Epstein-Barr Virus- (EBV-) Immortalized Lymphoblastoid Cell Lines (LCLs) Express High Level of CD23 but Low CD27 to Support Their Growth by Hooi-Yeen Yap, Thin-Sam Siow, Sook-Khuan Chow, Sin-Yeang Teow

“…This study demonstrates the generation of 15 LCLs from sixteen rheumatoid arthritis (RA) patients and a healthy volunteer using B95-8 marmoset-derived EBV. …”
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Regulation of fibronectin and collagens type I, III and VI by TNF-α, TGF-β, IL-13, and tofacitinib by Frederik S. Gillesberg, Martin Pehrsson, Anne-Christine Bay-Jensen, Peder Frederiksen, Morten Karsdal, Bent W. Deleuran, Tue W. Kragstrup, Satoshi Kubo, Yoshiya Tanaka, Joachim H. Mortensen

“…The in vitro findings were supported by clinical observations in patients with active rheumatoid arthritis, which had elevated serum type III collagen formation, indicating ongoing fibrogenesis during inflammation. …”
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Natural Killer T (NKT) Cells and Periodontitis: Potential Regulatory Role of NKT10 Cells by Samanta Melgar-Rodríguez, Emilio A. Cafferata, Nicolás I. Díaz, Miguel A. Peña, Luis González-Osuna, Carolina Rojas, Alfredo Sierra-Cristancho, Angélica M. Cárdenas, Jaime Díaz-Zúñiga, Rolando Vernal

“…Although the tissue-specific functions of NKT cells have not been fully elucidated, their activity has been associated with the pathogenesis of different inflammatory diseases with immunopathogenic similarities to periodontitis, including osteolytic pathologies such as rheumatoid arthritis and osteoporosis. In the present review, we revise and discuss the pathogenic characteristics of NKT cells in these diseases and their role in the pathogenesis of periodontitis; particularly, we analyze the potential regulatory role of the IL-10-producing NKT10 cells.…”
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Diagnostic Algorithm for Joint Pain in Patients with Inflammatory Bowel Disorders by A. I. Dolgushina, G. M. Khusainova, O. B. Nesmeyanova, N. V. Kirsh, O. V. Solovieva, E. A. Bogdanova

“…Use of a diagnostic algorithm allowed concomitant rheumatic disease detection in 7 (7.2%) patients from the IBD–joint pain cohort: 2 patients were diagnosed with psoriatic spondyloarthritis, 2 — rheumatoid arthritis, 1 — gout and 2 — with ankylosing spondylitis. …”
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Collapsing glomerulopathy associated with parvovirus B19 and systemic lupus erythematosus in a patient with APOL1 high-risk variant for nephropathy by Thaíza Passaglia Bernardes, Thalita Alvarenga Ferradosa Paula, Gabriel Teixeira Montezuma Sales, Patrícia Varela Calais, Renato Demarchi Foresto, Luiz Antonio Moura, Marcelino de Souza Durão Junior, João Bosco Pesquero, Gianna Mastroianni Kirsztajn

“…A 35-year-old woman with recent use of a JAK inhibitor due to rheumatoid arthritis presented with a 2-week history of fever, cervical adenopathy, and facial erythema. …”
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Chloroplast genome characteristics and phylogenetic analysis of Macropanax rosthornii (Harms) C.Y. Wu ex G. Hoo (Araliaceae) by Shuxin Du, Huiying Huang, Shuhui Yang, Tianyi Gu, Mengli Zhou, Ruihong Wang

“…M. rosthornii is a kind of high-quality wild ornamental plant resource and is also known for its effective medicinal treatment for fracture, rheumatoid arthritis, traumatic injury, infant malnutrition, etc. …”
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In situ forming gels as subcutaneous delivery systems of curcumin and piperine by Walter Pula, Alessia Pepe, Francesca Ferrara, Agnese Bondi, Paolo Mariani, Maria Grazia Ortore, Alessandra Pecorelli, John Ivarsson, Giuseppe Valacchi, Elisabetta Esposito

