-Monge, Alber Filba-Martinez, Turev Sarikurt, Salvador Alepuz, Josep Bordonau

“…Overall, the proposed approach enables a modular and scalable design of the energy storage system for a wide range of electric vehicles, from only two different standard battery modules and a standard power semiconductor device, while optimizing the battery size for any given battery power and energy specification. …”
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Emotion regulation-based internet-delivered cognitive behavioural therapy for premenstrual dysphoric disorder: study protocol for a randomised controlled trial in Sweden by Filipa Sampaio, Alkistis Skalkidou, Gerhard Andersson, Cornelia Weise, Johanna M. Hoppe, Maria Kleinstaeuber, Johan Vegelius, Erika Comasco, Maria Gröndal, Elisavet Kaltsouni, Felicia Sundström, Monica Buhrman

“…Furthermore, increasing the generally low accessibility of CBT for PMDD necessitates scalable and cost-effective ways to deliver treatment. …”
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AI versus human-generated multiple-choice questions for medical education: a cohort study in a high-stakes examination by Alex KK Law, Jerome So, Chun Tat Lui, Yu Fai Choi, Koon Ho Cheung, Kevin Kei-ching Hung, Colin Alexander Graham

“…Combining AI efficiency with expert oversight could optimise question creation for high-stakes exams, offering a scalable model for medical education that balances time efficiency and content quality.…”
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SPA14 liposomes combining saponin with fully synthetic TLR4 agonist provide adjuvanticity to hCMV vaccine candidate by Ernesto Luna, Sophie Ruiz, Marie Garinot, Cyril Chavagnac, Pankaj Agrawal, John Escobar, Laurent Revet, Marie-Jeanne Asensio, Fabienne Piras, Francis G. Fang, Donald R. Drake, Bachra Rokbi, Daniel Larocque, Jean Haensler

“…From a developability standpoint, SPA14 could be manufactured by a simple and scalable ethanol injection method, owing to the high solubility in ethanol of all its lipidic components, including E6020. …”
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Increasing the meaningful involvement of women in HIV cure-related research: a qualitative interview study in the United States by Karine Dubé, Elizabeth Barr, Morgan Philbin, Amaya Perez-Brumer, Brian Minalga, Beth Peterson, Dawn Averitt, Bridgette Picou, Krista Martel, Cecilia Chung, María Mejía, Martha Cameron, Gail Graham, Lynda Dee, Dázon Dixon Diallo, Ebony Gordon, Anastasia Korolkova, Typhanye Dyer, Judith D. Auerbach, Eileen Scully, Krista L. Dong, Sara Gianella

“…Meaningfully involving women across the gender spectrum in HIV cure research is needed to ensure that interventions are safe, effective, scalable, and acceptable for all people with HIV.…”
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Developing a Prototype Machine Learning Model to Predict Quality of Life Measures in People Living With HIV by Mercadal-Orfila G, Serrano López de las Hazas J, Riera-Jaume M, Herrera-Perez S

“…Furthermore, leveraging platforms like NAVETA for deploying these models presents a scalable approach to implementation, fostering patient-centered, value-based care.Keywords: machine-learning in healthcare, PROMs-PREMs, chronic HIV management, evidence-based medicine, NAVETA…”
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