Treatment Efficacy and Compliance in Patients with Diabetic Macular Edema Treated with Ranibizumab in a Real-Life Setting by Anne-Laurence Best, Franck Fajnkuchen, Sylvia Nghiem-Buffet, Typhaine Grenet, Gabriel Quentel, Corinne Delahaye-Mazza, Salomon Y. Cohen, Audrey Giocanti-Aurégan

“…Patients were monitored every 4 weeks for visual acuity (VA) and central retinal thickness (CRT) by SD-OCT. All patients received a loading dose of 3 monthly injections followed by retreatments on an as-needed basis. …”
Get full text

Comparative the effect of bisphenol A and bisphenol S on the development and spectral sensitivity of cone photoreceptors in zebrafish larvae (Danio rerio) by Liguo Qiu, Peng Yu, Qiang Li, Cuiping Wen, Haiyang Wang, Dongying Zhao, Tianyu Zhang, Chenghui Wang, Lixia Liu, Dongxue Li, Shiyong Wen, Yinghui Sun

“…Our data indicate that both BPS and BPA exposure can interfere with the development of cone cells, and two types of compounds disturb the transduction of photon signals within cone cells in different ways, which further impaired the retinal spectral sensitivity to the light signal. …”
Get full text

Efficacy of adalimumab in pediatric non-infectious uveitis with and without anterior segment inflammation by Chunbo Zhang, Xiaorong Xue, Jinan Xiao, Qiongge Li, Yuyao Zhai, Ying Chen

“…Secondary outcomes including best-corrected visual acuity (BCVA), inflammation parameters [anterior chamber cell (ACC), vitreous haze (VH)], retinal nerve fiber layer (RNFL) thickness, fluorescein angiography (FA) scores, as well as systemic immunosuppression therapy (IMT) and glucocorticoid load, were assessed. …”
Get full text

Association between systemic inflammatory response index and glaucoma incidence from 2005 to 2008 by Xiang Li, Yi Qing Sun, Xiao Dan Zhong, Zhi Jie Zhang, Jia Feng Tang, Zhan Yang Luo

“…Among participants who underwent non-mydriatic retinal imaging and Frequency Doubling Technology (FDT) visual field testing, 4,514 were included after excluding those with missing key variable data. …”
Get full text

Outcomes and Complications of Sutured Scleral-Fixated Foldable Intraocular Lens Implantation: A Retrospective Study of 5-Year Follow-Up by Ting Yu, Mengting Yu, Wenjie Wu, Xinna Wu, Suzhen Xiao, Jialiang Mao, Yanling Wang

“…Secondary epimacular membrane occurred in 5 eyes (9.62%) and retinal detachment (RD; 3 years postsurgery), subconjunctival suture knot exposure (5 years postsurgery), and persistent elevated IOP (in a GRAVES patient) occurred in 1 eye (1.92%) each. …”
Get full text

Peripapillary and Macular Flow Changes in Nonarteritic Anterior Ischemic Optic Neuropathy (NAION) by Optical Coherence Tomography Angiography (OCT-A) by Juejun Liu, Changzheng Chen, Lu Li, Zuohuizi Yi, Hongmei Zheng

“…Measures of the thickness of the peripapillary retinal nerve fiber layer (wRNFL) and macular ganglion cell complex (wGCC) of the whole image in SD-OCT, vessel density of the RPC (wRPC) and superficial and deep vascular complexes (wSVD, wDVD) in the whole image of OCT-A, and their superior- and inferior-hemi values (s/iRNFL, s/iGCC, s/iRPC, and s/iSVD) were assessed. …”
Get full text

Impact of Hyperglycemia on Tear Film and Meibomian Gland Dysfunction: A Cross-Sectional Study by Meng F, Zhou Y, Bao T, Pang Y, Shao Q, Wang L, Zhao J, Li W, Xu H, Yang Y, Zhang B

