Interleukin-29 Enhances Synovial Inflammation and Cartilage Degradation in Osteoarthritis by Lingxiao Xu, Qiuyue Peng, Wenhua Xuan, Xiaoke Feng, Xiangqing Kong, Miaojia Zhang, Wenfeng Tan, Meilang Xue, Fang Wang

“…We have recently shown that IL-29 was an important proinflammatory cytokine in pathogenesis of rheumatoid arthritis (RA). Inflammation also contributes to the pathogenesis of osteoarthritis (OA). …”
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HMGB1 Acts in Synergy with Lipopolysaccharide in Activating Rheumatoid Synovial Fibroblasts via p38 MAPK and NF-κB Signaling Pathways by Zheng-Wen He, Yang-Hua Qin, Zhi-Wei Wang, Yan Chen, Qian Shen, Sheng-Ming Dai

“…Synovial fibroblasts (SF) play a central role in the inflammatory and destructive process in rheumatoid arthritis (RA). High-mobility group box chromosomal protein 1 (HMGB1) or lipopolysaccharide (LPS) alone failed to induce significant changes in proliferation of cultured SF from RA patients, but premixed HMGB1 with LPS (HMGB1-LPS) significantly facilitated SF proliferation. …”
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An Innovative Method to Identify Autoantigens Expressed on the Endothelial Cell Surface: Serological Identification System for Autoantigens Using a Retroviral Vector and Flow Cytom... by Tsuyoshi Shirai, Hiroshi Fujii, Masao Ono, Ryu Watanabe, Tomonori Ishii, Hideo Harigae

“…Using SARF, we successfully identified three different membrane proteins: fibronectin leucine-rich transmembrane protein 2 (FLRT2) from patients with systemic lupus erythematosus (SLE), intercellular adhesion molecule 1 (ICAM-1) from a patient with rheumatoid arthritis, and Pk (Gb3/CD77) from an SLE patient with hemolytic anemia, as targets for AECAs. …”
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Administration of PDE4 Inhibitors Suppressed the Pannus-Like Inflammation by Inhibition of Cytokine Production by Macrophages and Synovial Fibroblast Proliferation by Katsuya Kobayashi, Toshio Suda, Haruhiko Manabe, Ichiro Miki

“…A marked proliferation of synovial fibroblasts in joints leads to pannus formation in rheumatoid arthritis (RA). Various kinds of cytokines are produced in the pannus. …”
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Prevalence of Autoimmune Diseases in Patients Treated With Immune Checkpoint Inhibitors: An Epidemiological Study Using A Global Network of Health Care Organizations by Pushti Khandwala, Devashish Desai, Arthur Lau

“…Results Patients who received ICIs (2.03% of total population) were younger (68.7 ± 12.6 vs 71.8 ± 13.9; P < 0.001), predominantly male (54% vs 41%; P < 0.0001), and White (68% vs 58%; P < 0.0001), had lower odds of developing systemic lupus erythematosus (SLE) (0.366% vs 0.437%, odds ratio [OR] 0.837; P = 0.0005) and systemic sclerosis (0.108% vs 0.135%, OR 0.796; P = 0.0151), and had higher odds of developing rheumatoid arthritis (RA) (2.194% vs 1.752%, OR 1.258; P < 0.0001 with hazard ratio 1.746; P < 0.0001). …”
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YKL-40 as a Novel Factor Associated with Inflammation and Catabolic Mechanisms in Osteoarthritic Joints by Tuija Väänänen, Anna Koskinen, Erja-Leena Paukkeri, Mari Hämäläinen, Teemu Moilanen, Eeva Moilanen, Katriina Vuolteenaho

“…YKL-40 is associated with tissue injury and inflammation, and consequently to diseases in which these mechanisms lead to tissue degradation, for example, asthma and rheumatoid arthritis. The purpose of the present study was to investigate if YKL-40 is also a significant factor in osteoarthritis (OA) by assessing associations of YKL-40 with mediators related to the pathogenesis of OA: cartilage destructing matrix metalloproteinases (MMPs) and proinflammatory cytokines interleukin-6 (IL-6) and interleukin-17 (IL-17). …”
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In Vivo PET Imaging of the Activated Immune Environment in a Small Animal Model of Inflammatory Arthritis by Benjamin L. Franc MD, MS, Sam Goth PhD, John MacKenzie MD, Xiaojuan Li PhD, Joseph Blecha MS, Tina Lam MS, Salma Jivan BS, Randall A. Hawkins MD, PhD, Henry VanBrocklin PhD

