Perspectives of proteomic analysis in ophthalmology by A.A. Krylova, A.V. Zakharchuk, O.I. Krivosheina, S.I. Pekov, I.A. Popov

“…The results of proteomic mapping of tear and aqueous humor in dry eye disease, keratoconus, glaucoma, cataract, age-related macular degeneration, and diabetic retinopathy are described. The association between the levels of identified proteins and their role in triggering pathological processes, e.g., oxidative stress with autophagy (and, as a result, tissue dystrophy), initiation of inflammation, and impairment of metabolic processes at the molecular level with activation of pathological proteolysis (that ultimately lead to cellular and tissue changes with the development of the above-mentioned diseases) are of particular importance. …”
Get full text

Association between Metformin and a Lower Risk of Age-Related Macular Degeneration in Patients with Type 2 Diabetes by Yu-Yen Chen, Ying-Cheng Shen, Yun-Ju Lai, Chun-Yuan Wang, Keng-Hung Lin, Shih-Chao Feng, Chiao-Ying Liang, Li-Chen Wei, Pesus Chou

“…Confounders included for adjustment were age, sex, and comorbidities (hypertension, hyperlipidemia, coronary artery disease, obesity, diabetic retinopathy, chronic kidney disease, and insulin treatment). …”
Get full text

Eligibility for faricimab in a real-world diabetic macular oedema population: a cross-sectional study by Helena Norberg, Inger Westborg, Ayat Al-Najjar

“…Individuals with registered proliferative diabetic retinopathy (DR) at the start of treatment were excluded. …”
Get full text

Investigation of the Mechanism Underlying Calcium Dobesilate-Mediated Improvement of Endothelial Dysfunction and Inflammation Caused by High Glucose by Yijun Zhou, Chaojun Qi, Shu Li, Xinghua Shao, Zhaohui Ni

“…Calcium dobesilate (CaD) is widely used to treat diabetic retinopathy. Recent studies have demonstrated that CaD exerts protective effects against diabetic nephropathy. …”
Get full text

Knowledge, attitude and practice regarding screening and managing diabetic microvascular complications among general practitioners of community health centres: a cross-sectional st... by Hua Yang, Jian Gao, Ying Yu, Cuiling Huang, Chengdian Lan, Zhangyan Chen

“…Objective To evaluate the knowledge, attitude and practice (KAP) regarding screening and managing diabetic microvascular complications, encompassing diabetic retinopathy (DR), diabetic kidney disease (DKD) and diabetic neuropathy (DN), among general practitioners (GPs).Design Cross-sectional study.Setting The online questionnaire survey was conducted between April and July 2023.Participants GPs from community health centres (CHCs) in all 16 districts of Shanghai were recruited.Primary and secondary outcome measures The data of sociodemographic characteristics, KAP scales, training experience and screening instruments for community screening and managing diabetic microvascular complications were collected. …”
Get full text

Analysis of Retinal Perfusion in Children, Adolescents, and Young Adults with Type 1 Diabetes Using Optical Coherence Tomography Angiography by Chiara Mameli, Alessandro Invernizzi, Alice Bolchini, Giorgio Bedogni, Elisa Giani, Maddalena Macedoni, Gianvincenzo Zuccotti, Chiara Preziosa, Marco Pellegrini

“…Patients underwent funduscopic examination for diabetic retinopathy (DR) screening during an annual visit for the screening of diabetes-related complications which included the evaluation of glycated hemoglobin (HbA1c), microalbuminuria, lipid profile, arterial pressure, and neurological assessment. …”
Get full text

Effect of ethnicity and other sociodemographic factors on attendance at ophthalmology appointments following referral from a Diabetic Eye Screening Programme: a retrospective cohor... by James Banks, Adnan Tufail, Ling Zhi Heng, Josef Huemer, Christopher G Owen, Alicja R Rudnicka, Yasir Khan, Abraham Olvera-Barrios, Michael Seltene, Mumina Khatun, Catherine A Egan, Zoe Ockrim, Matilda Pitt, Daisy Williams, Celestine Rutowska

“…Background/aims To examine the association between sociodemographic characteristics and attendance at Hospital Eye Service (HES) referrals from the Diabetic Eye Screening Programme (DESP), in a large, ethnically diverse urban population.Methods Retrospective cohort study (4 January 2016–12 August 2019) of people with diabetic retinopathy (DR) referred from an English DESP to a tertiary referral eye hospital. …”
Get full text

Prospects of two-port vitrectomy in the treatment of patients with epiretinal fibrosis by D.V. Borisova, I.A. Frolychev, N.A. Pozdeeva

“…Patients with concomitant retinal pathology (e.g. diabetic or post-thrombotic retinopathy) and glaucoma were not included in the study. …”
Get full text

Visual Acuity Outcomes and Influencing Factors in a Cohort of UK Real-World Diabetic Macular Oedema Patients During the First Two Years of Anti-VEGF Treatment by Qing Wen, Helene Karcher, David M. Wright, Samriddhi Buxy Sinha, Usha Chakravarthy, Catarina Santos, Franklin Igwe, Recivall Salongcay, Katie Curran, Tunde Peto

“…The injection number, interval, baseline VA, age, and proliferative diabetic retinopathy (PDR) significantly impacted VA outcomes. …”
Get full text

Risk of Microvascular Complications and Macrovascular Risk Factors in Early-Onset Type 1 Diabetes after at Least 10 Years Duration: An Analysis of Three Population-Based Cross-Sect... by Thaddäus Tönnies, Anna Stahl-Pehe, Christina Baechle, Katty Castillo, Oliver Kuss, Rhuphine Yossa, Lena M. E. Lindner, Reinhard W. Holl, Joachim Rosenbauer

