Developing a clinical prediction model to modify empirical antibiotics for non-typhoidal Salmonella bloodstream infection in children under-five in the Democratic Republic of Congo by Bieke Tack, Daniel Vita, Jules Mbuyamba, Emmanuel Ntangu, Hornela Vuvu, Immaculée Kahindo, Japhet Ngina, Aimée Luyindula, Naomie Nama, Tito Mputu, Justin Im, Hyonjin Jeon, Florian Marks, Jaan Toelen, Octavie Lunguya, Jan Jacobs, Ben Van Calster

“…Predictors were selected a priori based on systematic literature review. The prediction model was developed with multivariable logistic regression; a simplified scoring system was derived. …”
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Efficacy and safety of guanabenz acetate treatment for non-alcoholic fatty liver disease: a study protocol for a randomised investigator-initiated phase IIa study by Atsushi Nakajima, Yasushi Honda, Kento Imajo, Masato Yoneda, Yuji Ogawa, Takaomi Kessoku, Takashi Kobayashi, Anna Ozaki, Asako Nogami, Satoru Saito, Michihiro Iwaki, Kosuke Tanaka, Atsushi Yamamoto, Kota Takahashi, Yuki Kasai, Noritoshi Kobayashi

“…The results of this study will be submitted for publication in international peer-reviewed journals, and the key findings will be presented at international scientific conferences. …”
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Protocol for a phase IV double-blind randomised controlled trial to investigate the effect of the 13-valent pneumococcal conjugate vaccine and the 23-valent pneumococcal polysaccha... by Tao Chen, Duolao Wang, Konstantinos Liatsikos, Stephen B Gordon, Hassan Burhan, Ben Morton, Tinashe K Nyazika, Bradford D Gessner, Helen Hill, Andrea Collins, Josh Hamilton, Kelly Davies, Fred Fyles, Phoebe Hazenberg, Elizabeth Begier, Angela Hyder-Wright, Sherin Pojar, Christopher Myerscough, Jesus Reine, Ryan E Robinson, Britta Urban, Elena Mitsi, Carla Solorzano, Angela Quinn, Kaijie Pan, Annaliesa S Anderson, Christian Theilacker, Daniela M Ferreira, Kelly Convey, James Court, Madlen Farrar, Lisa Hitchins, Ashleigh Howard, Lauren Kerruish, Samuel Latham, Annabel Murphy, Elissavet Nikolaou, Angelina Peterson

“…Findings will be published in peer-reviewed journals.Trial registration number ISRCTN15728847, NCT04974294.…”
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Adaptive coping mechanisms use and associated factors among adult glaucoma patients attending the University of Gondar Comprehensive Specialized Hospital, Tertiary Eye Care and Tra... by Bisrat Misganaw Geremew, Biruk Fanta Alemayehu, Getenet Shumet Birhan, Biruk Lelisa Eticha, Mahtot Leykun Sisay, Woretaw Endalew Melese, Abebe Tilahun Mekonenne

“…Optometrists conducted interviews, reviewed medical records and administered a pretested, structured questionnaire based on the Brief Coping Orientation to Problems Experienced inventory. …”
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Prediction model study focusing on eHealth in the management of urinary incontinence: the Personalised Advantage Index as a decision-making aid by Huibert Burger, Henk van der Worp, Marco H Blanker, Marjolein Y Berger, Anne Martina Maria Loohuis, Nienke Wessels, Janny Dekker, Alec GGA Malmberg

“…Of the 350 screened women, 262 were eligible and randomised to app-based treatment or care as usual; 195 (74%) attended follow-up.Predictors Literature review and expert opinion identified 13 candidate predictors, categorised into two groups: Prognostic factors (independent of treatment type), such as UI severity, postmenopausal state, vaginal births, general physical health status, pelvic floor muscle function and body mass index; and modifiers (dependent on treatment type), such as age, UI type and duration, impact on quality of life, previous physical therapy, recruitment method and educational level.Main outcome measure Primary outcome was symptom severity after a 4-month follow-up period, measured by the International Consultation on Incontinence Questionnaire the Urinary Incontinence Short Form. …”
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Effect of photobiomodulation as preventive treatment of diabetic foot ulcer: randomised, controlled, double-blind, clinical trial protocol by Lara Jansiski Motta, Anna Carolina Ratto Tempestini Horliana, Kristianne Porta Santos Fernandes, Raquel Agnelli Mesquita-Ferrari, Sandra Kalil Bussadori, Roselene Lourenço, Silvana Torres Perez, Cinthya Cosme Gutierrez Duran, Alexandre Rocha Santos Padilha, Tainá Caroline dos Santos Malavazzi