“…Fanhua Meng,1,* Yuan Zhou,2,* Tong Bao,1,* Yunlei Pang,1 Qinglei Shao,1 Lifeng Wang,1 Jing Zhao,1 Wenchao Li,1 Haiyan Xu,1 Yajun Yang,1,2 Bozhou Zhang1,2 1Department of Retinal, Chifeng Chaoju Eye Hospital, Chifeng, People’s Republic of China; 2Department of Ocular Surface, Baotou Chaoju Eye Hospital, Baotou, People’s Republic of China*These authors contributed equally to this workCorrespondence: Yajun Yang; Bozhou Zhang, Department of ocular surface, Baotou Chaoju Eye Hospital, Baotou, Inner Mongolia Autonomous Region, 014060, People’s Republic of China, Email yangyajun@chaojueye.com; zhangbozhou@chaojueye.comPurpose: Elevated blood glucose levels may disrupt tear film and meibomian gland function, contributing to dry eye disease (DED) and meibomian gland dysfunction (MGD). …”
Get full text

Short-Term and Long-Term Effects of Bariatric Surgery on Diabetic Retinopathy: A Systematic Review by Erika Butkutė, Monika Zieniūtė, Agnė Morkūnaitė, Vilma Jūratė Balčiūnienė

“…This review seeks to evaluate the short- and long-term retinal outcomes of BS in diabetic patients. <i>Materials and Methods</i>: A systematic search of PubMed, Web of Science, and Cochrane Library was conducted following PRISMA 2020 guidelines, including the use of the PRISMA checklist and flow diagram. …”
Get full text

Contralateral Posterior Chamber Phakic Intraocular Lens Implantation as Rehabilitation of Refractive Lens Exchange with a Monofocal Intraocular Lens in a Young, Nonpresbyopic, Bila... by Kepa Balparda, Claudia Marcela Vanegas-Ramírez, Laura Segura-Muñoz, Manuela Gómez-Londoño

“…RLE in young pre-presbyopic highly myopic patients may not be an advisable alternative in most cases, because of the high risks of retinal complications observed. In addition, eliminating accommodation will cause significant limitations, and multifocal IOLs currently available are far from the quality of vision that a young human crystalline lens yields. …”
Get full text

Oxidative stress and retinopathy: evidence from epidemiological studies by Xiangliang Liu, Yu Chang, Yuguang Li, Yingrui Liu, Wei Song, Jin Lu, Naifei Chen, Jiuwei Cui

“…Conclusion Our study provides evidence that higher cumulative antioxidant exposure assessed by OBS is associated with a reduced risk and severity of retinopathy and lower all-cause mortality in U.S. adults with retinopathy, highlighting the importance of maintaining a favorable oxidative balance in retinal health.…”
Get full text

Shared Genes and Pathways in Ulcerative Colitis and Ankylosing Spondylitis: Functional Validation and Implications for Diagnosis by Li L, An G, Li F, Zhang D, Zhu X, Liang C, Zhao Y, Xie K, Zhou P, Zhu H, Jin X, Du L

“…Lin Li,&ast; Guangqi An,&ast; Fuzhen Li,&ast; Donghui Zhang, Xinyue Zhu, Chunyu Liang, Yu Zhao, Kunpeng Xie, Pengyi Zhou, Haiyan Zhu, Xuemin Jin,&ast; Liping Du&ast; Department of Ophthalmology, The First Affiliated Hospital of Zhengzhou University, Henan Province Eye Hospital, Henan International Joint Research Laboratory for Ocular Immunology and Retinal Injury Repair, Zhengzhou, Henan, People’s Republic of China&ast;These authors contributed equally to this workCorrespondence: Xuemin Jin; Liping Du, Department of Ophthalmology, The First Affiliated Hospital of Zhengzhou University, No. 1 Jianshe East Road, Zhengzhou, 450000, People’s Republic of China, Tel +8613603983193 ; +8613838191481, Email jinxuemin@zzu.edu.cn; dulplab@live.cnBackground: Associations between ulcerative colitis (UC) and ankylosing spondylitis (AS) have been reported in multiple studies, but the common etiologies of UC and AS remain unknown. …”
Get full text

Topographic correlation of microperimetry with foveal microstructure characteristics in idiopathic epiretinal membrane patients with an ectopic inner foveal layer by Qianqian Wang, Congyao Wang, Yihua Su, Fenfen Yu, Tingting Chen, Xia Dong, Pengxia Wan

“…Conclusions The presence of EIFL and decreased VD in the parafoveal region, factors that collectively elevate the risk of disease progression, are significantly and independently correlated with reduced microperimetric retinal sensitivity in patients with idiopathic ERM.…”
Get full text

Three-Year Outcomes of Patients with Neovascular Age-Related Macular Degeneration Treated with Aflibercept under the National Health Insurance Program in Taiwan by Kang-Jung Lo, Jin-Yu Chang, Hsin-Yi Chang, Shih-Hwa Chiou, De-Kuang Hwang, Shih-Jen Chen

