Extracecellulr vesicles (EVs) microRNAs (miRNAs) derived from mesenchymal stem cells (MSCs) in osteoarthritis (OA); detailed role in pathogenesis and possible therapeutics by Seyede Sara Pakdaman Kolour, Saeide Nematollahi, Masoud Dehbozorgi, Farnaz Fattahi, Fatemeh Movahed, Neda Esfandiari, Mohammad Saeed Kahrizi, Nima Ghavamikia, Bahareh Salmanian Hajiagha

“…Thus, the biosynthesis, chemical makeup, and mechanism of action of miRNAs-enriched EVs in OA are all thoroughly covered in this review. We additionally discussed how miRNA-enriched MSC-EVs might be used therapeutically to change intercellular interaction in OA.…”
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Application of Intelligent Disability Rating Method Based on Big Data Cloud Platform by WANG Yulong

“…In this paper, we have reviewed the studies on the methods and existing problems of disability rating at home and abroad. …”
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Early Stone Manipulation in Urinary Tract Infection Associated with Obstructing Nephrolithiasis by Megan L. Swonke, Ali M. Mahmoud, Elias J. Farran, Tamer J. Dafashy, Preston S. Kerr, Christopher D. Kosarek, Joseph Sonstein

“…In this case series, we retrospectively review four cases in which patients had a documented UTI secondary to an obstructive ureteral stone. …”
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Machine learning and public health policy evaluation: research dynamics and prospects for challenges by Zhengyin Li, Hui Zhou, Zhen Xu, Qingyang Ma

“…With the rise of big data, traditional evaluation methods face new challenges, requiring innovative approaches.MethodsThis article reviews the principles, scope, and limitations of traditional public health policy evaluation methods and explores the application of machine learning in evaluating public health policies. …”
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Russian authority and the Internet: safety vs freedom of speech by I. A. Lavrov, A. V. Sokol

“…Both texts of laws and their real results after adoption have been reviewed and analyzed. For each such action an assessment of public opinion in relation to these innovations has been adduced. …”
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How Hippo Signaling Pathway Modulates Cardiovascular Development and Diseases by Wenyi Zhou, Mingyi Zhao

“…Recent research has demonstrated a novel role of Hippo signaling in cardiovascular disease in the context of development, hypertrophy, angiogenesis, regeneration, apoptosis, and autophagy. In this review, we summarize the current knowledge of how Hippo signaling modulates pathological processes in cardiovascular disease and discuss potential molecular therapeutic targets.…”
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EUROPEAN PLASTIC ART IN ANTHROPOLOGICAL DIMENSION: FROM THE CLASSICS TO THE POSTMODERNISM by R. M. Rusin, I. V. Liashenko

“…Postmodern experiments stimulate blurring the borders between the traditional forms and genres of art. Review of canonical ideas about the creation and destruction, order and chaos in art illustrates conscious reorientation from the classical understanding of artistic creativity to the construction of artifacts-simulacra, which is a characteristic feature in the oeuvre of contemporary artists, ranging from the pop art to the present day. …”
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Interference in English managerial discourse exemplified by business cases by A. A. Gabets

“…The author examines 75 case studies published in Harvard Business Review from 2006 to 2024. The aims of the research are to reveal the types of discourses that are included in managerial discourse of case studies most often, to describe their qualities, lexical markers and the reasons for inclusion, to analyze their influence on the development of discourse in general. …”
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Blood-based biomarkers in mild behavioral impairment: an updated overview by Efthalia Angelopoulou, Xenia Androni, Chiara Villa, Alexandros Hatzimanolis, Nikolaos Scarmeas, Sokratis Papageorgiou

“…These findings offer insights into the underlying pathophysiology of MBI, and connection between neuropsychiatric symptoms and progression of AD. In this narrative review, we aim to summarize and critically discuss the emerging literature evidence linking MBI to blood-based biomarkers, hoping to shed more light on MBI’s pathophysiology, its connection to AD-related neurobiology, as well as its potential practical utility for predicting cognitive impairment, guiding early interventions and managing the risk for dementia.…”
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The role of DNA methylation in the disorders of bone metabolism by B. I. Yalaev, A. V. Tyurin, R. Y. Mirgalieva, R. I. Khusainova

“…Evidence exists that this mechanism alongside regulatory miRNAs and post-translational modifications makes a significant contribution to the central processes of bone remodeling; however, the results of various studies vary greatly, and, therefore, there is a need to understand the significance of the accumulated data and to make them consistent. The purpose of this review is to compile and systematize data on the role of DNA methylation in bone metabolism in normal and pathological conditions, in the formation of osteoporosis, and to assess achievements and trends in this field of research and technologies for studying DNA methylation.…”
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Exploring medical interns' knowledge on hypertension by Margarita Rosa Roméu Escobar, Luis Padrón Velázquez, Beatriz Sabina Roméu, Zulema Bos Rodríguez

“…A screening test was applied to 34% of the medical interns and the agenda of 2007-2008 and 2008-2009 medical licensing examinations was reviewed. <strong>Results:</strong> 73.4% of the medical interns passed the screening test. …”
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Prevalence of Dermatological Presentations of Canine Leishmaniasis in a Nonendemic Area: A Retrospective Study of 100 Dogs by Roberta Perego, Daniela Proverbio, Giada Bagnagatti De Giorgi, Eva Spada

