Trimethylamine-N-Oxide Promotes High-Glucose-Induced Dysfunction and NLRP3 Inflammasome Activation in Retinal Microvascular Endothelial Cells by Lidan Xue, Lili Huang, Yajing Tian, Xin Cao, Yu Song

“…Along with blood glucose levels, diabetic retinopathy (DR) development also involves endogenous risk factors, such as trimethylamine-N-oxide (TMAO), a product of intestinal flora metabolic disorder, which exacerbates diabetic microvascular complications. …”
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Retrospective observational cohort study of premature neonates screened for ROP with 7 years of follow-up assessing the visual outcomes and adequacy of preschool visual screening by Emma McAllister, Ruth Hamilton, Eoghan Millar, Alasdair Innes Simpson, Jacqueline Wright

“…Background Very premature infants screened for retinopathy of prematurity (ROP) that do not develop ROP still experience serious visual developmental challenges, and while it is recommended that all children in the UK are offered preschool visual screening, we aimed to explore whether this vulnerable group requires dedicated follow-up.Methods We performed a real-world retrospective observational cohort study of children previously screened for ROP in NHS Greater Glasgow and Clyde (Scotland) between 2013 and 2015. …”
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Prevalence and Risk Factors for Diabetic Lower Limb Amputation: A Clinic-Based Case Control Study by Beverly T. Rodrigues, Venkat N. Vangaveti, Usman H. Malabu

“…Risk factors most closely associated with amputation included diabetic retinopathy (p=0.00, OR 4.4), coronary artery bypass graft (CABG) surgery (p=0.01, OR 4.1), Charcot’s arthropathy (p=0.01, OR 2.9), and Indigenous ethnicity (p=0.01, OR 3.4). …”
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Eales’ Disease in Inuit: A Short Report and Clinical Update by Forshaw TRJ, Moldow B

“…There had been no sign of diabetic retinopathy during diabetic eye screening and the patient had been treated for tuberculosis in 2010. …”
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Prognostic Factor Analysis of Intraocular Pressure with Neovascular Glaucoma by Satoko Nakano, Takako Nakamuro, Katsuhiko Yokoyama, Kunihiro Kiyosaki, Toshiaki Kubota

“…We retrospectively reviewed 142 NVG patients (181 eyes) with ischemic retinal diseases [proliferative diabetic retinopathy (PDR) in 134 eyes, retinal vein occlusion (RVO) in 29, and ocular ischemic syndrome in 18]. …”
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Obesity, Metabolic Health, and Diabetic Complications in People With Type 1 Diabetes by Yuanjie Mao, Jen‐Tzer Gau, Ning Jiang

“…MHN), cardiac autonomic neuropathy (p < 0.001 in both MUO and MUN vs. MHN), retinopathy (p = 0.001 in MUO and p < 0.001 in MUN vs. …”
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High-Resolution Optical Coherence Tomography Retinal Imaging: A Case Series Illustrating Potential and Limitations by Olena Puzyeyeva, Wai Ching Lam, John G. Flanagan, Michael H. Brent, Robert G. Devenyi, Mark S. Mandelcorn, Tien Wong, Christopher Hudson

“…The series comprised four selected cases (one case each) of age-related macular degeneration (ARMD), diabetic retinopathy (DR), central retinal artery occlusion (CRAO), and branch retinal vein occlusion (BRVO). …”
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The Relationship between Diabetes-Related Complications and Obstructive Sleep Apnea in Type 2 Diabetes by Nantaporn Siwasaranond, Hataikarn Nimitphong, Areesa Manodpitipong, Sunee Saetung, Naricha Chirakalwasan, Ammarin Thakkinstian, Sirimon Reutrakul

“…Any diabetes-related complications (retinopathy, neuropathy, nephropathy, or coronary artery disease) were present in 55.5%, and 70.2% of the participants had hypertension. …”
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Intravitreal Melphalan for Vitreous Seeds: Initial Experience in China by Xunda Ji, Peiyan Hua, Jing Li, Jiakai Li, Junyang Zhao, Peiquan Zhao

“…Complications related to intravitreal melphalan included vitreous hemorrhage, cataract, salt-and-pepper retinopathy, and pupil posterior synechia. There was no case of epibulbar extension or systemic metastasis within the period of follow-up. …”
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Association between Genetic Variants and Diabetes Mellitus in Iranian Populations: A Systematic Review of Observational Studies by Mehrnoosh Khodaeian, Samaneh Enayati, Ozra Tabatabaei-Malazy, Mahsa M. Amoli

“…The search terms were “gene,” “polymorphism,” “diabetes,” and “diabetic complications”; nephropathy, retinopathy, neuropathy, foot ulcer, and CAD (coronary artery diseases); and Persian equivalents. …”
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Modern approaches to the treatment of idiopathic epiretinal membrane by V.A. Bogdanova, R.R. Fayzrakhmanov, O.A. Pavlovskiy, E.D. Bosov

“…ERM has been observed in cases of uveitis, retinal detachment, and diabetic retinopathy. In some cases, however, the underlying cause cannot be determined, and the condition is classified as idiopathic. …”
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Incomplete Antenatal Steroid Therapy Can Enhance Outcomes in Preterm Infants with Emergency Conditions by Sebnem Calkavur, Senem Alkan Ozdemir, Ruya Colak, Ezgi Yangin Ergon, Ferit Kulali, Tulin Gokmen Yildirim

