Mesenchymal Stem Cells: A Potential Therapeutic Approach for Amyotrophic Lateral Sclerosis? by Agnese Gugliandolo, Placido Bramanti, Emanuela Mazzon

“…In particular, mesenchymal stem cells (MSCs) seem the most suitable type of stem cells, thanks to their demonstrated beneficial effects in different experimental models, to the easy availability, and to the lack of ethical problems. In this review, we focused on the studies involving ALS rodent models and clinical trials in order to understand the potential beneficial effects of MSC transplantation. …”
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MPNs as Inflammatory Diseases: The Evidence, Consequences, and Perspectives by Hans Carl Hasselbalch, Mads Emil Bjørn

“…The MPN population has a substantial inflammation-mediated comorbidity burden. This review describes the evidence for considering the MPNs as inflammatory diseases, A Human Inflammation Model of Cancer Development, and the role of cytokines in disease initiation and progression. …”
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Autoimmune hepatitis: new in diagnostics, a pathogenesis and treatment by Ye. N. Shirokova, K. V. Ivashkin, V. T. Ivashkin

“…The aim of review. To generalize new data on diagnostics, pathogenesis and treatment of autoimmune hepatitis (AIH).Original positions. …”
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Unveiling promising sepsis biomarkers: a clinical perspective by Hong Zhang, Junpeng Zhao, Zhiping Wang, Mengxiang Huang, Zhonghua Tan, Feng Jiang, Yuhong Zhou, Linhua Wang, Mingbing Xiao

“…This article provides a comprehensive review of the diagnostic value of traditional and recently popular novel biomarkers for sepsis.…”
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Open challenges and opportunities in federated foundation models towards biomedical healthcare by Xingyu Li, Lu Peng, Yu-Ping Wang, Weihua Zhang

“…This approach not only enhances the capabilities of FMs in medical diagnostics and personalized treatment but also addresses critical concerns about data privacy and security in healthcare. This survey reviews the current applications of FMs in federated settings, underscores the challenges, and identifies future research directions including scaling FMs, managing data diversity, and enhancing communication efficiency within FL frameworks. …”
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Melittin: A Natural Component of Honeybee Venom as a Potential Anti-Cancer Therapy by Niamh Donnellan, Anne M Friel

“…Melittin’s biological functions, the potential methods of delivery and current trends in melittin development for therapy are presented and discussed in this review.…”
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Development Of Ship Archive Information System In XYZ Company With Scrum Methodology by Vika Insanittaqwa, M. Ihsan Alfani Putera, M. Fathurrahman Shidiq

“…The stages of this research include Requirement Gathering, Sprint Planning, Daily Meetings, Sprint Reviews, Sprint Retrospectives, and Deployment. A total of 55 Product Backlogs were completed over three Sprints. …”
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Management of Maillard reaction-derived reactive carbonyl species and advanced glycation end products by tea and tea polyphenols by Yue Luo, Jianan Zhang, Chi-Tang Ho, Shiming Li

“…The connection between the two topics was the main aim of this review, to address and update the antiglycation effect and mechanism of tea and tea polyphenols. …”
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Inhaled Therapy in Respiratory Disease: The Complex Interplay of Pulmonary Kinetic Processes by Jens Markus Borghardt, Charlotte Kloft, Ashish Sharma

“…The lung, as a target, represents an organ with a complex structure and multiple pulmonary-specific pharmacokinetic processes, including (1) drug particle/droplet deposition; (2) pulmonary drug dissolution; (3) mucociliary and macrophage clearance; (4) absorption to lung tissue; (5) pulmonary tissue retention and tissue metabolism; and (6) absorptive drug clearance to the systemic perfusion. In this review, we describe these pharmacokinetic processes and explain how they may be influenced by drug-, formulation- and device-, and patient-related factors. …”
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Epistolary legacy of Russian orientalists: Unpublished correspondence of A.E. Krymsky and V.F. Minorsky (1904–1925) by R.M. Valeev, O.D. Vasylyuk, R.Z. Valeeva, N.N. Diakov, S.A. Kirillina

“…This paper is a short review of some letters written by A.E. Krymsky and V.F. …”
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Optimal Dual RNA-Seq Mapping for Accurate Pathogen Detection in Complex Eukaryotic Hosts by Infanta Eden M., Umashankar Vetrivel

“…Existing analysis methods employ various combinations of open-source bioinformatics tools to process dual RNA-Seq data. Upon reviewing these methods, we intend to explore crucial criteria for selecting standard tools and methods, especially focusing on critical steps such as trimming and mapping reads to the reference genome. …”
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The worlds of limited-edition books (Arthur Clarke, Robert Heinlein, Wojciech Kajtoch, Stanisław Lem) by D.E. Martynov

“…This paper reviews four books, all dedicated to the study of the science fiction genre and the biography of science-fiction writers. …”
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Metabolic Perturbations and Severe COVID-19 Disease: Implication of Molecular Pathways by Ersilia Nigro, Fabio Perrotta, Rita Polito, Vito D’Agnano, Filippo Scialò, Andrea Bianco, Aurora Daniele

