Should We Adopt Increased Dilutions for Indirect Immunofluorescence in Pediatric Anti-Centromere Antibody Testing? Insights from a Three-Year Retrospective Study by Mehmet Soylu, Raziye Burcu Taşkın, Gülçin Aytaç, Güzide Aksu, Seyfi Durmaz, Miray Karakoyun, Şaziye Rüçhan Sertöz

“…Background/Objectives: Systemic autoimmune rheumatic diseases (SARDs) pose diagnostic challenges, particularly in pediatric populations, due to their diverse presentations and overlapping symptoms. …”
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Systemic Immune-inflammation Index in Evaluation of Inflammation in Rheumatoid Arthritis Patients by Amela DERVISEVIC, Almir FAJKIC, Elmedina JAHIC, Lejla DERVISEVIC, Zurifa AJANOVIC, Enisa ADEMOVIC, Asija ZACIRAGIC

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Serological Immunoglobulin-Free Light Chain Profile in Myasthenia Gravis Patients by Umberto Basile, Mariapaola Marino, Cecilia Napodano, Krizia Pocino, Paolo Emilio Alboini, Francesca Gulli, Amelia Evoli, Carlo Provenzano, Emanuela Bartoccioni

“…We assessed FLC levels in 34 sera from 17 AChR-MG and from 13 MuSK-MG patients, in comparison with 20 sera from patients with systemic autoimmune rheumatic diseases and 18 from healthy blood donors, along with titers of specific auto-abs and IgG subclass distribution. …”
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Identification of nuclear valosin-containing-protein-like as a target of anti-nuclear autoantibodies in systemic sclerosis by Zitao Zeng, Ramona Miske, Madeleine Scharf, Yvonne Denno, Anthonina Ott, Stefanie Brakopp, Bianca Teegen, Winfried Stöcker, Elise Siegert, Elise Siegert, Sandra Saschenbrecker, Christian Probst, Lars Komorowski

“…The prevalence of autoantibodies against this antigen was studied in 693 patients with systemic autoimmune rheumatic diseases (SARD) and 150 healthy controls.ResultsThe index patient serum displayed a homogeneous nucleolar staining pattern on HEp-2 cells and monkey liver by IFA but did not react with 27 known nuclear antigens. …”
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Genetic Polymorphisms of Toll-like receptors 2 and 9 as Susceptibility Factors for the Development of Ankylosing Spondylitis and Psoriatic Arthritis by Camila F. Oliveira-Toré, Amarilis G. Moraes, Gabriela F. Martinez, Janisleya S. F. Neves, Luciana C. Macedo, Marco A. Rocha-Loures, Marília G. Quirino, Hugo V. Alves, Ana M. Sell, Jeane E. L. Visentainer

“…Ankylosing spondylitis (AS) and psoriatic arthritis (PsA) are classified as spondyloarthritis (SpA), a group of inflammatory rheumatic diseases with complex genetic etiology. Toll-like receptors (TLRs) have an important role in the mechanism of innate immunity and may influence inflammatory responses. …”
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Circulating Adipokines and Response to Treatment in Patients With Early Rheumatoid Arthritis by Georgios K. Vasileiadis, Yuan Zhang, Tahzeeb Fatima, Ronald van Vollenhoven, Jon Lampa, Bjorn Gudbjornsson, Espen A. Haavardsholm, Dan Nordström, Gerdur Grondal, Kim Hørslev‐Petersen, Kristina Lend, Marte S. Heiberg, Merete Lund Hetland, Michael Nurmohamed, Till Uhlig, Tuulikki Sokka‐Isler, Anna Rudin, Cristina Maglio

“…Methods This study included 341 participants of the Nordic Rheumatic Diseases Strategy Trials and Registries trial with untreated early RA, randomized at baseline into four treatment arms: methotrexate combined with (1) prednisolone, (2) certolizumab, (3) abatacept, or (4) tocilizumab. …”
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Role of Positron Emission Tomography-Computed Tomography Scan in Reaching Definite Diagnosis in Patients With Fever of Unknown Origin and Inflammation of Unknown Origin in Rheumato... by Koreli UY, Torun ES, Adaş M

“…Majority of the definite diagnoses were rheumatic diseases with a very low proportion of infections and malignancies. …”
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Genetic Predictors of Poor Prognosis in Portuguese Patients with Juvenile Idiopathic Arthritis: Data from Reuma.pt by Ana Filipa Mourão, Maria José Santos, Sílvia Mendonça, Filipa Oliveira-Ramos, Manuel Salgado, Paula Estanqueiro, José Melo-Gomes, Fernando Martins, Ana Lopes, Bruno Filipe Bettencourt, Jácome Bruges-Armas, José Costa, Carolina Furtado, Ricardo Figueira, Iva Brito, Jaime Branco, João Eurico Fonseca, Helena Canhão

