Development, optimization and application of a universal fluorescence multiplex PCR-based assay to detect BCOR genetic alterations in pediatric tumors by Meng Zhang, Xingfeng Yao, Nan Zhang, Yongbo Yu, Chao Jia, Xiaoxing Guan, Wenjian Xu, Xin Ni, Yongli Guo, Lejian He

“…Abstract Background A number of genetic aberrations are associated with the BCL6-correpresor gene (BCOR), including internal tandem duplications (ITDs) and gene fusions (BCOR::CCNB3 and BCOR::MAML3), as well as YWHAE::NUTM2, which are found in clear cell sarcoma of the kidney (CCSK), sarcoma with BCOR genetic alterations, primitive myxoid mesenchymal tumor of infancy, and high-grade neuroepithelial tumors in children. …”
Get full text

Interference with the Autophagic Process as a Viral Strategy to Escape from the Immune Control: Lesson from Gamma Herpesviruses by Roberta Santarelli, Marisa Granato, Alberto Faggioni, Mara Cirone

“…A particular attention has been given to Epstein-Barr and Kaposi’s sarcoma associated Herpesvirus, viruses studied for many years in our laboratory. …”
Get full text

Primary Malignant Fibrous Histiocytoma: A Rare Case by Anastasios Katsourakis, George Noussios, Iosif Hadjis, Neofitos Evangelou, Efthimios Chatzitheoklitos

“…A diagnosis of MFN (undifferentiated high-grade pleomorphic sarcoma) was made. The patient received adjuvant chemotherapy with Gemcitabine. …”
Get full text

Nonbacterial Osteitis of the Clavicle: Longitudinal Imaging Series from Initial Diagnosis to Clinical Improvement by E. Roos, M. Maas, S. J. M. Breugem, G. R. Schaap, J. A. M. Bramer

“…The differential diagnoses were sarcoma, osteitis, and Langerhans cell histiocytosis. …”
Get full text

Synaptic Paths to Neurodegeneration: The Emerging Role of TDP-43 and FUS in Synaptic Functions by Shuo-Chien Ling

“…TAR DNA-binding protein-43 KDa (TDP-43) and fused in sarcoma (FUS) as the defining pathological hallmarks for amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD), coupled with ALS-FTD-causing mutations in both genes, indicate that their dysfunctions damage the motor system and cognition. …”
Get full text

Epigenetic and epitranscriptomic regulation during oncogenic γ-herpesvirus infection by Rajnish Kumar Singh, Ramakrishna Vangala, Atharva S. Torne, Dipayan Bose, Erle S. Robertson

“…Oncogenic gamma herpesviruses, including Epstein–Barr Virus (EBV) and Kaposi’s Sarcoma-associated Herpesvirus (KSHV), are opportunistic cancer-causing viruses and induces oncogenesis through complex mechanisms, which involves manipulation of cellular physiology as well as epigenetic and epitranscriptomic reprogramming. …”
Get full text

Extrafollicular Adenomatoid Odontogenic Tumors: A Series of Five Rare Cases with an Insight into Its Clinicopathological Aspects by Debarati Ray, Snehanjan Sarangi, Tathagata Bhattacharjee, Jay Gopal Ray

“…Mutation at codon 12 of KRAS oncogene (Kirsten rat sarcoma viral oncogene homolog) plays a pivotal role in the pathogenesis. …”
Get full text

A 27-Year-Old Severely Immunosuppressed Female with Misleading Clinical Features of Disseminated Cutaneous Sporotrichosis by Atiyah Patel, Victor Mudenda, Shabir Lakhi, Owen Ngalamika

“…We report the case of a severely immunosuppressed female who presented with disseminated cutaneous sporotrichosis which was initially diagnosed and treated as disseminated cutaneous Kaposi’s sarcoma.…”
Get full text

Resección de liposarcoma mixoide bajo anestesia combinada by Karen I. Lucio-Hernández, Cristian I. Ham-Armenta, Horacio Olivares-Mendoza

“…El liposarcoma es una de las histologías más comunes del sarcoma de tejidos blandos (STS), la mitad de estos son retroperitoneales y el 25% de las extremidades. …”
Get full text

Personalized screening strategies for TP53 R337H carriers: a retrospective cohort study of tumor spectrum in Li-Fraumeni syndrome adult carriersResearch in context by Pedro A.F. Galante, Gabriela D.A. Guardia, Janina Pisani, Renata L. Sandoval, Mateus C. Barros-Filho, Ana Carolina Leite Vieira Costa Gifoni, Diogo F.C. Patrão, Patricia Ashton-Prolla, Vitor Fiorin de Vasconcellos, Claire Freycon, Arnold Levine, Pierre Hainaut, Maria Isabel Achatz

