Embryonic Stem Cell-Derived Cardiomyocyte Heterogeneity and the Isolation of Immature and Committed Cells for Cardiac Remodeling and Regeneration by Kenneth R. Boheler, Robert N. Joodi, Hui Qiao, Ondrej Juhasz, Amanda L. Urick, Sandra L. Chuppa, Rebekah L. Gundry, Robert P. Wersto, Rong Zhou

“…Following transplantation into rodent hearts, bioluminescence imaging revealed that immature cells, but not more mature CMs, survived for at least one month following injection. …”
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APT imaging of hepatocellular carcinoma signals an effective therapeutic response in advance of tumor shrinkage by Xiaojing Wang, Keisuke Ishimatsu, Junjie Li, Xiaodong Wen, Weijun Ou, Arnida Anwar, Jaideep Chaudhary, Masaya Takahashi, A Dean Sherry, Ian R Corbin

“…Aim: The aim of this study was to assess the utility of weighted amide proton transfer (APTw) MRI in three different rodent models of hepatocellular carcinoma (HCC).Methods: APTw MRI was evaluated in models of diethylnitrosamine (DEN) induced HCC, N1S1 syngeneic orthotopic xenograft and human HepG2 ectopic xenograft.Results: All models of HCC showed a higher APTw signal over the surrounding normal tissues. …”
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Age-related cerebral ventriculomegaly occurs in patients with primary ciliary dyskinesia by Franziska Eisenhuth, Joy E. Agbonze, Adam M. R. Groh, Jesse M. Klostranec, David A. Rudko, Jo Anne Stratton, Adam J. Shapiro

“…However, the impact of PCD on the central nervous system remains poorly understood. Rodent models of PCD exhibit marked hydrocephalus leading to early animal mortality, however, most humans with PCD do not develop hydrocephalus for unknown reasons. …”
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The Krushinsky – Molodkina genetic rat strain as a unique experimental model of seizure states by I. I. Poletaeva, Z. A. Kostyna, N. M. Surina, I. B. Fedotova, Z. A. Zorina

“…The specific seizure pattern, the rodent proneness for audiogenic epilepsy, as well as abnormal postictal states (catalepsy, in particular) illustrate the importance of this phenomenon not only as a model of certain brain pathology, but also as a matter of general biological importance. …”
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Activation of Sphingosine 1-Phosphate Receptor 1 Enhances Hippocampus Neurogenesis in a Rat Model of Traumatic Brain Injury: An Involvement of MEK/Erk Signaling Pathway by Yuqin Ye, Zhenyu Zhao, Hongyu Xu, Xin Zhang, Xinhong Su, Yongxiang Yang, Xinguang Yu, Xiaosheng He

“…Recent studies suggested that S1PR1 was expressed abundantly in the hippocampus, a specific neurogenic region in rodent brain for endogenous neurogenesis throughout life. …”
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A simple and reliable method for claustrum localization across age in mice by Tarek Shaker, Gwyneth J. Dagpa, Vanessa Cattaud, Brian A. Marriott, Mariam Sultan, Mohammed Almokdad, Jesse Jackson

“…Abstract The anatomical organization of the rodent claustrum remains obscure due to lack of clear borders that distinguish it from neighboring forebrain structures. …”
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Quantitative, Dynamic Detection of Neuronal Na+ Transients Using Multi-photon Excitation and Fluorescence Lifetime Imaging (FLIM) in Acute Mouse Brain Slices by Sara Eitelmann, Karl Kafitz, Christine Rose, Jan Meyer

“…Here, we demonstrate the use of multi-photon-based rapidFLIM with the sodium indicator ION NaTRIUM Green-2 (ING-2) for the quantitative, dynamic determination of Na+ concentrations in neurons in acute rodent brain tissue slices. We describe the loading of the dye into neurons and present a procedure for its calibration in situ. …”
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Neuroplasticity and Neuroprotective Effect of Treadmill Training in the Chronic Mouse Model of Parkinson’s Disease by Ewelina Palasz, Wiktor Niewiadomski, Anna Gasiorowska, Anna Mietelska-Porowska, Grazyna Niewiadomska

“…Physical training confers protection to dopaminergic neurons in rodent models of parkinsonism produced by neurotoxins. …”
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CRISPR/Cas9, a universal tool for genomic engineering by A. V. Smirnov, A. M. Yunusova, V. A. Lukyanchikova, N. R. Battulin

“…For instance, the CRISPR/Cas9 was recently used to control HIV infection and to repair genetic abnormalities, such as Duchenne muscular dystrophy or retinitis pigmentosa, both in cell cultures and rodent models. A programmable nature of CRISPR/Cas9 facilitates the creation of transgenic organisms through sitespecific gene mutations, knock-ins or large chromosomal rearrangements (deletions, inversions and duplications). …”
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Antiviral and Immunoenhancing Properties of 7-Thia-8-Oxoguanosine and Related Guanosine Analogues by Donald F Smee, Howard B Cottam, Brahma S Sharma, Ganesh D Kini, Ganapathi R Revankar, Emmanuel A Ojo-Amaize, Robert W Sidwell, Weldon B Jolley, Roland K Robins

“…7-thia-8-oxoguanosine (TOGuo) is the first reported structure of a family of modified guanosine analogues exhibiting antiviral activity in rodent models. Its spectrum of action includes interferon-sensitive viruses such as alphaviruses, bunyaviruses, corona viruses, flaviviruses, picornaviruses and, to a lesser extent, herpesviruses. …”
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Kaempferol enhances ER-mitochondria coupling and protects motor neurons from mitochondrial dysfunction and ER stress in C9ORF72-ALS by Federica Pilotto, Paulien Hermine Smeele, Olivier Scheidegger, Rim Diab, Martina Schobesberger, Julieth Andrea Sierra-Delgado, Smita Saxena