“…The findings will be published in a peer-reviewed journal.Trial registration number NCT06353568, ClinicalTrials.gov.…”
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Adrenal hemorrhage in neonates: Incidence, perinatal characteristics and follow-up outcomes by Tek-Jū Tân, Yi-Li Hung, Chung-Min Shen, Wu-Shiun Hsieh

“…The perinatal characteristics and anthropometric measurements, the follow-up course and the clinical impact of NAH were reviewed in detail. Results: 7217 neonates had received abdominal ultrasonogram within seven days-of-life and 29 of them (0.4%) were diagnosed with NAH. …”
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Prognostic role of the pathological status following neoadjuvant chemoradiotherapy and surgery in esophageal squamous cell carcinoma by Xiaofeng Duan, Jie Yue, Shangren Wang, Fangdong Zhao, Wencheng Zhang, Shuo Qie, Hongjing Jiang

“…Methods Data of patients with cT2-4aN0-3 stage ESCC who underwent NCRT and esophagectomy during 2014–2022 were reviewed retrospectively. Survival differences were compared according to revised TN (rTN) stage (ypT0N0, ypT + N0, ypT0N+, and ypT + N+) using univariate and Cox regression analyses. …”
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Exploring Innovative Approaches for the Analysis of Micro- and Nanoplastics: Breakthroughs in (Bio)Sensing Techniques by Denise Margarita Rivera-Rivera, Gabriela Elizabeth Quintanilla-Villanueva, Donato Luna-Moreno, Araceli Sánchez-Álvarez, José Manuel Rodríguez-Delgado, Erika Iveth Cedillo-González, Garima Kaushik, Juan Francisco Villarreal-Chiu, Melissa Marlene Rodríguez-Delgado

“…Advancements in these innovative approaches pave the way for more accurate, scalable, and environmentally compatible detection solutions, contributing to improved monitoring and remediation strategies. This review highlights the potential of biosensors as advanced analytical methods, including a section on prospects that address the challenges that could lead to significant advancements in environmental monitoring, highlighting the necessity of testing the new sensing developments under real conditions (composition/matrix of the samples), which are often overlooked, as well as the study of peptides as a novel recognition element in microplastic sensing.…”
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Performance of HPV E4 and p16INK4a biomarkers in predicting regression of cervical intraepithelial neoplasia grade 2 (CIN2): protocol for a historical cohort study by David Jenkins, Mark H Stoler, Anne Hammer, Torben Steiniche, Lone Kjeld Petersen, Patti E Gravitt, Rikke Kamp Damgaard, Maurits NC de Koning, Wim GV Quint, John Doorbar, Johnny Kahlert

“…Results will be published in a peer-reviewed journal and presented at scientific meetings.Trial registration number NCT05049252.…”
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Myxedema Psychosis: Neuropsychiatric Manifestations and Rhabdomyolysis Unmasking Hypothyroidism by Sundus Sardar, Mhd-Baraa Habib, Aseel Sukik, Bashar Tanous, Sara Mohamed, Raad Tahtouh, Abdelrahman Hamad, Mouhand F. H. Mohamed

“…We report a case of myxedema psychosis and present a literature review discussing its presentation, diagnosis, management, and prognosis. …”
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Spectrum and Clinical Characteristics of Renal Diseases in Ghanaian Adults: A 13-Year Retrospective Study by Perditer Okyere, Isaac Okyere, Richard Kobina Dadzie Ephraim, Joseph Attakorah, Charlotte Osafo, Bernard Arhin, Sarah Bachelle, Albert Abaka-Yawson

“…A non-randomized sampling approach was used to include 1426 participants who were diagnosed with AKI, CKD, ESRD, and nephrotic syndrome at the nephrology unit of KATH during the years under review. All the 1426 patients were eligible for the study. …”
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Effect of prenatal multiple micronutrient supplementation on birth weight in Ethiopia: protocol for a pragmatic cluster-randomised trial by Joanna Schellenberg, Charles Opondo, Tanya Marchant, Lars Åke Persson, Masresha Tessema, Atkure Defar, Alemneh Kabeta Daba, Girum Taye, Senait Alemayehu, Elias Asfaw, Anene Tesfa, Bedasa Tessema, Kalkidan Zenebe

“…Facility surveys involving pregnant women and healthcare workers at baseline, midline and endline contribute to a process evaluation and cost and cost-effectiveness evaluation.Ethics and dissemination The study received ethical approval from the review boards at the Ethiopian Public Health Institute (EPHI-IRB-455-2022) and the London School of Hygiene & Tropical Medicine (LSHTM ref 28021). …”
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Hospital Financial Burden of Surgical Procedures for Periprosthetic Total Hip Arthroplasty Infection by Jesus M. Villa, MD, Tejbir S. Pannu, MD, MS, Robert B. Eysler, BA, Vivek Singh, MD, MPH, Alison K. Klika, MS, Carlos A. Higuera, MD