“…Abstract In this study an in situ forming gel for curcumin and piperine delivery is investigated as a long-lasting strategy in the local treatment of inflammatory and degenerative joint disease, such as osteoarthritis and rheumatoid arthritis. Particularly glyceryl monooleate, in association with phosphatidylcholine and ethanol, were employed. …”
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Prevalence of Fracture Risk Factors in Postmenopausal Women Enrolled in the POSSIBLE US Treatment Cohort by Nicole Yurgin, Sally Wade, Sacha Satram-Hoang, David Macarios, Marc Hochberg

“…RFs assessed at study entry were age >70 years; fracture since age 50; minimum T-score (hip/spine) ≤−2.5 at diagnosis; body mass index <18.5 kg/m2; rheumatoid arthritis; parental history of hip fracture; current smoking; and recent oral glucocorticoid use. …”
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A Rare Case of Acute Methotrexate Toxicity Leading to Bone Marrow Suppression by Samreen Khuwaja, Matthew Lyons, Beenish Zulfiqar

“…A 76-year-old male patient presented with oral ulcers, poor oral intake, and acute kidney injury within 3 weeks of initiating 15 mg weekly of methotrexate for seronegative rheumatoid arthritis. Complete blood count was suggestive of pancytopenia with hemoglobin of 10.8 g/dL, total white cell count 3.36 (1000/uL) (absolute neutrophil count 490 micro/L), platelets 19,000, serum albumin 3.1 g/dL, ESR elevated at 83 mm/hr, CRP elevated at 86.6 mg/L, and ferritin mildly elevated at 625 ng/mL. …”
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Diagnostic performance of optical spectral transmission compared to magnetic resonance imaging in patients with inflammatory arthritis by Konstantinos Triantafyllias, Mohammed Alhaddad, Andreas Schwarting, Veronika Balaklytska, Xenofon Baraliakos

“…MRI findings were quantified using the Rheumatoid Arthritis MRI Score (RAMRIS). Diagnostic accuracy of OST was evaluated using Receiver Operating Characteristics (ROC), while correlation analyses were conducted to explore relationships between OST and MRI, as well as disease activity markers. …”
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IL-21 Receptor Expression in Human Tendinopathy by Abigail L. Campbell, Nicola C. Smith, James H. Reilly, Shauna C. Kerr, William J. Leach, Umberto G. Fazzi, Brian P. Rooney, George A. C. Murrell, Neal L. Millar

“…The IL-21/IL-21R axis is a proinflammatory cytokine complex that has been associated with chronic inflammatory diseases including rheumatoid arthritis and inflammatory bowel disease. This project aimed to investigate the role and expression of the cytokine/receptor pair IL-21/IL-21R in human tendinopathy. …”
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Clinical Observation of Employment of Umbilical Cord Derived Mesenchymal Stem Cell for Juvenile Idiopathic Arthritis Therapy by Liming Wang, Yu Zhang, Hongtao Li, Jingxin Hong, Xiaobo Chen, Ming Li, Wen Bai, Jiangang Wang, Yongjun Liu, Mingyuan Wu

“…Juvenile idiopathic arthritis (JIA), known as Juvenile rheumatoid arthritis, is the most common type of arthritis in children aged under 17. …”
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The impact of uric acid on musculoskeletal diseases: clinical associations and underlying mechanisms by Jing Zhang, Na Sun, Wanhao Zhang, Wenjie Yue, Xiaochen Qu, Xiaochen Qu, Zhonghai Li, Zhonghai Li, Gang Xu, Gang Xu

“…Recently, due to the high prevalence of hyperuricemia (HUA), numerous clinical connections between SU and musculoskeletal disorders like sarcopenia, osteoarthritis (OA), rheumatoid arthritis (RA), intervertebral disc degeneration (IDD), and osteoporosis (OP) have been identified. …”
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Triptolide Inhibits Osteoclast Differentiation and Bone Resorption In Vitro via Enhancing the Production of IL-10 and TGF-β1 by Regulatory T Cells by Huihui Xu, Hongyan Zhao, Cheng Lu, Qi Qiu, Gui Wang, Jing Huang, Minghui Guo, Baosheng Guo, Yong Tan, Cheng Xiao

