Pathogenetic therapeutic approaches for endocrine diseases based on antisense oligonucleotides and RNA-interference by Olga Golounina, Ildar Minniakhmetov, Ramil Salakhov, Rita Khusainova, Ekaterina Zakharova, Igor Bychkov, Natalia Mokrysheva

“…The sequence-specific ASOs binding provides exceptional accuracy in N-of-1 approaches, when the oligonucleotide can be targeted to a patient’s exact mutant sequence. In this review we focus on diseases of the endocrine system and discuss potential RNA-targeted therapeutic opportunities in diabetes mellitus, including monogenic beta cell diabetes, and obesity, including syndrome obesity and monogenic obesity, as well as in non-monogenic or complex endocrine disorders. …”
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Prevalence and management of hypertension in Turner syndrome: data from the International Turner Syndrome (I-TS) registry by Shani A D Mathara Diddhenipothage, Katharina J Beck, Gayana Amiyangoda, Jillian Bryce, Luminita Cima, Katya De Groote, Yana Deyanova, Evgenia Globa, Gloria Herrmann, Anders Juul, Anna Sophie L Kjaer, Anette Tønnes Pedersen, Sukran Poyrazoglu, Ursina Probst-Scheidegger, Theo C J Sas, Simona Fica, Sumudu Nimali Seneviratne, Justyna Karolina Witczak, Elizabeth Orchard, Jeremy W Tomlinson, S Faisal Ahmed, Helen E Turner

“…Among patients with aortic disease (n = 9), 50% had systolic BP ≥ 130 mmHg and 66.6% had diastolic BP ≥ 80 mmHg during the last clinic review. Angiotensin-converting enzyme inhibitors were the most common (n = 16) medication prescribed, followed by angiotensin receptor blockers (n = 6), beta-blockers (n = 6) and calcium channel blockers (n = 6). …”
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Sociodemographic and Clinical Characteristics of Adolescents who Attempted Suicide and Differences in Clinical Characteristics Related to Tobacco, Alcohol, and Substance Use by Buket Canlan Özaydın, Mustafa Selahattin Yeşil, Börte Gürbüz Özgür, Hatice Aksu

“…The medical records of 237 adolescents referred from the pediatric emergency depart- ment to the child and adolescent psychiatry clinic for suicide attempts over the last 5 years were retrospec- tively reviewed. Clinical variables of adolescents with and without tobacco, alcohol, and substance use were compared. …”
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Drainage analysis on the Pondoktisuk Kebonkai Sta 1+700-1+800 road section, Nagrak District, Sukabumi Regency by Putranto Muhammad Luthfisal, Saputra Muhamad Fahmy, Pratama Mochamad Ridwan, Permadi Dio Damas, Sari Nita Kurnita, Saputri Utamy Sukmayu

“…The methodology used includes literature review, field observation, collection of primary data such as daily rainfall data over the past 14 years and catchment area data, as well as secondary data including field documentation and location maps. …”
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Evaluation of 30-day mortality in patients undergoing gastrointestinal endoscopy in a tertiary hospital: a 3-year retrospective survey by Philippe Bichard, Jean-Louis Frossard, Laurent Spahr, Nicolas Goossens, Olivier Chatelanat, Laurent Bochatay, Caroline Bastid

“…Our objective was to report death causes and rate following GI endoscopies in a tertiary university hospital.Design We retrospectively reviewed all GI procedures made between January 2017 and December 2019 in our tertiary hospital in Switzerland. …”
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Resuscitative Endovascular Balloon occlusion of the aorta in Impending Traumatic arrest: Is It Effective? by Jae Sik Chung, Oh Hyun Kim, Seongyup Kim, Ji Young Jang, Gyo Jin An, Pil Young Jung

“…Patients were divided into CPR and non-CPR groups. Results We reviewed 1,596 trauma patients with shock, of whom 23 patients underwent REBOA (1.4%). …”
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Parental preference for influenza vaccine for children in China: a discrete choice experiment by Gang Chen, Ping Liu, Xiaochen Ma, Hai Fang, Zhiyuan Hou, Hongguo Rong, Xiaozhen Lai, Shunping Li, Tiantian Gong