“…Our study was conducted in Reuma.pt, the Rheumatic Diseases Portuguese Register, which includes patients with JIA. …”
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Risk factors for Clostridioides difficile infection among patients diagnosed with inflammatory intestinal and rheumatological diseases in the biologic era by Helena Martínez-Lozano, Paula Saralegui-Gonzalez, Elena Reigadas, Pablo Ramón Fueyo-Peláez, Aurea García-García, José Miranda-Bautista, Luis Alcalá, Juan Carlos Nieto, María Elena Lobato-Matilla, Ignacio Marín-Jiménez, Patricia Muñoz, Luis Menchén

“…Methods We included patients diagnosed with IBD (IBD-cohort) and immune-mediated inflammatory rheumatic diseases (Rheuma-cohort). Risk factors for CDI were assessed using a logistic regression model. …”
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Long-term safety and sustained efficacy of bimekizumab in patients with ankylosing spondylitis (radiographic axial spondyloarthritis): 5-year results from BE AGILE (phase 2b) and i... by Sofia Ramiro, Désirée van der Heijde, Atul Deodhar, Xenofon Baraliakos, Denis Poddubnyy, Lianne S Gensler, Helena Marzo-Ortega, Natasha de Peyrecave, Victoria Navarro-Compán, Tetsuya Tomita, Carmen Fleurinck, Ute Massow, Thomas Vaux

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Early Postoperative Safety of Total Hip Arthroplasty in Systemic Lupus Erythematosus Patients by YANG Xingdong, YU Muyang, XU Yiming, ZHU Wei, HU Mingwei, WENG Xisheng, FENG Bin

“…After propensity score matching, 163 cases from SLE and control groups were included for analysis. (1) Regarding medical complications, compared with control group, SLE group showed significant differences in osteoporosis, respiratory system disorders, gastrointestinal diseases, urinary system disorders, hematologic abnormalities, and secondary or concomitant rheumatic diseases (all P < 0.05). (2) In terms of preoperative laboratory tests, SLE group had lower platelet counts, absolute lymphocyte counts, hemoglobin levels, hematocrit, albumin levels, blood glucose levels, and activated partial thromboplastin times than control group, while C-reactive protein, erythrocyte sedimentation rate, and D-dimer levels were higher (all P < 0.05). (3) Regarding surgical-related indicators, a higher proportion of patients in SLE group had an ASA grade > 2 (15.95% vs. 3.07%, P < 0.001), but intraoperative blood loss was significantly smaller [324.7 (200.0, 500.0) mL vs. 421.8 (200.0, 500.0) mL, P=0.005]. (4) In terms of complications, SLE group exhibited a significantly higher incidence of major complications than control group (8.59% vs. 1.23%, P=0.005), with a relative risk of 1.081 (95% CI: 1.028-1.136). …”
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Circulating Baseline CXCR3+Th2 and Th17 Cell Proportions Correlate With Trabecular Bone Loss After 48 Weeks of Biological Treatment in Early Rheumatoid Arthritis by Julia M. Scheffler, Christina Drevinge, Catharina Lindholm, Inger Gjertsson, Kristina Lend, Merete Lund Hetland, Mikkel Østergaard, Till Uhlig, Marte Schrumpf Heiberg, Espen A. Haavardsholm, Michael T. Nurmohamed, Jon Lampa, Tuulikki Sokka‐Isler, Dan Nordström, Kim Hørslev‐Petersen, Bjorn Gudbjornsson, Gerdur Gröndal, Ronald vanVollenhoven, Hans Carlsten, Mattias Lorentzon, Anna‐Karin Hultgård Ekwall, Anna Rudin, Ulrika Islander

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Meeting Report on “The International Congress on Autoimmune Pre-disease (2024)” by Justus Ohmes, Afsaneh Mehrpouyan, Julia Wimmer-Groß, Abdul Razzaque Ahmed, Kyle T. Amber, Swayanka Biswas, Angela Christiano, Shirin Emtenani, Stephanie Goletz, Jennifer Elisabeth Hundt, Laura Kirchhoff, Khalaf Kridin, Julie Lasselin, Matthias Laudes, Wing Yu Lee, Ralf J. Ludwig, Sripriya Murthy, Sadegh Mousavi, Tamas Nemeth, Mareike Neumann, Isa Popken, Rochi Saurabh, Alessia Maria Sbaraglia, Jovan Schanzenbacher, Carolin Schmidt, Leon F. Schmidt-Jimènez, Christian Willi Scheiner, Mareile Schlotfeldt, Nora Schoell, Farbod Bahreini, Sarah Stenger

