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29641
Deubiquitinases: Novel Therapeutic Targets in Immune Surveillance?
Published 2016-01-01“…Accumulative evidence shows that the ubiquitin system, and in particular ubiquitin-specific isopeptidases also known as deubiquitinases (DUBs), plays crucial roles in the control of these immune pathways. In this review we will give an up-to-date overview on the role of DUBs in the NF-κB pathway and inflammasome activation, two intrinsically related events triggered by activation of the membrane TLRs as well as the cytosolic NOD and NLR receptors. …”
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29642
Advancing Obsessive–Compulsive Disorder Research: Insights from Transgenic Animal Models and Innovative Therapies
Published 2025-01-01“…Although the development of animal models is ongoing, there remain many comprehensive summaries and updates in recent research, hampering efforts to develop novel treatments and enhance existing interventions. This review summarizes the phenotypes of several commonly used models and mechanistic insights from transgenic models of OCD, such as knockout mouse models. …”
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29643
Training and practice for specialist breast nurses in the center for breast diseases (乳腺病诊疗中心乳腺专科护士的培养与实践)
Published 2022-02-01“…The incidence of breast cancer has been increasing over the past decades around the world. This paper reviewed the studies about origins and development of training and practice for specialist breast nurses. …”
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29644
Suicide in Bangladesh: An Ecological Systems Analysis
Published 2025-01-01“…Methods We performed a narrative review and organized the risk factors and prevention strategies according to the socioecological model in the context of Bangladesh. …”
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29645
The Key to Unlocking the Chemotherapeutic Potential of PPARγ Ligands: Having the Right Combination
Published 2012-01-01“…Here we have compiled an extensive review, consolidating the existing literature, which overwhelmingly supports a beneficial effect of treating with PPARγ ligands in combination with existing chemotherapies versus their monotherapy in cancer. …”
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29646
Environmental Risk Assessment of Subway Station Construction to Achieve Sustainability Using the Intuitionistic Fuzzy Analytic Hierarchy Process and Set Pair Analysis
Published 2021-01-01“…An index system for environmental risk assessment is established based on a literature review and the rough set method. Subsequently, the IFAHP is used to calculate the indicator weights to describe the certainty, uncertainty, and hesitation degree of expert decisions in the weighting calculation by means of affiliation, nonaffiliation, and hesitation. …”
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29647
CUZD1 and Anti-CUZD1 Antibodies as Markers of Cancer and Inflammatory Bowel Diseases
Published 2013-01-01“…CUZD1 appears to be one of the relatively few biomarkers that serve as both cancer biomarker and autoantigen of autoantibodies in an autoimmune disease unrelated to cancerous organs. This review discusses the role of CUZD1 in cancer and autoimmunity. …”
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29648
Nanoparticles in Hormonal Regulation of the Female Reproductive System
Published 2025-01-01“…However, the accumulation of NPs in reproductive organs raises concerns about their potential toxicity, particularly in terms of oxidative stress, inflammation, and DNA damage. This review underscores the need for further research to fully understand the long-term effects of NPs on female reproductive health and to establish safe exposure limits. …”
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29649
Elements of mathematical phenomenology and analogies of electrical and mechanical oscillators of the fractional type with finite number of degrees of freedom of oscillations: linea...