“…We conducted three population-based cross-sectional surveys in Germany (N=1789) to obtain information on exposures and five outcomes (retinopathy, nephropathy, dyslipidemia, hypertension, and a composite endpoint combining all four outcomes). …”
Get full text

Aging-enhanced autophagy activity promotes fibrotic progression via the TGF-β2/Smad signaling pathway in trabecular meshwork cells—a new insight from POAG by Jin Han, Jun Wang, Ling Shen, Yiting Cai, Xuze Wang, Ailixiati Wumaier, Wei Chen, Wei Han

“…IntroductionGlaucoma, a leading cause of irreversible blindness, is characterized by optic neuropathy and retinopathy, with primary open-angle glaucoma (POAG) being the most prevalent form. …”
Get full text

Editorial by Teddy Surya Gunawan

“…Healthcare and safety remain pivotal in this issue, with studies delving into early autism screening using federated learning and diabetic retinopathy detection leveraging deep convolutional neural networks. …”
Get full text

Diagnosis and management of type 2 diabetes mellitus in patients with ischaemic heart disease and acute coronary syndromes - a review of evidence and recommendations by Muhammad Usman Shah, Muhammad Usman Shah, Alun Roebuck, Bala Srinivasan, Joanna Kate Ward, Paul Edward Squires, Claire Elizabeth Hills, Kelvin Lee, Kelvin Lee

“…It is characterised by persistently elevated blood glucose occurring as a result of peripheral insulin resistance and reduced insulin production which may lead to multiple long-term health conditions such as retinopathy, neuropathy, and nephropathy. The estimated number of individuals suffering from diabetes mellitus (DM) is expected to rise to 591 million by the year 2035 with 4.4 million in the United Kingdom (UK) alone, 90% of which is attributed to T2DM. …”
Get full text

Functional tests in children with type 1 diabetes and their correlation with hemoglobin A1c levels by V.R. Abdulina, I.S. Stepanova

“…Dynamic assessment of these parameters will help develop indicators of diabetic retinopathy in children with T1D.</i> </p> <p> <i><b>Keywords</b>: diabetes, ultrasound, optical coherence tomography, glycated hemoglobin.…”
Get full text

Lycium barbarum polysaccharide inhibits retinal neovascularization and inflammation in vitro and in vivo by Bin Wu, Xue Wang, Wei Zhang, Xin Wang, Qi-Miao Wang, Ya-Ju Pang, Yi-Chun Kong

“…In vivo experiments, C57 mice were divided into three groups: control group (normal rearing group), the oxygen-induced ischemic retinopathy (OIR) group, and the OIR with 50 mg/kg LBP group. …”
Get full text

CCAAT/Enhancer-Binding Protein β Mediates Oxygen-Induced Retinal Neovascularization via Retinal Vascular Damage and Vascular Endothelial Growth Factor by Tingting Li, Xuan Cai, Xiangning Wang, Xueyan Zhang, Hui Zhang, Biwei Xu, Shiwei Li, Jianyan Hu, Qiang Wu

“…To evaluate the role of CCAAT/enhancer-binding protein β (C/EBP β) in retinal neovascularization (RNV) in an oxygen-induced retinopathy (OIR) model. Methods. Rats with OIR were exposed to alternating hypoxic and hyperopic conditions for 14 days. …”
Get full text

Response to Aflibercept Therapy in Three Types of Choroidal Neovascular Membrane in Neovascular Age-Related Macular Degeneration: Real-Life Evidence in the Czech Republic by Jan Nemcansky, Alexandr Stepanov, Michal Koubek, Miroslav Veith, Yun Min Klimesova, Jan Studnicka

“…Best-corrected visual acuity (BCVA) and central retinal thickness (CRT) were measured using Early Treatment Diabetic Retinopathy Study (ETDRS) charts and spectral-domain optical coherence tomography (OCT). …”
Get full text

Computational analysis of reproducibility and image quality of 2011 and 2017 models of Heidelberg Spectralis SD-OCT machines by Kyoung A Viola Lee, Corey Tesdahl, Keith Zimmerman, Kimberly Jun, Sabrina Khalil, Alexander Shahin, Abdullah Abou-Samra, Ramesh Ayyala, Radouil Tzekov

“…Methods and testing: TRT measurements were performed using the Posterior Pole Algorithm (PPA) and Early Treatment Diabetic Retinopathy Study (ETDRS) grid protocols. Reproducibility was evaluated using Average Pairwise Pearson Correlation (APPC), while image quality was measured by Signal-to-Noise Ratio (SNR) and Contrast-to-Noise Ratio (CNR). …”
Get full text

Interactive effect of phenylalanine with duration of diabetes on the risk of small vessel disease in Chinese patients with T2DM by Jun Zheng, Wei Zhang, Yu-Yang Miao, Xue-Rui Li, Wei-Ming Luo, Xi-Lin Yang, Zhong-Ze Fang, Qiang Zhang

“…SVD was defined as patients with diabetic nephropathy (DN) or diabetic retinopathy (DR) alone, or both. Serum amino acids were measured by mass spectrometry (MS) technology. …”
Get full text

Therapeutic applications of artemisinin in ophthalmic diseases by Hao Sun, Ping Zhao, Lianghui Zhao, Zhizhong Zhao, Haoyu Chen, Cong Ren, Bin Guo

“…To better explore and perfect the mechanism of action of artemisinin in ophthalmic diseases, and to better promote the clinical application of artemisinin, this study reviews the latest progress of artemisinin treatment for uveitis, uveal melanoma, age-related macular degeneration, diabetic retinopathy, ocular neovascularization, and dry eye, and it will provide theoretical support for the large-scale application of artemisinin in ophthalmic diseases in the future.…”
Get full text