“…Background: Evolving immune-mediated therapeutic strategies for rheumatoid arthritis (RA) may benefit from an improved understanding of the complex role that T-cell activation plays in RA. …”
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Integrating electronic health records and GWAS summary statistics to predict the progression of autoimmune diseases from preclinical stages by Chen Wang, Havell Markus, Avantika R. Diwadkar, Chachrit Khunsriraksakul, Laura Carrel, Bingshan Li, Xue Zhong, Xingyan Wang, Xiaowei Zhan, Galen T. Foulke, Nancy J. Olsen, Dajiang J. Liu, Bibo Jiang

“…We derive PRS for the progression from preclinical rheumatoid arthritis and systemic lupus erythematosus in the BioVU biobank and validate them in All of Us. …”
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VDR Polymorphisms in Autoimmune Connective Tissue Diseases: Focus on Italian Population by Andrea Latini, Giada De Benedittis, Carlo Perricone, Serena Colafrancesco, Paola Conigliaro, Fulvia Ceccarelli, Maria Sole Chimenti, Lucia Novelli, Roberta Priori, Fabrizio Conti, Cinzia Ciccacci, Paola Borgiani

“…We analyzed three VDR polymorphisms in 695 Italian patients with autoimmune connective tissue diseases (308 with systemic lupus erythematosus (SLE), 195 with primary Sjogren’s syndrome (pSS), and 192 with rheumatoid arthritis (RA)) and in 246 healthy controls with the aim to evaluate a possible association of VDR SNPs with susceptibility to these diseases in the Italian population. …”
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Modulatory Effect of 1,25-Dihydroxyvitamin D3 on IL1β-Induced RANKL, OPG, TNFα, and IL-6 Expression in Human Rheumatoid Synoviocyte MH7A by Xiaoke Feng, Chengyin Lv, Fang Wang, Ke Gan, Miaojia Zhang, Wenfeng Tan

“…Receptor activator of nuclear factor κB ligand (RANKL) plays a crucial role in the bone erosion of rheumatoid arthritis (RA) by prompting osteoclastogenesis. …”
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Therapeutic Effects of the Superoxide Dismutase Mimetic Compound Me2DO2A on Experimental Articular Pain in Rats by Lorenzo Di Cesare Mannelli, Daniele Bani, Andrea Bencini, Maria Luisa Brandi, Laura Calosi, Miriam Cantore, Anna Maria Carossino, Carla Ghelardini, Barbara Valtancoli, Paola Failli

“…Superoxide anion () is overproduced in joint inflammation, rheumatoid arthritis, and osteoarthritis. Increased production leads to tissue damage, articular degeneration, and pain. …”
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Enhanced effect of the immunosuppressive soluble HLA-G2 homodimer by site-specific PEGylation by Chisato Yamada, Kimiko Kuroki, Naoyoshi Maeda, Hiroshi Watanabe, Ami Takahashi, Katsumi Maenaka

“…The administration of the ectodomain of HLA-G2, designated the soluble HLA-G2 homodimer, showed significant immunosuppressive effects in mouse models of rheumatoid arthritis and systemic lupus erythematosus, presumably by binding to a mouse ortholog of LILRB2, paired immunoglobulin-like receptor B. …”
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Paucity of viral infection symptoms in patients with immune-mediated inflammatory diseases by Carola Berking, Georg Schett, Andreas Ramming, Raja Atreya, Markus F Neurath, Bernhard Manger, Filippo Fagni, Arnd Kleyer, Milena L Pachowsky, Axel J Hueber, Stefan Kleinert, Karin Manger, Florian Schuch, Monika Ronneberger, David Simon, Michael Sticherling, Koray Tascilar, Christine Meder, Moritz Leppkes, Peter Dietrich, Verena Schoenau, Daniela Bohr, Fabian Hartmann, Selahattin Alp Temiz, Ioanna Minopoulou, Louis Schuster, Melek Yalcin Mutlu, Gerhard Kroenke, Till Orlemann, Johanna Mößner

“…Patients with rheumatoid arthritis were overrepresented in the lower-frequency subclusters of the intermediate and oligo-/asymptomatic clusters. …”
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A versatile platform based on matrix metalloproteinase-sensitive peptides for novel diagnostic and therapeutic strategies in arthritis by Mingyang Li, Tao Deng, Quan Chen, Shenghu Jiang, Hang Li, Jiayi Li, Shenglan You, Hui-qi Xie, Bin Shen