“…The event featured various talks and posters from young researchers and international experts and emphasized early interventions and prevention in autoimmune diseases with a focus on systemic rheumatic diseases, pemphigus, and pemphigoid diseases.…”
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Trends to shorter diagnostic delay in spondyloarthritis patients during the last decades and association with clinical presentation: data from ASAS-COMOSPA study by Robert Landewé, Désirée van der Heijde, Filip van den Bosch, Maxime Dougados, Anna Molto, Stefan Siebert, Juergen Braun, Yuko Kaneko, Adeline Ruyssen-Witrand, Martin Soubrier, Atsuo Taniguchi, Masato Okada, Alain Cantagrel, Shigeto Kobayashi, Jon Packham, Philippe Goupille, Rene-Marc Flipo, Alain Saraux, Philippe Gaudin, Roberto Caporali, Raj Sengupta, James Cheng-Chung Wei, Tetsuya Tomita, Fernando Pimentel-Santos, Alberto Ortiz, Gaëlle Varkas, Alejandro Martínez, Shigeyoshi Tsuji, Alejandro Alvarellos, José Maldonado-Cocco, Yoshinori Taniguchi, Fadoua Allali, Raquel Almodovar González, Elena Alonso Blanco-Morales, Maria Aparicio Espinar, Pamir Atagunduz, Pauline Bakker, Leila Benbrahim, Bahia Benchekroun, Alberto Berman, Pedro Carvalho, Gustavo Casado, Francisco Colombres, Eugenio del Miguel Mendieta, Vanesa Duarte, Cristina Fernandez Carballido, Manuel Fernandez-Prada, Pilar Font Ugalde, Dolors Grados Cánovas, Jordi Gratacós Masmitjá, Vittorio Grosso, Naomi Ichikawa, Hisashi Inoue, Taku Kawasaki, Manjari Lahiri, Hernán Maldonado-Ficco, Kazuo Matsui, Ramón Mazzuchelli Esteban, Corinne Micelli, Chisun Min, Mitsuhiro Morita, Juan Mulero Mendoza, Gisela Pendón, Dora Pereira, Hanan Rkain, Oscar Rillo, Carlos Rodriguez Lozano, Adrián Salas, Carlos Salinas-Ramos, Amelia Santosa, Caroline Spiegel, Carmen Stolwijk, Kurisu Tada, Naoho Takizawa, Chung Tei Chou, Lay-Keng Teoh, Wen-Chan Tsai, Olga Tsyplenkova, Kiana Vakil-Gilani, Rafael Valle-Oñate, Virginia Villaverde, Ai Yap, Pedro Zarco Montejo, Juan C Barreira, Juan D Diaz-Garcia, Michel De Bandt, Astrid van Tubergen, Rodolfo Pérez-Alamino, T Marhadour, Christian Waimann, Mari CruzFernandez Espartero, Jose Raul NogueraPons, José A PereiradaSilva

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Impact of glucocorticoids on patients’ quality of life: a qualitative study assessing face validity and feasibility of the Steroid PRO in patients with inflammatory gastroenterolog... by Shaney L Barratt, Emma Dures, Mwidimi Ndosi, Michelle Sharp, Sebastian E Sattui, Jill Dawson, Susan M Goodman, Sarah L Mackie, Tom Creed, Catherine L Hill, Joanna C Robson, Pamela Richards, Susan Bridgewater, Christine A Silverthorne, Jen Orme, Anne-Marie T Sweeney, Elizabeth Arthurs, Genevieve Osborne, Giles Dunhill, Richard P Ramonell, Timothy Patton

“…Initially developed and validated in rheumatic diseases, the Steroid PRO demonstrates potential for broader application in patients with other inflammatory conditions. …”
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Application of PET/CT in the differential diagnosis of SAPHO syndrome mimicking metastatic cervical spine tumors by Changjun Chen, Dayong Peng, Wenping Pan, Meng Chen

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Collagenous Colitis and Spondylarthropathy by Kaouther Ben Abdelghani, Hana Sahli, Leila Souabni, Selma Chekili, Salwa Belhadj, Selma Kassab, Ahmed Laatar, Leith Zakraoui

“…This association suggests a systemic kind of rheumatic disease of collagenous colitis.…”
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A Short Version of the Pain Anxiety Symptoms Scale (PASS-20): Preliminary Development and Validity by Lance M McCracken, Lara Dhingra

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Evaluation of comorbidity burden on disease progression and mortality in patients with interstitial pneumonia with autoimmune features: A retrospective cohort study. by Elena K Joerns, Michelle A Ghebranious, Traci N Adams, Una E Makris

“…This study was conducted to evaluate the association of individual comorbidities, the Charlson Comorbidity Index (CCI), and the Rheumatic Disease Comorbidity Index (RDCI) with lung disease progression and transplant/mortality outcomes in patients with IPAF.…”
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COVID-19: An Emerging Culprit of Inflammatory Arthritis by Muhammad Shariq Mukarram, Muhammad Ishaq Ghauri, Sehrish Sethar, Nasir Afsar, Amir Riaz, Khizra Ishaq

“…In this case series of 5 patients, we discuss the occurrence of bilaterally symmetrical polyarthritis in patients, previously free from any rheumatic disease, after encountering COVID-19 infection. …”
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