Preclinical Positron Emission Tomographic Imaging of Acute Hyperoxia Therapy of Chronic Hypoxia during Pregnancy by Alexander Zheleznyak, Joel R. Garbow, Michal Neeman, Suzanne E. Lapi

“…Herein we report first-in-mouse PET imaging of fetuses employing both tracers [ 18 F]FDG (metabolism) and 64 Cu-ATSM (hypoxia). [ 18 F]FDG PET/CT imaging allowed clear visualization of placental-fetal structures and supported quantification of tracer uptake, making this a sensitive tool for monitoring placental function in preclinical rodent models. These measurements illustrate the potentially irreversible damage generated by chronic exposure to hypoxia, which cannot be corrected by acute exposure to hyperoxia.…”
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Functional evolution of mammalian odorant receptors. by Kaylin A Adipietro, Joel D Mainland, Hiroaki Matsunami

“…Here we investigated the functional properties of primate and rodent ORs to determine how well evolutionary distance predicts functional characteristics. …”
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Our journey with François Gros by Butler-Browne, Gillian, Mouly, Vincent

“…She characterized the expression profile of different myosin isoforms during both human and rodent development. Vincent Mouly joined this laboratory for his PhD in 1982, and defined the different populations of myoblasts appearing during development in birds and then in humans. …”
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Caroli's Disease: Current Knowledge of Its Biliary Pathogenesis Obtained from an Orthologous Rat Model by Yasunori Sato, Xiang Shan Ren, Yasuni Nakanuma

“…The development of the polycystic kidney (PCK) rat, an orthologous rodent model of Caroli's disease with CHF as well as ARPKD, has allowed the molecular pathogenesis of the disease and the therapeutic options for its treatment to be examined. …”
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Early Social Enrichment Improves Social Motivation and Skills in a Monogenic Mouse Model of Autism, the Oprm1−/− Mouse by Luciana Garbugino, Eleonora Centofante, Francesca R. D’Amato

“…Environmental enrichment has been proven to have positive effects on both behavioral and physiological phenotypes in rodent models of mental and neurodevelopmental disorders. …”
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Quantitative assessment of brain metabolism in mice using non-contrast MRI at 11.7T by Xiuli Yang, Yuguo Li, Hanzhang Lu, Zhiliang Wei

“…However, its application in preclinical studies, particularly with rodent animals, is constrained by the need for arterial input function measurements and on-site cyclotron facilities for tracer preparation. …”
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Translocator Protein (18 kDa) Mapping with [I]-CLINDE in the Quinolinic Acid Rat Model of Excitotoxicity: A Longitudinal Comparison with Microglial Activation, Astrogliosis, and Ne... by Nicolas Arlicot, Claire Tronel, Sylvie Bodard, Lucette Garreau, Brice de la Crompe, Inge Vandevelde, Denis Guilloteau, Daniel Antier, Sylvie Chalon

“…These findings provide the possibility of a therapeutic temporal window to compare the differential effects of antiinflammatory treatments in slowing down neurodegeneration in this rodent model, with potential applications to humans.…”
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Roles of Brain Angiotensin II in Cognitive Function and Dementia by Masaki Mogi, Jun Iwanami, Masatsugu Horiuchi

“…Moreover, basic experiments suggest a role of brain angiotensin II in neural injury, neuroinflammation, and cognitive function and that RAS blockade attenuates cognitive impairment in rodent dementia models of AD. Therefore, RAS regulation is expected to have therapeutic potential for AD. …”
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Effects of Microtubule Stabilization by Epothilone B Depend on the Type and Age of Neurons by Eun-Hae Jang, Aeri Sim, Sun-Kyoung Im, Eun-Mi Hur

“…Several studies have demonstrated the therapeutic potential of applying microtubule- (MT-) stabilizing agents (MSAs) that cross the blood-brain barrier to promote axon regeneration and prevent axonal dystrophy in rodent models of spinal cord injury and neurodegenerative diseases. …”
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Olfactory Bulb Field Potentials and Respiration in Sleep-Wake States of Mice by Jakob Jessberger, Weiwei Zhong, Jurij Brankačk, Andreas Draguhn

“…It is well established that local field potentials (LFP) in the rodent olfactory bulb (OB) follow respiration. This respiration-related rhythm (RR) in OB depends on nasal air flow, indicating that it is conveyed by sensory inputs from the nasal epithelium. …”
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人肿瘤细胞ERCC2 基因表达与抗癌药耐药的相关性 by L

“…【目的】探讨切割修复交叉互补基因2(excision repair cross-complementing rodent repair deficiency gene 2, ERCC2) 表达与人肿瘤对抗癌药耐药的关系。…”
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Hantavirus pulmonary syndrome in Santa Cruz, Bolivia: outbreak investigation and antibody prevalence study. by Joel M Montgomery, Patrick J Blair, Darin S Carroll, James N Mills, Alberto Gianella, Naomi Iihoshi, Ana M Briggiler, Vidal Felices, Milagros Salazar, James G Olson, Raisa A Glabman, Daniel G Bausch