“…Triptolide, a purified component of Tripterygiumwilfordii Hook F, has been shown to have immunosuppressive and anti-inflammatory properties in rheumatoid arthritis (RA). Although triptolide has demonstrated that it could suppress bone destruction in collagen-induced mice, its therapeutic mechanism remains unclear. …”
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Real life experience of a screening strategy for latent tuberculosis before treatment with biologicals in indian patients with rheumatic diseases by Anand N Malaviya, Ravita Thakaran, Roopa Rawat, Sanjiv Kapoor, Shriram Garg, Sadhana S Baghel, Christy Messi, Vivekanand, Qamar Zaheer

“…Results: A total of 730 patients (265 rheumatoid arthritis, 400 axial spondyloarthritis [axSpA], 34 psoriatic arthritis, and 31 others) were considered for bDMARDs. …”
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The Identification of Key Genes and Pathways in Glioma by Bioinformatics Analysis by Mingfa Liu, Zhennan Xu, Zepeng Du, Bingli Wu, Tao Jin, Ke Xu, Liyan Xu, Enmin Li, Haixiong Xu

“…PPI network and module analysis found 12 hub genes, which were enriched in synaptic vesicle cycling rheumatoid arthritis and collecting duct acid secretion. …”
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Circulating CD3+HLA-DR+ Extracellular Vesicles as a Marker for Th1/Tc1-Type Immune Responses by Ryutaro Oba, Motomichi Isomura, Akira Igarashi, Kinya Nagata

“…To evaluate the clinical usefulness of these EVs, we measured the serum levels in patients with inflammatory diseases, including Epstein-Barr virus (EBV, n=13) infection, atopic dermatitis (AD, n=10), rheumatoid arthritis (RA, n=20), and osteoarthritis (OA, n=20) and compared the levels with those of healthy adults (n=20). …”
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IL-1β and IL-6 Are Highly Expressed in RF+IgE+ Systemic Lupus Erythematous Subtype by Yongkang Wu, Bei Cai, Junlong Zhang, Beilei Shen, Zhuochun Huang, Chunyu Tan, Carla C. Baan, Lanlan Wang

“…Rheumatoid factor (RF) is one key indicator for rheumatoid arthritis (RA) while immunoglobulin E (IgE) is associated with type I hypersensitivity. …”
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Disruption of Gut Microbiota and Associated Fecal Metabolites in Collagen-Induced Arthritis Mice During the Early Stage by Wu D, Yin M, Cao D, Zhang X, Zhu Y, Wei Y, Li Y, Wen C, Zhou J

“…Dehong Wu,1,&ast; Mengdi Yin,2,&ast; Dandan Cao,2,&ast; Xiafeng Zhang,2 Yichun Zhu,2 Ying Wei,2 Yiling Li,2 Chengping Wen,2 Jia Zhou2 1Department of Rheumatology, The Second Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, Zhejiang, 310005, People’s Republic of China; 2Institute of Basic Research in Clinical Medicine, College of Basic Medical Sciences, Zhejiang Chinese Medical University, Hangzhou, 310053, People’s Republic of China&ast;These authors contributed equally to this workCorrespondence: Jia Zhou; Chengping Wen, Email zhoujia@zcmu.edu.cn; chengpw2010@126.comBackground: Rheumatoid arthritis (RA) is a chronic autoimmune disease and increasing evidence suggests that disturbances in the composition and function of gut microbiota are potentially implicated in the progression of RA. …”
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The Role of Yersinia enterocolitica O:3 Lipopolysaccharide in Collagen-Induced Arthritis by Katarzyna Kasperkiewicz, Anna S. Świerzko, Marta Przybyła, Janusz Szemraj, Jarosław Barski, Mikael Skurnik, Andrzej Kałużyński, Maciej Cedzyński

“…Having an adjuvant activity, LPS may enhance production of anticollagen antibodies, involved in the pathogenesis of rheumatoid arthritis. Furthermore, its ability to activate complement contributes to the inflammation. …”
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