Medication following bariatric surgery for type 2 diabetes mellitus (BY-PLUS) study: rationale and design of a randomised controlled study by Alexander Dimitri Miras, Carel le Roux, Alexis Sudlow, Ricardo Vitor Cohen, Hassan Kahal, Dimitri J Pournaras, Jill Townley, Helen Heneghan

“…The primary endpoints are the proportion of patients in each arm with an HbA1c<6.5% (48 mmol/mol) at 1 year and the proportion of patients in each arm achieving the composite endpoint of HbA1c<6.5% (48 mmol/mol), BP<130/80 mm Hg and LDL<2.6 mmol/L at 5 years.Ethics and dissemination The local institutional review board approved this study. This study represents the first RCT to examine the safety and efficacy of combining bariatric surgery with intensive medical therapy compared with bariatric surgery and usual care for long-term diabetes control.Trial registration number NCT04432025.…”
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The Real-World Clinical Outcomes of Heavily Pretreated HER2+ and HER2-Low Metastatic Breast Cancer Patients Treated with Trastuzumab Deruxtecan at a Single Centre by Anna-Maria Lazaratos, Matthew Dankner, Aalya Hamouda, Soumaya Labidi, Victor Cohen, Lawrence Panasci, Jennifer E. Friedmann, François Patenaude, Cristiano Ferrario, Mark Basik, April A. N. Rose, Parvaneh Fallah

“…Background: Trastuzumab deruxtecan (TDXd) is an antibody–drug conjugate that has demonstrated impressive activity in randomized controlled clinical trials in the context of patients with HER2-amplified and HER2-low metastatic breast cancer. We aimed to review the activity and adverse event profile of TDXd in heavily pretreated breast cancer patients in real practice. …”
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Laparoscopy and Laparotomy for Endometrioid Adenocarcinoma: Short- and Long-Term Outcomes’ Comparison by Lan Hong, Xiuzhen Wang, Shengtan Wang, Wei Li, Lang Zheng, Jun Liu, Haocheng Gao, Xiaohang Liu, Guifei Li, Lifan Shen, Hengzhi Zhuang, Genhai Zhu

“…Basic information for the patients, their perioperative indexes, and recurrence rates were reviewed to assess the therapeutic effect of these two approaches for endometrioid adenocarcinoma. …”
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Efficacy and safety of intravenous immunoglobulin with rituximab versus rituximab alone in childhood-onset steroid-dependent and frequently relapsing nephrotic syndrome: protocol f... by Djamal Djeddi, Julien Hogan, Aubriana Perez, Anne-Laure Sellier-Leclerc, Isabelle Vrillon, Francoise Broux, Francois Nobili, Jerome Harambat, Lucie Bessenay, V Audard, Camille Faudeux, Denis Morin, Christine Pietrement, Stephanie Tellier, Philippe Eckart, Annie Lahoche, G Roussey-Kesler, Tim Ulinski, Olivia Boyer, Emmanuelle Plaisier, Sylvie Cloarec, Anne Jolivot, Vincent Guigonis, Sophie Guilmin-Crepon, Veronique Baudouin, Claire Dossier, Georges Deschênes

“…Results of the primary study and the secondary aims will be disseminated through peer-reviewed publications.Trial registration number NCT03560011.…”
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Tumour necrosis factor inhibitors in Ulcerative colitis: real-world data on Therapeutic drug monitoring and evaluation of current treatment targets (STRIDE II) by Jonas Andre Lundekvam, Marte Lie Høivik, Karoline Anisdahl, Milada Cvancarova Småstuen, David J. Warren, Nils Bolstad, Asle Wilhelm Medhus

“…We report real-world data in ulcerative colitis patients receiving first-line tumour necrosis factor inhibitor (TNFi) treatment followed by TDM, and assess how implementation of the STRIDE II recommendations might affect clinical practice.Methods Adult, biologically naïve UC patients starting TNFi between 2014 and 2021 at Oslo University Hospital were included in a medical chart review study, and data were collected at three and twelve months after the start of treatment. …”
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Predicting the effects of introducing an emergency transport system in low-income and middle-income countries: a spatial-epidemiological modelling study by Justine Davies, Dmitri Nepogodiev, Stephen Tabiri, Richard Lilford, Srinivasa Vittal Katikireddi, Samuel I Watson, Katie Scandrett

“…The model incorporates components to both predict travel times across an area of interest under different scenarios and predict survival for emergency conditions as a function of time to receive care. We review potentially relevant data sources for different model parameters. …”
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High-intensive physical rehabilitation approach in children and adolescents with acquired brain injury during subacute phase (REHABILITY): a feasibility study protocol by Jan Willem Gorter, Christiaan Gmelig Meyling, Olaf Verschuren, Ingrid Rentinck, Irene van der Steen, Raoul Engelbert

“…We aim to disseminate our findings in peer-reviewed journals and present at national and international conferences.…”
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Three-Year Point Prevalence Survey of Antimicrobial Use in a Chinese University Hospital by Fa-Hong Jing, Qiang Wang, Tian-Jiao He, Na Xin, Yao-Wei Wang, Yang Han, Xin Wang, Zhuo Li

“…The indications for antimicrobials were not documented in 54.5% of the prescriptions. Stop/review date was documented for 36.8% of prescriptions. …”
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Virtual reality and speech analysis for the assessment of impulsivity and decision-making: protocol for a comparison with neuropsychological tasks and self-administered questionnai... by Marta Ruiz, Maria Luisa Barrigon, Antonio Artes, Philippe Courtet, Enrique Baca-Garcia, Jorge Lopez-Castroman, Santiago de Leon-Martinez, Elena Parra-Vargas, Irene Chicchi-Giglioli, Alejandro Albán Porras-Segovia