“…Mortality and bronchopulmonary dysplasia at discharge and stage ≥2 retinopathy were analyzed as secondary outcomes. RESULTS: We found that 54 infants were born with an incomplete dose, 55 infants with complete dose and 38 infants with no steroid therapy. …”
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Distribution of Pupil Size and Associated Factors: Results from the Population-Based Gutenberg Health Study by Marian Kiel, Stephanie D. Grabitz, Susanne Hopf, Thomas Koeck, Philipp S. Wild, Irene Schmidtmann, Karl J. Lackner, Thomas Münzel, Manfred E. Beutel, Norbert Pfeiffer, Alexander K. Schuster

“…This should be taken into account when planning nonmydriatic fundus photography-based screening programs, for instance, for diabetic retinopathy.…”
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Efficacy Comparison of Intravitreal Anti-VEGF Therapy for Three Subtypes of Neovascular Age-Related Macular Degeneration: A Systematic Review and Meta-Analysis by Jianqing Li, Jiayi Xu, Yiyi Chen, Jiaju Zhang, Yihong Cao, Peirong Lu

“…At 12 months, the mean changes in Early Treatment of Diabetic Retinopathy Study (ETDRS) letters were 6.38, 8.12, and 9.37, while the MT decrease was 126.51, 126.52, and 139.85 μm, respectively. …”
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Automated Detection of Macular Diseases by Optical Coherence Tomography and Artificial Intelligence Machine Learning of Optical Coherence Tomography Images by Soichiro Kuwayama, Yuji Ayatsuka, Daisuke Yanagisono, Takaki Uta, Hideaki Usui, Aki Kato, Noriaki Takase, Yuichiro Ogura, Tsutomu Yasukawa

“…The diagnoses involved normal eyes (n=570) and those with wet age-related macular degeneration (AMD) (n=136), diabetic retinopathy (DR) (n=104), epiretinal membranes (ERMs) (n=90), and another 19 diseases. …”
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Prevalence of Chronic Complications, Their Risk Factors, and the Cardiovascular Risk Factors among Patients with Type 2 Diabetes Attending the Diabetic Clinic at a Tertiary Care Ho... by Maulee Hiromi Arambewela, Noel P. Somasundaram, Hettiarachchige Buddhi Pradeep Ranjan Jayasekara, Mahesh P. Kumbukage, Pulukkutti Mudiyanselage Sarath Jayasena, Chandrasekara Mudalige Priyanka Hemanthi Chandrasekara, Kurukulasuriya Ravindra Alexis Sudath Fernando, Divadalage Priyantha Kusumsiri

“…Prevalence of CAD, stroke, and peripheral vascular disease were 10.6%, 1.1%, and 4.7% while diabetic retinopathy, neuropathy, nephropathy, diabetic foot, and lower extremity amputation (LEA) were 26.1%, 62.6%, 50.8%, 2.6%, and 1.3%, respectively. …”
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Sub-Clinical Regional Macular Changes in Self-Reported Diabetic Subjects: Vascular and Retinal Layer Analysis Using Swept-Source OCT by Challa NK, Alghamdi WM, Alluwimi MS, Alshammeri S

“…Duration of diabetes has shown a significantly high positive correlation (r = 0.77, P < 0.01) with superior macular VD.Conclusion: The findings of this study suggest that the diabetic macula experiences significant ganglion cell layer (GCL) thinning and reduced superficial capillary plexus (SCP) vascular density even before the onset of clinical retinopathy. Swept-source OCT proves to be an essential tool for detecting these early changes in diabetic patients.Keywords: tomography, age, RNFL, SCPVD, FAZ, diabetes mellitus…”
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The protective role of GLP-1 in neuro-ophthalmology by Sohum Sheth, Aashay Patel, Marco Foreman, Mohammed Mumtaz, Akshay Reddy, Ramy Sharaf, Siddharth Sheth, Brandon Lucke-Wold

“…Furthermore, the preclinical works which unravel the effects of GLP-1 in ocular dynamics and the preclinical literature regarding GLP-1RA use in the management of several neuro-ophthalmic conditions, including diabetic retinopathy (DR), glaucoma, and idiopathic intracranial hypertension (IIH) are discussed.…”
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Ocular Aberrations and Retinal Thickness Variations After Moderate-Term Reading on Electronic Devices by Age by María Arcas-Carbonell, Elvira Orduna-Hospital, María Mechó-García, María Munarriz-Escribano, Ana Sanchez-Cano

“…Parameters such as total aberration, high-order aberration (HOA), low-order aberration (LOA), and retinal thickness in the nine Early Treatment Diabetic Retinopathy Study (ETDRS) areas were measured. The sample was analyzed as a whole and divided into five age groups by decade. …”
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Analysis of the morbidity characteristics and related factors of pulmonary nodules in patients with type 2 diabetes mellitus: a retrospective study by Jie Yang, Wenna Wang, Yizhen Lu, Chunyao Li, Shuwu Wei, Weiwei Sun

“…Results Compared to the non-PNs group, the PNs Patients in the group had a longer duration of diabetes, higher age, serum creatinine (SCR), blood urea nitrogen (BUN) and the lower albumin (ALB) and body mass index (BMI); women, diabetic retinopathy (DR), diabetic peripheral neuropathy (DPN), and estimated glomerular filtration rate (eGFR) < 60 ml/min1.73m2 were more represented in the PNs group; there were fewer patients with overweight in the PNs group. …”
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