“…Specifically, the ultra-sensitive MSP diagnostic probes could significantly advance the early diagnosis and detection of osteoarthritis (OA), while MSP-based drug carriers for rheumatoid arthritis (RA) can intelligently release anti-inflammatory drugs effectively during flare-ups, or even before symptoms manifest. …”
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Eosinophilia predicts poor clinical outcomes in recent-onset arthritis: results from the ESPOIR cohort by Sandrine Jousse-Joulin, Alain Saraux, Thierry Marhadour, Divi Cornec, Gilles Chiocchia, Valérie Devauchelle-Pensec, Gabriel J Tobón, Dewi Guellec, Morgane Milin, Olivier Vittecocq

“…Objectives To determine the prevalence of eosinophilia in patients with recent-onset arthritis suggestive of rheumatoid arthritis (RA) and to describe their features and outcomes.Methods We performed an ancillary study of data from a French prospective multicentre cohort study monitoring clinical, laboratory and radiographic data in patients with inflammatory arthritis of 6 weeks to 6 months duration. …”
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Do all patients with rheumatic Diseases have a higher risk of COVID 19? Initial results from the Karnataka Rheumatology Association COVID 19 Cohort Study (KRACC) by Vineeta Shobha, K Chanakya, Vikram Haridas, Sharath Kumar, Pramod Chebbi, Benzeeta Pinto, Vikramraj Jain, Subramaniam Ramaswamy, Shiv Prasad, Abhishek Patil, Vijay K Rao, G C Yathish, B G Dharmanand, Ramesh Jois, Ashwini Kamath, Chethana Dharmapalaiah, K N Sangeeta, Ramya Janardana, C Srinivasa, A S Harshini, Nagaraj Srinivasulu, Yogesh Preet Singh, Shweta Singhai, K M Mahendranath, S Chandrashekara

“…Results: Among 3807 participants, the majority were women (2.9:1), mean age was 43.8 (+14.3) years, rheumatoid arthritis (52.1%), and systemic lupus erythematosus (14.8%) were the most frequent diagnosis. …”
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Description of a new surgical approach for elbow arthroplasty: Selective Triceps-On Medial Paraolecranon (STOMP) approach by Carlos Prada, MD, Sirat Khan, MBBS, PhD, Thomas Goetz, MD, Bashar Alolabi, MD, MSc

“…The main indications leading to elbow arthroplasty was rheumatoid arthritis (n = 18, 49%) followed by primary or secondary elbow osteoarthritis (n = 9, 24%) and distal humeral fracture (n = 7, 19%). …”
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Causal association between non-thyroidal autoimmune diseases and Graves' ophthalmopathy: A mendelian randomization study by Lan Ma, Xue Jiang, Zhijia Hou, Dongmei Li

“…Materials: Single nucleotide polymorphisms (SNPs) associated with inflammatory bowel disease (IBD), multiple sclerosis (MS), psoriasis vulgaris (PV), type 1 diabetes (T1D), systemic lupus erythematosus (SLE), and rheumatoid arthritis (RA) were obtained from the IEU Open genome-wide association studies (GWAS) database, GWAS data for GO were obtained from the FinnGen database. …”
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Association of real life postural transitions kinematics with fatigue in neurodegenerative and immune diseases by Robbin Romijnders, Arash Atrsaei, Rana Zia Ur Rehman, Lea Strehlow, Jèrôme Massoud, Chloe Hinchliffe, Victoria Macrae, Kirsten Emmert, Ralf Reilmann, C. Janneke van der Woude, Geert Van Gassen, Frédéric Baribaud, Teemu Ahmaniemi, Meenakshi Chatterjee, Bruno Kusznir Vitturi, Clémence Pinaud, Jérôme Kalifa, Stefan Avey, Wan-Fai Ng, Clint Hansen, Nikolay V. Manyakov, Walter Maetzler

“…This study investigates the relationship between sit-to-stand and stand-to-sit transitions and self-reported physical and mental fatigue in participants with Parkinson’s, Huntington’s, rheumatoid arthritis, systemic lupus erythematosus, primary Sjögren’s syndrome and inflammatory bowel disease. …”
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Prevalence, influencing factors, and prediction model construction of anemia in ankylosing spondylitis based on real-world data: An exploratory study. by Yifan Gong, Kun Yang, Zhaoyang Geng, Hongxiao Liu

“…<h4>Methods</h4>In November 2023, we accessed the database from China Rheumatoid Arthritis Registry of Patients with Chinese Medicine (CERTAIN). …”
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