“…Here, we investigated the mode of action and therapeutic effect of a naturally occurring dietary flavanol, kaempferol in preclinical rodent and human models of C9ORF72-ALS. Notably, kaempferol treatment of C9ORF72-ALS human patient-derived motor neurons/neurons, resolved mitochondrial deficits, promoted resiliency against severe ER stress, and conferred neuroprotection. …”
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Mesenchymal Stromal Cell Therapy in Ischemia/Reperfusion Injury by Pascal Rowart, Pauline Erpicum, Olivier Detry, Laurent Weekers, Céline Grégoire, Chantal Lechanteur, Alexandra Briquet, Yves Beguin, Jean-Marie Krzesinski, François Jouret

“…MSC have demonstrated immunomodulatory, anti-inflammatory, and tissue repair properties in rodent studies and in preliminary clinical trials, which may open novel avenues in the management of IRI and SOT.…”
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Topically Applied Connective Tissue Growth Factor/CCN2 Improves Diabetic Preclinical Cutaneous Wound Healing: Potential Role for CTGF in Human Diabetic Foot Ulcer Healing by F. R. Henshaw, P. Boughton, L. Lo, S. V. McLennan, S. M. Twigg

“…Topical application of CTGF/CCN2 to rodent diabetic and control wounds was examined. In parallel research, correlation of CTGF wound fluid levels with healing rate in human diabetic foot ulcers was undertaken. …”
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The R18 Polyarginine Peptide Is More Effective Than the TAT-NR2B9c (NA-1) Peptide When Administered 60 Minutes after Permanent Middle Cerebral Artery Occlusion in the Rat by D. Milani, N. W. Knuckey, R. S. Anderton, J. L. Cross, B. P. Meloni

“…The TAT-NR2B9c peptide, which is known to be neuroprotective in rodent and nonhuman primate stroke models, served as a positive control. …”
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Three-Dimensional Aspects of the Lingual Papillae and Their Connective Tissue Cores in the Tongue of Rats: A Scanning Electron Microscope Study by Gabriela de Souza Reginato, Cristina de Sousa Bolina, Ii-sei Watanabe, Adriano Polican Ciena

“…The morphological characteristics of the lingual papillae of Sprague Dowley rats, three-dimensional SEM images, and the types of papillae on the dorsal surface were similar to those reported previously in other rodent mammals. The maceration technique revealed the details of extracellular matrix with varied shapes form of connective tissue cores.…”
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Molecular study of the status of Angiostrongylus cantonensis in rats in Haiti by Fedna Jimmy, Borne Romain, Rieffel Dominique, Bornette Gudrun, Henrys Jean-Hugues, Grenouillet Frédéric, Raoul Francis

“…Parasite DNA was amplified using PCR targeting either the nematode ITS2 gene for rodent lung tissue or cox1 for isolated worms. Subsequent sequencing allowed parasite identification. …”
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Age and diet affect self-resilience of intestinal microbiome in mice by Chenyi Shao, Shenmin Chen, Huan Yang, Mufan Li, Yinhui Liu, Shu Wen, Jing Xiao, Li Tang

“…This study aimed to investigate the self-resilience of the gut microbiome at different ages and the effects of diet on its recovery capacity in adulthood.MethodsA rodent model of antibiotic-induced dysbiosis was used. …”
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Investigation of the Effects of Fosfomycin in Kidney Damage Caused by CLP-Induced Sepsis by Ilknur Esen Yildiz, Tolga Mercantepe, Ilkay Bahceci, Medeni Arpa, Sule Batcik, Yasin Yildiz, Levent Tumkaya

“…This study aimed to investigate the potential therapeutic effects of fosfomycin (FOS), a broad-spectrum antibiotic with immunomodulatory properties, on kidney damage induced by cecal ligation and puncture (CLP)-induced sepsis in a rodent model. In total, 24 rats were randomly divided into three groups. …”
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Systemic Inflammatory Responses and Lung Injury following Hip Fracture Surgery Increases Susceptibility to Infection in Aged Rats by Hao Zhang, Tiansheng Sun, Zhi Liu, Jianzheng Zhang, Xiaowei Wang, Jia Liu

“…The present study investigates the systemic inflammatory response and pulmonary conditions following hip fracture surgery as a means of identifying risk factors for lung infections using an aged rodent model. Aged, male Sprague-Dawley rats (8 animals per group) underwent a sham procedure or hip fracture plus femoral intramedullary pinning. …”
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Bio-orthogonal crosslinking and hyaluronan facilitate transparent healing after treatment of deep corneal injuries with in situ-forming hydrogels by Fang Chen, Uiyoung Han, Thitima Wungcharoen, Youngyoon Amy Seo, Peter Le, Li Jiang, Nae-Won Kang, Euisun Song, Kyeongwoo Jang, David Mundy, Gabriella Maria Fernandes-Cunha, Sarah Heilshorn, David Myung

“…Here we performed a direct, side-by-side comparison of a composite hyaluronan-collagen (HA-Col) hydrogel crosslinked by either photochemistry or bio-orthogonal chemistry to ascertain the impact of reaction specificity on corneal wound healing. Testing in rodent and rabbit models suggests that composite HA-Col gels crosslinked by bio-orthogonal chemistry results in more rapid and optically favorable wound healing compared to the same composition crosslinked by photochemistry as well as bio-orthogonally crosslinked collagen alone. …”
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