Published 2024-10-01“…Following the ideas about analogies, mathematical, qualitative, and structural, introduced by Mihailo Petrović in Elements of Mathematical Phenomenology (Serbian Royal Academy, Belgrade, 1911), in this paper we present our research results focused on analogies of fractional-type oscillation models between mechanical and electrical oscillators, with a finite number of degrees of freedom of oscillation. In addition to reviewing basic results, we investigate new constitutive relations and generalizations of the energy dissipation function, mechanical dissipative element of fractional type, and electrical resistor of dissipative fractional type. …”
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29650
Understanding the concept of health literacy: A strategy to improve nursing practice
Published 2024-12-01“…Nurses’ understanding of the concept of HL and strategies to reduce HL demands is crucial to delivery of effective nursing practice. This review will provide a clear understanding of the concept of HL which is essential for nurses to effectively educate patients and provide holistic care. …”
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29651
Synthesis and Characterization of Nickel Nanoparticles: Biological and Photocatalytic Properties
Published 2025-01-01“…Furthermore, nickel nanoparticles' cytotoxic activity demonstrates their capacity to kill cancer cells, and their photocatalytic activity demonstrates their efficiency in breaking down organic contaminants. This review highlights the value of ecologically benign synthetic methods and creates new avenues for developing nickel nanoparticle applications in health and the environment.…”
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29652
Carrier-Based Drug Delivery System for Treatment of Acne
Published 2014-01-01“…The objective of the present review is to discuss the conventional delivery systems available for acne, their drawbacks, and limitations. …”
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29653
Charmless Quasi-Two-Body B Decays in Perturbative QCD Approach: Taking B⟶KR⟶K+K− as Examples
Published 2022-01-01“…Because of complicate dynamics, it is very hard for us to study the whole phase space in a specific approach. In this review, we take B⟶KR⟶K+K− decays as examples and show the application of the perturbative QCD (PQCD) approach in studying the quasi-two-body B decays, where two particles move collinearly with large energy and the bachelor one recoils back. …”
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29654
Socio-psychological features of the process of transformation of the social structure of society and the process of communication in the digital space
Published 2019-02-01“…The main directions of changes in the cognitive and communicative aspects of communication, the negative consequences of the preference of the online environment to live communication and the impact on human mental activity, the development of addictive trends in communication by means of digital technologies, scenarios of conflict situations in the digital communication space and their impact on the social life of an individual are reviewed. Revealed the possible scenarios of the impact of the lack of non-verbal component and the critical thinking on coding and decoding of a particular information message.…”
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29655
Bispecific antibodies and CLEM: an analytical approach to advanced cell imaging for therapeutic strategies
Published 2025-01-01“…This synergy not only deepens our understanding of BsAbs’ mechanisms of action but also provides critical insights into their spatial distribution, binding kinetics, and functional dynamics in live cells. In this review, the integration of BsAbs and CLEM paves the way for targeted therapeutic strategies, fostering the development of more effective treatments that can adapt to the complexities of disease pathology.…”
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29656
Local anesthesia with and without conscious sedation versus general anesthesia for oral surgical procedures in pediatric patients: a retrospective cross-sectional study
Published 2024-12-01“…Methods: We performed a retrospective chart review of 192 pediatric patients who underwent 227 minor oral surgery procedures between 2017 and 2019 at the Oral and Maxillofacial Surgery Department at Hospital Clínico Universitario in Valencia, Spain. …”
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29657
Clinical Presentation of Preeclampsia and the Diagnostic Value of Proteins and Their Methylation Products as Biomarkers in Pregnant Women with Preeclampsia and Their Newborns
Published 2018-01-01“…The clinical presentation of PE and data gathered for the biochemical markers placental growth factor (PlGF), soluble Feline McDonough Sarcoma- (fms-) like tyrosine kinase-1 (sFlt-1), asymmetric dimethylarginine (ADMA), and methyl-lysine is being reviewed with the aim of providing both a clinical and biochemical understanding of how these biomarkers might assist in the diagnosis of PE or indicate its severity.…”
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29658
IDH-mutant gliomas in children and adolescents - from biology to clinical trials
Published 2025-01-01“…Here, we describe the biology of mIDH gliomas and review the literature regarding the emergence of mIDH inhibitors, including clinical trials in adults. …”
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29659
Treatment of Palatal Myoclonus with Botulinum Toxin Injection
Published 2013-01-01“…We present suggestions on titrating the botulinum toxin dose to optimal levels. A review of the literature on the use of botulinum toxin for palatal myoclonus and some common complications are discussed.…”
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29660
Targeting Fibrosis: From Molecular Mechanisms to Advanced Therapies
Published 2025-01-01“…Although the mechanisms of fibrosis are still largely unknown, multiple therapeutic strategies targeting identified molecular mechanisms have greatly attenuated fibrotic lesions in clinical trials. In this review, the organ‐specific molecular mechanisms of fibrosis is systematically summarized, including cardiac fibrosis, hepatic fibrosis, renal fibrosis, and pulmonary fibrosis. …”
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