CryoEM structure and small-angle X-ray scattering analyses of porcine retinol-binding protein 3 by Vineeta Kaushik, Luca Gessa, Nelam Kumar, Matyáš Pinkas, Mariusz Czarnocki-Cieciura, Krzysztof Palczewski, Jiří Nováček, Humberto Fernandes

“…To function effectively, retinoids must shuttle between these two cell types. …”
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Trifarotene alleviates skin photoaging injury by inhibition of JNK/c-Jun/MMPs by Fei Xuan, Yang Lele Zixin, Zhang Jingjing, Li Xiang, Pan Mengtian, Xu Guangchen, Zhang Cuixia, Liu Fei, Fang Weirong

“…Multiple approaches (topical or systemic retinoids, antioxidants, alpha-hydroxy acids, laser, surgery) are used in the treatment of photoaged skin, and the use of topical retinoids is currently a primary clinical treatment. …”
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Clinical and Histopathological Findings in a Patient of Darier–White Disease with Acrokertasosis Verruciformis of Hopf by Vikash Paudel, Manish Bhakta Pradhan, Brijesh Shrestha, Sumit Paudel

“…Although there are no curative treatments for DD, topical corticosteroids and systemic retinoids may be used to control inflammation and hyperkeratosis. …”
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Disseminate and Recurrent Infundibular Folliculitis: Case Report and Literature Review by Qifeng Meng, Qunyan Li, Yingdong Wang, Haoran Li, Yu Zhang

“…This disease is diagnosed based on clinical features and histopathology and is preferentially treated with retinoids.…”
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Impact of Retinoic Acid on Immune Cells and Inflammatory Diseases by Luana de Mendonça Oliveira, Franciane Mouradian Emidio Teixeira, Maria Notomi Sato

“…Although vitamin A is crucial for maintaining homeostasis at the intestinal barrier and equilibrating immunity and tolerance, including gut dysbiosis, retinoids perform a wide variety of functions in many settings, such as the central nervous system, skin aging, allergic airway diseases, cancer prevention and therapy, and metabolic diseases. …”
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Promising New Treatments for Psoriasis by Sarah Dubois Declercq, Roxane Pouliot

“…Currently, several treatments are available to help control psoriasis such as methotrexate, ciclosporin, and oral retinoids. However, the available treatments are only able to relieve the symptoms and lives of individuals. …”
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Mediators of Inflammation in Topical Therapy of Skin Cancers by Vlad Mihai Voiculescu, Cristina Victoria Lisievici, Mihai Lupu, Cristina Vajaitu, Carmen Cristina Draghici, Alexandra Victoria Popa, Iulia Solomon, Teona Ioana Sebe, Maria Magdalena Constantin, Constantin Caruntu

“…The latest data suggest that therapies such as imiquimod (IMQ), ingenol mebutate (IM), 5-fluorouracil (5-FU), retinoids, and nonsteroidal anti-inflammatory drugs (NSAIDs) have been used with success in the topical treatment of some cancers. …”
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Diet-Induced Adipocyte Browning by Oskar Wojciech Wiśniewski, Aleksander Rajczewski, Agnieszka Szumigała, Magdalena Gibas-Dorna

“…We discuss browning properties of amino acids, carbohydrates, fatty acids, and retinoids, as well as present adipocyte browning potential of the wide range of non-nutrients, including glucosinolates, alkaloids, terpenes and terpenoids, flavonoids and other phenolic compounds. …”
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Exploring The Influence Of Vitamin D In The Management Of Acne Vulgaris: A Pilot Study by Aqsa Naheed, Aashi Mughal, Tehzeeb Zehra, Rahila Aamir, Samina Fida, Taha Naveed

“…Exclusion criteria included the use of topical or oral treatments for acne, including retinoids, as well as those with a history of multivitamin or systemic steroid intake, and patients with any chronic disease. …”
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Therapeutic Implications of PPARγ in Human Osteosarcoma by Eric R. Wagner, Bai-Cheng He, Liang Chen, Guo-Wei Zuo, Wenli Zhang, Qiong Shi, Qing Luo, Xiaoji Luo, Bo Liu, Jinyong Luo, Farbod Rastegar, Connie J. He, Yawen Hu, Barrett Boody, Hue H. Luu, Tong-Chuan He, Zhong-Liang Deng, Rex C. Haydon

“…Thus, safe and effective PPAR agonists and/or retinoid derivatives can be then used as adjuvant therapeutic drugs for OS therapy. …”
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Prolonged Serum Alanine Aminotransferase Elevation Associated with Isotretinoin Administration by Roya S. Nazarian, Elizabeth Zheng, Caroline Halverstam, Steven R. Cohen, Allan W. Wolkoff