“…The most common cancers were breast cancer and soft tissue sarcoma in females, and soft tissue sarcoma and prostate cancer in males. …”
Get full text

Role of exosomes in diagnosis, prognostication, and treatment of pediatric solid tumors by Shaikh M. Ghufran, Morgan L. Brown, Elizabeth A. Beierle

“…Studies highlighting the potential applications and clinical utility of exosomes and their molecular constituents as prognosticators and therapies in common childhood solid tumors, including neuroblastoma, medulloblastoma, sarcoma, and hepatoblastoma, have been overviewed. …”
Get full text

Mediastinal Teratoma with Neuroendocrine Features in 34-Year-Old Male with Syncope by Peter A. Andrawes, Masood A. Shariff, Qing Chang, Fanyi Kong, Frank M. Rosell

“…Somatic-type malignancy, defined as any sarcoma, carcinoma, leukemia, or lymphoma developing in a germ cell tumor, occurs in approximately 2% of all germ cell tumors. …”
Get full text

Total Metacarpal Reconstruction with Fascia-Wrapped Fibular Graft Following Ewing Tumor Resection in a Growing Patient by Samer Abdel Al, MD, Muhamad A. Al-Qawasmi, MD, Muntaser Abu Shokor, MD, Hamza M. Khalaf, MD, Mohammad A. Alattar, PT

“…Reconstructing a digit after complete metacarpal removal because of sarcoma resection is a complex challenge, especially in growing individuals. …”
Get full text

First Description of a Primitive Neuroectodermal Tumor Arising in the Nose by Habib Rizk, Aline Khazzaka, Amer Sebaaly, Maguy Cherfan, Roland Tomb, Riad Sarkis

“…Immunohistochemistry was in favor of a primitive neuroectodermal tumor (PNET)/Ewing’s sarcoma lesion, excluding epithelial, lymphoid, and other tumors. …”
Get full text

Retroperitoneal Malignant Fibrous Histiocytoma Can Mimic a Hydatid Cyst by Gurcan Erbay, Serife Ulusan, Zafer Koc, Emine Tuba Canpolat, Kenan Calıskan

“…Malignant fibrous histiocytoma is the second most common soft-tissue sarcoma in adults. After the extremities, the retroperitoneal space is the second most common site of this tumor. …”
Get full text

Majocchi’s Granuloma after Topical Corticosteroids Therapy by Fu-qiu Li, Sha Lv, Jian-xin Xia

“…The clinical manifestations of MG are many and varied, except the common presentations of erythema, papule and nodules, and Kaposi sarcoma-like and molluscum-like lesions have been reported in literatures (Kim et al. (2011), Bord et al. (2007), and Lillis et al. (2010)). …”
Get full text

Cardiac Myxoid Spindle Cell Tumor in a Neonate by Reza Abbaszadeh, Fatemeh Naderi, Amir Hossein Jalali, Yaser Toloueitabar

“…Introduction: Different subtypes of cardiac tumors containing spindle cells have been described as cardiac sarcoma. However, benign types have not been reported so far. …”
Get full text

Clinical forms of 5 cases of circumcised penile cancer in immunocompetent subjects in Abidjan (Ivory Coast) by Evrard Kouame Yao, Abraham Hognou Yao, Donafologo Daouda Yeo, Tawakaltu Adebayo, Michel Tuo, Freddy Junior Zouan, Noel Coulibaly

“…Case presentations A 44-year-old patient with a circumcised penis, diagnosed with a fusosarcoma (a rare type of sarcoma) of the penis. Three patients (ages 61, 59, and 70) were diagnosed with squamous cell carcinoma, the most common type of penile cancer. …”
Get full text

Angiosarcoma Arising in a Patient with a 10-Year-Old Hemangioma by Michael J. Nathenson, Diana Molavi, Albert Aboulafia

“…The patient was managed as having a high grade sarcoma with wide resection and radiation. She declined systemic adjuvant chemotherapy after a thorough discussion about the risks and benefits of chemotherapy, and she currently remains disease free one year after the surgery.…”
Get full text

Expandable Total Humeral Replacement in a Child with Osteosarcoma by Eric R. Henderson, Jidi Gao, John Groundland, Odion Binitie, G. Douglas Letson

Get full text