“…Multivariate analysis showed that final VA was significantly associated with VA at year 1, the presence of retinal pigment epithelial detachment at year 1, and receiving more than four injections in the first year. …”
Get full text

Optical Coherence Tomography May Help Distinguish Glaucoma from Suprasellar Tumor-Associated Optic Disc by Michael Mimouni, Hadas Stiebel-Kalish, Irena Serov, Gabriel Chodick, Mohammad Zbedat, Dan D. Gaton

“…The main outcome measures were the retinal nerve fiber layer (RNFL) thickness, disc area, cup volume, cup/disc ratio, and rim area. …”
Get full text

Subthreshold Micropulse Laser (577 nm) Therapy with an Individual Approach for Power Titration in Patients with Chronic Central Serous Chorioretinopathy (Pilot Study) by Taras Kustryn, Oleg Zadorozhnyy, Illia Nasinnyk, Nataliya Pasyechnikova, Andrii Korol

“…The secondary outcome measures were as follows: central retinal thickness (CRT) and maximum subretinal fluid height (SRFH) according to optical coherence tomography, number of laser sessions, and treatment safety at 6-month follow-up. …”
Get full text

Evaluation of Changes in Macular Perfusion Detected by Optical Coherence Tomography Angiography following 3 Intravitreal Monthly Bevacizumab Injections for Diabetic Macular Edema i... by Ayman G. Elnahry, Ahmed A. Abdel-Kader, Karim A. Raafat, Khaled Elrakhawy

“…Pretreatment and posttreatment OCTA images were automatically aligned using a commercially available retina alignment software (i2k Align Retina software); then the fractal dimension (FD), vascular density (VD), and skeleton VD changes were obtained at the full retinal thickness (Full) and superficial (SCP) and deep (DCP) capillary plexuses after processing images using a semiautomated program. …”
Get full text

Derivation and Characterization of Isogenic <i>OPA1</i> Mutant and Control Human Pluripotent Stem Cell Lines by Katherine A. Pohl, Xiangmei Zhang, Johnny Jeonghyun Ji, Linsey Stiles, Alfredo A. Sadun, Xian-Jie Yang

“…Although <i>OPA1</i> is broadly expressed, human <i>OPA1</i> mutations predominantly affect retinal ganglion cells (RGCs) that are responsible for transmitting visual information from the retina to the brain. …”
Get full text

Early impairment of magnocellular visual pathways mediated by isolated-check visual evoked potentials in primary open-angle glaucoma: a cross-sectional study by Yangfan Yang, Minbin Yu, Zidong Chen, Qiaona Ye, Yanmei Fan, Pingping Liu, Zitian Liu, Kezheng Xu

“…The SNRs at 8% and 32% depths of modulation (DOM) were significantly correlated with temporal-side retinal nerve fibre layer (RNFL) thickness in early POAG in MC-biased stimulation (p=0.017, p=0.020, respectively). …”
Get full text

The Role of OCT Angiography in the Assessment of Epiretinal Macular Membrane by Daniela Bacherini, Francesco Dragotto, Tomaso Caporossi, Chiara Lenzetti, Lucia Finocchio, Alfonso Savastano, Maria Cristina Savastano, Francesco Barca, Martina Dragotto, Lorenzo Vannozzi, Francesco Nasini, Francesco Faraldi, Stanislao Rizzo, Gianni Virgili, Fabrizio Giansanti

“…The FAZ area and perimeter after surgery significantly increased during the follow-up (p < 0.001) at baseline retinal and choroidal plexi with a lower PD or VD correlated with worse visual acuity (p < 0.05 for all plexi). …”
Get full text

Early Detection of Microvascular Changes in Patients with Diabetes Mellitus without and with Diabetic Retinopathy: Comparison between Different Swept-Source OCT-A Instruments by Stela Vujosevic, Caterina Toma, Edoardo Villani, Valentina Gatti, Marco Brambilla, Andrea Muraca, Maria Chantal Ponziani, Gianluca Aimaretti, Alessandro Nuzzo, Paolo Nucci, Stefano De Cilla’

“…Further, larger longitudinal studies are needed to better understand microvascular damage at very early stages of diabetic retinal disease and to define the strengths and weaknesses of different OCT-A devices.…”
Get full text