“…Isotretinoin is a highly effective oral retinoid derivative for severe forms of acne. Despite its high margin of safety, isotretinoin carries a risk of teratogenicity and mild to massive elevations of serum cholesterol and triglyceride levels, as well as infrequent transaminitis. …”
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Identification of Macrophage Genotype and Key Biological Pathways in Circulating Angiogenic Cell Transcriptome by Bert R. Everaert, Steven J. Van Laere, Robrecht Lembrechts, Vicky Y. Hoymans, Jean-Pierre Timmermans, Christiaan J. Vrints

“…Pathway analysis revealed previously unrecognized biological processes in CACiv, such as riboflavin metabolism and liver X receptor (LXR)/retinoid X receptor (RXR) and farnesoid X receptor (FXR)/retinoid X receptor (RXR) pathways. …”
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Influence of the Number of Axial Bexarotene Ligands on the Cytotoxicity of Pt(IV) Analogs of Oxaliplatin by Yulia N. Nosova, Ilia V. Zenin, Varvara P. Maximova, Ekaterina M. Zhidkova, Kirill I. Kirsanov, Ekaterina A. Lesovaya, Anna A. Lobas, Mikhail V. Gorshkov, Olga N. Kovaleva, Elena R. Milaeva, Markus Galanski, Bernhard K. Keppler, Alexey A. Nazarov

“…We present the synthesis and cytotoxic potencies of new Pt(IV) complexes with bexarotene, an anticancer drug that induces cell differentiation and apoptosis via selective activation of retinoid X receptors. In these complexes bexarotene is positioned as an axial ligand. …”
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Tolerance to Systemic Isotretinoin Therapy in Two Patients Using Highly Wettable Contact Lenses by Ayşegül Arman, D. Deniz Demirseren, Gulsen Akoglu

“…Highly wettable contact lenses that provide increase in the tear film stability may be used during systemic retinoid therapy under close followups. Although isotretinoin affects ocular glands, the differences between tolerances to this retinoid therapy need to be investigated in larger patient groups using contact lenses.…”
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The Role of the Enterohepatic Circulation of Bile Salts and Nuclear Hormone Receptors in the Regulation of Cholesterol Homeostasis: Bile Salts as Ligands for Nuclear Hormone Recept... by Richard N Redinger

“…It is the coordinated action of LXR and FXR, each dimerized to retinoid X receptor, that signal nuclear DNA response elements to encode proteins that prevent excessive cholesterol accumulation and bile salt toxicity, respectively. …”
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Activated receptors for peroxisomic proliferators. Its role in the atherosclerosis, obesity and high blood pressure. by Mikhail Benet Rodríguez, Yosvel Curbelo Pérez

“…These receptors join to direct hexameric repetitions in the form of heterodimers with the retinoid receptor. PPAR receptors regulate the expressions of a great variety of genes that codify the proteins that are implied in the lipid metabolism, the energetic homeostasis, the cellular differentiation and the formation of tumours. …”
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Solution Structures of PPARγ2/RXRα Complexes by Judit Osz, Maxim V. Pethoukhov, Serena Sirigu, Dmitri I. Svergun, Dino Moras, Natacha Rochel

“…PPARγ must heterodimerize with its dimeric partner, the retinoid X receptor (RXR), to bind DNA and associated coactivators such as p160 family members or PGC-1α to regulate gene networks. …”
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Identification of Bexarotene as a PPARγ Antagonist with HDX by David P. Marciano, Dana S. Kuruvilla, Bruce D. Pascal, Patrick R. Griffin

“…The retinoid x receptors (RXRs) are the pharmacological target of Bexarotene, an antineoplastic agent indicated for the treatment of cutaneous T cell lymphoma (CTCL). …”
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Diagnosis dan Tatalaksana Steatosistoma by Puridelko Kampar, Sri Lestari

“…Masih belum ada terapi standar untuk steatosistoma, terapi sistemik dengan pemberian retinoid oral, tetrasiklin 1 g/ hari, atau minosiklin 100-200 mg/ hari. …”
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The Key to Unlocking the Chemotherapeutic Potential of PPARγ Ligands: Having the Right Combination by Graham Skelhorne-Gross, Christopher J. B. Nicol

“…In spite of this, several groups reported exciting results with therapeutic regimens that combine PPARγ ligands with other compounds: chemotherapeutic agents, retinoid x receptor (RXR)α agonists, statins, or cell-to-cell signaling molecules in preclinical cancer models and human trials. …”
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