“…The medical records of 131 dogs with CanL were reviewed and, of these, 115/131 dogs (88%) had dermatological manifestations of which 100/131 dogs (76%) met the inclusion criteria. …”
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Analysis Of The Cognitive Content Of Two Types Of Swimming According To Content Organization Indicators And Their Impact On Technical Performance And Achievement by Muhammad Suhail Najm Al-Hamdani, Doaa Subhan Mahmoud Al-Zuhairi

“…University curricula need continuous review, analysis, change, and development due to their strong association with methodological variables. …”
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Invert classroom method for gerontogeriatric training in Medicine students by Juan Carlos Baster Moro, Luis Aníbal Alonso Betancourt, Silvia María Pérez Pérez

“…<br /><strong>Methods:</strong> a cross-sectional observational study was carried out using scientific methods: document review, direct observation in the field, analysis, synthesis, induction, deduction, systemic and descriptive statistics.…”
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Ginsenosides Rg1, Rb1 and rare ginsenosides: Promising candidate agents for Parkinson's disease and Alzheimer's disease and network pharmacology analysis by Mingchun Jiang, Jiaxin Chi, Yifan Qiao, Jinpeng Wang, Zhixin Zhang, Jia Liu, Xinhao Sheng, Liangjie Yuan

“…By analysing the existing research advances and network pharmacology results, we found that the neuroprotective effects of ginsenosides, primarily mediated through anti-inflammation, anti-apoptosis and anti-oxidative stress, etc, may be associated with the PI3K/Akt, BDNF/TrkB, MAPKs, NF-κB, Nrf2 and Wnt/β-catenin signalling pathways. This review systematically summarises the different roles and mechanisms of ginsenosides Rg1, Rb1, and rare ginsenosides in PD and AD and provides new strategies for the treatment of neurodegenerative disorders. …”
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Mesenchymal stem cells and their extracellular vesicle therapy for neurological disorders: traumatic brain injury and beyond by Aref Yarahmadi, Masoumeh Dorri Giv, Reza Hosseininejad, Azin Rezaie, Narges Mohammadi, Hamed Afkhami, Hamed Afkhami, Hamed Afkhami, Arastoo Farokhi

“…Extensive investigations have been conducted on the regulatory properties of MSCs and their manipulation, tagging, and transportation techniques for brain-related applications. This review explores the progress and prospects of MSC therapy in TBI, focusing on mechanisms of action, therapeutic benefits, and the challenges and potential limitations of using MSCs in treating neurological disorders.…”
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PORTFOLIO CONSIDERED AS A PROCESS ENHANCE COGNITION OF MATHEMATICS DISCIPLINES AT UNIVERSITY by Lyudmila S. Klentak

“…As part of the transition to a federal state educational standards of higher education, which declared the formation of the mandatory electronic student portfolios, including the preservation of the student work, reviews and evaluations of these work by all participants in the educational process, it follows that there is a need to use this innovative approach. …”
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Risk-Stratified Cardiovascular Screening Including Angiographic and Procedural Outcomes of Percutaneous Coronary Interventions in Renal Transplant Candidates by Julian König, Martin Möckel, Eda Mueller, Wolfgang Bocksch, Seema Baid-Agrawal, Nina Babel, Ralf Schindler, Petra Reinke, Peter Nickel

“…In 267 patients evaluated 2003 to 2006, screening tests performed were reviewed and PCI characteristics correlated with major adverse cardiovascular events (MACE) during a follow-up of 55 months. …”
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Pineal cyst in bipolar patient with normolithiaemia and positive fibromyalgic tender points by Salvatore Marrone, MD, Antonio Alessandro Biancardino, MD, Evier Andrea Giovannini, MD, Federica Paolini, MD, Benedetta Maria Campisi, MD, Jaime Mandelli, MD, Domenico Santangelo, MD, Salvatore Fanara, MD, Giuseppe Vaccaro, MD, Michele Vecchio, MD, Domenico Gerardo Iacopino, MD, PhD, Luigi Basile, MD

“…In addition, the incomplete blood-brain barrier of the pineal gland raises the possibility that chronic lithium therapy, commonly used for psychiatric disorders and also known for its hyperplastic effects, could facilitate cysts formation through lithium accumulation and epithelial stimulation.We report the case of a 49-year-old woman with bipolar disorder on long-term lithium treatment who presented with a pineal cyst and clinical symptoms consistent with fibromyalgia. A review of the literature highlights possible links between pineal cyst formation, systemic inflammation associated with rheumatological disorders and prolonged lithium exposure.Although the hyperplastic properties of lithium in glandular tissue are well documented, there is no conclusive evidence directly linking lithium use to the development of pineal cysts in humans. …”
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Promising Neutrophil-Associated Biomarkers in Lung Diseases of Patients with Antisynthetase Syndrome and Dermatomyositis by Lei Liu, Jundi Wang, Peiyu Zhang, Wenjia Sun, Xiuliang Zhu, Xiujuan Sun, Jing Xue, Huaxiang Wu

“…We carried out a retrospective review of the medical records of 46 cases of ASS and DM diagnosed at the Second Hospital of Zhejiang University College of Medicine, between January 2017 and December 2020. …”
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