“…The findings will be presented in a series of manuscripts that will be submitted to peer-reviewed journals for publication.Trial registration number NCT05109845; Pre-results.…”
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Randomised cross-over trial of vildagliptin and pioglitazone as add-on therapy in patients with type 2 diabetes: predicting Which One is Right Here (WORTH) study protocol by Yannan Jiang, Tony R Merriman, Rui Qian Yeu, Rebecca Brandon, Dale Griffiths, Kate Smallman, Allan Moffitt, Glenn Doherty, Ryan Paul, Jennie Harré Hindmarsh, Kerry Macaskill-Smith, Brandon Orr-Walker, Rinki Murphy

“…Results will be reported in articles submitted to peer-reviewed journals, as well as in presentations at national and international meetings.Trial registration number ACTRN12618001907235.…”
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Perinatal Outcomes among Cases of Predicted and Unpredicted Macrosomia by Merita Isaku, Enxhi Vrapi, Tedi Bimbashi, Ina Cala, Kizjona Perdja, Redi Hoxhallari, Astrit Bimbashi

“…Data were stored in a secure database. The review board of the institution approved the study. …”
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Predicting Gestational Diabetes Mellitus in the first trimester using machine learning algorithms: a cross-sectional study at a hospital fertility health center in Iran by Somayeh Kianian Bigdeli, Marjan Ghazisaedi, Seyed Mohammad Ayyoubzadeh, Sedigheh Hantoushzadeh, Marjan Ahmadi

“…Risk factors for designing predictive models were identified through literature review, expert opinions, and clinical specialists’ input. …”
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Sleep Disorders and Reproductive Health: Mechanisms, Consequences, and Potential Interventions by Magdalena Rosa-Bończak Rosa, Patrycja Marta, Filip Maciej Huzarski, Klaudia Anna Pawełek, Gabriela Monika Ferfecka, Agata Ossolińska, Natalia Morawiecka, Lucyna Stolarska, Oliver Carlton, Weronika Kłosowicz

“…Both primary research and systematic reviews, as well as meta-analyses with high methodological quality and statistical significance, were analyzed. …”
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Risk Evaluation of Pyrolyzed Biochar from Multiple Wastes by Shem M. Ndirangu, Yanyan Liu, Kai Xu, Shaoxian Song

“…This paper aims at demonstrating the significance of biochar risk evaluation and reviewing risk evaluation from the aspects of pyrolysis process, feedstock, and sources of hazards in biochar and their potential effects and the methods used in risk evaluation. …”
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A checklist of indigenous flora in the Richtersveld National Park confirms high plant diversity in the arid north-western tip of South Africa by Pieter van Wyk, Hugo Bezuidenhout, Norbert Jürgens

“…The role of the peculiar biogeographical position and the high diversity of unique habitats within extreme environmental gradients were discussed in a review of published evidence. Reference to distribution and habitat was presented for each species in the appendices. …”
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Comparison of MRI and CT in the Evaluation of Unilateral Maxillary Sinus Opacification by Elise Chua, Annakan V. Navaratnam, Dominic St Leger, Vincent Lam, Samit Unadkat, Alexander Weller

“…Two head and neck radiologists independently reviewed each imaging modality and recorded both a final diagnosis and Likert-scale diagnostic certainty score. …”
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Exposure to lead and cadmium released from ceramics and glassware by Mimoza Rahovica, Arif Latifi, Evgenija Kiroska Petreska, Tatjana Kadifkova Panovska

“…It is believed that the migrated lead comes from the full exterior decoration. Upon reviewing the measured and calculated Pb values in the remaining glassware, it is evident that in all the other samples analyzed from each category, it does not surpass the values above the MPML. …”
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Comparison of Analytic Hierarchy Process and Frequency Ratio Methods in Landslide Susceptibility Analysis: Example of Akçaabat and Düzköy districts of Trabzon province by Melek Dalkes, Mehmet Seren Korkmaz

“…A total of 13 criteria which are respectively; slope, curvature, lithology, precipitation, aspect, topographic wetness index (TWI), distance to rivers, distance to highways, distance to fault lines, land use, soil type, elevation and normalized difference vegetation index (NDVI) for landslide susceptibility are evaluated as effective to cause landslides as a result of the literature review. Pairwise comparisons are made to determine the importance of the effects of each criterion on landslide formation and the weights between the criteria by using the AHP method. …”
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Incidence and Mechanisms of Coronary Perforations during Rotational Atherectomy in Modern Practice by Yen-Hsiang Wang, Wei-Jhong Chen, Yu-Wei Chen, Chih-Hung Lai, Chieh-Shou Su, Wei-Chun Chang, Chi-Yen Wang, Kae-Woei Liang, Tsun-Jui Liu, Wen-Lieng Lee

“…The procedure details, angiography, and clinical information were reviewed in detail. Results. A total of 479 RAs were performed with 11 perforations in 10 procedures among 9 patients documented. …”
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Recommendations of the Russian Gastroenterological Association in Diagnosis and Treatment of Gastroesophageal Reflux Disease by V. T. Ivashkin, I. V. Maev, A. S. Trukhmanov, T. L. Lapina, O. A. Storonova, O. V. Zayratyants, O. B. Dronova, Yu. A. Kucheryavyy, S. S. Pirogov, R. G. Sayfutdinov, Yu. P. Uspenskiy, A. A. Sheptulin, D. N. Andreev, D. E. Rumyantseva

“…Current recommendations provide an up-to-date evidential medicial review of GERD and guidelines to advance special medical care and timely preventive measures.…”
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