“…Five attributes were identified based on literature review and qualitative interviews, including protection rate, duration of vaccine-induced protection, risk of serious side effects, location of manufacturer and out-of-pocket cost.Setting Multistage sampling design was used. …”
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Obstacle avoidance and formation control of multiple unmanned vehicles in complex environments based on artificial potential field method by Yilin MEI, Likun CUI, Xueyan HU, Guangqi HU, Hao WANG

“…However, in complex environments, issues such as high collision rates and unstable formations in multivehicle obstacle avoidance and formation control persist. A review of existing literature reveals that most research focuses on static obstacle environments, which do not accurately reflect real-world conditions. …”
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Clinical presentations and outcomes of celiac disease in children and adolescents at a tertiary care center in Lebanon by Dana Andari, Rima Hanna-Wakim, Sarah Khafaja, Nadine Yazbeck

“…The aim of this 10-year-retrospective study was to describe the common clinical presentations, diagnostic modalities, and the effect of the gluten-free- diet (GFD) on the growth of children and adolescents with celiac disease.MethodsThis was a retrospective chart review of subjects aged 6 months to 18 years who visited the Pediatric Gastroenterology clinic at the American University of Beirut Medical Center (AUBMC) between January 1, 2013, and June 30, 2023, and who were diagnosed with celiac disease based on serological markers and/or changes on histology of the small intestinal mucosal biopsies for those who underwent upper endoscopy, or HLA typing expressing the HLA-DQ2 or DQ8 gene for few subjects.ResultsThe study included 90 patients with celiac disease, of whom 64 were newly diagnosed during the study period. …”
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Minimally invasive needle tenotomy vs. platelet rich plasma injection in the treatment of chronic elbow epicondylitis by Chantal T. Nguyen, MD, Michelle H. Lee, MD, Matthew W. Kaufman, MD, Yue Meng, MD, Jyotsna A. Koduri, MD, Geoffrey Abrams, MD, Emilie V. Cheung, MD, Michael T. Freehill, MD, Eugene Y. Roh, MD

“…Methods: A retrospective review of 51 adults (n = 23 for MINT; n = 28 for PRP) was conducted to investigate long-term outcomes in pain relief (via visual analog scale or VAS) and improvements in upper extremity function (via quick disability of the arm, shoulder, and hand questionnaire or qDASH). …”
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Identifying barriers and potential solutions to improve equitable access to community eye services: an exploratory sequential mixed methods study protocol by Min Kim, David Macleod, Michael Gichangi, Andrew Bastawrous, Matthew J Burton, Jacqueline Ramke, Oathokwa Nkomazana, Sailesh Mishra, Shalinder Sabherwal, Luke Nelson Allen, Abhishek Roshan, Sarah Karanja, Ari Ho-Foster, Keneilwe Motlhatlhedi, Nigel Bolster, Mohd Javed, Malebogo Tlhajoane, Bakgaki Ratshaa, John Tlhakanelo

“…We will disseminate our findings through local community advisory boards, national eye screening meetings, in peer-reviewed journals and at conferences.…”
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Efficacy and safety of perioperative analgesia in PENG block for children undergoing hip surgery with developmental dysplasia: study protocol for a randomized, double-blinded, non-... by Mingzhe Xu, Yi He, Zhi Li, Bin Du

“…The trial’s final results will be published in a peer-reviewed scientific journal. Discussion We expect this trial to provide some evidences that PENG block is safe and effective for perioperative analgesia in pediatric patients undergoing open hip surgery. …”
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Direct-Acting Antivirals in Hepatitis C Treatment for Renal Impairment: Liver Safety Concerns and Effectiveness in Peritoneal Dialysis by Hsuan-Yu Hung, Wei-Liang Hung, Ye Gu, Chung-Yu Chen