“…Methods: Retrospective chart review of 596 unilateral THA reoperations (473 patients) performed at a single institution (January 2015 to November 2020). …”
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Integrating BRCA testing into routine prostate cancer care: a multidisciplinary approach by SIUrO and other Italian Scientific Societies by Giulia Mammone, Simona Borghesi, Nicolò Borsellino, Anna Caliò, Roberta Ceccarelli, Alessia Cimadamore, Giario Natale Conti, Laura Cortesi, Rolando Maria D’Angelillo, Gaetano Facchini, Lorena Incorvaia, Alberto Lapini, Luigi Mearini, Giovanni Pappagallo, Paolo Prontera, Daniela Turchetti, Grazia Sirgiovanni, Sergio Bracarda, on behalf of the Italian Society of Uro-Oncology (SIUrO)

“…The proposed mini-counseling program outlined essential steps for patient identification, information provision, and multidisciplinary review, aiming to streamline BRCA testing processes. …”
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Global insights into MRSA bacteremia: a bibliometric analysis and future outlook by Jia-Yi Lin, Jia-Yi Lin, Jia-Kai Lai, Jia-Kai Lai, Jian-Yi Chen, Jian-Yi Chen, Jia-Yu Cai, Jia-Yu Cai, Zhan-Dong Yang, Zhan-Dong Yang, Liu-Qingqing Yang, Liu-Qingqing Yang, Liu-Qingqing Yang, Ze-Tao Zheng, Ze-Tao Zheng, Xu-Guang Guo, Xu-Guang Guo, Xu-Guang Guo

“…Despite extensive research, the rapid development of MRSA antibiotic resistance has outpaced current treatment methods, increasing the difficulty of treatment. Therefore, reviewing research on MRSA BSIs is crucial.MethodsThis study conducted a bibliometric analysis, retrieving and analyzing 1,621 publications related to MRSA BSIs from 2006 to 2024. …”
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Efficacy of contralateral acupuncture in women with migraine without aura: protocol for a randomised controlled trial by Ling Zhao, Qifu Li, Yanan Wang, Jialei Feng, Xinghe Zhang, Siwen Zhao, Chonghui Xing, Yongli Song, Xuanxiang Zeng, Meng Kong, Yunqiu Zheng, Taipin Guo

“…The results of this study will be published in a peer-reviewed journal and presented at conferences.Trial registration number Chinese Clinical Trial Registration Center (ChiCTR2100051479).…”
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Analysis of the efficacy and factors affecting the prognosis of intracranial dissecting aneurysm treated with multi-stent overlap technique by Xiaolin Li, Huojun Hu, Lei Wang, Gao Yuan, Changtao Fu, Jinyang Ma, Quan Shao, Zhao Kang

“…Methods Clinical data from 69 IDA patients treated with multistate-assisted spring coil embolization at the hospital between January 2017 and October 2023 were retrospectively reviewed, including clinical and imaging data gathered at admission and discharge. …”
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The role of gut microbiota in disease management: Ayurvedic perspectives on metabolic diseases and health by Bhawana Jangra, Shreyanshi Kulshreshtha, Alok Goyal, Sanjay M. Jachak

“…They are well documented and used for treating conditions like IBS, chronic diarrhoea, constipation, ulcerative colitis, Agnimandya (digestive impairment), Mandagni (impaired digestive fire) and other gut-related diseases. Purpose: This review is aimed at collecting scientific insights on gut health, focusing on traditional medicinal plants like Babool, Turmeric, Ashwagandha, Ghrit kumari, Tulsi, Harad, Baheda, Amala, and the Triphala formulation. …”
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Admission outcomes and their associated factors among children admitted to the paediatric emergency unit within 24 hours of Dilla University Referral Hospital, Ethiopia, 2023: a cr... by Binyam Tariku Seboka, Tomas Yeheyis, Yihenew Ayehu Dessie, Samuel Jigso Dube, Abel Desalegn Demeke, Mekdes Mekonnen Feleke, Abdo Hajo Jarso, Asresu Feleke Bati, Etaferaw Udo, Selam Tadele Markos, Chalachew Kassaw, Amdehiwot Aynalem Debebe, Ephrem Geja Gechere

“…Overall model fitness was checked using the likelihood ratio test.Result Out of 885 patient charts reviewed, the magnitude of patients improved, transferred, died, referred and discharged against medical advice was 51%, 40.9%, 7.6%, 0.1% and 0.4%, respectively. …”
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