Primary extraskeletal osteosarcoma of rectal mesentery: a rare case and literature review by Zhikui Huo, Yao Sun, Jinghui Chang, Guo-Dong Li, Jian Shi, Cheng Quan, Li-Na Zhang, Ting-Ting Yang, Feng-Jia Shang, Yong-Ping Yang

“…Abstract Background Extraskeletal osteosarcoma (ESOS) is a rare kind of sarcoma with a low preoperative diagnosis and a poor prognosis. …”
Get full text

Modulation of gut microbiota in targeted cancer therapy: insights on the EGFR/VEGF/KRAS pathways by Li Gong, Shixue Yang, Junli Huang, Yongsheng Li

“…Key oncogenic targets, including epidermal growth factor receptor (EGFR), vascular endothelial growth factor (VEGF), and kirsten rat sarcoma viral oncogene homologue (KRAS), have emerged as focal points in the development of targeted agents. …”
Get full text

Can Primary Cardiac Myxofibrosarcoma Grow Quickly from Zero to a Size Leading to Left-Sided Heart Failure within 9 Months? by Levan Karazanishvili, Eduard Limonjiani

“…Our case is an example of how fast a cardiac sarcoma can grow. Nine months before the presentation, the patient underwent an echocardiography that did not show any signs of tumor growth. …”
Get full text

Eribulin Provides a Remarkable Effect in Trabectedin-Resistant Myxoid Liposarcoma by Hironari Tamiya, Hideaki Sabe, Katsunari Yamashita, Yoshinori Imura, Toru Wakamatsu, Satoshi Takenaka

“…Adriamycin-based chemotherapy is commonly used for malignant soft tissue sarcoma including myxoid liposarcoma. However, in the case of unavailability or failure of the adriamycin-based regimen, trabectedin or eribulin can produce a good antitumor effect for myxoid liposarcoma. …”
Get full text

A case report of infantile fibrosarcoma with BRAF gene mutation with incomplete intestinal obstruction by Fan Zhu, Liang Fan, Guanhua Cui, Hai Jian, Hongjie Zhou, Jianfeng Xu, Fengshun Chen

“…A review of this case alongside 20 reported cases of intestinal IFS revealed that intestinal perforation and obstruction were the most common presentations, with favorable overall prognoses.ConclusionIntestinal IFS is a rare soft tissue sarcoma predominantly occurring in early infancy. …”
Get full text

An MR Brain Images Classifier System via Particle Swarm Optimization and Kernel Support Vector Machine by Yudong Zhang, Shuihua Wang, Genlin Ji, Zhengchao Dong

“…The abnormal brain MR images consist of the following diseases: glioma, metastatic adenocarcinoma, metastatic bronchogenic carcinoma, meningioma, sarcoma, Alzheimer, Huntington, motor neuron disease, cerebral calcinosis, Pick’s disease, Alzheimer plus visual agnosia, multiple sclerosis, AIDS dementia, Lyme encephalopathy, herpes encephalitis, Creutzfeld-Jakob disease, and cerebral toxoplasmosis. …”
Get full text

Novel Chemokine-Based Immunotoxins for Potent and Selective Targeting of Cytomegalovirus Infected Cells by Katja Spiess, Mads G. Jeppesen, Mikkel Malmgaard-Clausen, Karen Krzywkowski, Thomas N. Kledal, Mette M. Rosenkilde

“…Many viruses encode internalizing receptors suggesting that not only HCMV but also, for instance, Epstein-Barr virus and Kaposi’s sarcoma-associated herpesvirus may be targeted by FTPs.…”
Get full text

A Case of Recurrent Mesocolon Myxoid Liposarcoma and Review of the Literature by Amar M. Eltweri, Gianpiero Gravante, Sarah Louise Read-Jones, Sonpreet Rai, David J. Bowrey, Ian Gordon Haynes

“…Liposarcoma is the second most common soft tissue sarcoma affecting predominantly the retroperitoneal space and extremities. …”
Get full text

Adjuvant Radiochemotherapy with a 23-Month Overall Survival Time in a Patient after a Surgery due to Splenic Hemangiosarcoma Rupture: A Case Report with the Literature Review by M. Bilski, D. Surdyka, I. Paśnik, M. Bilska, P. Cisek, P. Korona, J. Szumiło, L. Grzybowska-Szatkowska

“…Spleen sarcoma is one of the most rare soft tissue malignancies. …”
Get full text

Adamantinoma-Like Ewing’s Family Tumor of the Sino Nasal Region: A Case Report and a Brief Review of Literature by Pushpa Mahadevan, Subramaniam Ramkumar, V. P. Gangadharan

“…Ewing's sarcoma family of tumors (EFTs) are malignant mesenchymal tumors with a predilection for bone and soft tissue. …”
Get full text

Human Immunodeficiency Virus – Acquired Immunodeficiency Syndrome dengan Sarkoma Kaposi by Riry Febrina Ersha, Armen Ahmad

“…Sebuah temuan baru yang mengarah pada pertumbuhan, isolasi dan karakterisasi dari sebuah virus herpes baru yang dikenal dengan kaposi’s sarcoma-associated herpes virus (KSHV) atau human herpes virus type 8 (HHV-8) dari lesi sarkoma kaposi (SK). …”
Get full text