“…The study was approved by the DMF-CYCH Institutional Review Board (CYCH IRB No.: 2021010). <b>Results:</b> In 837 patients, DILI risk, expressed as incidence rate ratios (IRR), was 0.64 (95% CI 0.25–1.63) in the NKF group and 1.29 (95% CI 0.12–14.23) in the CKD group. …”
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Balance and Gait Improvements of Postoperative Rehabilitation in Patients with Parkinson’s Disease Treated with Subthalamic Nucleus Deep Brain Stimulation (STN-DBS) by Kazunori Sato, Noriaki Aita, Yoshihide Hokari, Eriko Kitahara, Mami Tani, Nana Izawa, Kozo Hatori, Ryota Nakamura, Fuyuko Sasaki, Satoko Sekimoto, Takayuki Jo, Genko Oyama, Taku Hatano, Yasushi Shimo, Hirokazu Iwamuro, Atsushi Umemura, Nobutaka Hattori, Toshiyuki Fujiwara

“…Sixteen patients were reviewed retrospectively from February 2016 to March 2017. …”
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Ethical aspects of clinical trials in Russia and BRICS countries: an overview by Sergey Y. Simeniv, Alexander L. Khokhlov, Olga N. Soldatova, Nathalia V. Pyatigorskaya

“…The aim of the study: To review and compare the legislative frameworks and regulations of ethical aspects of clinical trials in Russia and the BRICS countries, which possess significant scientific, industrial, and economic potential – China, India, and Brazil. …”
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Development and Videographic Evaluation of a Vascular Access Simulation-Based Curriculum for Surgical and Medical Trainees by Alaska Pendleton, MD, MPH, Tiffany R. Bellomo, MD, Srihari K. Lella, MD, Kristen Jogerst, MD, Ada Stefanescu, MD, MSc, Douglas Drachman, MD, Nikolaos Zacharias, MD, Anahita Dua, MD, MBA, MSc

“…All recordings were reviewed and scored by 2 blinded, independent investigators. …”
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Continuous Improvements and Future Challenges of Air Pollution Control at an Advanced Semiconductor Fab by Hsueh-Hsing Lu, Ming-Chun Lu, Thi-Cuc Le, Zhiping An, David Y. H. Pui, Chuen-Jinn Tsai

“…Abstract This study reviews the air pollution control strategy at an advanced semiconductor fab focusing on its continuous improvements and future challenges. …”
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Causes of death among older children and adolescents (5–19 years) in the Magu Health and Demographic Surveillance Study, Tanzania, 1995–2022 by Sophia Kagoye, Milly Marston, Yasson Abha, Eveline T. Konje, Mark Urassa, Jim Todd, Ties Boerma

“…Methods Using longitudinal data from the Magu Health and Demographic Surveillance System in northwest Tanzania, we identified leading causes of death among 5–19-year-olds from verbal autopsy interviews, using physician review and a Bayesian probabilistic model (InSilicoVA). …”
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Comparison of glycosylated fibronectin versus soluble fms-like tyrosine kinase/placental growth factor ratio testing for the assessment of pre-eclampsia: protocol for a multicentre... by Marcus Green, Chao Wang, Sarah Fisher, Amarnath Bhide, Ramesh Ganapathy, Basky Thilaganathan, Nouran Elbarbary

“…The results of this study will be published in peer-reviewed journals and presented at scientific conferences.Trial registration number ISRCTN13430018…”
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Personalised Lung Cancer Screening (PLuS) study to assess the importance of coexisting chronic conditions to clinical practice and policy: protocol for a multicentre observational... by Yi Guo, Dongyu Zhang, Rafael Meza, Jihyoun Jeon, Dejana Braithwaite, Gerard A Silvestri, Michael K Gould, Jiang Bian, Bruno Hochhegger, Shama D Karanth, Christopher G Slatore, Martin Tammemagi, Mattthew Schabath, Meghann Wheeler, Frederic J Kaye

“…To our knowledge, this is the first study to combine observational data and simulation models to estimate the long-term impact of LCS with LDCT.Ethics and dissemination The study was approved by the Kaiser Permanente Southern California Institutional Review Board and VA Portland Health Care System. The results will be disseminated through publications and presentations at national and international conferences. …”
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