“…Precipitation in the months preceding the outbreak was particularly heavy in comparison to other years, suggesting a possible climatic or ecological influence on rodent populations and risk of hantavirus transmission to humans. …”
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DNA Damage Induced by Alkylating Agents and Repair Pathways by Natsuko Kondo, Akihisa Takahashi, Koji Ono, Takeo Ohnishi

“…., endnuclease xeroderma pigmentosum complementation group F-excision repair cross-complementing rodent repair deficiency complementation group 1), Fanconi anemia repair, and homologous recombination. …”
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The Vertebral Column, Ribs, and Sternum of the African Giant Rat (Cricetomys gambianus Waterhouse) by Matthew Ayokunle Olude, Oluwaseun Ahmed Mustapha, Temitope Kehinde Ogunbunmi, James Olukayode Olopade

“…The vertebral column is adapted for strong muscular attachment and actions helping the rodent suited for speed, agility, dexterity, and strength which might enable it to overpower prey and escape predation.…”
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Indirectly acquired fear memories have distinct, sex-specific molecular signatures from directly acquired fear memories. by Shaghayegh Navabpour, Morgan B Patrick, Nour A Omar, Shannon E Kincaid, Yeeun Bae, Jennifer Abraham, Jacobi McGrew, Madeline Musaus, W Keith Ray, Richard F Helm, Timothy J Jarome

“…However, as the focus has remained on those directly experiencing the traumatic event, whether indirectly acquired fear memories that underlie PTSD have the same molecular signature as those that are directly acquired remains unknown. Here, using a rodent indirect fear learning paradigm where one rat (observer) watches another rat (demonstrator) associate an auditory cue with foot shock, we found that fear can be indirectly acquired by both males and females regardless of the sex or novelty (familiarity) of the demonstrator animal. …”
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Aging-regulated TUG1 is dispensable for endothelial cell function. by Anna Theresa Gimbel, Susanne Koziarek, Kosta Theodorou, Jana Felicitas Schulz, Laura Stanicek, Veerle Kremer, Tamer Ali, Stefan Günther, Sandeep Kumar, Hanjoong Jo, Norbert Hübner, Lars Maegdefessel, Stefanie Dimmeler, Sebastiaan van Heesch, Reinier A Boon

“…The evolutionary conserved Taurine Upregulated Gene 1 (TUG1) is a ubiquitously expressed gene that is one of the highest expressed genes in human and rodent endothelial cells (ECs). We here show that TUG1 expression decreases significantly in aging mouse carotid artery ECs and human ECs in vitro, indicating a potential role in the aging endothelial vasculature system. …”
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G1 Cell Cycle Arrest Is Induced by the Fourth Extracellular Loop of Meningococcal PorA in Epithelial and Endothelial Cells by Matthew Vassey, Rininta Firdaus, Akhmed Aslam, Lee M. Wheldon, Neil J. Oldfield, Dlawer A. A. Ala’Aldeen, Karl G. Wooldridge

“…The 37/67 kDa laminin receptor (LamR) was previously identified as a receptor mediating meningococcal binding to rodent and human brain microvascular endothelial cells, which form part of the BBB. …”
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Analyzing the relationship between gene expression and phenotype in space-flown mice using a causal inference machine learning ensemble by James A. Casaletto, Ryan T. Scott, Makenna Myrick, Graham Mackintosh, Hamed Chok, Amanda Saravia-Butler, Adrienne Hoarfrost, Jonathan M. Galazka, Lauren M. Sanders, Sylvain V. Costes

“…Abstract Spaceflight has several detrimental effects on human and rodent health. For example, liver dysfunction is a common phenotype observed in space-flown rodents, and this dysfunction is partially reflected in transcriptomic changes. …”
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Radiation-Induced Growth Retardation and Microstructural and Metabolite Abnormalities in the Hippocampus by Shaefali P. Rodgers, Janice A. Zawaski, Iman Sahnoune, J. Leigh Leasure, M. Waleed Gaber

“…This study evaluates the acute and long-term impact of CRT delivered during childhood/adolescence on the brain and body using a rodent model. Rats received CRT, either 4 Gy fractions × 5 d (fractionated) or a cumulative dose of 20 Gy (single dose) at 28 d of age. …”
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The MAPK MEK1/2-ERK1/2 Pathway and Its Implication in Hepatocyte Cell Cycle Control by Jean-Philippe Guégan, Christophe Frémin, Georges Baffet

“…In this paper, we will focus on MEK1/2-ERK1/2 activations and roles in normal rodent hepatocytes in vitro and in vivo after partial hepatectomy and in human hepatocarcinoma cells. …”
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