Structural basis for the interaction between the Drosophila RTK Sevenless (dROS1) and the GPCR BOSS by Jianan Zhang, Yuko Tsutsui, Hengyi Li, Tongqing Li, Yueyue Wang, Salma Laraki, Sofia Alarcon-Frias, Steven E. Stayrook, Daryl E. Klein

“…Abstract Sevenless, the Drosophila homologue of ROS1 (University of Rochester Sarcoma) (herein, dROS1) is a receptor tyrosine kinase (RTK) essential for the differentiation of Drosophila R7 photoreceptor cells. …”
Get full text

Liposarcomas of the hypopharynx: a systematic review of the literature by Andrea Corvino, Giuseppe Riva, Matteo Sensini, Massimiliano Garzaro, Giancarlo Pecorari

“…Introduction: Liposarcomas are considered the most common type of soft tissue sarcoma in adults. They represent approximately 20% of all mesenchymal malignancies and most frequently involve the retroperitoneum, trunk and extremities. …”
Get full text

Pan-cancer analysis of SOX2: Prognostic implications and potential as a therapeutic target in immune checkpoint modulation by Shoukai Yu, Lingmei Qian, Liling Xu, Jun Ma

“…Significant downregulation of SOX2 expression was observed in colorectal adenocarcinoma, esophageal carcinoma, rectum adenocarcinoma, stomach adenocarcinoma, and testicular germ cell tumors, whereas its expression was upregulated in cervical squamous cell carcinoma, glioblastoma multiforme, lower grade glioma, lung adenocarcinoma, and lung squamous cell carcinoma.Survival analysis showed that low SOX2 expression correlated with better prognosis in bladder cancer, liver hepatocellular carcinoma, kidney renal clear cell carcinoma, and sarcoma, whereas high SOX2 expression was associated with poor prognosis in lung adenocarcinoma, and lung squamous cell carcinoma, glioblastoma multiforme, lower grade glioma. …”
Get full text

The Studies of Chlorogenic Acid Antitumor Mechanism by Gene Chip Detection: The Immune Pathway Gene Expression by Tian Yi Kang, Hua Rong Yang, Jie Zhang, Dan Li, Jie Lin, Li Wang, XiaoPing Xu

“…Here, we have utilized a whole mouse genome oligo microarray (4*44K) to analyze gene expression level of female BALB/c mice (implanted with EMT-6 sarcoma cells) after treatment with low, medium, and high-dose CA (5 mg/kg, 10 mg/kg, and 20 mg/kg), docetaxel, interferon, and normal saline separately at 6 time points (3rd, 6th, 9th, 12th, 15th, and 18th days after administration). …”
Get full text

A Disentangled Representation-Based Multimodal Fusion Framework Integrating Pathomics and Radiomics for KRAS Mutation Detection in Colorectal Cancer by Zhilong Lv, Rui Yan, Yuexiao Lin, Lin Gao, Fa Zhang, Ying Wang

“…Kirsten rat sarcoma viral oncogene homolog (namely KRAS) is a key biomarker for prognostic analysis and targeted therapy of colorectal cancer. …”
Get full text

Liposarcoma in the Inguinal Canal: Challenges in Preoperative Diagnosis and Importance of Routine Pathological Examination of “Hernia Sacs” by Christopher A. Febres-Aldana, Jin Min, Marc Rafols, Irvin Willis, John Alexis

“…Liposarcoma is the most common histologic subtype of soft tissue sarcoma in the retroperitoneum. The distinction of primary cord liposarcomas, which arise in and are confined to the inguinal canal, from inguinoscrotal extension of a retroperitoneal tumor is mandatory. …”
Get full text

An Analysis of Biopsies for Suspected Skin Cancer at a Tertiary Care Dermatology Clinic in the Western Cape Province of South Africa by Johann de Wet, Minette Steyn, Henry F. Jordaan, Rhodine Smith, Saskya Claasens, Willem I. Visser

“…The most commonly occurring malignancies were basal cell carcinoma (BCC) (54.8%), squamous cell carcinoma (SCC) (18.9%), squamous cell carcinoma in-situ (SCCI) (8.0%), Kaposi’s sarcoma (KS) (6.7%), malignant melanoma (MM) (6.1%), and keratoacanthoma (KA) (4.6%). …”
Get full text

TMEM147 Correlates with Immune Infiltration and Serve as a Potential Prognostic Biomarker in Hepatocellular Carcinoma by Sheng Cheng, Jutang Li, Ming Xu, Qun Bao, Jiaoxiang Wu, Peng Sun, Bo Han

“…Mechanistic studies revealed that high TMEM147 expression was linked to the B lymphocyte, antigen response, IL6 signaling pathway, cell cycle, Kirsten rat sarcoma viral oncogene homolog (KRAS) signaling pathway, and myelocytomatosis oncogene (MYC) targets. …”
Get full text

Myogenesis gone awry: the role of developmental pathways in rhabdomyosarcoma by Annika L. Gustafson, Annika L. Gustafson, Annika L. Gustafson, Adam D. Durbin, Kristin B. Artinger, Heide L. Ford, Heide L. Ford, Heide L. Ford

“…Rhabdomyosarcoma is a soft-tissue sarcoma that occurs most frequently in pediatric patients and has poor survival rates in patients with recurrent or metastatic disease. …”
Get full text