“…Although symptoms are highly heterogeneous (ranging from absence of symptoms to severe acute respiratory failure), patients with metabolic-associated diseases often experience worse COVID-19 outcomes. This review investigates the association between metabolic disorders and COVID-19 severity, exploring the molecular mechanisms potentially underlying this relationship and those that are responsible for more severe COVID-19 outcomes. …”
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Clinical Impact of Prophylactic Antibiotic Treatment for Self-Expandable Metallic Stent Insertion in Patients with Malignant Colorectal Obstruction by Jong-Sun Kim, Wan-Sik Lee, Cho-Yun Chung, Hyung-Chul Park, Dae-Seong Myung, Chan-Young Oak, Mi-Young Kim, Mi-Ok Jang, Seung-Ji Kang, Hee-Chang Jang, Sung-Bum Cho, Hyun-Soo Kim, Young-Eun Joo

“…We performed a retrospective review of 224 patients who underwent self-expandable metallic stent (SEMS) insertion for malignant colorectal obstruction from May 2004 to December 2012. …”
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The AβA2V paradigm: From molecular insights to therapeutic strategies in Alzheimer’s disease and primary tauopathies by Luisa Diomede, Andrea Conz, Michele Mosconi, Tatiana Stoilova, Matteo Paloni, Matteo Salvalaglio, Alfredo Cagnotto, Laura Colombo, Marcella Catania, Giuseppe Di Fede, Fabrizio Tagliavini, Mario Salmona

“…The mutation offers new insights into the molecular mechanisms of the disease, particularly regarding the contrasting roles of the A2V and A2T mutations in amyloid β peptide aggregation and toxicity. This review aims to describe relevant studies on A2V-mutated variants of the amyloid β peptide, revealing a protective effect against amyloid-β and tau pathology. …”
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Driving sustainability in the automotive industry: bio-coated materials and modern strategies by Daniel Mendanha, Denise Carvalho, Mário Silva, Sofia Silva, Pedro Ferreira, Raquel Rodrigues, Carla J. Silva, Cristina Oliveira, Rita Marques

“…Moreover, given the increasing need for recycling and product life-cycle consideration, there is a growing pursuit of mono-material approaches to facilitate and improve the recycling of the selected materials. This review explores and summarizes the current sustainability challenges in the automotive industry and highlights the bio-coated materials and alternative strategies currently under exploration.…”
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Crosstalk between Tumor-Infiltrating Immune Cells and Cancer-Associated Fibroblasts in Tumor Growth and Immunosuppression of Breast Cancer by Jarupa Soongsathitanon, Pranisa Jamjuntra, Nuttavut Sumransub, Supaporn Yangngam, Marjorie De la Fuente, Glauben Landskron, Peti Thuwajit, Marcela A. Hermoso, Chanitra Thuwajit

“…The immune cells including tumor-infiltrating lymphocytes (TILs) (cytotoxic T cells (CTLs), regulatory T cells (Tregs), and helper T cell (Th)), monocyte-infiltrating cells (MICs), myeloid-derived suppressor cells (MDSCs), mast cells (MCs), and natural killer cells (NKs) play an important part in the immunological balance, fluctuating TME between protumoral and antitumoral responses. In this review article, we have summarized the impact of these immunological players together with CAF secreted substances in driving BC progression. …”
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Integrating Modern Technologies into Traditional Anterior Cruciate Ligament Tissue Engineering by Aris Sopilidis, Vasileios Stamatopoulos, Vasileios Giannatos, Georgios Taraviras, Andreas Panagopoulos, Stavros Taraviras

“…Tissue engineering is a multidisciplinary field that could contribute to the formation of a tissue-engineered ACL graft manufactured by a combination of the appropriate stem-cell type, a suitable scaffold, and specific growth factors, combined with mechanical stimuli. In this review, we discuss the aspects that constitute the creation of a successful tissue-engineered graft while also underlining the current drawbacks that arise for each issue. …”
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Liver Cirrhosis: Evaluation, Nutritional Status, and Prognosis by Hiroki Nishikawa, Yukio Osaki

“…Based on these backgrounds, several methods for evaluating nutritional status in patients with chronic liver disease have been developed and they have been preferably used in the clinical field practice. In this review, we will summarize the current knowledge in the field of LC from the viewpoints of diagnostic method, nutritional status, and clinical outcomes.…”
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Biomaterial-assisted organoid technology for disease modeling and drug screening by Yunyuan Shao, Juncheng Wang, Anqi Jin, Shicui Jiang, Lanjie Lei, Liangle Liu

“…The evolution of biomaterials plays a pivotal role in supporting the culture and development of organ tissues, thereby facilitating more accurate disease state modeling and the rigorous evaluation of drug efficacy and safety profiles. In this review, we will explore the roles that various biomaterials play in organoid development, examine the fundamental principles and advantages of utilizing these technologies in constructing disease models, and highlight recent advances and practical applications in drug screening using disease-specific organoid models. …”
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